Uploaded June 2026 | Updated September 2026, 3 weeks ago
Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing
Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point, how MDMA triggers a BDNF dependent pathway that repairs trauma all the way down to the epigenetic code, and why your antidepressant may be blocking the very brain states required for real healing.
-Order Dr. Rabin’s Book ‘A Simple Guide to Being Alive’: apolloneuro.com/pages/a-simple-guide-to-being-alive
Host Dave Asprey sits down with Dr. Dave Rabin, MD, PhD, a senior research scientist at the Florida Institute for Human and Machine Cognition, Executive Director of The Board of Medicine, and co-founder and Chief Medical Officer of Apollo Neuroscience. Dr. Rabin received his MD and PhD in neuroscience from Albany Medical College and specialized in psychiatry at the University of Pittsburgh Medical Center. He has spent 20 years studying chronic stress and non-invasive therapies for treatment-resistant illness, and his primary research on MDMA assisted therapy for severe PTSD has demonstrated that trauma can be reversed at the epigenetic level, offering a genuine path to a cure. His upcoming book A Simple Guide to Being Alive publishes June 1, 2026 and is a science-backed manual for anyone who has ever felt overwhelmed by the modern world.
You'll Learn:
-Why nearly 50% of psychiatric patients never get better and what treatment-resistant actually means
-How ketamine therapy works, why it is legal in every state, and why it is the safest place to start
-The exact BDNF pathway through which MDMA repairs fear extinction in the amygdala
-How MDMA assisted therapy produces measurable epigenetic repair of the cortisol receptor gene damaged by trauma
-Why SSRIs and SNRIs block the insula mediated brain states required for real emotional healing
-Why combining serotonergic psychedelics with SSRIs puts you at risk of life-threatening serotonin syndrome
-Why trauma passes down up to 14 generations and what you can do to stop the cycle now
-Why smartphones put your nervous system into a toxic overstimulation state before the day -even starts
-How the FDA rejected MDMA therapy after 88% of patients responded and who paid to make that happen
Resources:
• Order Dr. Rabin’s Book ‘A Simple Guide to Being Alive’: apolloneuro.com/pages/a-simple-guide-to-being-alive
• Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at daveasprey.com/2026-clean-nicotine-roadmap
• Dave Asprey's Latest News | Go to daveasprey.com to join Inside Track today.
Thank you to our sponsors!
- Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off.
- iRestore | Reverse hair loss at irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
- OneSkin | For a limited time, try OneSkin with 15% off at oneskin.co/DAVE.
- LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave
Timestamps:
00:00 – Trailer
01:34 – Dave Rabin Introduction
05:01 – Psychedelics and Psychiatry
08:35 – Psychedelic Safety and Dosing
14:53 – Serotonin Syndrome Warning
21:17 – Vagus Nerve and Safety
27:36 – Smartphones and Chronic Stress
34:18 – Defining Trauma
38:00 – Trauma and Epigenetics
40:23 – MDMA Cortisol Gene Repair
44:44 – Therapy vs. Medicine Alone
49:15 – FDA MDMA Rejection
55:35 – Ketamine Personal Experience
59:15 – Closing and Book Recommendation
Connect with Dave Asprey!
Website: daveasprey.com
TikTok: tiktok.com/@daveaspreyofficial
Instagram: instagram.com/dave.asprey
Facebook: facebook.com/Daveaspreyofficial
X: https://x.com/daveasprey
YouTube: youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: instagram.com/TheHumanUpgradePodcast https://m.facebook.com/Thehumanupgrade
Danger Coffee: dangercoffee.com/discount/dave15?
Dave Asprey’s BEYOND Conference: beyondconference.com
Dave Asprey’s New Book - Heavily Meditated: daveasprey.com/heavily-meditated
Dave's favorite supplements: shopsuppgradelabs.com/discount/DAVE15
Join my Substack: substack.daveasprey.com
Upgrade Labs: upgradelabs.com
40 Years of Zen: 40yearsofzen.com
Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing
Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point, how MDMA triggers a BDNF dependent pathway that repairs trauma all the way down to the epigenetic code, and why your antidepressant may be blocking the very brain states required for real healing.
