Uploaded June 2026 | Updated September 2026, 2 weeks ago
Watch Dr. Epstein's full talk here:
youtube.com/watch?v=8bfv_G3DMcg
00:00 Can Gleason 6 Turn Into Gleason 7?
00:24 Does Gleason 6 Usually Stay the Same?
00:51 Recurrence and Changes in Gleason Grade
01:20 Why Gleason 7 Is Not All the Same
01:45 The Importance of Gleason Pattern 4
02:17 Why the Amount of Pattern 4 Matters
02:50 Understanding 3+4 vs 4+3 Beyond the Score
03:32 How Pathologists Report Percent Pattern 4
03:53 Why MRI Information Isn't Always Included
04:13 Pattern 4 Cutoffs for Active Surveillance
04:36 The Problem: Lack of Long-Term Data
05:02 Is 5%, 10%, or 20% Pattern 4 Safe?
05:20 What Patients Should Know About Pattern 4
Don't know your stage? Take the quiz: visit prostatecancerstaging.org
To learn more about prostate cancer, visit pcri.org
Sign up for our newsletter here to receive the latest updates on prostate cancer and the PCRI: pcri.org/join
Who we are:
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at pcri.org or contact our free helpline with any questions that you have at pcri.org/helpline. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
Watch Dr. Epstein's full talk here:
youtube.com/watch?v=8bfv_G3DMcg
00:00 Can Gleason 6 Turn Into Gleason 7?
00:24 Does Gleason 6 Usually Stay the Same?
00:51 Recurrence and Changes in Gleason Grade
01:20 Why Gleason 7 Is Not All the Same
01:45 The Importance of Gleason Pattern 4
02:17 Why the Amount of Pattern 4 Matters
02:50 Understanding 3+4 vs 4+3 Beyond the Score
03:32 How Pathologists Report Percent Pattern 4
03:53 Why MRI Information Isn't Always Included
04:13 Pattern 4 Cutoffs for Active Surveillance
04:36 The Problem: Lack of Long-Term Data
05:02 Is 5%, 10%, or 20% Pattern 4 Safe?
05:20 What Patients Should Know About Pattern 4
Don't know your stage? Take the quiz: visit prostatecancerstaging.org
To learn more about prostate cancer, visit pcri.org
Sign up for our newsletter here to receive the latest updates on prostate cancer and the PCRI: pcri.org/join
Who we are:
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at pcri.org or contact our free helpline with any questions that you have at pcri.org/helpline. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
