Uploaded August 2024 | Updated September 2026, 2 weeks ago
In 2022, news broke that a critical, groundbreaking Alzheimer's research paper had allegedly been a fraud, and the media began to speculate how many billions of dollars and thousands of hours of scientists’ time had been wasted.
But then the news articles stopped and research continued and now, there are two potentially helpful Alzheimer's disease drugs on the market. Since then, the evidence for fraud in that paper has piled up, but so has evidence for protein buildup in the brain causing Alzheimers. So did fabricated scientific results accidentally set us on the right path towards a breakthrough?
#alzheimersresearch
#scientificfraud
#amyloidbeta
Credits:
Executive Producer:
Matthew Radcliff
Producers:
Andrew Sobey
Elaine Seward
Darren Weaver
Writers:
Alex Dainis, Ph.D.
Hosts:
Alex Dainis, Ph.D.
Scientific Consultants:
Michelle Boucher, Ph.D.
Leila Duman, Ph.D.
Claire Butler, Ph.D.
Executive in Charge for PBS: Maribel Lopez
Director of Programming for PBS: Gabrielle Ewing
Assistant Director of Programming for PBS: John Campbell
Reactions is a production of the American Chemical Society.
© 2024 American Chemical Society. All rights reserved.
Sources:
mdpi.com/1420-3049/25/24/5789
medlineplus.gov/genetics/gene/apoe
ncbi.nlm.nih.gov/pmc/articles/PMC3181715/#:~:text=On%20November%203%2C%201906%2C%20a,her%20admission%20for%20paranoia%2C%20progressive
ncbi.nlm.nih.gov/pmc/articles/PMC9254908
nia.nih.gov/health/alzheimers-causes-and-risk-factors/what-happens-brain-alzheimers-disease#:~:text=In%20Alzheimer's%20disease%2C%20however%2C%20abnormal,the%20synaptic%20communication%20between%20neurons.
ncbi.nlm.nih.gov/pmc/articles/PMC9254908
https://medicine.wustl.edu/news/alzheimers-blood-test-performs-as-well-as-fda-approved-spinal-fluid-tests/
molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00605-8
https://www.rockefeller.edu/news/34522-unlocking-how-the-new-alzheimers-drug-lecanemab-works/
nejm.org/doi/full/10.1056/NEJMoa2212948
ncbi.nlm.nih.gov/books/NBK459119
science.org/content/article/potential-fabrication-research-images-threatens-key-theory-alzheimers-disease
science.org/content/blog-post/faked-beta-amyloid-data-what-does-it-mean
researchgate.net/publication/7237743_A_specific_amyloid-_protein_assembly_in_the_brain_impairs_memory ←- retracted paper
In 2022, news broke that a critical, groundbreaking Alzheimer's research paper had allegedly been a fraud, and the media began to speculate how many billions of dollars and thousands of hours of scientists’ time had been wasted.
But then the news articles stopped and research continued and now, there are two potentially helpful Alzheimer's disease drugs on the market. Since then, the evidence for fraud in that paper has piled up, but so has evidence for protein buildup in the brain causing Alzheimers. So did fabricated scientific results accidentally set us on the right path towards a breakthrough?
#alzheimersresearch
#scientificfraud
#amyloidbeta
Credits:
Executive Producer:
Matthew Radcliff
Producers:
Andrew Sobey
Elaine Seward
Darren Weaver
Writers:
Alex Dainis, Ph.D.
Hosts:
Alex Dainis, Ph.D.
Scientific Consultants:
Michelle Boucher, Ph.D.
Leila Duman, Ph.D.
Claire Butler, Ph.D.
Executive in Charge for PBS: Maribel Lopez
Director of Programming for PBS: Gabrielle Ewing
Assistant Director of Programming for PBS: John Campbell
Reactions is a production of the American Chemical Society.
© 2024 American Chemical Society. All rights reserved.
Sources:
mdpi.com/1420-3049/25/24/5789
medlineplus.gov/genetics/gene/apoe
ncbi.nlm.nih.gov/pmc/articles/PMC3181715/#:~:text=On%20November%203%2C%201906%2C%20a,her%20admission%20for%20paranoia%2C%20progressive
ncbi.nlm.nih.gov/pmc/articles/PMC9254908
nia.nih.gov/health/alzheimers-causes-and-risk-factors/what-happens-brain-alzheimers-disease#:~:text=In%20Alzheimer's%20disease%2C%20however%2C%20abnormal,the%20synaptic%20communication%20between%20neurons.
ncbi.nlm.nih.gov/pmc/articles/PMC9254908
https://medicine.wustl.edu/news/alzheimers-blood-test-performs-as-well-as-fda-approved-spinal-fluid-tests/
molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00605-8
https://www.rockefeller.edu/news/34522-unlocking-how-the-new-alzheimers-drug-lecanemab-works/
nejm.org/doi/full/10.1056/NEJMoa2212948
ncbi.nlm.nih.gov/books/NBK459119
science.org/content/article/potential-fabrication-research-images-threatens-key-theory-alzheimers-disease
science.org/content/blog-post/faked-beta-amyloid-data-what-does-it-mean
researchgate.net/publication/7237743_A_specific_amyloid-_protein_assembly_in_the_brain_impairs_memory ←- retracted paper
