Uploaded August 2026 | Updated September 2026, 2 weeks ago
Real hypothyroidism adds mostly water, not fat. Treat it for a year and the roughly 4 kilos that come off are almost all water; in 100 patients the median change was near zero. #thyroid #hypothyroidism #weightloss
Real hypothyroidism adds mostly water, not fat. Treat it for a year and the roughly 4 kilos that come off are almost all water; in 100 patients the median change was near zero. #thyroid #hypothyroidism #weightloss



![Does Training Frequency Matter for Strength and Size?
If you have three lifts planned for the day but split them hours apart, are you leaving strength and size on the table? The short answer from Jordan and Dr. Austin Baraki: it is fine. The longer answer is a useful window into how they think about programming.
Frequency is a tool to distribute training load, not an independent driver of adaptation. When you equate volume, the frequency signal mostly disappears: Schoenfeld’s 2016 meta-analysis showed a small hypertrophy edge for higher frequency, but the volume was not actually equated, and the 2019 update with 25 studies erased the difference. Strength data tell the same story. Where Jordan goes slightly beyond the evidence: he suspects splitting volume up lets you accumulate more total training load over months and years because you lift fresher, and that higher-skill lifts like the overhead press may benefit from frequent, low-fatigue exposure.
They extend the same logic to cardiorespiratory fitness, where the old 10-minute bout minimum has been dropped entirely, while still arguing that some longer sessions matter if maximizing fitness is the goal. The practical takeaway: distribute your training by preference and logistics, prioritize adherence, and do not worry that splitting a session hurts your results. Full AMA episode and references linked below.
Resources:
Subscribe to BBM Plus for the full unabridged Direct Line: https://barbellmedicine.supercast.com/
Barbell Medicine coaching and templates: https://www.barbellmedicine.com/
Signal book pre-order: https://www.barbellmedicine.com/shop/learning/signal/
Schoenfeld B.J. et al. 2016. Effects of resistance training frequency on measures of muscle hypertrophy: a systematic review and meta-analysis. Sports Med 46(11):1689-1697.
https://pubmed.ncbi.nlm.nih.gov/27102172/
Schoenfeld B.J. et al. 2019. How many times per week should a muscle be trained to maximize hypertrophy? J Sports Sci 37(11):1286-1295.
https://pubmed.ncbi.nlm.nih.gov/30558493/
Becker T. et al. 2022. Resistance training frequency and strength outcomes: meta-analysis. [verify] Does Training Frequency Matter for Strength and Size?](https://i.ytimg.com/vi/aUL6twnRME8/mqdefault.jpg)


![They Removed the Tumor and the Weight Got Worse: Acquired Hypothalamic Obesity
The surgery works, the tumor is gone, the hormones are replaced, and the patient gains weight faster than before. This segment explains why: the operation touched the circuit that sets body weight. We walk the POMC brake and the AgRP accelerator, and set the record straight on leptin.
Timestamps:
00:00:00 The name: a tumor built from tooth tissue
00:00:18 Surgery, and what it costs
00:02:11 The new mystery: gaining weight faster than ever
00:08:09 The diagnosis: acquired hypothalamic obesity
00:13:45 How the brain sets weight: the brake and the accelerator
00:16:35 What about leptin?
Resources
Barbell Medicine coaching and templates: https://www.barbellmedicine.com
Plus podcast subscription: https://www.barbellmedicine.com/shop/subscriptions/plus-podcast-subscription/
Barbell Medicine Premium: https://www.barbellmedicine.com/shop/subscriptions/barbell-medicine-premium/
Signal (book pre-order): https://www.barbellmedicine.com/shop/learning/signal/
1. Brijmohan A, et al. Acquired hypothalamic obesity following craniopharyngioma resection in a young adult [case report]. 2025. PMCID: PMC12268545; PMID: 40677794.
2. Miller JL, et al; TRANSCEND investigators. Setmelanotide in acquired hypothalamic obesity: a phase 3 randomized trial. N Engl J Med. 2026.
3. Rhythm Pharmaceuticals. FDA approves IMCIVREE (setmelanotide) for acquired hypothalamic obesity. News release. March 19, 2026.
4. US Food and Drug Administration. FDA approves first treatment for weight management for people with certain rare genetic conditions (setmelanotide). 2020.
5. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997;387(6636):903-908.
6. Farooqi IS, Jebb SA, Langmack G, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med. 1999;341(12):879-884.
7. Krude H, Biebermann H, Luck W, et al. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet. 1998;19(2):155-157.
8. Farooqi IS, Keogh JM, Yeo GS, et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med. 2003;348(12):1085-1095.
9. Clément K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998;392(6674):398-401.
10. Fabbrini E, Tamboli RA, Magkos F, et al. Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults. Gastroenterology. 2010;139(2):448-455.
11. Klein S, Fontana L, Young VL, et al. Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N Engl J Med. 2004;350(25):2549-2557.
12. Guyenet SJ. The Hungry Brain: Outsmarting the Instincts That Make Us Overeat. Flatiron Books; 2017. They Removed the Tumor and the Weight Got Worse: Acquired Hypothalamic Obesity](https://i.ytimg.com/vi/bHZa0G-JDfk/mqdefault.jpg)



