Uploaded February 2025 | Updated September 2026, 3 weeks ago
Linked videos:
youtu.be/UEc-AK_A4GU?si=OzXzh_UNZAj7-dCT
youtu.be/ObKrzxHT0n0?si=I2d8t780w9wHW4B8
*MUST WATCH* youtu.be/VxVYHP0WNfA?si=57DzfyuGSP0vJYdS
youtu.be/t2a3DBCJeP0?si=bbgaggqbvSDBMea9
Sources:
1. Imperato-McGinley J. 5 alpha-metabolism in finasteride-treated subjects and male pseudohermaphrodites with inherited 5 alpha-reductase deficiency. A review. Eur Urol. 1991;20 Suppl 1:78-81. doi:10.1159/000471751
2. Sawaya ME, Price VH. Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol. 1997;109(3):296-300. doi:10.1111/1523-1747.ep12335779
3. Drake L, Hordinsky M, Fiedler V, et al. The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. J Am Acad Dermatol. 1999;41(4):550-554.
4. Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB, Hobbs S. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor. The Journal of Clinical Endocrinology & Metabolism. 2004;89(5):2179-2184. doi:10.1210/jc.2003-030330
5. Olsen EA, Hordinsky M, Whiting D, et al. The importance of dual 5α-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride. Journal of the American Academy of Dermatology. 2006;55(6):1014-1023. doi:10.1016/j.jaad.2006.05.007
6. Hobo Y, Nishikawa J, Taniguchi Asai N, et al. Evaluation of the therapeutic effects of AGA drugs by measuring finasteride, dutasteride, and dihydrotestosterone in hair. Clinica Chimica Acta. 2023;547:117456. doi:10.1016/j.cca.2023.117456
Linked videos:
youtu.be/UEc-AK_A4GU?si=OzXzh_UNZAj7-dCT
youtu.be/ObKrzxHT0n0?si=I2d8t780w9wHW4B8
*MUST WATCH* youtu.be/VxVYHP0WNfA?si=57DzfyuGSP0vJYdS
youtu.be/t2a3DBCJeP0?si=bbgaggqbvSDBMea9
Sources:
1. Imperato-McGinley J. 5 alpha-metabolism in finasteride-treated subjects and male pseudohermaphrodites with inherited 5 alpha-reductase deficiency. A review. Eur Urol. 1991;20 Suppl 1:78-81. doi:10.1159/000471751
2. Sawaya ME, Price VH. Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol. 1997;109(3):296-300. doi:10.1111/1523-1747.ep12335779
3. Drake L, Hordinsky M, Fiedler V, et al. The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. J Am Acad Dermatol. 1999;41(4):550-554.
4. Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB, Hobbs S. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor. The Journal of Clinical Endocrinology & Metabolism. 2004;89(5):2179-2184. doi:10.1210/jc.2003-030330
5. Olsen EA, Hordinsky M, Whiting D, et al. The importance of dual 5α-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride. Journal of the American Academy of Dermatology. 2006;55(6):1014-1023. doi:10.1016/j.jaad.2006.05.007
6. Hobo Y, Nishikawa J, Taniguchi Asai N, et al. Evaluation of the therapeutic effects of AGA drugs by measuring finasteride, dutasteride, and dihydrotestosterone in hair. Clinica Chimica Acta. 2023;547:117456. doi:10.1016/j.cca.2023.117456

![PTD-DBM, a new hair loss treatment from Korea you can buy right now.
Disclaimer: I am not affiliated with Labcorp. My girlfriend works for the company and gave me the T-shirt.
Videos
https://youtu.be/6hL6Ef4cD78
https://youtu.be/RUEQ0TtjlDA
https://youtu.be/P9pYHfYaqME
https://youtu.be/HBCxY8PnLZ8
https://youtu.be/iPsivIbsi-Y
Sources
1. Ryu YC, Lee DH, Shim J, et al. KY19382, a novel activator of Wnt/β-catenin signaling, promotes hair re-growth and hair follicle neogenesis. Accessed November 3, 2025. https://www.authorea.com/users/333112/articles/459387-ky19382-a-novel-activator-of-wnt-%CE%B2-catenin-signaling-promotes-hair-re-growth-and-hair-follicle-neogenesis?commit=648b16f4cab7566f98fe2417ef9812f709b2c692
2. Blog. Accessed November 3, 2025. https://dermaregeon.com/post/hairregeon-ptd-dbm-hair-booster-a-revolutionary-approach-to-hair-restoration
3. Main. CK Regeon Inc. Accessed November 3, 2025. http://ckregeon.com/
4. Leirós GJ, Attorresi AI, Balañá ME. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia. Br J Dermatol. 2012;166(5):1035-1042. doi:10.1111/j.1365-2133.2012.10856.x
5. Lee SH, Kim MY, Kim HY, et al. The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. J Exp Med. 2015;212(7):1061-1080. doi:10.1084/jem.20141601
6. Kim H, Choi S, Yoon J, et al. Small molecule inhibitors of the Dishevelled‐CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy. EMBO Mol Med. 2016;8(4):375-387. doi:10.15252/emmm.201505714
7. Ji-young S. Korean scientists develop potential drug candidate for hair loss. The Korea Herald. November 21, 2017. Accessed November 3, 2025. https://www.koreaherald.com/article/1510736
8. Kim D, Garza LA. The Negative Regulator CXXC5: Making WNT Look a Little Less Dishevelled. Journal of Investigative Dermatology. 2017;137(11):2248-2250. doi:10.1016/j.jid.2017.07.826
9. Lee SH, Seo SH, Lee DH, Pi LQ, Lee WS, Choi KY. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis. J Invest Dermatol. 2017;137(11):2260-2269. doi:10.1016/j.jid.2017.04.038
10. Mun-hee C. Korean Scientists Develop Potential Drug Candidate for Hair Loss. Businesskorea. November 22, 2017. Accessed November 2, 2025. https://www.businesskorea.co.kr/news/articleView.html?idxno=19896
11. Premanand A, Reena Rajkumari B. Androgen modulation of Wnt/β-catenin signaling in androgenetic alopecia. Arch Dermatol Res. 2018;310(5):391-399. doi:10.1007/s00403-018-1826-8
12. Thought F. PTD-DBM Update: Q&A With Dr. Kang-Yell Choi. Follicle Thought. July 29, 2019. Accessed November 3, 2025. https://folliclethought.com/newsite/ptd-dbm-update-qa-with-dr-kang-yell-choi/
13. Choi BY. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss. Int J Mol Sci. 2020;21(14):4915. doi:10.3390/ijms21144915
14. Zhang Y, Zu D, Chen Z, Ying G. An update on Wnt signaling pathway in cancer. Transl Cancer Res. 2020;9(2):1246-1252. doi:10.21037/tcr.2019.12.50
15. Ryu YC, Kim Y rin, Park J, et al. Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus. BMB Reports. 2022;55(11):559-564. doi:10.5483/BMBRep.2022.55.11.081
16. Ryu YC, Park J, Kim YR, et al. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2. Cells. 2023;12(4):555. doi:10.3390/cells12040555
17. Inc CR. [헬스코리아뉴스] 발상 전환 일으킨 씨케이리제온 … ‘재생=바이오의약품’ 통념 깬 바이오벤처. CK Regeon Inc. October 1, 2025. Accessed November 3, 2025. http://ckregeon.com/?kboard_content_redirect=73 PTD-DBM, a new hair loss treatment from Korea you can buy right now.](https://i.ytimg.com/vi/xzwpAiNEZjg/mqdefault.jpg)






