Uploaded April 2026 | Updated September 2026, 2 weeks ago
Exciting news - pre-order my debut book
https://linktr.ee/HealthySBTH?utm_source=linktree_profile_share<sid=9db12bc6-b7d3-4df4-bc5c-260e0303792c
You've seen the headlines. You've watched the celebrities transform. Maybe you've even wondered, quietly, if it could be for you. But what is the science really saying?
This week on Live Well Be Well, I sit down with Dr. Jack Mosley, GP registrar, and author of Food Noise. Jack brings a perspective that is honest, nuanced, and completely free of hype. We get into what these drugs can genuinely do, who they are truly for, and why taking them without lifestyle support is like putting on noise-cancelling headphones without ever learning to listen to yourself.
Here's What We Dive Into:
- Why up to 40% of weight lost on GLP-1 medications can come from lean muscle, not fat, and why that matters more than the number on the scale.
- What "food noise" actually is and why silencing it with medication is only half the story.
- The 80% reality: why most people regain all their weight within 20 months of stopping and what the 20% who don't have in common.
- Why these are not cosmetic medications, who they are genuinely for, and the real risks of microdosing without clinical need.
- How self-compassion, not willpower, is the missing piece in any sustainable approach to weight and health.
Love,
Sarah Ann 💛
***
Want to put what Jack shared into practice? The Fast 800 combines intermittent fasting, nutrition, and guided lifestyle support in one place. Co-founded by his father Dr. Michael Mosley. Try it free for 7 days:
👉 thefast800.com
***
This episode is sponsored by:
DIOME: Rest deeper. Stay grounded.
Rested is available now and Grounded lands later this month.
👉 Get 20% off with code SARAH20 at DIOME.CO
***
The Great British Veg Out
How to support your gut, energy, and hormones by eating more — not less.
👉 sarahmacklin.substack.com/p/the-great-british-veg-out
Reset Your Health
If your body feels off after stress, travel, or burnout — this is where to start.
👉 sarahmacklin.substack.com/s/reset-your-health-in-30-days
👉 Practical beats perfect.
Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.
open.substack.com/pub/sarahmacklin/p/download-your-free-5-recipes-to-relieve
👉 If this resonates, you can join the thousands who read
The Compassionate Cure each week. sarahmacklin.substack.com
***
Let’s be friends!
📷 Instagram: instagram.com/sarahannmacklin
📹 Subscribe:youtube.com/@livewellbewellsarah
🐦 Twitter: https://x.com/SarahAnnMacklin
📱 TikTok: tiktok.com/@livewellbewellpodcast
💌 Newsletter: sarahmacklin.substack.com
***
If You Enjoyed This Episode, You Might Also Like:
Fat Loss, Metabolism & The Myth Holding You Back | Dr Andy Galpin
youtu.be/ZXLWY5HcPXE
Ozempic, GLP-1 Drugs & The Truth About Weight Loss | Former FDA Chief Explains
youtu.be/tzsfsu-aGbY
The MOST Surprising Food That Fights Disease & Helps With Losing Weight | Doug Evans
youtu.be/YRuYfCmIz74
***
Sign up to Sarah’s Compassionate Cure newsletter:
Science Simplified, Health Humanised.
Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact.
sarahmacklin.substack.com
***
Highlights
00:00:00 Intro
00:01:45 The obesity crisis: how we got here and what's driving it
00:04:10 The string test: a simple way to assess your metabolic health
00:06:30 Muscle loss on GLP-1 medications and the stat no one is talking about
00:10:20 Benefits of GLP-1 drugs: heart disease, sleep apnea, and beyond
00:12:00 Food noise explained and how these drugs work like noise-cancelling headphones
00:15:00 GLP-1 and addiction: alcohol, opioids, and the reward system
00:20:30 Side effects, hair loss, and the dangers of unregulated sources
00:23:30 Microdosing Ozempic: what you really need to know
00:35:00 Shame spirals and the role of self-compassion in sustainable change
00:41:00 Managing cravings without medication: urge surfing and habit stacking
00:47:00 Weight regain after stopping: the 20-month reality check
00:50:30 The Mediterranean diet, the 5:2, and the Fast 800 programme
01:05:30 What live well, be well means to Dr. Jack Mosley
***
Love what you’re hearing?
My small ask is to please rate and review Live Well Be Well. This helps the show expand and allows me to keep producing these with the best quality guests. It means a huge amount to me, so thank you.
Exciting news - pre-order my debut book
https://linktr.ee/HealthySBTH?utm_source=linktree_profile_share<sid=9db12bc6-b7d3-4df4-bc5c-260e0303792c
You've seen the headlines. You've watched the celebrities transform. Maybe you've even wondered, quietly, if it could be for you. But what is the science really saying?
This week on Live Well Be Well, I sit down with Dr. Jack Mosley, GP registrar, and author of Food Noise. Jack brings a perspective that is honest, nuanced, and completely free of hype. We get into what these drugs can genuinely do, who they are truly for, and why taking them without lifestyle support is like putting on noise-cancelling headphones without ever learning to listen to yourself.
Here's What We Dive Into:
- Why up to 40% of weight lost on GLP-1 medications can come from lean muscle, not fat, and why that matters more than the number on the scale.
- What "food noise" actually is and why silencing it with medication is only half the story.
