Uploaded May 2025 | Updated September 2026, 3 days ago

---

Watch our latest EASD Early Career Academy Journal Club recording featuring Dr. Alfonso Galderisi, Associate Professor of Paediatrics at Yale University, as he discusses his recent research on metabolic phenotypes in preclinical type 1 diabetes.
In a study, published in Diabetologia, Dr. Galderisi reveals that in individuals with stage 2 type 1 diabetes, beta cell function and insulin clearance demonstrate distinct trajectories, influenced by both natural progression and responses to immunotherapy like teplizumab.
The significant metabolic heterogeneity among individuals at risk of type 1 diabetes, identified as slow- and rapid-progressors, challenge the traditional view on disease progression and response to treatment.
This work underscores the potential of using metabolic metrics to refine preclinical stages of type 1 diabetes and improve the design of future prevention trials.
Watch the recording now to learn more and read the corresponding paper here: link.springer.com/article/10.1007/s00125-024-06323-0
#diabetes #type1diabetes #diabetesresearch #t1d