Exercise Blocked 55% of Age-Related Muscle Changes @nicknorwitzMDPhD
Exercise Blocked 55% of Age-Related Muscle Changes  @nicknorwitzMDPhD
Uploaded August 2026 | Updated September 2026, 1 week ago
Deep dive: open.substack.com/pub/staycuriousmetabolism/p/scientists-just-discovered-how-exercise?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Muscle biopsies showed that regularly trained older adults lacked about 55% of the age-related gene-expression changes usually observed in aging. Many of these changes involved mitochondria and muscle metabolism, suggesting that consistent exercise may preserve important features of muscle biology during aging. For the full mechanisms, limitations, and nuance, watch the long-form breakdown linked above.

#HealthyAging #ExerciseScience #MuscleHealth #Mitochondria #LongevityScience #GeneExpression #StayCurious
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Nick Norwitz MD PhD |

Exercise Blocked 55% of Age-Related Muscle Changes

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