The More Data You Have, The Further You Are From The Truth Heme Review 2023-05-10 | Dr Pavlos Msaouel: faculty.mdanderson.org/profiles/pavlos_msaouel.htmlProduced by @chubbyemu Audio only version: https://spotifyanchor-web.app.link/e/C3WPkgNWZzb0:00 Pretext and context MD Anderson Cancer Center1:42 The Early Experiences That Shaped Dr Msaouel3:39 The System of Cancer Research In the United States5:25 FDA Drug Approvals and Special Designations For Oncology11:09 A trade-off in our current system12:35 Whoops 😞 I misspoke 14:35 Randomized trials are not supposed to be representative of a population18:10 Inference for the treatment of Katie Coleman (metastatic oncocytoma)25:12 It is much more valuable to refute hypotheses than to confirm them28:05 All Models Are Wrong, But Some Are Useful30:05 Recasting the Bias-Variance Trade-off as the Patient Relevance-Robustness Trade-off33:38 High Relevance, Low Robustness: Subjective Bayes34:46 High Robustness, Low Relevance: Pure Randomization41:47 Signal To Noise Ratio45:49 The Big Data Paradox53:41 How the Big Data Paradox fits in with Katie Coleman's case54:33 How the Big Data Paradox fits in with other branches of medicine57:54 How do we rectify subjectivity in The Truth?01:00:43 How do we address the problems introduced by the Big Data Paradox?01:04:21 Duality in nature and a Twitter argument re: the Evidence-Based Deep Medicine Iceberg01:07:03 Why the ideas coming from MD Anderson are coming from MD Anderson01:09:39 Where you can find Dr MsaouelDr Msaouel: twitter.com/PavlosMsaouelHeme Review: twitter.com/HemeReviewProduction Assistant: Nick BrownSecret channel: @BigEmus Cancer Patient Speaks With Her Oncologist ► youtu.be/Nddft_nc3YcA Woman Had A Headache Lasting 3 Days (Katie's case) ► youtu.be/i9fLEvgZzREReferences:Stephen Senn. Statistical Issues in Drug Development.Why representativeness should be avoided. academic.oup.com/ije/article/42/4/1012/656034Commentary: Representativeness is usually not necessary and often should be avoided. academic.oup.com/ije/article/42/4/1018/658638Impervious to Randomness: Confounding and Selection Biases in Randomized Clinical Trials. tandfonline.com/doi/full/10.1080/07357907.2021.1974030A Causal Framework for Making Individualized Treatment Decisions in Oncology. mdpi.com/2072-6694/14/16/3923Causal Diagram Techniques for Urologic Oncology Research. sciencedirect.com/science/article/pii/S1558767320301932Causal inference and the data-fusion problem.pnas.org/doi/10.1073/pnas.1510507113Causal Inference: What If. Miguel A Hernán and James M. Robins. https://www.hsph.harvard.edu/miguel-hernan/wp-content/uploads/sites/1268/2023/04/hernanrobins_WhatIf_31mar23.pdfThere is Individualized Treatment. Why Not Individualized Inference? arxiv.org/abs/1510.08539Unrepresentative big surveys significantly overestimated US vaccine uptake. nature.com/articles/s41586-021-04198-4Unrepresentative Big Surveys Significantly Overestimate US Uptake arxiv.org/pdf/2106.05818.pdfStatistical Modeling: The Three Cultures. https://hdsr.mitpress.mit.edu/pub/uo4hjcx6/release/1How “centaur AI” will radically reshape the future of healthcare. bigthink.com/health/how-centaur-ai-will-radically-reshape-the-future-of-healthcare
I Abruptly Stopped Drinking Caffeine And This Happened Heme Review 2022-12-21 | @chubbyemu Caffeine Dry Scoop: youtu.be/sylqJ0NEVJwHappened while filming this video: youtu.be/LKNfFm0QDXQMusic by @Lifeformed: lifeformed.bandcamp.comTimestamps:0:00 Pretext0:29 I Used To Self-Mix Supplements2:25 Mixing The Wrong Supplements Causes Accidents2:54 Caffeine Mechanism of Action4:12 Caffeine and Sleep5:09 Why Caffeine Isn't As "Strong" As Other Stimulants5:52 How Caffeine Dependency Develops7:09 Chubbyemu's Caffeine Withdrawal11:15 Caffeine Withdrawal PharmacobiologyReferences:The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine A1 Receptor. mdpi.com/1422-0067/22/1/320Caffeine Withdrawal. ncbi.nlm.nih.gov/books/NBK430790A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. pubmed.ncbi.nlm.nih.gov/15448977Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. pubmed.ncbi.nlm.nih.gov/20492310Coffee, CYP1A2 genotype, and risk of myocardial infarction. pubmed.ncbi.nlm.nih.gov/16522833
The Boy Who Put On A Sock That Had A Spider In It Heme Review 2022-06-08 | @chubbyemu video: youtu.be/xtVvtsPgfewHeme Review Podcast: https://anchor.fm/chubbyemuBehind the scenes channel: @BigEmus Music by @Lifeformed ► lifeformed.bandcamp.comAll Heme Review videos (playlist) ► youtube.com/playlist?list=PLAHeV2H_YiGUYhHOF4wRMCuqBIJvrnWqSDaddy Longlegs by VengolisLoxosceles gaucho by HaliesSome images by Getty ImagesReferences:CMS Malaque, RS Vetter, M Entres. Loxosceles spiders. Critical Care toxicology. link.springer.com/referenceworkentry/10.1007/978-3-319-17900-1_119Myth: Idiopathic wounds are often due to brown recluse or other spider bites throughout the United States ncbi.nlm.nih.gov/pmc/articles/PMC1071166Correspondance: Bites of the Brown Recluse Spider. nejm.org/doi/full/10.1056/nejm200505123521922Spider Bites: Part 1. lacerationrepair.com/wound-blog/spider-bitesBrown Recluse Pest Management Tips for The Spider That's Not As Common As You