- The 80% reality: why most people regain all their weight within 20 months of stopping and what the 20% who don't have in common.
- Why these are not cosmetic medications, who they are genuinely for, and the real risks of microdosing without clinical need.
- How self-compassion, not willpower, is the missing piece in any sustainable approach to weight and health.
Love,
Sarah Ann 💛
***
Want to put what Jack shared into practice? The Fast 800 combines intermittent fasting, nutrition, and guided lifestyle support in one place. Co-founded by his father Dr. Michael Mosley. Try it free for 7 days:
👉 thefast800.com
***
This episode is sponsored by:
DIOME: Rest deeper. Stay grounded.
Rested is available now and Grounded lands later this month.
👉 Get 20% off with code SARAH20 at DIOME.CO
***
The Great British Veg Out
How to support your gut, energy, and hormones by eating more — not less.
👉 sarahmacklin.substack.com/p/the-great-british-veg-out
Reset Your Health
If your body feels off after stress, travel, or burnout — this is where to start.
👉 sarahmacklin.substack.com/s/reset-your-health-in-30-days
👉 Practical beats perfect.
Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.
open.substack.com/pub/sarahmacklin/p/download-your-free-5-recipes-to-relieve
👉 If this resonates, you can join the thousands who read
The Compassionate Cure each week. sarahmacklin.substack.com
***
Let’s be friends!
📷 Instagram: instagram.com/sarahannmacklin
📹 Subscribe:youtube.com/@livewellbewellsarah
🐦 Twitter: https://x.com/SarahAnnMacklin
📱 TikTok: tiktok.com/@livewellbewellpodcast
💌 Newsletter: sarahmacklin.substack.com
***
If You Enjoyed This Episode, You Might Also Like:
Fat Loss, Metabolism & The Myth Holding You Back | Dr Andy Galpin
youtu.be/ZXLWY5HcPXE
Ozempic, GLP-1 Drugs & The Truth About Weight Loss | Former FDA Chief Explains
youtu.be/tzsfsu-aGbY
The MOST Surprising Food That Fights Disease & Helps With Losing Weight | Doug Evans
youtu.be/YRuYfCmIz74
***
Sign up to Sarah’s Compassionate Cure newsletter:
Science Simplified, Health Humanised.
Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact.
sarahmacklin.substack.com
***
Highlights
00:00:00 Intro
00:01:45 The obesity crisis: how we got here and what's driving it
00:04:10 The string test: a simple way to assess your metabolic health
00:06:30 Muscle loss on GLP-1 medications and the stat no one is talking about
00:10:20 Benefits of GLP-1 drugs: heart disease, sleep apnea, and beyond
00:12:00 Food noise explained and how these drugs work like noise-cancelling headphones
00:15:00 GLP-1 and addiction: alcohol, opioids, and the reward system
00:20:30 Side effects, hair loss, and the dangers of unregulated sources
00:23:30 Microdosing Ozempic: what you really need to know
00:35:00 Shame spirals and the role of self-compassion in sustainable change
00:41:00 Managing cravings without medication: urge surfing and habit stacking
00:47:00 Weight regain after stopping: the 20-month reality check
00:50:30 The Mediterranean diet, the 5:2, and the Fast 800 programme
01:05:30 What live well, be well means to Dr. Jack Mosley
***
Love what you’re hearing?
My small ask is to please rate and review Live Well Be Well. This helps the show expand and allows me to keep producing these with the best quality guests. It means a huge amount to me, so thank you.
![Is Porn Healthy or Unhealthy? The Truth [Explained] | Silva Neves](https://i.ytimg.com/vi/pUWMqzKV254/mqdefault.jpg "Is Porn Healthy or Unhealthy? The Truth [Explained] | Silva Neves
Exciting news - pre-order my debut book 👇😆✌🏼
https://linktr.ee/HealthySBTH?utm_source=linktree_profile_share<sid=9db12bc6-b7d3-4df4-bc5c-260e0303792c
What if everything you thought you knew about porn being harmful—or harmless—was based on incomplete science? The real answer is far more nuanced than most people expect.
***
This episode is sponsored by:
NOWATCH: The compassionate health tracker
Connecting body and mind with unique stress recovery insights so you can live fully today
15% off with code LWBW15 at https://nowatch.com/
DIOME: Rest deeper. Stay grounded.
Rested is available now and Grounded lands later this month.
👉 Get 20% off with code SARAH20 at DIOME.CO
***
The Great British Veg Out
How to support your gut, energy, and hormones by eating more — not less.
👉 https://sarahmacklin.substack.com/p/the-great-british-veg-out
Reset Your Health
If your body feels off after stress, travel, or burnout — this is where to start.
👉 https://sarahmacklin.substack.com/s/reset-your-health-in-30-days
👉 Practical beats perfect.
Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.
https://sarahannmacklin.com/5_free_recipes
👉 If this resonates, you can join the thousands who read
The Compassionate Cure each week.
https://sarahmacklin.substack.com/
***
Let’s be friends!
📷 Instagram: https://www.instagram.com/sarahannmacklin/
📹 Subscribe: http://www.youtube.com/@livewellbewellsarah
🐦 Twitter: https://x.com/SarahAnnMacklin
📱 TikTok: https://www.tiktok.com/@livewellbewellpodcast
💌 Newsletter: https://sarahmacklin.substack.com/")
