Uploaded October 2019 | Updated September 2026, 2 weeks ago
Vinod Khosla is an Entrepreneur, Venture Capitalist, and Philanthropist. It was an honor to have a conversation with the Silicon Valley legend that I've admired for many years. Vinod co-founded Sun Microsystems over 30 years ago, a company that grew to over 36,000 employees and invented so much foundational software technology like the Java programming language, NFS, and they pretty much mainstreamed the 'idea' of open source. After a successful exit, he's been using his billionaire status to invest in ambitious technologists trying to improve human life. He's got the coolest investment portfolio I've seen yet, and in this hour long interview we discuss everything from AI to education to startup culture. I know that my microphone volume should be higher in this one, I'll fix that the next podcast. Enjoy!
Time markers of our discussion topics below:
2:55 The Future of Education
4:36 Vinod's Dream of an AI Tutor
5:50 Vinod Offers Siraj a Job
6:35 Choose your Teacher with DeepFakes
8:04 Mathematical Models
9:10 Books Vinod Loves
11:00 What is Learning?
14:00 The Flaws of Liberal Arts Degrees
16:10 Indian Culture
21:11 A Day in the Life of Vinod Khosla
23:50 Valuing Brutal Honesty
24:30 Distributed File Storage
30:30 Where are we Headed?
33:32 Vinod on Nick Bostrom
38:00 Vinod's Rockstar Recruiting Ability
43:00 The Next Industries to Disrupt
49:00 Vinod Offers Siraj Funding for an AI Tutor
51:48 Virtual Reality
52:00 Contrarian Beliefs
54:00 Vinod's Love of Learning
55:30 USA vs China
Vinod's 'Awesome' Video:
youtube.com/watch?v=STtAsDCKEck
Khosla Ventures Blog posts:
khoslaventures.com/blog/all
Books we discussed:
Scale by Geoffrey West:
amzn.to/2rs7UV7
Factfulness by Hans Roesling:
amzn.to/2GHUlgg
Mindset by Carol Dwicke:
amzn.to/2icCNey
36 Dramatic Situations by Mike Figgis:
amzn.to/2ol14Vi
Sapiens by Yuval Noah Harari:
amzn.to/2amA7J5
21 Lessons for the 21st Century by Yuval Noah Harari:
amzn.to/2PKIJZY
The Third Pillar by Raghuram R:
bit.ly/2ASU98K
Zero to One by Peter Thiel:
amzn.to/2ae3NTM
----------------------------------------------------------------------------------
INSTAGRAM: bit.ly/312pLUb
FACEBOOK: bit.ly/2OqOhx1
TWITTER: bit.ly/2OHYLbB
WEBSITE: bit.ly/2OoVPQF
Find my podcast on these sites:
iTunes: podcasts.apple.com/us/podcast/siraj-raval-podcast/id1468351190
Anchor: https://anchor.fm/sirajraval
Google Podcasts: google.com/podcasts?feed=aHR0cHM6Ly9hbmNob3IuZm0vcy9iZmIxMGMwL3BvZGNhc3QvcnNz
Spotify: open.spotify.com/show/4qf0D4LRvdlfZBkq1qqywT
Breaker: https://www.breaker.audio/siraj-raval-podcast
Overcast: https://overcast.fm/itunes1468351190/siraj-raval-podcast
iTunes:
Learn Machine Learning in 3 Months for free:
youtube.com/watch?v=Cr6VqTRO1v0
My Startup Tutorial Playlist:
youtube.com/watch?v=oeraUtRgsbI&list=PL2-dafEMk2A4n3aP_rzgqA8lVGknkSN2p
Join us in the Wizards Slack channel:
wizards.herokuapp.com
Hit the Join button above to sign up to become a member of my channel for access to exclusive live streams!
