Uploaded July 2026 | Updated September 2026, 3 weeks ago
What if a disease that looks like multiple sclerosis is actually something entirely different? In this episode of Tomorrow’s Cure, host Lindsey Seavert sits down with Mayo Clinic neurologists Eoin Flanagan, M.D., B.Ch., and Brenda Banwell, M.D., from Johns Hopkins to explore myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), a rare autoimmune neurological disorder often mistaken for multiple sclerosis (MS).
Learn how MOG antibodies help define this distinct disease and why early diagnosis and treatment are critical. The conversation also covers the 2023 international diagnostic criteria for MOGAD, advances in MRI and antibody testing, emerging relapse-prevention therapies, and promising research targeting the IL-6 pathway.
00:00 Introduction: Why MOGAD Diagnosis Matters
00:01 Meet the Experts
00:01:35 What Is MOGAD?
00:03:00 How MOGAD Was Discovered
00:06:35 MOGAD vs. Multiple Sclerosis (MS)
00:09:20 The Journey to an Accurate Diagnosis
00:13:25 How MOGAD Is Diagnosed
00:16:10 Common Symptoms of MOGAD
00:18:05 Why MOGAD Is More Common in Children
00:19:20 The Emotional Impact of Diagnosis
00:21:25 How MOGAD Is Treated Today
00:23:30 New Clinical Trials and Emerging Therapies
00:26:25 Long-Term Outlook for Patients
00:27:15 Biomarkers and The Future of Research
00:29:45 Why Clinical Trials Matter
00:32:45 Key Takeaways: Early Diagnosis Saves Vision & Function
00:35:30 Precision Medicine and What's Next for MOGAD
00:38:45 Final Thoughts
Subscribe to Tomorrow’s Cure for conversations with the experts advancing the future of medicine, one breakthrough at a time.
This podcast is for informational purposes only and should not be relied upon as professional, medical or legal advice. Always consult with a qualified health care provider for any medical advice. The appearance of any guest does not imply an endorsement of them, their employer, or any entity they represent. The views and opinions are those of the speakers and do not necessarily reflect the views of Mayo Clinic. Reference to any product, service or entity does not constitute an endorsement or recommendation by Mayo Clinic.
What if a disease that looks like multiple sclerosis is actually something entirely different? In this episode of Tomorrow’s Cure, host Lindsey Seavert sits down with Mayo Clinic neurologists Eoin Flanagan, M.D., B.Ch., and Brenda Banwell, M.D., from Johns Hopkins to explore myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), a rare autoimmune neurological disorder often mistaken for multiple sclerosis (MS).
Learn how MOG antibodies help define this distinct disease and why early diagnosis and treatment are critical. The conversation also covers the 2023 international diagnostic criteria for MOGAD, advances in MRI and antibody testing, emerging relapse-prevention therapies, and promising research targeting the IL-6 pathway.
00:00 Introduction: Why MOGAD Diagnosis Matters
00:01 Meet the Experts
00:01:35 What Is MOGAD?
00:03:00 How MOGAD Was Discovered
00:06:35 MOGAD vs. Multiple Sclerosis (MS)
00:09:20 The Journey to an Accurate Diagnosis
00:13:25 How MOGAD Is Diagnosed
00:16:10 Common Symptoms of MOGAD
00:18:05 Why MOGAD Is More Common in Children
00:19:20 The Emotional Impact of Diagnosis
00:21:25 How MOGAD Is Treated Today
00:23:30 New Clinical Trials and Emerging Therapies
00:26:25 Long-Term Outlook for Patients
00:27:15 Biomarkers and The Future of Research
00:29:45 Why Clinical Trials Matter
00:32:45 Key Takeaways: Early Diagnosis Saves Vision & Function
00:35:30 Precision Medicine and What's Next for MOGAD
00:38:45 Final Thoughts
Subscribe to Tomorrow’s Cure for conversations with the experts advancing the future of medicine, one breakthrough at a time.
This podcast is for informational purposes only and should not be relied upon as professional, medical or legal advice. Always consult with a qualified health care provider for any medical advice. The appearance of any guest does not imply an endorsement of them, their employer, or any entity they represent. The views and opinions are those of the speakers and do not necessarily reflect the views of Mayo Clinic. Reference to any product, service or entity does not constitute an endorsement or recommendation by Mayo Clinic.