Think. entomologytoday.org/2018/01/29/brown-recluse-pest-management-tips-for-the-spider-thats-not-as-common-as-you-think/brown-recluse-range-mapThe Chilean Recluse. fdacs.gov/content/download/68159/file/Pest_Alert_-_Loxosceles_laeta,_The_Chilean_Recluse.pdfBrown recluse spider (Loxosceles reclusa) envenomation leading to acute hemolytic anemia in six adolescents. ncbi.nlm.nih.gov/pmc/articles/PMC4902007Acute kidney injury and dermonecrosis after Loxosceles reclusa envenomation. ncbi.nlm.nih.gov/pmc/articles/PMC4119339Bites of Brown Recluse Spiders and Suspected Necrotic Arachnidism. nejm.org/doi/full/10.1056/NEJMra041184CASE OF ARACHNOIDISM (SPIDER BITE). jamanetwork.com/journals/jama/article-abstract/265718Detection of Loxosceles species venom in dermal lesions: A comparison of 4 venom recovery methods.annemergmed.com/article/S0196-0644(02)04713-3/fulltextBrown spider (Loxosceles sp.) bite and COVID-19: A case report. sciencedirect.com/science/article/pii/S0041010122000861Loxosceles intermedia spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis. sciencedirect.com/science/article/pii/S000649712036568X?via%3DihubNecrotic arachnidism. pubmed.ncbi.nlm.nih.gov/11260528Brown Recluse Michigan. ncbi.nlm.nih.gov/pmc/articles/PMC8384389An Infestation of 2,055 Brown Recluse Spiders (Araneae: Sicariidae) and No Envenomations in a Kansas Home: Implications for Bite Diagnoses in Nonendemic Areas. academic.oup.com/jme/article/39/6/948/862215
The Boy Who Rubbed 1 Tube Of Pain Relief Cream Between His Legs Heme Review 2022-05-16 | @chubbyemu video of this case: youtu.be/Le-IKCLGT9AA Toddler Drank His Mom's Essential Oils: youtu.be/TZr0nt2hxbsAudio-podcast version of this video: https://anchor.fm/chubbyemuInterview With a DNP Accident Survivor: youtu.be/o15HCjtSkugTweet me: twitter.com/HemeReviewIG me: instagram.com/HemeReviewPatient portrayed by Abram CutshallMom and her toddler portrayed by Megan Pulley and her son2-4-Dinitrophenol is also an uncoupler of oxidative phosphorylation on top of salicylateReferences:Salicylate Toxicity from Exposure to a Methylsalicylate-Containing Rubefacient. ncbi.nlm.nih.gov/pmc/articles/PMC4786239Regional variation in percutaneous penetration of 14C cortisol in man. jidonline.org/article/S0022-202X(15)47268-9/pdfAnatomy and physiology of chronic s pain ncbi.nlm.nih.gov/pmc/articles/PMC5503924Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. pubmed.ncbi.nlm.nih.gov/10634967 ISPAD Clinical Practice Consensus Guidelines 2018: DKA and the hyperglycemic hyperosmolar state. pubmed.ncbi.nlm.nih.gov/29900641Salicylates. Goldfrank, Lewis R, and Neal Flomenbaum. Goldfrank's Toxicologic Emergencies. New York: McGraw-Hill, 2006.Unconscious Uncoupling – Managing pH in Salicylate. Tox and Hound. toxandhound.com/toxhound/phinasaCounterproductive effects of sodium bicarbonate in DKA. pubmed.ncbi.nlm.nih.gov/8550770Anti-Inflammatory Drugs in Patients with Ischemic Heart Disease. Journal of Clinical Medicine 10(13):2835Risk Factors for Cerebral Edema in Children with Diabetic Ketoacidosis. N Engl J Med 2001; 344:264-269. Risk Factors for Cerebral Edema in Children with Diabetic KetoacidosisRole of the mitochondrial permeability transition in salicylate toxicity to cultured rat hepatocytes: implications for the pathogenesis of Reye's syndrome. Toxicol Appl Pharmacol . 1997 Dec;147(2):431-41. pubmed.ncbi.nlm.nih.gov/9439738
The Student Who Ate 5-Day Old Pasta And His Liver Shut Down Heme Review 2022-04-18 | @chubbyemu video: youtu.be/5ujTYLV2Qo4Audio only version: https://anchor.fm/chubbyemu/episodes/The-Student-Who-Ate-5-Day-Old-Pasta-And-His-Liver-Shut-Down-e1hb47qTweet me: twitter.com/hemereviewIG me: instagram.com/hemereviewMain channel: @chubbyemu Behind the scenes channel: @BigEmus A Student Ate 5 Day Old Pasta For Lunch. This Is How His Liver Shut Down. References:Fulminant Liver Failure in Association with the Emetic Toxin of Bacillus cereus. nejm.org/doi/full/10.1056/NEJM199704173361604Sudden Death of a Young Adult Associated with Bacillus cereus Food Poisoning. ncbi.nlm.nih.gov/pmc/articles/PMC3232990Acute Liver Failure after Ingestion of Fried Rice Balls: A Case Series of Bacillus cereus Food Poisonings. doi.org/10.3390 toxins14010012Fatal Family Outbreak of Bacillus cereus-Associated Food Poisoning. ncbi.nlm.nih.gov/pmc/articles/PMC1233987Bacillus cereus and its food poisoning toxins. pubmed.ncbi.nlm.nih.gov/9435100Liver Zonation – Revisiting Old Questions With New Technologies. frontiersin.org/articles/10.3389/fphys.2021.732929/fullBacillus cereus food poisoning. nejm.org/doi/full/10.1056/NEJM197801192980306Tox and Hound: D and Toxin-Induced Hepatic Microvesicular Steatosis toxandhound.com/toxhound/ff-microvesicular-steatosisENCEPHALOPATHY AND FATTY DEGENERATION OF THE VISCERA. A DISEASE ENTITY IN CHILDHOOD. pubmed.ncbi.nlm.nih.gov/14055046Whatever happened to Reye’s syndrome? Did it ever really exist? pubmed.ncbi.nlm.nih.gov/10470768Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA. pubmed.ncbi.nlm.nih.gov/22120519Prevalence of Alcoholic Fatty Liver Disease Among Adults in the United States, 2001-2016.pubmed.ncbi.nlm.nih.gov/31063562Goldfrank's Toxicologic Emergencies 11th ed.
