Uploaded March 2024 | Updated September 2026, 2 weeks ago
Oral enclomiphene citrate lowers IGF-1 in men with secondary hypogonadism while raising testosterone
Conclusions: Endocrine profile indicate that enclomiphene citrate stimulates the pituitary, resulting in increased LH and FSH and eventually T. The results on IGF-1 cannot be attributed to T since topicals, when used, raised T but not IGF-1 whereas only enclomiphene citrate raised T but lowered IGF-1. Enclomiphene citrate is different from topicals and may be a new way to relieve low T in men with an intact hypothalamus-pituitary-testicular axis. If Androxal can lower hGH or IGF-1 in aging men at risk for prostate cancer, its use in men with secondary hypogonadism is an important new treatment.
aacrjournals.org/cancerres/article/73/8_Supplement/1326/586892/Abstract-1326-Oral-enclomiphene-citrate-lowers-IGF
Results: All treatments raised T into the normal range (300-1000 ng/dL), but placebo did not in ZA-202. Androxal elevated LH and FSH. Gels decreased LH and FSH strongly. Unexpected was the strong action of Androxal to lower serum IGF-1 in all three trials. Both Androxal and topicals lowered serum IGF-1 but Androxal was more effective. An example is given from ZA-204 below. Dose groups showed no differences in IGF-1 before (p = 0.94) but significance after treatment (p = 0.03)
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#bodybuilding #fitness #bodybuilder
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Oral enclomiphene citrate lowers IGF-1 in men with secondary hypogonadism while raising testosterone
Conclusions: Endocrine profile indicate that enclomiphene citrate stimulates the pituitary, resulting in increased LH and FSH and eventually T. The results on IGF-1 cannot be attributed to T since topicals, when used, raised T but not IGF-1 whereas only enclomiphene citrate raised T but lowered IGF-1. Enclomiphene citrate is different from topicals and may be a new way to relieve low T in men with an intact hypothalamus-pituitary-testicular axis. If Androxal can lower hGH or IGF-1 in aging men at risk for prostate cancer, its use in men with secondary hypogonadism is an important new treatment.
aacrjournals.org/cancerres/article/73/8_Supplement/1326/586892/Abstract-1326-Oral-enclomiphene-citrate-lowers-IGF
Results: All treatments raised T into the normal range (300-1000 ng/dL), but placebo did not in ZA-202. Androxal elevated LH and FSH. Gels decreased LH and FSH strongly. Unexpected was the strong action of Androxal to lower serum IGF-1 in all three trials. Both Androxal and topicals lowered serum IGF-1 but Androxal was more effective. An example is given from ZA-204 below. Dose groups showed no differences in IGF-1 before (p = 0.94) but significance after treatment (p = 0.03)
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#bodybuilding #fitness #bodybuilder
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![Intro to Selank Nootropic Overview | Habit-Forming Peptide That Can HELP Manage ADHD? [PEDucation]](https://i.ytimg.com/vi/VsVaeigZYtg/mqdefault.jpg "Intro to Selank Nootropic Overview | Habit-Forming Peptide That Can HELP Manage ADHD? [PEDucation]
The 40th episode of the PEDucation series, Russo introduces a nootropic peptide he has been using for the last five years to help condition mRNA to adapt his dopamine and GABA receptors to increase resilience when doing boring or un-stimulating tasks such as office work. Only bioavailable access is to be administered via the nasal passage.
Study Mentioned:
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757669/
TIMESTAMPS
0:00 Intro
0:36 Skip the Sip - LIKE this Video!!
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#Nootropic #Selank #Peptide #BrainHealth")
