EASD 2025: SURPASS-CVOT - A Comparison of Tirzepatide and Dulaglutide @EASDiabetes
EASD 2025: SURPASS-CVOT - A Comparison of Tirzepatide and Dulaglutide  @EASDiabetes
Uploaded January 2026 | Updated September 2026, 3 days ago
At the EASD 2025 Annual Meeting in Vienna, the SURPASS-CVOT trial results were revealed, providing crucial insights for the management of type 2 diabetes. In this EASD TV interview, Prof. Tina Vilsbøll (EASD Honorary Secretary) and Prof. Hertzel Gerstein (EASD-Independent Advisor and McMaster University) discuss the trial outcomes, their significance for clinical practice, and the future of personalized medicine in diabetes care.

Key takeaways:
- Comparative efficacy: tirzepatide (15 mg weekly) was found non-inferior to dulaglutide (1.5 mg weekly) in reducing major cardiovascular events (MACE: MI, stroke, cardiovascular death).
- Patient-centred impact: This trial emphasises therapies that improve both metabolic control and cardiovascular outcomes, benefiting patients directly.
- Large-scale evidence: Over 13,000 participants make this the second largest and longest cardiovascular outcomes trial for diabetes.
- Transdisciplinary approach: Collaboration between diabetologists, cardiologists, nephrologists, and neurologists is shaping future research and guideline development.
- Personalised medicine: The results add another layer to tailor treatment strategies based on patient-specific needs and risk profiles.

This interview highlights how teaching, research, and outcomes trials are transforming diabetes care beyond glucose control, providing therapies that truly matter to patients.
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European Association for the Study of Diabetes |

EASD 2025: SURPASS-CVOT - A Comparison of Tirzepatide and Dulaglutide

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