The Woman Who Ate 23 Bananas After Fasting 7 Days And Had Refeeding Syndrome Heme Review 2021-11-09 | @chubbyemu A Woman Ate 23 Bananas: youtu.be/nQC_GDTNkQQA Mom Tried Keto Diet: youtu.be/W74jOR9V6UAThe Weird Time When Energy Drinks Fixed My Insomnia: youtu.be/d_qKA6KTvs8Audio Podcast: https://anchor.fm/chubbyemuTweet me: twitter.com/hemereviewIG me: instagram.com/hemereviewReferences:Mechanism of hypokalemia in magnesium deficiency. Huang CL, Kuo E. J Am Soc Nephrol. 2007;18:2649–2652. pubmed.ncbi.nlm.nih.gov/17804670Hypophosphatemia and Rhabdomyolysis ncbi.nlm.nih.gov/pmc/articles/PMC371889A Case of Hemodynamically Unstable Sick Sinus Syndrome Secondary to Refeeding Syndrome ncbi.nlm.nih.gov/pmc/articles/PMC8148626Review of the Refeeding Syndrome. January 2006Nutrition in Clinical Practice 20(6):625-33. EMCrit Refeeding Syndrome emcrit.org/ibcc/refeedingRefeeding syndrome: what it is, and how to prevent and treat it. BMJ. 2008 Jun 28; 336(7659): 1495–1498. ncbi.nlm.nih.gov/pmc/articles/PMC2440847
The Weird Time When Energy Drinks Fixed My Insomnia Heme Review 2021-09-18 | Mug is here 😳 ► crowdmade.com/collections/chubbyemu@chubbyemu energy drink video ► youtu.be/tAtaIZD0EbsA Student Ate Only Chips And Fries For 10 Years ► youtu.be/VINtwoyaF_8A Mom Ate 5 Day Old Sushi 🍣 ► youtu.be/R0d6Dpx2li4Vitamin B12 deficiency can cause neurologic problems. It's stored in the liver and isn't made in humans. It needs to be sourced via diet.
Interview With A Renal Medullary Carcinoma Survivor Heme Review 2021-08-21 | @chubbyemu video: youtube.com/watch?v=3E75UvmY9GAA Brief Discussion On Renal Medullary Carcinoma: youtu.be/j7WGP6sJBLkAudio version of this video: https://anchor.fm/chubbyemu/episodes/Interview-With-A-Rare-Renal-Medullary-Carcinoma-Survivor-e167o99Sickle Cell means Sickle Hemoglobinopathy, including Sickle Cell Disease, Sickle Cell Trait, Beta Thalassemia, Sickle Cell Hemoglobin-CContact Cora: twitter.com/RMCAwarenessCora Facebook: facebook.com/RMCSupportA Man Felt Pain In His Back. This Is What Happened To His Kidneys.IG me: instagram.com/hemereviewTweet me: twitter.com/hemereviewThank you Dr Nizar Tannir, Dr Pavlos Msaouel, Cora and Herman Connor, and Dr Loren StaggProduction Assistant: Nick BrownRenal Medullary Carcinoma is a sickle cell related kidney malignancy that is usually diagnosed in young patients (median age at diagnosis 28 years old). It is considered a rare malignancy but likely afflicts more people than prior literature suggests given that review of that literature shows patients more in line with Renal Medullary Carcinoma rather than Collecting Duct Carcinoma. 3 year overall survival of RMC is 3%. Upfront chemotherapy then surgery is the suggested treatment. Response rate to platinum based chemotherapies, gemcitabine, doxorubicin is 29%.
A Drepanocyte Caused Vasoocclusion. This Is What Happened To The Renal Medulla. Heme Review 2021-08-18 | @chubbyemu video: youtu.be/3E75UvmY9GAInterview with Herman Connor: youtu.be/w5zLOZE-GocAudio version of this podcast available at https://anchor.fm/chubbyemu/episodes/A-Sickle-Cell-Caused-Vasoocclusion--This-Is-What-Happened-To-The-Kidney-Medulla-e1646lnTweet Dr Msaouel: twitter.com/pavlosmsaouelIG me: instagram.com/hemereviewTweet me: twitter.com/hemereviewThank you Dr Nizar Tannir, Dr Pavlos Msaouel, Cora and Herman Connor, and Dr Loren StaggProduction Assistant: Nick BrownMusic by @Lifeformed ► lifeformed.bandcamp.comSome images courtesy Getty ImagesRenal Medullary Carcinoma is a sickle cell related kidney malignancy that is usually diagnosed in young patients (median age at diagnosis 28 years old). It is considered a rare malignancy but likely afflicts more people than prior literature suggests given that review of that literature shows patients more in line with Renal Medullary Carcinoma rather than Collecting Duct Carcinoma. 3 year overall survival of RMC is 3%. Upfront chemotherapy then surgery is the suggested treatment. Response rate to platinum based chemotherapies, gemcitabine, doxorubicin is 29%.References:Renal medullary carcinoma. The seventh sickle cell nephropathy. Am J Surg Pathol. 1995 Jan;19(1):1-11. pubmed.ncbi.nlm.nih.gov/7528470A Model Linking Sickle Cell Hemoglobinopathies and SMARCB1 Loss in Renal Medullary Carcinoma. Clin Cancer Res. 2018 May 1;24(9):2044-2049. pubmed.ncbi.nlm.nih.gov/29440190Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma. Clin Genitourin Cancer. 2019 Feb;17(1):1-6. pubmed.ncbi.nlm.nih.gov/30287223Five decades of urologic pathology: the accelerating expansion of knowledge in renal cell neoplasia. Hum Pathol. 2020 Jan;95:24-45. pubmed.ncbi.nlm.nih.gov/31655169GG Malouf, NM Tannir, P Rao, P Msaouel. Renal Medullary Carcinoma in Rare Kidney Tumors.Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. Cancer Cell. 2020 May 11;37(5):720-734.e13. pubmed.ncbi.nlm.nih.gov/32359397The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. pubmed.ncbi.nlm.nih.gov/10591208High-intensity exercise is a risk factor for renal medullary carcinoma in individuals with sickle cell trait. Preprint. Atypical carcinoma of kidney originating from collecting duct epithelium. Urology. 1982 Jan;19(1):89-92. pubmed.ncbi.nlm.nih.gov/7058597Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae. Genetics. 1984 Dec;108(4):845-58. pubmed.ncbi.nlm.nih.gov/6392017Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J. 1996 Oct 1; 15(19): 5370–5382. ncbi.nlm.nih.gov/pmc/articles/PMC452280
A Discussion On Breast Malignancy And Military Burn Pit Exposure Heme Review 2021-06-21 | @chubbyemu Video: youtu.be/LKNfFm0QDXQDr Bora Lim is a breast specialist, Associate Professor of Medicine, Director of Translational Research, and Associate Director for Clinical Science at Baylor College of MedicineShe can be reached on Twitter at twitter.com/naboralaAudio version of this episode: https://anchor.fm/chubbyemu/episodes/On-Breast-Malignancy-and-Military-Burn-Pit-Exposure-e136rjcTimestamps:0:00 Introduction0:29 What is Breast Malignancy?1:39 How does Breast Malignancy develop?3:45 What are the risk factors for Breast Malignancy?6:46 Brief on industrial chemicals7:14 On burning waste8:05 About burn pits9:11 Burn pits as a likely health hazard10:32 Dr Lim's veteran patient with stage 3 disease11:46 Why is breast malignancy different?14:51 Survival difference between Stage 2 and Stage 417:09 What is HR+ / HER2- disease?19:18 What is ovarian suppression / ablation?21:19 Do squamous and basal carcinomas increase Breast Malignancy risk?21:54 Breast augmentation and risk of malignancy22:16 What happens when Breast Malignancy mutates?22:59 What happens when the malignancy spreads?25:33 What can a veteran do if they've been exposed to burn pits?26:56 New revelations and research on bone metastases29:10 What can researchers do to establish a stronger link of burn pit exposure with malignancies?Tweet me: twitter.com/hemereviewIG me: instagram.com/hemereviewFB me: facebook.com/hemereviewProduction Assistant: Nick BrownA Marine Inhaled Burning Garbage Fumes While Deployed. This Is What Happened To Her Organs.
