Uploaded December 2025 | Updated September 2026, 2 weeks ago
We cover the complete reaction mechanism for E1 in organic chemistry step-by-step, showing exactly how the leaving group departs, how the Lewis base attacks the beta hydrogen, Zaitsev's Rule for regioselectivity, stereoselectivity of cis- / trans- (Z / E) products, major vs minor products, and more. Using clear diagrams and curved arrows, we'll walk through how to predict products, avoid common mistakes, and more. Also called unimolecular elimination
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🧬If you need a refresher on chirality for mechanisms to make sense, start here: youtube.com/playlist?list=PLvUW25kBaMMupOdw1Wgy8YauiQ40J_5nx
⚗️For all of my ochem videos in one place: youtube.com/playlist?list=PLvUW25kBaMMuKRkW9gDV7vlAk4Y9WRU7c
🥼If you need to take the MCAT: youtube.com/playlist?list=PLvUW25kBaMMuJZI5IVWO8X0syBANn-YqY
🥽As an Amazon Affiliate, I earn from qualifying purchases at no extra cost to you.
🥼Need a molecular model kit or other chem supplies? amazon.com/shop/chemnut?ccs_id=11f20bce-5f74-427b-85fb-bdf66849405a
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0:00 E1 Overall Reaction
0:54 E1 Mechanism
4:38 Where will the double bond go? (Regioselectivity & Zaitsev's Rule)
7:20 Will E or Z / cis or trans predominate? (Stereoselectivity)
9:04 Advanced Stereoselectivity Example
10:00 Newman Projection
11:56 Molecular Model
13:34 Product
15:19 E1 vs E2
16:51 E1 vs SN1
Citations:
Paula Yurkanis Bruice, "Organic Chemistry" 8th ed
openstax.org/details/books/organic-chemistry
openstax.org/details/books/chemistry-2e
Periodic Table used with permission from sciencenotes.org/printable-periodic-table
Music: youtu.be/lL6AsbG07xY
We cover the complete reaction mechanism for E1 in organic chemistry step-by-step, showing exactly how the leaving group departs, how the Lewis base attacks the beta hydrogen, Zaitsev's Rule for regioselectivity, stereoselectivity of cis- / trans- (Z / E) products, major vs minor products, and more. Using clear diagrams and curved arrows, we'll walk through how to predict products, avoid common mistakes, and more. Also called unimolecular elimination
📘Master the Mechanisms! Grab the Organic Chemistry Reaction Mechanisms Survival Guide: payhip.com/b/rYbBp
🧠Full Mechanisms Playlist: youtube.com/playlist?list=PLvUW25kBaMMtvqt_IBtezyBX_kk447pxZ
🍵Buy the Professor a tea to keep the videos coming: patreon.com/c/ChemistryinaNutshell
🧬If you need a refresher on chirality for mechanisms to make sense, start here: youtube.com/playlist?list=PLvUW25kBaMMupOdw1Wgy8YauiQ40J_5nx
⚗️For all of my ochem videos in one place: youtube.com/playlist?list=PLvUW25kBaMMuKRkW9gDV7vlAk4Y9WRU7c
🥼If you need to take the MCAT: youtube.com/playlist?list=PLvUW25kBaMMuJZI5IVWO8X0syBANn-YqY
🥽As an Amazon Affiliate, I earn from qualifying purchases at no extra cost to you.
🥼Need a molecular model kit or other chem supplies? amazon.com/shop/chemnut?ccs_id=11f20bce-5f74-427b-85fb-bdf66849405a
🔬Start any shopping journey here: amzn.to/3IXuAcS
0:00 E1 Overall Reaction
0:54 E1 Mechanism
4:38 Where will the double bond go? (Regioselectivity & Zaitsev's Rule)
7:20 Will E or Z / cis or trans predominate? (Stereoselectivity)
9:04 Advanced Stereoselectivity Example
10:00 Newman Projection
11:56 Molecular Model
13:34 Product
15:19 E1 vs E2
16:51 E1 vs SN1
Citations:
Paula Yurkanis Bruice, "Organic Chemistry" 8th ed
openstax.org/details/books/organic-chemistry
openstax.org/details/books/chemistry-2e
Periodic Table used with permission from sciencenotes.org/printable-periodic-table
Music: youtu.be/lL6AsbG07xY
