Uploaded May 2026 | Updated September 2026, 3 weeks ago
In this episode, Dave Asprey talks with Dr. Andrew Salzman about aging at the cellular level, especially how inflammation, NAD depletion, mitochondrial stress, and gut barrier breakdown may drive the loss of energy and resilience over time.
The conversation then moves into a deeper theory: aging may begin in the gut. Salzman argues that when tight junctions weaken, bacterial fragments can leak through the gut lining, trigger low-grade inflammation, reduce ATP and NAD, and create a vicious cycle that affects the entire body.
The episode also reframes creatine as more than a gym supplement, presenting it as an energy-delivery system that helps move fast energy to the places cells need it most, including the gut, brain, heart, and muscles.
Connect with Dave Asprey!
Website: daveasprey.com
TikTok: tiktok.com/@daveaspreyofficial
Instagram: instagram.com/dave.asprey
Facebook: facebook.com/Daveaspreyofficial
X: https://x.com/daveasprey
YouTube: youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: instagram.com/TheHumanUpgradePodcast https://m.facebook.com/Thehumanupgrade
Danger Coffee: dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: beyondconference.com
Dave Asprey’s New Book - Heavily Meditated: daveasprey.com/heavily-meditated
Dave's favorite supplements: shopsuppgradelabs.com/discount/DAVE15
Join my Substack: substack.daveasprey.com
Upgrade Labs: upgradelabs.com
40 Years of Zen: 40yearsofzen.com
In this episode, Dave Asprey talks with Dr. Andrew Salzman about aging at the cellular level, especially how inflammation, NAD depletion, mitochondrial stress, and gut barrier breakdown may drive the loss of energy and resilience over time.
The conversation then moves into a deeper theory: aging may begin in the gut. Salzman argues that when tight junctions weaken, bacterial fragments can leak through the gut lining, trigger low-grade inflammation, reduce ATP and NAD, and create a vicious cycle that affects the entire body.
The episode also reframes creatine as more than a gym supplement, presenting it as an energy-delivery system that helps move fast energy to the places cells need it most, including the gut, brain, heart, and muscles.
Connect with Dave Asprey!
Website: daveasprey.com
TikTok: tiktok.com/@daveaspreyofficial
Instagram: instagram.com/dave.asprey
Facebook: facebook.com/Daveaspreyofficial
X: https://x.com/daveasprey
YouTube: youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: instagram.com/TheHumanUpgradePodcast https://m.facebook.com/Thehumanupgrade
Danger Coffee: dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: beyondconference.com
Dave Asprey’s New Book - Heavily Meditated: daveasprey.com/heavily-meditated
Dave's favorite supplements: shopsuppgradelabs.com/discount/DAVE15
Join my Substack: substack.daveasprey.com
Upgrade Labs: upgradelabs.com
40 Years of Zen: 40yearsofzen.com
