Science News | Watch a model of the protein LRP2 open and close | Science News @ScienceNewsMag | Uploaded February 2023 | Updated October 2024, 7 hours ago.
This 3-D model of the protein LRP2 shows how it transforms from a more open structure at near-neutral pH outside of a cell to a crumpled-up shape at the acidic pH inside a cell. These pH-driven changes in shape let LRP2 snag molecules outside of a cell and release them inside. Two copies of one protein — one pink and one blue — make up LRP2.
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Video: A. Beenken et al/Cell 2023