Uploaded August 2026 | Updated September 2026, 3 weeks ago

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NLRP3 is a central inflammasome pathway that acts as a major master switch for systemic inflammation. Triggered by everything from proteobacteria to cellular stress molecules like CD44 and RAGE, activating NLRP3 cascades down through NF-kB and sparks widespread inflammatory responses across the body. Targeting and modulating NLRP3 is quickly becoming one of the most critical targets in modern longevity and regenerative medicine.

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