-Order Dr. Rabin’s Book ‘A Simple Guide to Being Alive’: apolloneuro.com/pages/a-simple-guide-to-being-alive
Host Dave Asprey sits down with Dr. Dave Rabin, MD, PhD, a senior research scientist at the Florida Institute for Human and Machine Cognition, Executive Director of The Board of Medicine, and co-founder and Chief Medical Officer of Apollo Neuroscience. Dr. Rabin received his MD and PhD in neuroscience from Albany Medical College and specialized in psychiatry at the University of Pittsburgh Medical Center. He has spent 20 years studying chronic stress and non-invasive therapies for treatment-resistant illness, and his primary research on MDMA assisted therapy for severe PTSD has demonstrated that trauma can be reversed at the epigenetic level, offering a genuine path to a cure. His upcoming book A Simple Guide to Being Alive publishes June 1, 2026 and is a science-backed manual for anyone who has ever felt overwhelmed by the modern world.
You'll Learn:
-Why nearly 50% of psychiatric patients never get better and what treatment-resistant actually means
-How ketamine therapy works, why it is legal in every state, and why it is the safest place to start
-The exact BDNF pathway through which MDMA repairs fear extinction in the amygdala
-How MDMA assisted therapy produces measurable epigenetic repair of the cortisol receptor gene damaged by trauma
-Why SSRIs and SNRIs block the insula mediated brain states required for real emotional healing
-Why combining serotonergic psychedelics with SSRIs puts you at risk of life-threatening serotonin syndrome
-Why trauma passes down up to 14 generations and what you can do to stop the cycle now
-Why smartphones put your nervous system into a toxic overstimulation state before the day -even starts
-How the FDA rejected MDMA therapy after 88% of patients responded and who paid to make that happen
Resources:
• Order Dr. Rabin’s Book ‘A Simple Guide to Being Alive’: apolloneuro.com/pages/a-simple-guide-to-being-alive
• Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at daveasprey.com/2026-clean-nicotine-roadmap
• Dave Asprey's Latest News | Go to daveasprey.com to join Inside Track today.
Thank you to our sponsors!
- Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off.
- iRestore | Reverse hair loss at irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
- OneSkin | For a limited time, try OneSkin with 15% off at oneskin.co/DAVE.
- LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave
Timestamps:
00:00 – Trailer
01:34 – Dave Rabin Introduction
05:01 – Psychedelics and Psychiatry
08:35 – Psychedelic Safety and Dosing
14:53 – Serotonin Syndrome Warning
21:17 – Vagus Nerve and Safety
27:36 – Smartphones and Chronic Stress
34:18 – Defining Trauma
38:00 – Trauma and Epigenetics
40:23 – MDMA Cortisol Gene Repair
44:44 – Therapy vs. Medicine Alone
49:15 – FDA MDMA Rejection
55:35 – Ketamine Personal Experience
59:15 – Closing and Book Recommendation
Connect with Dave Asprey!
Website: daveasprey.com
TikTok: tiktok.com/@daveaspreyofficial
Instagram: instagram.com/dave.asprey
Facebook: facebook.com/Daveaspreyofficial
X: https://x.com/daveasprey
YouTube: youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: instagram.com/TheHumanUpgradePodcast https://m.facebook.com/Thehumanupgrade
Danger Coffee: dangercoffee.com/discount/dave15?
Dave Asprey’s BEYOND Conference: beyondconference.com
Dave Asprey’s New Book - Heavily Meditated: daveasprey.com/heavily-meditated
Dave's favorite supplements: shopsuppgradelabs.com/discount/DAVE15
Join my Substack: substack.daveasprey.com
Upgrade Labs: upgradelabs.com
40 Years of Zen: 40yearsofzen.com