Join us at the School of AI:
theschool.ai
Signup for my newsletter for exciting updates in the field of AI:
goo.gl/FZzJ5w
And please support me on Patreon:
patreon.com/user?u=3191693 Join my AI community: chatgptschool.io Sign up for my AI Sports betting Bot, WagerGPT! (500 spots available): https://www.wagergpt.xyz
Vinod Khosla is an Entrepreneur, Venture Capitalist, and Philanthropist. It was an honor to have a conversation with the Silicon Valley legend that I've admired for many years. Vinod co-founded Sun Microsystems over 30 years ago, a company that grew to over 36,000 employees and invented so much foundational software technology like the Java programming language, NFS, and they pretty much mainstreamed the 'idea' of open source. After a successful exit, he's been using his billionaire status to invest in ambitious technologists trying to improve human life. He's got the coolest investment portfolio I've seen yet, and in this hour long interview we discuss everything from AI to education to startup culture. I know that my microphone volume should be higher in this one, I'll fix that the next podcast. Enjoy!
Time markers of our discussion topics below:
2:55 The Future of Education
4:36 Vinod's Dream of an AI Tutor
5:50 Vinod Offers Siraj a Job
6:35 Choose your Teacher with DeepFakes
8:04 Mathematical Models
9:10 Books Vinod Loves
11:00 What is Learning?
14:00 The Flaws of Liberal Arts Degrees
16:10 Indian Culture
21:11 A Day in the Life of Vinod Khosla
23:50 Valuing Brutal Honesty
24:30 Distributed File Storage
30:30 Where are we Headed?
33:32 Vinod on Nick Bostrom
38:00 Vinod's Rockstar Recruiting Ability
43:00 The Next Industries to Disrupt
49:00 Vinod Offers Siraj Funding for an AI Tutor
51:48 Virtual Reality
52:00 Contrarian Beliefs
54:00 Vinod's Love of Learning
55:30 USA vs China
Vinod's 'Awesome' Video:
youtube.com/watch?v=STtAsDCKEck
Khosla Ventures Blog posts:
khoslaventures.com/blog/all
Books we discussed:
Scale by Geoffrey West:
amzn.to/2rs7UV7
Factfulness by Hans Roesling:
amzn.to/2GHUlgg
Mindset by Carol Dwicke:
amzn.to/2icCNey
36 Dramatic Situations by Mike Figgis:
amzn.to/2ol14Vi
Sapiens by Yuval Noah Harari:
amzn.to/2amA7J5
21 Lessons for the 21st Century by Yuval Noah Harari:
amzn.to/2PKIJZY
The Third Pillar by Raghuram R:
bit.ly/2ASU98K
Zero to One by Peter Thiel:
amzn.to/2ae3NTM
----------------------------------------------------------------------------------
INSTAGRAM: bit.ly/312pLUb
FACEBOOK: bit.ly/2OqOhx1
TWITTER: bit.ly/2OHYLbB
WEBSITE: bit.ly/2OoVPQF
Find my podcast on these sites:
iTunes: podcasts.apple.com/us/podcast/siraj-raval-podcast/id1468351190
Anchor: https://anchor.fm/sirajraval
Google Podcasts: google.com/podcasts?feed=aHR0cHM6Ly9hbmNob3IuZm0vcy9iZmIxMGMwL3BvZGNhc3QvcnNz
Spotify: open.spotify.com/show/4qf0D4LRvdlfZBkq1qqywT
Breaker: https://www.breaker.audio/siraj-raval-podcast
Overcast: https://overcast.fm/itunes1468351190/siraj-raval-podcast
iTunes:
Learn Machine Learning in 3 Months for free:
youtube.com/watch?v=Cr6VqTRO1v0
My Startup Tutorial Playlist:
youtube.com/watch?v=oeraUtRgsbI&list=PL2-dafEMk2A4n3aP_rzgqA8lVGknkSN2p
Join us in the Wizards Slack channel:
wizards.herokuapp.com
Hit the Join button above to sign up to become a member of my channel for access to exclusive live streams!
