Treating Insulin Resistance with Metformin in Bipolar Disorder

Metabolic Mind | Treating Insulin Resistance with Metformin in Bipolar Disorder - Cindy Calkin, MD @metabolicmind | Uploaded December 2022 | Updated October 2024, 3 hours ago.
In a groundbreaking trial, Dr. Cindy Calkin and colleagues demonstrated how Metformin, a diabetes medication, significantly improved treatment resistant bipolar disorder. Before and after images of the blood brain barrier suggest a mechanism of action of improved insulin resistance in this patient population, adding further evidence of the metabolic underpinnings of mental illness.

Dr. Calkin is an Associate Professor of Psychiatry and Medical Neuroscience at Dalhousie University. The results of this study further supports the notion that metabolic therapies can improve symptoms of severe mental illness.

Bio: medicine.dal.ca/departments/department-sites/psychiatry/our-people/faculty/cynthia-calkin.html
This video was recorded at the first ever Metabolic Psychiatry roadmap retreat, hosted by Baszucki Group and the Milken Institute for Strategic Philanthropy in May, 2022 in Santa Barbara. The conference brought together physicians, neuroscientists, dieticians, entrepreneurs, venture capitalists and philanthropists to build community in the emerging field of Metabolic Psychiatry.

Learn more about metabolic psychiatry and meet the visionary Metabolic Mind Award Winners at tinyurl.com/Baszucki-Group

About us:
Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission over time will be to provide resources and build community in metabolic psychiatry.

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Other resources for Metabolic Psychiatry, metabolic neuroscience and ketogenic metabolic therapy for mental disorders:

Diagnosis Diet - diagnosisdiet.com

New Study: Serious Mental Illness Improves on Ketogenic Diet -
psychologytoday.com/us/blog/diagnosis-diet/202207/new-study-serious-mental-illness-improves-ketogenic-diet

The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review
ncbi.nlm.nih.gov/pmc/articles/PMC9728807
Chris Palmer MD - chrispalmermd.com

Stanford Metabolic Psychiatry- metabolicpsychiatry.com
What Is Metabolic Psychiatry? 5 Questions Answered by Dr. Shebani Sethi
https://med.stanford.edu/news/all-news/2022/11/metabolic-psychiatry.html

Baszucki Group - baszuckigroup.com/our-work/metabolism-mental-health

BipolarCast: Keto + Bipolar youtube channel, Hosted by Matt Baszucki and Iain Campbell, PhD
youtube.com/channel/UCDB-iMvEJ-HeHqpamIN5JWw
twitter.com/IainCampbellPhD

Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

#MetabolicMind
#KetoForMentalHealth
#MetabolicPsychiatry
#BipolarTreatment
#MetabolicNeuroscience
#KetogenicMetabolicTherapy

#NutritionalKetosis
#MentalIllnessTreatment
#MentalHealthIsMetabolicHealth
#insulinresistance #metformin

Does Keto Cause Atrial Fibrillation (AFib)?

Carnivore Diet for Inflammatory Bowel Disease: New Source of Hope? With Nick Norwitz, PhD

Keto, Microbiome, and Depression: A New RCT led by Dr. Timur Liwinski

$Long-Term Safety of Ketogenic Diets - with Dr. Bret Scher In this video, Dr. Bret Scher addresses common misconceptions and concerns surrounding the long-term safety and nutritional adequacy of ketogenic diets. Dr. Scher emphasizes the importance of weighing potential risks against known benefits. For instance, psychotropic medications, despite often worsening overall physical and metabolic health, are considered beneficial because they can alleviate symptoms of serious mental illnesses. In contrast, many patients experience incredible benefits from ketogenic therapy without harmful side effects. In numerous cases, a medical keto diet can even put psychiatric conditions like bipolar disorder, schizophrenia, and major depression into complete remission. What Youll Learn: ▪️Long-Term Safety: Is it safe to maintain ketosis over an extended period? ▪️Nutritional Adequacy: Can a ketogenic diet lead to nutrient deficiencies or disordered eating habits? ▪️Fiber and Phytonutrients: Are fiber intake and phytonutrients compromised on a ketogenic diet? ▪️Heart Disease Risk: Is there an increased risk of heart disease with long-term ketosis? ▪️Short-Term vs. Long-Term Outcomes: Is ketosis only effective for short-term outcomes? There is a lot of information circulating online touting the risks of long-term ketogenic diets that is completely unfounded. Dr. Scher tackles these prevalent questions, analyzing scientific evidence and dispelling myths surrounding ketogenic diets. Related Resources: Does Keto Cause Heart Disease? https://www.youtube.com/watch?v=pKmNhQbtDLI&t=6s Studies Referenced: _Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bipolar and Schizophrenia: A Pilot Trial_ https://www.sciencedirect.com/science/article/pii/S0165178124001513?via%3Dihub _The Ketogenic Diet for Refractory Mental Illness: A Retrospective Analysis of 31 Inpatients_ https://pubmed.ncbi.nlm.nih.gov/35873236/ If you or a loved one are looking to begin ketogenic therapy for a psychiatric condition, visit this page for resources: https://www.metabolicmind.org/families-and-peers Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. Timestamps 0:00 Introduction 1:51 Weighing the benefits & adverse effects of medical treatments 3:47 Why do people think long-term keto is dangerous? 4:19 Have people been on a keto diet long-term? 5:17 Nutrient deficiencies in a keto diet 8:05 Is there an increased risk of heart disease on a keto diet? 9:14 Does a ketogenic diet increase the risk for disordered eating? 9:31 Does ketogenic therapy work for longer than 6 months? 11:12 Is ketosis harmful long-term? 11:43 Conclusion$ $Six Things Mental Health Clinicians Should Know About Ketogenic Therapy- with Dr. Bret Scher Ketogenic therapy has a wide range of applications, from type 2 diabetes to psychiatric conditions like major depression, bipolar disorder, and schizophrenia. Many non-communicable diseases can be traced to metabolic dysfunction, and medical keto is a powerful intervention that can repair metabolism and restore health. As awareness of the therapeutic potential of a medical keto diet grows, more patients are increasingly interested in exploring this type of metabolic therapy. However many clinicians may not be familiar with the nuances of implementing a medical keto diet. This video aims to provide insight into - The difference between a keto diet and ketogenic therapy - The distinction between ketosis is not the same as ketoacidosis - Over a hundred years of research on medical keto for epilepsy, demonstrating the neurological impact, safety, and efficacy of ketogenic therapy Join Dr. Scher as he explores these topics and more to better support patients with this promising therapy that has a growing evidence base for both physical and psychiatric conditions. Related Resources: What Is the Difference between a Keto Diet and Ketogenic Therapy? - With Dr. Bret Scher: https://www.youtube.com/watch?v=4iMXUpLYLkk&t=1s Studies referenced: Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bipolar and Schizophrenia: A Pilot Trial https://www.sciencedirect.com/science/article/pii/S0165178124001513?via%3Dihub The Ketogenic Diet for Refractory Mental Illness: A Retrospective Analysis of 31 Inpatients https://pubmed.ncbi.nlm.nih.gov/35873236/ Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. Timestamps 0:00 Introduction 1:32 Ketogenic therapy is not the same thing as a keto diet 2:12 What happens to the body in ketosis 2:53 Ketosis is not ketoacidosis 3:15 Ketogenic therapy has been used for epilepsy 3:55 Ketogenic therapy can improve brain and body health 4:34 Emerging evidence suggests ketogenic therapy as a treatment for serious mental illness 7:20 Conclusion #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis #MentalIllness #AlternativeTreatment #MedicalKeto #KetogenicTherapy #KetoDiet$

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