A Discussion On Over-The-Counter Cough Syrup Misuse Heme Review 2021-05-24 | See @chubbyemu video youtu.be/WPxb2IG9MOkFeaturing: Dr Sonal JagasiaPatient GG depicted by @MerryRoseHowley Additional patient depictions by @JustinWhangYt Video with @JustinWhangYt : youtu.be/QKIobyk6IscAudio version of this podcast: https://anchor.fm/chubbyemuTweet me: twitter.com/hemereviewIG me: instagram.com/hemereviewFB me: facebook.com/hemereviewDextromethorphan is an over the counter cough medicine. It is for coughs. Misuse of it can cause life threatening side effects.Thumbnail case courtesy of Dr Derek Smith, Radiopaedia.org, rID: 53692References: Dextromethorphan, chlorphenamine and serotonin toxicity: case report and systematic literature review. pubmed.ncbi.nlm.nih.gov/21175434Case of Serotonin Syndrome Initially Presenting as Diffuse Body Pain. ncbi.nlm.nih.gov/pmc/articles/PMC6196581Serotonin Syndrome. ncbi.nlm.nih.gov/pmc/articles/PMC3865832Bromism: An overlooked and elusive toxidrome from chronic dextromethorphan misuse. pubmed.ncbi.nlm.nih.gov/31864868Dextromethorphan-induced serotonin syndrome. pubmed.ncbi.nlm.nih.gov/19238739Cognitive Deterioration from Long-Term Misuse of Dextromethorphan:A Case Report. ncbi.nlm.nih.gov/pmc/articles/PMC1188627Pediatric Fatalities Associated With Over the Counter (Nonprescription) Cough and Cold Medications. pubmed.ncbi.nlm.nih.gov/19101060"DXM": a new drug of. pubmed.ncbi.nlm.nih.gov/9624331
Hepatitis From Possibly Contaminated Alkaline Water Heme Review 2021-04-12 | This video up to date as of April 11, 2021Audio version: https://anchor.fm/chubbyemu/episodes/Hepatitis-From-Possibly-Contaminated-Alkaline-Water-euogm7Statement from water company CEO: youtube.com/watch?v=faCsru9Ctgk@InsideEdition video about this case: youtube.com/watch?v=lmEpmyc7g9YLocal News talking about the water: youtube.com/watch?v=oGQJcnlk5agOn March 13, the FDA was alerted to five cases of acute non-viral hepatitis (resulting in acute liver failure) in infants and children that occurred in November 2020 with an unknown cause reported to the Southern Nevada Health District. All five patients had been hospitalized but have since recovered. All patients were reported to have consumed “Real Water” brand alkaline water. These patients came from four different households. Five additional people, two adults and three children, from two of the four households were reported to have experienced other symptoms as well. Less severe symptoms included fever, vomiting, nausea, loss of appetite, and fatigue.
Why You Should Be Careful With Psyllium Husk Fiber Supplement Heme Review 2021-04-05 | @chubbyemu video about Fiber Supplement: youtube.com/watch?v=1MggKIfEld4@HemeReview Audio-only episode A Grandma Collapsed From Abdominal Pain. This Is What Happened To Her Colon: https://anchor.fm/chubbyemu/episodes/A-Grandma-Collapsed-From-Abdominal-Pain--This-Is-What-Happened-To-Her-Colon-eu9rolPsyllium husk fiber supplement can be part of a healthy diet, but it must be taken correctly. It has been shown to lower cholesterol levels to an extent, but is best in combination with a proper diet. Always take care to mix psyllium husk with more than enough water. It can become thick and cause problems if it isn't.Audio podcast: https://anchor.fm/chubbyemuTweet me: twitter.com/hemereviewIG me: instagram.com/hemereviewFB me: facebook.com/hemereviewReferences:Potential Benefits of Dietary Fibre Intervention in Inflammatory Bowel Disease ncbi.nlm.nih.gov/pmc/articles/PMC4926452Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia academic.oup.com/ajcn/article/70/4/466/4729069Anaphylaxis following psyllium ingestion pubmed.ncbi.nlm.nih.gov/6736485Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia academic.oup.com/ajcn/article/71/6/1433/4729388
Interview With A Stage 4 Lung Cancer Survivor (Jill Hamer-Wilson) Heme Review 2021-03-30 | Audio-only Podcast version: https://anchor.fm/chubbyemu/episodes/Interview-With-A-Stage-4-Lung-Cancer-Survivor-Jill-Hamer-Wilson-etthjnJill's Blog: throughthevalley.caThe White Ribbon Project: twitter.com/TheWRP4LCLUNGevity Foundation: lungevity.orgGO2 Foundation: go2foundation.orgLung Cancer Canada: lungcancercanada.caLung Foundation Australia: https://lungfoundation.com.auLung Cancer Europe (LUCe): https://www.lungcancereurope.euTweet me: twitter.com/hemereviewFB me: facebook.com/hemereviewIG me: instagram.com/hemereviewMain channel: @chubbyemu
A Discussion Of Dinitrophenol In Weight Loss Heme Review 2021-03-03 | @East-Bound's personal recount of case: youtu.be/7BpymtR2vpA@East-Bound Interview: youtu.be/o15HCjtSkug@chubbyemu video on this case: youtu.be/ChPeG19qKUo@HemeReview Podcast version: https://anchor.fm/chubbyemu2,4-Dinitrophenol (DNP) is a chemical that is not approved for weight loss in the United States. It is a classic case of efficacy, but without safety in the setting of weight loss. This setting of weight loss can be prone to chemical misuse, further exacerbating understanding in human systems. Christopher is one of 2 - 3 cases documented in literature to have survived an accident with DNP for weight loss. As of 2021, one organization has permission from the US FDA to investigate DNP in some neurodegenerative disorders. These are rare diseases with limited standards of care, therefore extenuating circumstances to find anything that could potentially improve patient outcomes.Tweet me: twitter.com/hemereviewIG me: instagram.com/hemereviewFB me: facebook.com/hemereviewReferences: Role of dantrolene in dinitrophenol (DNP) : A continuing question? Am J Emerg Med. 2019 Jun;37(6):1216.e1-1216.e2. pubmed.ncbi.nlm.nih.gov/309482572,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity . J Med Toxicol. 