Uploaded May 2021 | Updated September 2026, 3 weeks ago
Asthma is an disease which affects 300 million people. Currently, we can treat asthma but there is no cure. However, there might soon be an asthma vaccine which could cure allergy induced asthma. But how would this allergy induced asthma vaccine work? Could the asthma vaccine replace inhalers?
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Asthma is a complicated disease with different subtypes. One asthma subtype is allergy induced asthma. In allergy induced asthma, immune cells in the lungs are activated. After encountering a trigger (tree pollen, dust mites, mold,..) the immune system overreacts in allergy induced asthma. T helper 2 cells recruit other parts of the immune system by producing IL-4 and IL-13 and cause swellings of the lung. The airways then become blocked by mucus.
Currently, we cannot cure allergy induced asthma. However, an allergy induced asthma vaccine has been shown to alleviate asthma symptoms in mice. This vaccine injects IL-4 and IL-13 linked to the diphteria proteins. The immune system starts to fight the diphteria proteins and the linked IL-4 and IL-13. This then reduced allergy symptoms in mice and is therefore a potential allergy induced asthma vaccine. Human trials will probably start in the next years.
We can also try to prevent asthma since there are several risk factors. Risk factors for asthma include smoking, air pollution, obesity and fast food. Also genetics and epigenetics play a role in provoking asthma. The hygiene hypothesis claims that our increased hygiene and less exposure to parasites leads to higher incidences of asthma cases. This has been quite well documented. But let's see whether an allergy induced asthma vaccine can really cure people all around the world!
00:00-01:29 Intro
1:29-4:40 - How Allergy-Induced Asthma Works
4:40-7:02- A potential Asthma Vaccine?
7:02-10:01 Why do We Have Asthma?
For your reading:
Conde, Eva, et al. "Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice." Nature communications 12.1 (2021): 1-14.
Hammad, Hamida, and Bart N. Lambrecht. "The basic immunology of asthma." Cell (2021).
Lovinsky-Desir, Stephanie, and Rachel L. Miller. "Epigenetics, asthma, and allergic diseases: a review of the latest advancements." Current allergy and asthma reports 12.3 (2012): 211-220.
Images:
Some pictures were derived from Servier Medical Art by Servier. You can find over 3000 free medical images here: smart.servier.com
Syrringe Injection by Marco Verch, CC-BY 2.0
Inhaler by NIAID, CC BY 2.0
Music:
Title: Rudolph by Lukrembro soundcloud.com/lukrembo
Title: Art of Silence by Uniq soundcloud.com/uniqofficial
Title: Outside Visitors, The Illstrumentalist
Title: Biscuit by Lukrembo soundcloud.com/lukrembo
Title: Way home by Tokyo Music Walker soundcloud.com/user-356546060
Title: Parallel by Ross Budgen youtube.com/channel/UCw5HZUiqgbhO3RFDiVNwwmg (CCA 4.0 )
Title: Black heat by Ross Budgen youtube.com/channel/UCw5HZUiqgbhO3RFDiVNwwmg (CCA 4.0 )
About Clemens Steinek:
CLEMENS STEINEK is a PhD student/youtuber (LifeLabLearner) who is currently conducting stem cell research in Germany.
Asthma is an disease which affects 300 million people. Currently, we can treat asthma but there is no cure. However, there might soon be an asthma vaccine which could cure allergy induced asthma. But how would this allergy induced asthma vaccine work? Could the asthma vaccine replace inhalers?
🔬 Subscribe for more awesome biomedical research: bit.ly/2SRMqhC
🔬Tweet me your science questions:
Twitter: twitter.com/CSteinek
Asthma is a complicated disease with different subtypes. One asthma subtype is allergy induced asthma. In allergy induced asthma, immune cells in the lungs are activated. After encountering a trigger (tree pollen, dust mites, mold,..) the immune system overreacts in allergy induced asthma. T helper 2 cells recruit other parts of the immune system by producing IL-4 and IL-13 and cause swellings of the lung. The airways then become blocked by mucus.
Currently, we cannot cure allergy induced asthma. However, an allergy induced asthma vaccine has been shown to alleviate asthma symptoms in mice. This vaccine injects IL-4 and IL-13 linked to the diphteria proteins. The immune system starts to fight the diphteria proteins and the linked IL-4 and IL-13. This then reduced allergy symptoms in mice and is therefore a potential allergy induced asthma vaccine. Human trials will probably start in the next years.
We can also try to prevent asthma since there are several risk factors. Risk factors for asthma include smoking, air pollution, obesity and fast food. Also genetics and epigenetics play a role in provoking asthma. The hygiene hypothesis claims that our increased hygiene and less exposure to parasites leads to higher incidences of asthma cases. This has been quite well documented. But let's see whether an allergy induced asthma vaccine can really cure people all around the world!
00:00-01:29 Intro
1:29-4:40 - How Allergy-Induced Asthma Works
4:40-7:02- A potential Asthma Vaccine?
7:02-10:01 Why do We Have Asthma?
For your reading:
Conde, Eva, et al. "Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice." Nature communications 12.1 (2021): 1-14.
Hammad, Hamida, and Bart N. Lambrecht. "The basic immunology of asthma." Cell (2021).
Lovinsky-Desir, Stephanie, and Rachel L. Miller. "Epigenetics, asthma, and allergic diseases: a review of the latest advancements." Current allergy and asthma reports 12.3 (2012): 211-220.
Images:
Some pictures were derived from Servier Medical Art by Servier. You can find over 3000 free medical images here: smart.servier.com
Syrringe Injection by Marco Verch, CC-BY 2.0
Inhaler by NIAID, CC BY 2.0
Music:
Title: Rudolph by Lukrembro soundcloud.com/lukrembo
Title: Art of Silence by Uniq soundcloud.com/uniqofficial
Title: Outside Visitors, The Illstrumentalist
Title: Biscuit by Lukrembo soundcloud.com/lukrembo
Title: Way home by Tokyo Music Walker soundcloud.com/user-356546060
Title: Parallel by Ross Budgen youtube.com/channel/UCw5HZUiqgbhO3RFDiVNwwmg (CCA 4.0 )
Title: Black heat by Ross Budgen youtube.com/channel/UCw5HZUiqgbhO3RFDiVNwwmg (CCA 4.0 )
About Clemens Steinek:
CLEMENS STEINEK is a PhD student/youtuber (LifeLabLearner) who is currently conducting stem cell research in Germany.