Join us at the School of AI:
theschool.ai
Signup for my newsletter for exciting updates in the field of AI:
goo.gl/FZzJ5w
And please support me on Patreon:
patreon.com/user?u=3191693 Join my AI community: chatgptschool.io Sign up for my AI Sports betting Bot, WagerGPT! (500 spots available): https://www.wagergpt.xyz





![I Used AlphaFold 3 To Cure Cancer (Tutorial)
I asked Claude to find a cancer protein with no known cure and design a potential cure (that it codenamed DualStrike). Then I used Googles AlphaFold 3 to simulate its effectiveness. The results showed that DualStrike (a novel treatment for Lymphoma [Blood Cancer]) can theoretically increase the 5 year survival rate of from 80% up to 90-95%. Finally, I asked ChatGPTs o1-preview to write an end-to-end research paper on the process to enable any elementary biochemist to verify the in-silico results with a wet-lab. In this video, Ill explain each step I took so that you can do the same for your own creative ideas around Scientific discovery. The year is 2025 and AI is truly democratizing Science to a level where any human on Earth with enough motivation can make a meaningful contribution using AI tools effectively. I hope this video inspires Wizards around the world to use AI for Scientific discovery. Enjoy!
Code & Research Paper:
https://github.com/llSourcell/DualStrike_AI_For_Lymphoma
Sign up for HPC-AI:
https://hpc-ai.com/account/signup?invitation_code=invite_c3HJ41XXWr
Want more AI/ML education? Connect with me here:
X: https://x.com/sirajraval
Instagram: https://www.instagram.com/sirajraval
Linkedin: https://www.linkedin.com/in/sirajraval/
TikTok: https://www.tiktok.com/@sirajraval
Facebook: https://www.facebook.com/sirajology
Design your own AI trading bot (no code):
https://www.tradergpt.co
Join my AI Sports Betting community:
https://wagergpt.xyz/
⏱️ **Chapters:**
0:00 Introduction: Using AI to Design a Novel Cancer Treatment
1:16 Introducing Sponsor: HPC AIs Computing Cluster
1:59 The Big Deal: Introduction to AlphaFold
2:06 Evolution of AlphaFold: From Version 1 to 3
2:59 Finding a Missing Protein in the AlphaFold Database
4:17 Identifying the NPM-ALK Fusion Protein
4:43 Generating the FASTA Sequence with Claude
5:41 Understanding Protein Folding and AIs Role
6:35 Designing a Potential Treatment with AI
7:03 Developing a Dual-Site Inhibitor with Claude
7:54 Generating 3D Models with AlphaFold
8:38 Testing the Inhibitor with Molecular Docking Software (MolModa)
10:30 Generating the Research Paper and Code with o1-preview
13:27 Prompt Hack: Improving AI Outputs
13:41 Utilizing HPC AIs Computing Cluster for Experiments
14:31 Conclusion and Encouragement to Innovate with AI
15:14 Outro and Closing Remarks
Dont forget to like, share, and subscribe for more deep dives into AI advancements!
AlphaFold 1 explained:
https://www.youtube.com/watch?v=cw6_OP5An8s
AlphaFold 2 explained:
https://www.youtube.com/watch?v=GQH-zWUylPY
I Asked O1-Preview to reproduce O1-Preview:
https://youtu.be/sf7Ntg72qCI
I Built a Sports Betting Bot with ChatGPT:
https://youtu.be/IDthta5sUGQ
I Built a Trading Bot with ChatGPT:
https://www.youtube.com/watch?v=fhBw3j_O9LE
Watch ChatGPT Build an AI Startup:
https://www.youtube.com/watch?v=hL2hLFUwuqQ
Watch ChatGPT Build a Finance Startup:
https://www.youtube.com/watch?v=on623d5EfPw
Watch Me Build a Startup Playlist:
https://www.youtube.com/watch?v=oeraUtRgsbI&list=PL2-dafEMk2A4n3aP_rzgqA8lVGknkSN2p&index=1
🔔 Subscribe and hit the notification bell to join the AI revolution! I Used AlphaFold 3 To Cure Cancer (Tutorial)](https://i.ytimg.com/vi/kll90oM9CoQ/mqdefault.jpg)