2011 Sep;7(3):205-12. pubmed.ncbi.nlm.nih.gov/21739343Ambient temperature and mortality from unintentional . JAMA. 1998 Jun 10;279(22):1795-800. pubmed.ncbi.nlm.nih.gov/9628710Dinitrophenol as a Medicine. Cells. 2019 Mar; 8(3): 280. ncbi.nlm.nih.gov/pmc/articles/PMC6468406The Interaction of Highly Active Uncouplers With Mitochondria. Biochimica et Biophysica Acta, 639 (1981) 225-242.Beware the yellow slimming pill: fatal 2,4-dinitrophenol. BMJ Case Rep. 2016 Apr 4;2016. pubmed.ncbi.nlm.nih.gov/27045052Dantrolene is not the answer to 2,4-dinitrophenol poisoning: more heated debate. BMJ Case Rep. 2018 Dec 19;11(1):e225323. pubmed.ncbi.nlm.nih.gov/30573533The effect of 2,4-dinitrophenol on adipose-tissue metabolism. Biochem J. 1969 Feb;111(4):431-44. pubmed.ncbi.nlm.nih.gov/4388239The mechanism of uncoupling of oxidative phosphorylation by 2,4-dinitrophenol. J Biol Chem. 1967 Oct 25;242(20):4577-83. pubmed.ncbi.nlm.nih.gov/4964808MECHANISMS OF DINITROPHENOL TOXICITY. Simon E.W. Biological Reviews. Vol 28. (4). Nov 1953.Identification and Importance of Brown Adipose Tissue in Adult Humans. nejm.org/doi/full/10.1056/NEJMoa0810780Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes Rev. 2001 Nov;2(4):255-65. pubmed.ncbi.nlm.nih.gov/12119996LC-MS-MS analysis of 2,4-dinitrophenol and its phase I and II metabolites. J Ana Toxicol. Jan-Feb 2007;31(1):55-61. pubmed.ncbi.nlm.nih.gov/17389084Uncouplers of oxidative phosphorylation. Environ Health Perspect. 1990 Jul;87:213-8. pubmed.ncbi.nlm.nih.gov/2176586Texas Woman Charged with Selling Misbranded fda.gov/inspections-compliance-enforcement-and-criminal-investigations/press-releases/texas-woman-charged-selling-misbranded-drug
Conversation With A Rare Dinitrophenol Accident Survivor (DNP For Weight Loss) Heme Review 2021-02-26 | Patient in this case is @East-Bound (check out his YouTube Channel!)@chubbyemu video of this case: youtube.com/watch?v=ChPeG19qKUoChristopher's recount of his case: youtube.com/watch?v=7BpymtR2vpAAudio podcast for Heme Review: https://anchor.fm/chubbyemuTweet me: twitter.com/hemereviewIG me: instagram.com/hemereviewFB me: facebook.com/hemereviewTimestamps:0:00 - Introduction 0:30 - Can you tell me about yourself?1:21 - How did you get into lifting weights?3:14 - Bernard talking about his high school experience4:12 - What was your relationship like with the gym?5:48 - How did things change in Christopher's life at the end of high school?8:17 - Other people's perception of weight9:24 - Christopher describing long time girlfriend cheating on him10:32 - People judging others based on weight14:45 - How did you get back in to fitness during college?17:54 - Weight loss plateau20:54 - Weight loss supplements24:46 - Transition from supplements to harder weight loss chemicals31:04 - What is clenbuterol like?33:40 - How did you come across DNP?35:41 - What is being on DNP like?40:00 - How long did you take DNP for?44:58 - What do you remember from day of accident?50:19 - Tales from the emergency room, September 3 201551:10 - Waking up in the ICU55:25 - How did the accident change your relationship with the gym?57:54 - What would you tell someone thinking of taking DNP today?2,4-Dinitrophenol (DNP) is a chemical that is not approved for weight loss. It is a classic case of efficacy, but without safety in the setting of weight loss. This setting of weight loss can be prone to chemical misuse, further exacerbating understanding in human systems. Christopher is one of 2 - 3 cases documented in literature to have survived an accident with DNP for weight loss. As of 2021, one organization has permission from the US FDA to investigate DNP in some neurodegenerative disorders. These are rare diseases with limited standards of care, therefore extenuating circumstances to find anything that could potentially improve patient outcomes.References: Role of dantrolene in dinitrophenol (DNP) : A continuing question? Am J Emerg Med. 2019 Jun;37(6):1216.e1-1216.e2. pubmed.ncbi.nlm.nih.gov/309482572,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity . J Med Toxicol. 2011 Sep;7(3):205-12. pubmed.ncbi.nlm.nih.gov/21739343Ambient temperature and mortality from unintentional . JAMA. 1998 Jun 10;279(22):1795-800. pubmed.ncbi.nlm.nih.gov/9628710Beware the yellow slimming pill: fatal 2,4-dinitrophenol. BMJ Case Rep. 2016 Apr 4;2016. pubmed.ncbi.nlm.nih.gov/27045052Dantrolene is not the answer to 2,4-dinitrophenol poisoning: more heated debate. BMJ Case Rep. 2018 Dec 19;11(1):e225323. pubmed.ncbi.nlm.nih.gov/30573533The effect of 2,4-dinitrophenol on adipose-tissue metabolism. Biochem J. 1969 Feb;111(4):431-44. pubmed.ncbi.nlm.nih.gov/4388239The mechanism of uncoupling of oxidative phosphorylation by 2,4-dinitrophenol. J Biol Chem. 1967 Oct 25;242(20):4577-83. pubmed.ncbi.nlm.nih.gov/4964808MECHANISMS OF DINITROPHENOL TOXICITY. Simon E.W. Biological Reviews. Vol 28. (4). Nov 1953.Identification and Importance of Brown Adipose Tissue in Adult Humans. nejm.org/doi/full/10.1056/NEJMoa0810780Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes Rev. 2001 Nov;2(4):255-65. pubmed.ncbi.nlm.nih.gov/12119996LC-MS-MS analysis of 2,4-dinitrophenol and its phase I and II metabolites. J Ana Toxicol. Jan-Feb 2007;31(1):55-61. pubmed.ncbi.nlm.nih.gov/17389084Uncouplers of oxidative phosphorylation. Environ Health Perspect. 1990 Jul;87:213-8. pubmed.ncbi.nlm.nih.gov/2176586Texas Woman Charged with Selling Misbranded fda.gov/inspections-compliance-enforcement-and-criminal-investigations/press-releases/texas-woman-charged-selling-misbranded-drug
