Uploaded April 2026 | Updated September 2026, 1 week ago
A 27-year-old woman presented with a 2-week history of joint pain, fever, sore throat, and a nonpruritic rash that worsened during febrile episodes. Physical examination was notable for generalized lymphadenopathy and swelling of the wrists, knees, and ankles. Laboratory studies showed neutrophilic leukocytosis, an elevated C-reactive protein level and erythrocyte sedimentation rate, and ferritin level of 4053 μg per liter (reference range, 10 to 200). An antinuclear antibody was negative. What is the most likely diagnosis? Submit your answer at NEJM.org.
#nejm
A 27-year-old woman presented with a 2-week history of joint pain, fever, sore throat, and a nonpruritic rash that worsened during febrile episodes. Physical examination was notable for generalized lymphadenopathy and swelling of the wrists, knees, and ankles. Laboratory studies showed neutrophilic leukocytosis, an elevated C-reactive protein level and erythrocyte sedimentation rate, and ferritin level of 4053 μg per liter (reference range, 10 to 200). An antinuclear antibody was negative. What is the most likely diagnosis? Submit your answer at NEJM.org.
#nejm
