Uploaded April 2024 | Updated September 2026, 1 week ago
How Do Ozempic and Wegovy Work?
Ozempic and Wegovy are synthetic GLP-1 molecules named Semaglutide. Ozempic is approved for type II diabetes mellitus and protection against cardiac events in type II DM patients. Wegovy is approved for weight loss in obese and overweight individuals and for protection against cardiac events in obese and overweight individuals. Let's review the mechanism of action and the side effects of these drugs.
If you like this content and want more, click here: drbeen.com/med-nerd
Want to join my uncensored talks? Join me on patreon or substack:
Patreon: patreon.com/mobeensyed?fan_landing=true
Substack: mobeensyedmd.substack.com
Want to support this work?:
BuyMeACoffee: buymeacoffee.com/drmobeensyed
PayPal: paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #Weight_Loss
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
FDA Approves First Treatment to Reduce Risk of Serious Heart Problems Specifically in Adults with Obesity or Overweight | FDA
fda.gov/news-events/press-announcements/fda-approves-first-treatment-reduce-risk-serious-heart-problems-specifically-adults-obesity-or
Ozempic for weight loss: Does it work, and what do experts recommend?
https://health.ucdavis.edu/blog/cultivating-health/ozempic-for-weight-loss-does-it-work-and-what-do-experts-recommend/2023/07
Semaglutide delays 4-hour gastric emptying in women with polycystic ovary syndrome and obesity - PubMed
pubmed.ncbi.nlm.nih.gov/36511825
The metabolic role of vagal afferent innervation | Nature Reviews Gastroenterology & Hepatology
nature.com/articles/s41575-018-0062-1
Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow | American Journal of Physiology-Gastrointestinal and Liver Physiology
journals.physiology.org/doi/full/10.1152/ajpgi.1998.275.5.G984
Wegovy® Pen Instructions | Wegovy® (semaglutide) Injection 2.4 mg
wegovy.com/taking-wegovy/how-to-use-the-wegovy-pen.html
Incretin
en.wikipedia.org/wiki/Incretin
Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms - PubMed
pubmed.ncbi.nlm.nih.gov/9357836
Give the Receptor a Brake: Slowing Gastric Emptying by GLP-1 | Diabetes | American Diabetes Association
diabetesjournals.org/diabetes/article/63/2/407/34120/Give-the-Receptor-a-Brake-Slowing-Gastric-Emptying
GLP-1 Localisation and Proglucagon Gene Expression in Healthy and Diabetic Mouse Ileum - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC6200298/#:~:text=For%20instance%2C%20proglucagon%20is%20cleaved,13%2C%2016%2C%2027).
What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell? - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC8218725
Glucagon-Like Peptide-1 Receptor Agonists for Chronic Weight Management - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC10533252
Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow | American Journal of Physiology-Gastrointestinal and Liver Physiology
journals.physiology.org/doi/full/10.1152/ajpgi.1998.275.5.G984
Why Ozempic Causes Diarrhea and How to Manage Your Symptoms - GoodRx
goodrx.com/ozempic/diarrhea
Wegovy (Semaglutide): Uses, Side Effects & Weight Loss
drugwatch.com/drugs/wegovy/#:~:text=Wegovy%20carries%20a%20black%20box,same%20effects%20occur%20in%20humans.
Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss | Gastroenterology | JAMA | JAMA Network
jamanetwork.com/journals/jama/fullarticle/2810542
The metabolic role of vagal afferent innervation | Nature Reviews Gastroenterology & Hepatology
nature.com/articles/s41575-018-0062-1
What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell? - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC8218725
Enteroendocrine cell - Wikipedia
en.wikipedia.org/wiki/Enteroendocrine_cell#:~:text=in%20the%20duodenum.-,L%20cell,in%20the%20duodenum%20and%20jejunum.
What is ilial brake?
inslag.indd
https://scholarlypublications.universiteitleiden.nl/access/item%3A2956466/view
Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC5483000/#:~:text=Distinct%20neuronal%20cell%20populations%2C%20particularly,glucose%20metabolism%20and%20energy%20expenditure.