The Body After Eating Several Pounds Licorice Candy Heme Review 2020-10-05 | Patient VP portrayed by John Posner@chubbyemu version youtu.be/qg76qIZ4BQ8Based on N Engl J Med 2020; 383:1263-1275. Link below.Audio-only version: https://anchor.fm/chubbyemuTikTokers Taking Benadryl ► youtu.be/ZNA_NtcutYYBitcoin Miner Heatstroke ► youtu.be/QSXzRWiuvxEA Bitcoin Miner Heatstroked In His Sleep ► youtu.be/QSXzRWiuvxETweet me: twitter.com/hemereviewIG me: instagram.com/hemereviewFB me: facebook.com/hemereviewSome music by @Lifeformed ► lifeformed.bandcamp.comLicorice candy has glycyrrhizin which increases cortisol (stress hormone) levels in the body. This causes hypokalemia. Hypo- low. Kal- kalium (potassium). emia- presence in blood. Potassium signals muscle relaxation. Low potassium, low relaxation. Heart can't relax, then it stops.Real licorice candy is not easy to get in the United States. It's not at big chain grocery stores. Most of what you can buy from the big brands is licorice flavored, and won't do this.These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.References:A 54-Year-Old Man with Sudden Cardiac Arrest. N Engl J Med 2020; 383:1263-1275. nejm.org/doi/full/10.1056/NEJMcpc2002420The Pharmacological Activities of Glycyrrhizinic Acid (“Glycyrrhizin”) and Glycyrrhetinic Acid. Sweeteners. 2018 : 245–261. ncbi.nlm.nih.gov/pmc/articles/PMC7123798Sustained Leukocyte Count during Rising Cortisol Level. Acta Haematologica 118(2):73-6. researchgate.net/publication/6298458nobelprize.org/prizes/medicine/1964/bloch/lectureLicorice-Induced Hypermineralocorticoidism. N Engl J Med 1991; 325:1223-1227. nejm.org/doi/full/10.1056/NEJM199110243251706Young WF, et. al. Apparent mineralocorticoid excess syndromes (including chronic licorice ingestion). In: UpToDate, Post, TW (Ed), UpToDate, Waltham, MA, 2019.Quinkler M, Stewart PM. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 2003; 88:2384.Funder JW. Apparent mineralocorticoid excess. J Steroid Biochem Mol Biol 2017; 165:151.Funder JW. 11 beta-Hydroxysteroid dehydrogenase: new answers, new questions. Eur J Endocrinol 1996; 134:267.
TikTokers Taking Too Much Benadryl Heme Review 2020-09-15 | @chubbyemu version: youtu.be/NaAFOrudj0gPatient JC portrayed by Jacqueline ConleyPodcast (audio only) version: https://anchor.fm/chubbyemuTweet me: twitter.com/hemereviewIG me: instagram.com/hemereviewFB me: facebook.com/hemereviewReferences:The Pharmacology and Use of H1-Receptor-Antagonist. N Engl J Med 1994; 330:1663-1670Advances in H1-Antihistamines. N Engl J Med 2004; 351:2203-2217Cardiac arrest caused by diphenhydramine overdose. Acute Med Surg. 2018 Oct; 5(4): 380–383.IV Lipid Emulsion Infusion in the Treatment of Severe Diphenhydramine. Am J Case Rep. 2019 May 29;20:758-763.Diphenhydramine with Intraventricular Conduction Delay Treated with Hypertonic Sodium Bicarbonate and IV Lipid Emulsion. West J Emerg Med. 2014 Nov; 15(7): 855–858.Diphenhydramine in a 26-year-old Woman. J Emerg Nurs. 2008 Dec;34(6):543-4.
A Brief Discussion of Heatstroke Heme Review 2020-08-15 | Listen to this episode in podcast format ▶️ https://anchor.fm/chubbyemu@chubbyemu video of this case ▶️ youtu.be/fr8bp8a2QS4The Body After Drinking A Snowglobe ▶️ youtu.be/elzijduKNS8The Body After 2 Gallons Coffee In 3 Hours ▶️ youtu.be/rn-WLpa_nyQTweet me: twitter.com/hemereviewFB me: facebook.com/hemereviewIG me: instagram.com/hemereviewMusic by @Lifeformed Heatstroke is a serious problem and the heatwaves that cause it, claim more lives on average than any other weather event in USA. While generally thought to affect the elderly and the very young, it can affect people of all ages, not just because of the heat in the environment (classic heatstroke) but also because of activity (exertional heatstroke). The problems caused by heatstroke sometimes happen but don't appear clinically, like GI ischemia.Bitcoin is a decentralized cryptocurrency that's used in peer to peer transactions. This happened in 2011 when individual people could still mine coins, but now, miners are usually pools or in large facilities in places that have cheap electricity and cool climate to save on computer cooling costs.The followup: web.archive.org/web/20110612111539/http://www.bitcoinminingaccidents.comReferences:0 Heat Stroke. Compr Physiol 5:611-647, 2015.1 Heatstroke N Engl J Med 2019; 380:2449-2459.2 Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia. Am J Physiol Heart Circ Physiol 280: H509–H521, 2001.3 The Impact of Mild Heat Stress During Prolonged Running On Gastrointestinal Integrity, Gastrointestinal Symptoms, Systemic Endotoxin and Cytokine Profiles. Int J Sports Med 2018; 39: 255–263.4 Heat stroke: Role of the systemic inflammatory response. J Appl Physiol (1985). 2010 Dec;109(6):1980-8.5 Endotoxaemia in exhausted runners after a long-distance race. S Afr Med J. 1988 May 7;73(9):533-6.6 Pathogenesis of nonocclusive ischemic colitis. Ann Surg. 1986 Jun;203(6):590-9.
