Uploaded March 2026 | Updated September 2026, 2 weeks ago
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For more information, visit pcri.org
0:33 What is a Gleason Score, and how is it determined?
4:41 What do three, four, and five mean in the context of Gleason?
6:52 Why is a Gleason Score of three counted if it doesn't metastasize?
7:22 Are 50% of all prostate cancers Gleason 6?
7:53 Cna Gleason 6 ever metastasize at all?
8:11 Does one's amount of positive cores correlate with severity of cancer?
8:32 Why does the percentage of positive tissue in each core matter?
10:30 Can the number of positive cores indicate tumor size?
10:50 Does having more biopsied lesions mean one's cancer is more aggressive?
11:26 Should one always get a second opinion on their biopsy results?
12:27 How long do practitioners keep biopsy slides?
12:38 How does a high positive percentage core affect treatment?
13:37 What should one do if they're unconfident in the results of a random biospy?
13:58 How do MRI scans compare with PSMA scans?
14:21 Are DREs ever helpful if used in conjunction with other biopsy methods?
14:45 How do you counsel men with higher grade disease?
15:44 Are seminal vesicles or lymph nodes ever biopsied as well?
16:24 What advice should those getting random needle biopsies keep in mind?
18:04 Alex's conclusions
Don't know your stage? Take the quiz: visit prostatecancerstaging.org
To learn more about prostate cancer, visit pcri.org
Sign up for our newsletter here to receive the latest updates on prostate cancer and the PCRI: pcri.org/join
Who we are:
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at pcri.org or contact our free helpline with any questions that you have at pcri.org/helpline. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
Donate to PCRI: pcri.org/donate
For more information, visit pcri.org
0:33 What is a Gleason Score, and how is it determined?
4:41 What do three, four, and five mean in the context of Gleason?
6:52 Why is a Gleason Score of three counted if it doesn't metastasize?
7:22 Are 50% of all prostate cancers Gleason 6?
7:53 Cna Gleason 6 ever metastasize at all?
8:11 Does one's amount of positive cores correlate with severity of cancer?
8:32 Why does the percentage of positive tissue in each core matter?
10:30 Can the number of positive cores indicate tumor size?
10:50 Does having more biopsied lesions mean one's cancer is more aggressive?
11:26 Should one always get a second opinion on their biopsy results?
12:27 How long do practitioners keep biopsy slides?
12:38 How does a high positive percentage core affect treatment?
13:37 What should one do if they're unconfident in the results of a random biospy?
13:58 How do MRI scans compare with PSMA scans?
14:21 Are DREs ever helpful if used in conjunction with other biopsy methods?
14:45 How do you counsel men with higher grade disease?
15:44 Are seminal vesicles or lymph nodes ever biopsied as well?
16:24 What advice should those getting random needle biopsies keep in mind?
18:04 Alex's conclusions
Don't know your stage? Take the quiz: visit prostatecancerstaging.org
To learn more about prostate cancer, visit pcri.org
Sign up for our newsletter here to receive the latest updates on prostate cancer and the PCRI: pcri.org/join
Who we are:
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at pcri.org or contact our free helpline with any questions that you have at pcri.org/helpline. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
