Uploaded October 2021 | Updated September 2026, 3 days ago
Is it possible that Motor Proteins are a result of Darwinian Evolution or even Extended Modern Synthesis?
Can you imagine a large city without any transportation system, roads, or traffic?
Eukaryotic cells are like huge cities that demand the presence of such a system!
Motor proteins are magnificent nano-robots that move materials, products, and even organelles around in the cell, from target to destination, using a dynamic system of "railroads", and powered by the same ATP hydrolysis chemical energy cycle of the cell to produce walking-like motion.
You have to see those motors to appreciate how much they resemble robots and how elegant and graphic their motility and interaction with cargo in the cell is unmistakably intricately designed for the purposes of the cell. Kinesin and Dynein motors move along Microtubules, a special linear structure that assembles and disassembles to produce railroads or tracks for the motors to move along! The motors come in families with hundreds of variants each, and even come with adaptors that make the various types specifically suited or specialized according to cargo type!
Eukaryotic cells cannot survive without the function of motor proteins like kinesin and dynein, but the motors are not present in Prokaryotes which have a much smaller size and no compartmentalization like the eukaryotic cells. The latter would even depend on Microtubules and Motors during its own very critical job of splitting up of chromatin during cell division, hence reproduction, and its very survival.
This poses a set of challenges to the Theory of Evolution that can be quite paradoxical too, some of which are:
1. Specificity and intricacy of the integrated design of the motors themselves and with other components of the system including the Microtubules, ATP catalysis, and the cargo itself, makes it astronomically unlikely that those systems can evolve or co-evolve using Darwinian mechanisms based on "random" mutation and natural selection.
2. The absence of motors in prokaryotes defies the hypothesis than eukaryotes have evolve from them.
3. The chicken or egg paradox between the existence of the system in eukaryotes and the very existence of eucayotes that cannot exist without their motors and tubules setup, even for the very basic function of cell division, set aside the essential cargo distribution role!
Read more, with references about the topic on article 5 of the evolution course, for more:
findingtruthchannel.com/courses/is-evolution-true-or-false/lessons/article-5-motor-proteins-an-engineering-marvel
And join the course here: findingtruthchannel.com/courses/is-evolution-true-or-false
===
Some of the videos partially shown during the session for educational purposes:
A very interesting video explaining the catalytic process here: youtu.be/YAva4g3Pk6k
The Workhorse of the Cell: Kinesin: youtu.be/gbycQf1TbM0
Kinetochore and Mitosis: youtu.be/IvJrDsRuWxQ
===
References:
Read this article in nature to appreciate the complexity of one of the motor protein families (Kinesin) and its various specialties in the cell (Kinesin superfamily motor proteins and intracellular transport: nature.com/articles/nrm2774?proof=t).
Read about microtubules here: en.wikipedia.org/wiki/Microtubule
Read: Scientists discover a molecular motor has a ‘gear’ for directional switching: phys.org/news/2017-01-scientists-molecular-motor-gear.html
It should be interesting to read this article to notice how we, humans, are reverse engineering this brilliant transport system to unlock now horizons in nanotechnology and synthetic chemistry (arstechnica.com/science/2013/11/with-dna-and-proteins-researchers-build-transit-for-lugging-molecular-cargo
Read: Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin: sciencedirect.com/science/article/pii/S096098221930689X
A recent amazing study uncovered a shocking mechanism, where a specific type of kinesin motors is guided to ferry chromosomal motion during mitosis: Read from phys.org/news/2015-05-cell-division-chromosomes-microtubule-highway.html
Patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeleton: ncbi.nlm.nih.gov/pmc/articles/PMC2867816
Estimation of functionally beneficial proteins: sciencedirect.com/science/article/abs/pii/S0022283604007624
===
For more like this:
Don't forget to subscribe to the website for content notifications, courses, and more:
Web: findingtruthchannel.com/register
FB: facebook.com/c/findingturthchannel
YT: YouTube.com/c/findingtruthchannel
===
#MotorProtiens #Kinesin #Evolution
Watch, like, and share with loved ones:
youtu.be/WdANj90TirQ
Is it possible that Motor Proteins are a result of Darwinian Evolution or even Extended Modern Synthesis?