The Body After Drinking A Snowglobe Heme Review 2020-07-20 | A Dad Mistakenly Drank A Snowglobe. This Is What Happened To His Kidneys: youtu.be/UrbylXMU8MwA Man Drank 2 Liters Moonshine In 2 Hours. This Is what Happened To His Brain: youtu.be/4DQUrg0Yhu4The Body After Drinking 2 Gallons Coffee In 3 Hours: youtube.com/watch?v=rn-WLpa_nyQ&list=PLAHeV2H_YiGUYhHOF4wRMCuqBIJvrnWqS&index=6&t=1sAll Heme Review episodes (playlist): youtube.com/playlist?list=PLAHeV2H_YiGUYhHOF4wRMCuqBIJvrnWqSTweet me: twitter.com/hemereviewFB me: facebook.com/hemereviewIG me: instagram.com/hemereviewMusic by Lifeformed ► lifeformed.bandcamp.comMusic by T4N3 ► soundcloud.com/t4n3Additional photos courtesy Radiopaedia.org, and Wellcome Collection.Pathology slides courtesy BMJ Case Reports, September 12 2019Most snowglobes are just made of water, but some can contain ethylene glycol. Most of those usually don't contain enough ethylene glycol to cause damage, but keep the word "usually" in mind. A homemade snowglobe can contain concentrations of anything, which is what happened in this case.Ethylene glycol can cause a profound high anion gap metabolic acidosis, and we'll explain the science, chemistry and physiology behind that in this episode.References:Delayed ethylene glycol presenting with abdominal pain and multiple cranial and peripheral neuropathies: a case report. Journal of Medical Case Reports volume 4, Article number: 220 (2010).Multiple Cranial Nerve Deficits After Ethylene Glycol. Ann Emerg Med. 1991 Feb;20(2):208-10. pubmed.ncbi.nlm.nih.gov/1996809Antidotes OH that form toxic metabolites. Br J Clin Pharmacol. 2016 Mar; 81(3): 505–515. ncbi.nlm.nih.gov/pmc/articles/PMC4767193Toxic Alcohols. N Engl J Med 2018; 378:270-280. nejm.org/doi/full/10.1056/NEJMra1615295Ethylene glycol ingestion masked by concomitant ethanol ingestion. Case Reports 2012;2012:bcr1220115326. casereports.bmj.com/content/2012/bcr.12.2011.5326Challenges in the Diagnosis of Ethylene Glycol Poisoning. Ann Clin Biochem. 2014 Mar;51(pt2):167-78. pubmed.ncbi.nlm.nih.gov/24215789Emmett M, Narins RG. Clinical use of the anion gap. Medicine (Baltimore) 1977;56:38-54.Uribarri J, Oh MS, Carroll HJ. D-lactic acidosis: a review of clinical presentation, biochemical features, and pathophysiologic mechanisms. Medicine (Baltimore) 1998;77:73-82.Judge BS. Metabolic acidosis: differentiating the causes in the poisoned patient. Med Clin North Am 2005;89:1107-1124.Kosten TR, O’Connor PG. Management of drug and alcohol withdrawal. N Engl J Med 2003;348:1786-1795. nejm.org/doi/full/10.1056/NEJMra020617A 49 Year Old Man With Obtundation Followed By Agitation And Acidosis. N Engl J Med 2015; 372:465-473. nejm.org/doi/full/10.1056/NEJMcpc1410940Integration of Acid-Base And Electrolyte Disorders. N Engl J Med 2014; 371:1821-1831. nejm.org/doi/full/10.1056/NEJMra1215672Calcium Kidney Stones. N Engl J Med 2010; 363:954-963. nejm.org/doi/full/10.1056/NEJMcp1001011
The Body After 2 Gallons Coffee In 3 Hours Heme Review 2020-05-19 | 2 Gallons = 7.6 Liters@chubbyemu case report video ► youtu.be/wj_AOzSSDMMHeme Review playlist ► youtube.com/playlist?list=PLAHeV2H_YiGUYhHOF4wRMCuqBIJvrnWqSIG me: instagram.com/hemereviewFb me: facebook.com/hemereviewTweet me: twitter.com/hemereviewAudio podcast version: https://anchor.fm/chubbyemuMusic by @Lifeformed Some caffeine is OK. 1-2 cups of coffee can generally be ok. Unreasonably large amounts of caffeine NOT OK.References:[0] Hensher C, Vogel J. Insulin Euglycemic Therapy in the Treatment of Caffeine. Chest. 2020 May;157(5):e145-e149. pubmed.ncbi.nlm.nih.gov/32386647[1] Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion. J Control Release. 2015 Jan 28; 198: 62–70.[2] Rall TW, Sutherland EW. Formation of a Cyclic Adenine Ribonucleotide By Tissue Particles. J Biol Chem 1958, 232:1065-1076.[3] A Case of Exercise-Induced Rhabdomyolysis Associated With A Weight Loss Dietary Supplement. Military Medicine, 172, 6:656, 2007.[4] Yamada Y, et. al. The mode of action of caffeine on catecholamine release from perfused adrenal glands of cat. Br. J. Pharmacol. (1989), 98, 351-356.[5] Effects of Caffeine on Plasma Renin Activity, Catecholamines and Blood Pressure. N Engl J Med 1978; 298:181-186.[6] Caffeine resulting in severe rhabdomyolysis and acute renal failure. American Journal of Emergency Med 32 (2014) 111.e3-111.e4.[7] Eteng, MU, et. al. Recent advanced in caffeine and theobromine toxicities: a review. Plant Foods for Human Nutrition 51: 231-243, 1997.[8] Jabbar SB, et. al. Caffeine: A case report and review of literature. Am J Forensic Med Pathol. Vol 34, N4, Dec 2013.[9] Bioh G. et. al. Survival of caffeine. BMJ Case Rep 2013. bcr-2012-007454.
