Ketamine Therapy: Does it Work? @pbsvitals
Ketamine Therapy: Does it Work?  @pbsvitals
Uploaded April 2023 | Updated September 2026, 1 week ago
Interest in ketamine therapy has jumped off since its rapid-acting antidepressant effects were first discovered. The therapy has been a huge boon for people with treatment-resistant depression, or folks who’ve tried all kinds of typical antidepressant treatments with no luck. But is ketamine therapy right for you? And what should we make of the rapidly growing ketamine telehealth industry? Vitals host Alok Patel answers all your questions and more, with the help of Dr. Gerard Sanacora of the Yale Depression Research Program and Dr. Hannah McLane, a ketamine-assisted therapy provider.

🩺🥼 Vitals is a series that’s taking a new approach to health and medicine. Hosts Alok Patel, MD, and Sheena Williams RN are going beyond the headlines to answer your questions on the latest health topics. No judgment, no taboos. Just 100% science-based information.

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Find our experts and hosts:

:: Sheena William, RN ::
Twitter: @Keepingitkinky1
Instagram: @keepingitkinky

:: Alok Patel, MD ::
Website: alokpatelmd.com
Twitter: @AlokPatelMD
Instagram: @alokpatelmd

:: Hannah McLane, MD MPH::
Instagram: @drhannah.io
Website: https://soundmind.center/drhannah

:: Gerard Sanacora, MD PhD::
Professor of Psychology, Yale School of Medicine; Director, Yale Depression Research Program.

The exact mechanisms by which ketamine interacts with the neurotransmitter glutamate are not fully understood. To learn more, check out the following article: nature.com/articles/s41380-021-01246-3

To learn more about ketamine therapy:
- cambridge.org/core/journals/bjpsych-open/article/ketamine-for-the-treatment-of-mental-health-and-substance-use-disorders-comprehensive-systematic-review/36E261BFA62CDA6459B88F7777415FDA
- smithsonianmag.com/science-nature/a-brief-history-of-ketamines-use-to-treat-depression-180980106
- nytimes.com/2023/02/20/us/ketamine-telemedicine.html
- webmd.com/depression/features/what-does-ketamine-do-your-brain

This episode of Vitals is licensed exclusively to YouTube.


00:00 What is ketamine therapy?
02:03 How it works: what we know
03:00 Who's it for?
03:27 Esketamine vs. Ketamine
04:31 Off-label ketamine therapy
05:09 Ketamine via telemedicine?
06:54 Ketamine uses under study?
07:49 Ketamine-assisted psychotherapy
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Ketamine Therapy: Does it Work?

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