Can you imagine a large city without any transportation system, roads, or traffic?
Eukaryotic cells are like huge cities that demand the presence of such a system!
Motor proteins are magnificent nano-robots that move materials, products, and even organelles around in the cell, from target to destination, using a dynamic system of "railroads", and powered by the same ATP hydrolysis chemical energy cycle of the cell to produce walking-like motion.
You have to see those motors to appreciate how much they resemble robots and how elegant and graphic their motility and interaction with cargo in the cell is unmistakably intricately designed for the purposes of the cell. Kinesin and Dynein motors move along Microtubules, a special linear structure that assembles and disassembles to produce railroads or tracks for the motors to move along! The motors come in families with hundreds of variants each, and even come with adaptors that make the various types specifically suited or specialized according to cargo type!
Eukaryotic cells cannot survive without the function of motor proteins like kinesin and dynein, but the motors are not present in Prokaryotes which have a much smaller size and no compartmentalization like the eukaryotic cells. The latter would even depend on Microtubules and Motors during its own very critical job of splitting up of chromatin during cell division, hence reproduction, and its very survival.
This poses a set of challenges to the Theory of Evolution that can be quite paradoxical too, some of which are:
1. Specificity and intricacy of the integrated design of the motors themselves and with other components of the system including the Microtubules, ATP catalysis, and the cargo itself, makes it astronomically unlikely that those systems can evolve or co-evolve using Darwinian mechanisms based on "random" mutation and natural selection.
2. The absence of motors in prokaryotes defies the hypothesis than eukaryotes have evolve from them.
3. The chicken or egg paradox between the existence of the system in eukaryotes and the very existence of eucayotes that cannot exist without their motors and tubules setup, even for the very basic function of cell division, set aside the essential cargo distribution role!
Read more, with references about the topic on article 5 of the evolution course, for more:
findingtruthchannel.com/courses/is-evolution-true-or-false/lessons/article-5-motor-proteins-an-engineering-marvel
And join the course here: findingtruthchannel.com/courses/is-evolution-true-or-false
===
Some of the videos partially shown during the session for educational purposes:
A very interesting video explaining the catalytic process here: youtu.be/YAva4g3Pk6k
The Workhorse of the Cell: Kinesin: youtu.be/gbycQf1TbM0
Kinetochore and Mitosis: youtu.be/IvJrDsRuWxQ
===
References:
Read this article in nature to appreciate the complexity of one of the motor protein families (Kinesin) and its various specialties in the cell (Kinesin superfamily motor proteins and intracellular transport: nature.com/articles/nrm2774?proof=t).
Read about microtubules here: en.wikipedia.org/wiki/Microtubule
Read: Scientists discover a molecular motor has a ‘gear’ for directional switching: phys.org/news/2017-01-scientists-molecular-motor-gear.html
It should be interesting to read this article to notice how we, humans, are reverse engineering this brilliant transport system to unlock now horizons in nanotechnology and synthetic chemistry (arstechnica.com/science/2013/11/with-dna-and-proteins-researchers-build-transit-for-lugging-molecular-cargo
Read: Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin: sciencedirect.com/science/article/pii/S096098221930689X
A recent amazing study uncovered a shocking mechanism, where a specific type of kinesin motors is guided to ferry chromosomal motion during mitosis: Read from phys.org/news/2015-05-cell-division-chromosomes-microtubule-highway.html
Patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeleton: ncbi.nlm.nih.gov/pmc/articles/PMC2867816
Estimation of functionally beneficial proteins: sciencedirect.com/science/article/abs/pii/S0022283604007624
===
For more like this:
Don't forget to subscribe to the website for content notifications, courses, and more:
Web: findingtruthchannel.com/register
FB: facebook.com/c/findingturthchannel
YT: YouTube.com/c/findingtruthchannel
===
#MotorProtiens #Kinesin #Evolution
Watch, like, and share with loved ones:
youtu.be/WdANj90TirQ
