E2 Stereochemistry: The 180° Anti-Periplanar Rule (Snippet) @ChemistryinaNutshell
E2 Stereochemistry: The 180° Anti-Periplanar Rule (Snippet)  @ChemistryinaNutshell
Uploaded November 2025 | Updated September 2026, 1 week ago
Why does E2 produce the trans- product instead of cis-? It all comes down to the anti-periplanar geometry. We use Newman Projections to show you exactly how the molecule must rotate before it can react. BONUS: I'll show you which Newman Projections you can totally skip to save time on your exam.

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0:00 cis- vs trans- Major & Minor Products
0:40 Newman Projection Leading to Major Product
1:37 Newman Projection Leading to Minor Product
2:07 Why these lead to major vs minor
3:33 Newman Projections You Can Ignore
4:35 and CAN'T ignore

Citations:
Paula Yurkanis Bruice, "Organic Chemistry" 8th ed
openstax.org/books/organic-chemistry/pages/11-4-the-sn1-reaction

Music: youtu.be/lL6AsbG07xY
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E2 Stereochemistry: The 180° Anti-Periplanar Rule (Snippet)

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