How Do Ozempic and Wegovy Work?
Ozempic and Wegovy are synthetic GLP-1 molecules named Semaglutide. Ozempic is approved for type II diabetes mellitus and protection against cardiac events in type II DM patients. Wegovy is approved for weight loss in obese and overweight individuals and for protection against cardiac events in obese and overweight individuals. Let's review the mechanism of action and the side effects of these drugs.
If you like this content and want more, click here: drbeen.com/med-nerd
Want to join my uncensored talks? Join me on patreon or substack:
Patreon: patreon.com/mobeensyed?fan_landing=true
Substack: mobeensyedmd.substack.com
Want to support this work?:
BuyMeACoffee: buymeacoffee.com/drmobeensyed
PayPal: paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #Weight_Loss
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
FDA Approves First Treatment to Reduce Risk of Serious Heart Problems Specifically in Adults with Obesity or Overweight | FDA
fda.gov/news-events/press-announcements/fda-approves-first-treatment-reduce-risk-serious-heart-problems-specifically-adults-obesity-or
Ozempic for weight loss: Does it work, and what do experts recommend?
https://health.ucdavis.edu/blog/cultivating-health/ozempic-for-weight-loss-does-it-work-and-what-do-experts-recommend/2023/07
Semaglutide delays 4-hour gastric emptying in women with polycystic ovary syndrome and obesity - PubMed
pubmed.ncbi.nlm.nih.gov/36511825
The metabolic role of vagal afferent innervation | Nature Reviews Gastroenterology & Hepatology
nature.com/articles/s41575-018-0062-1
Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow | American Journal of Physiology-Gastrointestinal and Liver Physiology
journals.physiology.org/doi/full/10.1152/ajpgi.1998.275.5.G984
Wegovy® Pen Instructions | Wegovy® (semaglutide) Injection 2.4 mg
wegovy.com/taking-wegovy/how-to-use-the-wegovy-pen.html
Incretin
en.wikipedia.org/wiki/Incretin
Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms - PubMed
pubmed.ncbi.nlm.nih.gov/9357836
Give the Receptor a Brake: Slowing Gastric Emptying by GLP-1 | Diabetes | American Diabetes Association
diabetesjournals.org/diabetes/article/63/2/407/34120/Give-the-Receptor-a-Brake-Slowing-Gastric-Emptying
GLP-1 Localisation and Proglucagon Gene Expression in Healthy and Diabetic Mouse Ileum - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC6200298/#:~:text=For%20instance%2C%20proglucagon%20is%20cleaved,13%2C%2016%2C%2027).
What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell? - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC8218725
Glucagon-Like Peptide-1 Receptor Agonists for Chronic Weight Management - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC10533252
Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow | American Journal of Physiology-Gastrointestinal and Liver Physiology
journals.physiology.org/doi/full/10.1152/ajpgi.1998.275.5.G984
Why Ozempic Causes Diarrhea and How to Manage Your Symptoms - GoodRx
goodrx.com/ozempic/diarrhea
Wegovy (Semaglutide): Uses, Side Effects & Weight Loss
drugwatch.com/drugs/wegovy/#:~:text=Wegovy%20carries%20a%20black%20box,same%20effects%20occur%20in%20humans.
Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss | Gastroenterology | JAMA | JAMA Network
jamanetwork.com/journals/jama/fullarticle/2810542
The metabolic role of vagal afferent innervation | Nature Reviews Gastroenterology & Hepatology
nature.com/articles/s41575-018-0062-1
What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell? - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC8218725
Enteroendocrine cell - Wikipedia
en.wikipedia.org/wiki/Enteroendocrine_cell#:~:text=in%20the%20duodenum.-,L%20cell,in%20the%20duodenum%20and%20jejunum.
What is ilial brake?
inslag.indd
https://scholarlypublications.universiteitleiden.nl/access/item%3A2956466/view
Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC5483000/#:~:text=Distinct%20neuronal%20cell%20populations%2C%20particularly,glucose%20metabolism%20and%20energy%20expenditure.
