Ep 381 - Q&A: GLP-1s, Tendon Training, & Rep Ranges @IronCulturePodcast
Ep 381 - Q&A: GLP-1s, Tendon Training, & Rep Ranges  @IronCulturePodcast
Uploaded July 2026 | Updated September 2026, 3 hours ago
Trexler and Helms open with an overview of the new MASS issue (body recomposition, a protein consensus paper, reverse dieting) and a powerlifting World Championships recap before diving into a rapid-fire listener Q&A. Along the way they tackle whether protein needs scale with training volume, the science behind a supplement that's been called "Nature's Ozempic," evaluating protein quality based on food labels, dieting while chasing endurance adaptations, protecting tendons and bone when shifting from powerlifting to bodybuilding, and the myths around rep ranges and muscle shape. The back half centers on GLP-1 drugs like tirzepatide — their surprising off-label effects, who's actually a good candidate, and whether they should be banned in natural bodybuilding — before closing with a rapid-fire round on lengthened partials and the volume-versus-frequency question.

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Chapters
0:00 — Intro, audio gremlins & the new MASS issue
6:35 — Powerlifting news: World Championships & squat records
11:43 — Do protein requirements scale with training volume?
16:54 — PGX: is "Nature's Ozempic" actually legit?
22:44 — Protein quality & % Daily Value on food labels
26:42 — Chasing endurance adaptations while dieting in a deficit
36:47 — Protecting tendons & bone when leaving powerlifting
45:32 — Rep ranges, muscle "hardness" & fiber-type myths
50:16 — Tirzepatide & GLP-1s: are they really the wonder drug?
1:01:03 — Should GLP-1s be banned in natural bodybuilding?
1:11:06 — Rapid fire: lengthened partials & the volume/frequency question
1:15:34 — Wrap-up & sign-off
Ep 381 - Q&A: GLP-1s, Tendon Training, & Rep RangesEp. 249- The Spirit of Bodybuilding (ft. Dr. Mike Israetel)Ep. 243- Its Not JUST About Calories (ft. Eric Trexler)Ep 324 - WORLD PREMIERE: Front Page FitnessEp 218 Science is Flawed, but Can be FixedEp. 211- Training Specificity Revisited & New Diet Break DataEp. 258- The Rise of Lifting Anti-ScienceEp 323 - MASS Makes HistoryEp 386 - Sleep, Hypertrophy, and CreatineEp 338 – The many eras of evidence-based fitness (ft. Dr. Jim Stoppani)Ep 355 - Mindset of a Bodybuilding Champion (ft. Oscar Moscat)Ep 281-Is Saturated Fat Inherently Fattening?
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Ep 381 - Q&A: GLP-1s, Tendon Training, & Rep Ranges

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