Metabolic Mind | Improving Quality of Life in Bipolar Disorder - with Mayo Clinic's Dr. Mark Frye @metabolicmind | Uploaded February 2024 | Updated October 2024, 3 hours ago.
Individuals with bipolar disorder are at an increased risk for heart attack, stroke, diabetes, and obesity, often resulting in a decreased lifespan. Clinicians must address this critical issue. There is a complicated, interconnected set of factors driving this correlation, including: medications that increase cardiometabolic burden, symptoms of the illness itself, as well genetic factors that confer risk for both bipolar disorder and metabolic complications. Dr. Mark Frye has more than twenty-five years of experience as a clinician, researcher and advocate. He is the former chair of the psychiatry department at Mayo Clinic, where he is now a professor of psychiatry. He is also the director of the scientific advisory board for the Depression and Bipolar Support Alliance (DBSA).
Dr. Frye sees the early signals of the efficacy of ketogenic therapy for some patients with mental health conditions as really impressive and encouraging. He would like to see further research and exploration of the biomarkers, mechanisms, and neurobiology behind this intervention so that it could be targeted to the individual patients most likely to benefit. There is a need for the whole field to shift toward precision psychiatry.
Dr. Mark Frye
https://www.mayo.edu/research/faculty/frye-mark-a-m-d/bio-00077016
Studies discussed:
Treating Insulin Resistance With Metformin as a Strategy to Improve Clinical Outcomes in Treatment-Resistant Bipolar Depression (the TRIO-BD Study): A Randomized, Quadruple-Masked, Placebo-Controlled Clinical Trial https://pubmed.ncbi.nlm.nih.gov/35120...
Insulin Resistance and Blood-Brain Barrier Dysfunction Underlie Neuroprogression in Bipolar Disorder https://pubmed.ncbi.nlm.nih.gov/34113...
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at metabolicmind.org
About us:
Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
Timestamps
0:00 Introduction
1:58 Dr. Frye's approach to treating patients
4:02 Advances in psychiatry
6:31 Gaps that still remain in psychiatry treatment
8:37 Why regulatory approvals are needed in psychiatric care
11:04 Cardiometabolic burden in bipolar disorder
15:43 Bipolar depression
17:07 Insulin resistance & depression
19:54 Dr. Frye's on ketogenic therapy (a keto diet) for mental health
24:35 Is a specific mechanism needed to support the use of keto for mood disorders?
27:08 Balancing being a psychiatry researcher, clinician, and advocate
29:52 Adopting nutritional practices in psychiatry care
34:15 A systems approach to addressing nutrition in psychiatry
36:28 Nutrition as a medical intervention & the support systems needed
39:44 What's next for Dr. Mark Frye
41:50 Conclusion & what Dr. Mark Frye does for his mental health
#MetabolicMind
#KetoForMentalHealth
#MetabolicPsychiatry
#BipolarDisorder
#MetabolicNeuroscience
#KetogenicMetabolicTherapy
#NutritionalKetosis
#MentalIllness
#AlternativeTreatment
#CardioMetabolicRisk
#Obesity
#Diabetes
#MedicationSideEffects
Individuals with bipolar disorder are at an increased risk for heart attack, stroke, diabetes, and obesity, often resulting in a decreased lifespan. Clinicians must address this critical issue. There is a complicated, interconnected set of factors driving this correlation, including: medications that increase cardiometabolic burden, symptoms of the illness itself, as well genetic factors that confer risk for both bipolar disorder and metabolic complications. Dr. Mark Frye has more than twenty-five years of experience as a clinician, researcher and advocate. He is the former chair of the psychiatry department at Mayo Clinic, where he is now a professor of psychiatry. He is also the director of the scientific advisory board for the Depression and Bipolar Support Alliance (DBSA).
Dr. Frye sees the early signals of the efficacy of ketogenic therapy for some patients with mental health conditions as really impressive and encouraging. He would like to see further research and exploration of the biomarkers, mechanisms, and neurobiology behind this intervention so that it could be targeted to the individual patients most likely to benefit. There is a need for the whole field to shift toward precision psychiatry.
Dr. Mark Frye
https://www.mayo.edu/research/faculty/frye-mark-a-m-d/bio-00077016
Studies discussed:
Treating Insulin Resistance With Metformin as a Strategy to Improve Clinical Outcomes in Treatment-Resistant Bipolar Depression (the TRIO-BD Study): A Randomized, Quadruple-Masked, Placebo-Controlled Clinical Trial https://pubmed.ncbi.nlm.nih.gov/35120...
Insulin Resistance and Blood-Brain Barrier Dysfunction Underlie Neuroprogression in Bipolar Disorder https://pubmed.ncbi.nlm.nih.gov/34113...
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at metabolicmind.org
About us:
Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
Timestamps
0:00 Introduction
1:58 Dr. Frye's approach to treating patients
4:02 Advances in psychiatry
6:31 Gaps that still remain in psychiatry treatment
8:37 Why regulatory approvals are needed in psychiatric care
11:04 Cardiometabolic burden in bipolar disorder
15:43 Bipolar depression
17:07 Insulin resistance & depression
19:54 Dr. Frye's on ketogenic therapy (a keto diet) for mental health
24:35 Is a specific mechanism needed to support the use of keto for mood disorders?
27:08 Balancing being a psychiatry researcher, clinician, and advocate
29:52 Adopting nutritional practices in psychiatry care
34:15 A systems approach to addressing nutrition in psychiatry
36:28 Nutrition as a medical intervention & the support systems needed
39:44 What's next for Dr. Mark Frye
41:50 Conclusion & what Dr. Mark Frye does for his mental health
#MetabolicMind
#KetoForMentalHealth
#MetabolicPsychiatry
#BipolarDisorder
#MetabolicNeuroscience
#KetogenicMetabolicTherapy
#NutritionalKetosis
#MentalIllness
#AlternativeTreatment
#CardioMetabolicRisk
#Obesity
#Diabetes
#MedicationSideEffects