A Future Of Medicine Heme Review 2020-05-04 | When I say future, I mean many hundreds of years.The Farmer Who Removed His Melanoma With A Pocket Knife ▶️youtu.be/bxGS07U-B98The Truth About The Hydroxychloroquine Study ▶️ youtu.be/smI60BngTnsChinese Doctors Explain▶️youtu.be/b4zely3ofBkAudio version of Heme👏Review👏Podcast ▶️https://anchor.fm/chubbyemuTweet me: twitter.com/HemeReviewIG me: instagram.com/HemeReviewMusic by @Lifeformed References:[0] Chapman PB et. al. Vemurafenib in patients with BRAFV600 mutation-positive metastatic melanoma: final overall survival results of the randomized BRIM-3 study.Ann Oncol. 2017 Oct 1;28(10):2581-2587. ncbi.nlm.nih.gov/pubmed/28961848[1] Chapman PB. Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation. N Engl J Med 2011; 364:2507-2516. nejm.org/doi/full/10.1056/NEJMoa1103782[2] Amy Harmon. New Drugs Stir Debate on Rules of Clinical Trials. New York Times, September 19, 2010. nytimes.com/2010/09/19/health/research/19trial.html
The Farmer Who Removed His Skin Cancer With A Pocket Knife Heme Review 2020-04-13 | Original Video about the Farmer KC ▶️youtube.com/watch?v=KKaJhQBusH8Audio version of Heme👏Review👏Podcast ▶️https://anchor.fm/chubbyemuSome music by @Lifeformed check out his music at his Bandcamp ▶️lifeformed.bandcamp.comOther music inspired by Bobby PrinceReferences:[0] Melanoma brain metastases: current areas of investigation and future directions. Cancer J. 2017 Jan-Feb; 23(1): 68–74. ncbi.nlm.nih.gov/pmc/articles/PMC5300745[1] The metastatic cycle: metastatic niches and cancer cell dissemination. J Dtsch Dermatol Ges. 2014 Nov;12(11):1012-9. ncbi.nlm.nih.gov/pubmed/25307562[2] BRAF Targets in Melanoma: Biological Mechanisms, Resistance, and Drug Discovery. Humana Press. 2015.[3] Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature2002;417:949-954. ncbi.nlm.nih.gov/pubmed/12068308?dopt=Abstract[4] MAP kinase pathways: the first twenty years. Biochim Biophys Acta. 2007 Aug;1773(8):1150-60. Epub 2006 Nov 15. ncbi.nlm.nih.gov/pmc/articles/PMC2043147[5] Transport Phenomena. Bird, Stewart, Lightfoot, 2nd Ed.#melanoma #oncology
A Brief Discussion of Hydroxychloroquine In COVID-19 (March 2020) Heme Review 2020-04-09 | This episode was recorded on and is current up to Friday March 27 2020Heme Review Podcast (full audio) ▶️https://anchor.fm/chubbyemuUnderstanding COVID-19 From Cases Described By Doctors In China ▶️youtube.com/watch?v=b4zely3ofBkVideo by @chubbyemu What (Hydroxy)chloroquine Does To The Body ▶️youtube.com/watch?v=ILowf7Tw7QYA Student Ate 5 Day Old Pasta For Lunch. This Is How His Liver Shut Down ▶️youtube.com/watch?v=5ujTYLV2Qo4A Man Drank 1 Bottle Rubbing Alcohol For COVID-19. This Is What Happened To His Brain ▶️youtu.be/BMSgoppbXiUMusic by @Lifeformed Papers described in show:- Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open- label non-randomized clinical trial. Gautret et. al. (Google Doc: drive.google.com/file/d/186Bel9RqfsmEx55FDum4xY_IlWSHnGbj/view, version as preprint submission: sciencedirect.com/science/article/pii/S0924857920300996)- Statistical review of Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. zenodo.org/record/3724167#.Xn7LRy2ZPAy- White NJ. The treatment of malaria. N Engl J Med. 1996;335(11):800.- Warhurst DC et. al. Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties. J Antimicrob Chemother. 2003;52(2):188. Epub 2003 Jul 1.- Metal Ionophores- An Emerging Class of Anticancer Drugs. iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.253- Chloroquine is a Zinc Ionophore. ncbi.nlm.nih.gov/pmc/articles/PMC4182877/#pone.0109180-Ding1- Treatment of Severe Chloroquine Poisoning. ncbi.nlm.nih.gov/pubmed/15837026#coronavirus #COVID19 #sarscov2
Understanding COVID-19 From Cases Described By Doctors In China Heme Review 2020-03-15 | This episode is current up to Friday March 6To hear the audio as a podcast: https://anchor.fm/chubbyemuGuest Appearance: Dr. Joe Akin, PhD, Immunologist alumnus from Harvard Medical school, of refigure.orgPlease check out refigure.org/: Save and organize journal figures in one-click. (not sponsored)Cross-reactivity of anti-SARS coronavirus antibodies to 2019 coronavirus: refigure.org/collections/item/47e25c50-51e1-11ea-80e3-85045318a762Music by Lifeformed. Please check out his music at his Bandcamp: lifeformed.bandcamp.comAdditional music inspired by Robert PrinceCOVID-19 Disease (Playlist) ► youtube.com/playlist?list=PL26HeTCO57qcOqYV6-5ZB9xleo_PaHxi4We NEED More Testing Kits! | Coronavirus Front Line(Doctor Mike) ► youtube.com/watch?v=DfMl6W6N7-ACOVID-19 Mutation and Evolution (Dr. John Campbell) ► youtube.com/watch?v=FYPZHA-UjUY3 COVID-19 Cases Described By Doctors In China ► youtu.be/Q0A0LyMru3IHow Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment (Medcram) ► youtube.com/watch?v=okg7uq_HrhQPapers described in show:Clinical Course And Outcomes Of Critically Ill Patients With SARS-CoV-2 Pneumonia In Wuhan, China: a single-centered, retrospective, observational study. Lancet. doi.org/10.1016/S2213-2600(20)30079-5Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal Of Medicine. doi.org/10.1056/NEJMoa2002032Early Transmission Dynamics in Wuhan, China, Of Novel Coronavirus-Infected Pneumonia. New England Journal Of Medicine. doi.org/10.1056/NEJMoa2001316A Novel Coronavirus from Patients With Pneumonia in China, 2019. New England Journal Of Medicine. doi.org/10.1056/NEJMoa2001017#novelcoronavirus #COVID19 #sarscov2
