SciShow | This Simple Test Could Detect Half of All Cancers @SciShow | Uploaded 8 months ago | Updated 11 hours ago
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Cancer is a complicated disease, and there's no simple blood test for early detection and screening to spot cancer in general. That might be changing thanks to LINE-1, a retrotransposon gene that doesn't do anything.
Hosted by: Hank Green (he/him)
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Sources:
https://www.pnas.org/doi/pdf/10.1073/pnas.2115999119
https://www.activemotif.com/blog-line-1
https://www.quantamagazine.org/the-complex-truth-about-junk-dna-20210901/
https://www.nature.com/scitable/topicpage/transposons-the-jumping-genes-518/
https://www.pnas.org/doi/pdf/10.1073/pnas.2115999119
https://www.nature.com/articles/ng.3945
https://mobilednajournal.biomedcentral.com/articles/10.1186/s13100-016-0070-z
https://www.news-medical.net/news/20231101/Highly-sensitive-blood-test-shows-promise-for-early-detection-of-common-deadly-cancers.aspx
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710400/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563416/
https://www.pnas.org/doi/pdf/10.1073/pnas.2115999119
https://www.pnas.org/doi/pdf/10.1073/pnas.2115999119
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873040/#:~:text=DNA%20hypomethylation%20is%20a%20ubiquitous,often%20associated%20with%20tumor%20progression
https://www.nature.com/articles/s41598-023-33932-3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399582/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856164/
https://www.cancer.org/cancer/understanding-cancer/genes-and-cancer/oncogenes-tumor-suppressor-genes.html#:~:text=Tumor%20suppressor%20genes%20are%20normal,which%20can%20lead%20to%20cancer
https://www.pnas.org/doi/10.1073/pnas.2115999119#:~:text=In%20rare%20cases%2C%20derepressed%20LINE,additional%20effects%20on%20genome%20stability
https://medlineplus.gov/genetics/gene/tp53/
https://www.pnas.org/doi/pdf/10.1073/pnas.2115999119
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005969/
Image Sources:
https://www.gettyimages.com/detail/video/doctor-helps-woman-check-her-blood-sugar-levels-with-stock-footage/1412222826
https://www.gettyimages.com/detail/video/doctor-takes-blood-test-on-glass-in-laboratory-closeup-stock-footage/1397270359
https://www.gettyimages.com/detail/video/cancer-cells-stock-footage/1370327644
https://www.activemotif.com/blog-line-1
https://en.wikipedia.org/wiki/File:Retrotransposons.png
https://www.gettyimages.com/detail/video/structure-of-the-human-line-1-orf1p-trimer-stock-footage/1456762175
https://www.gettyimages.com/detail/video/dna-sequence-animation-stock-footage/468606238
https://commons.wikimedia.org/wiki/File:DNA_Transposon.png
https://www.gettyimages.com/detail/video/dna-test-stock-footage/1169799928
https://www.gettyimages.com/detail/video/extreme-close-up-of-human-blood-under-microscope-stock-footage/1475978712
https://www.gettyimages.com/detail/video/cancer-cells-stock-footage/1405578892
https://www.gettyimages.com/detail/video/colonography-or-ct-scan-of-colon-3d-rendering-image-with-stock-footage/1214297625
https://www.gettyimages.com/detail/video/strand-molecule-model-stock-footage/1297346034
https://commons.wikimedia.org/wiki/File:P53.png
https://www.gettyimages.com/detail/video/cancer-cell-growth-animation-stock-footage/537984570
https://www.gettyimages.com/detail/video/body-loop-stock-footage/472896811
https://www.gettyimages.com/detail/video/red-blood-cells-in-artery-stock-footage/1398259189
https://www.gettyimages.com/detail/video/doctor-talks-with-patient-and-takes-notes-stock-footage/1456004480
https://www.gettyimages.com/detail/video/male-patient-getting-a-cat-scan-at-the-hospita-stock-footage/1455615261
https://www.gettyimages.com/detail/video/finger-pricking-to-measure-blood-glucose-extreme-macro-stock-footage/1126442691
Visit https://brilliant.org/scishow/ to get started learning STEM for free. The first 200 people will get 20% off their annual premium subscription and a 30-day free trial.
Cancer is a complicated disease, and there's no simple blood test for early detection and screening to spot cancer in general. That might be changing thanks to LINE-1, a retrotransposon gene that doesn't do anything.
Hosted by: Hank Green (he/him)
----------
Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow
----------
Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever: Adam Brainard, Alex Hackman, Ash, Bryan Cloer, charles george, Chris Mackey, Chris Peters, Christoph Schwanke, Christopher R Boucher, Eric Jensen, Harrison Mills, Jaap Westera, Jason A, Saslow, Jeffrey Mckishen, Jeremy Mattern, Kevin Bealer, Matt Curls, Michelle Dove, Piya Shedden, Rizwan Kassim, Sam Lutfi
----------
Looking for SciShow elsewhere on the internet?
SciShow Tangents Podcast: https://scishow-tangents.simplecast.com/
TikTok: https://www.tiktok.com/@scishow
Twitter: http://www.twitter.com/scishow
Instagram: http://instagram.com/thescishow
Facebook: http://www.facebook.com/scishow
#SciShow #science #education #learning #complexly
----------
Sources:
https://www.pnas.org/doi/pdf/10.1073/pnas.2115999119
https://www.activemotif.com/blog-line-1
https://www.quantamagazine.org/the-complex-truth-about-junk-dna-20210901/
https://www.nature.com/scitable/topicpage/transposons-the-jumping-genes-518/
https://www.pnas.org/doi/pdf/10.1073/pnas.2115999119
https://www.nature.com/articles/ng.3945
https://mobilednajournal.biomedcentral.com/articles/10.1186/s13100-016-0070-z
https://www.news-medical.net/news/20231101/Highly-sensitive-blood-test-shows-promise-for-early-detection-of-common-deadly-cancers.aspx
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710400/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563416/
https://www.pnas.org/doi/pdf/10.1073/pnas.2115999119
https://www.pnas.org/doi/pdf/10.1073/pnas.2115999119
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873040/#:~:text=DNA%20hypomethylation%20is%20a%20ubiquitous,often%20associated%20with%20tumor%20progression
https://www.nature.com/articles/s41598-023-33932-3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399582/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856164/
https://www.cancer.org/cancer/understanding-cancer/genes-and-cancer/oncogenes-tumor-suppressor-genes.html#:~:text=Tumor%20suppressor%20genes%20are%20normal,which%20can%20lead%20to%20cancer
https://www.pnas.org/doi/10.1073/pnas.2115999119#:~:text=In%20rare%20cases%2C%20derepressed%20LINE,additional%20effects%20on%20genome%20stability
https://medlineplus.gov/genetics/gene/tp53/
https://www.pnas.org/doi/pdf/10.1073/pnas.2115999119
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005969/
Image Sources:
https://www.gettyimages.com/detail/video/doctor-helps-woman-check-her-blood-sugar-levels-with-stock-footage/1412222826
https://www.gettyimages.com/detail/video/doctor-takes-blood-test-on-glass-in-laboratory-closeup-stock-footage/1397270359
https://www.gettyimages.com/detail/video/cancer-cells-stock-footage/1370327644
https://www.activemotif.com/blog-line-1
https://en.wikipedia.org/wiki/File:Retrotransposons.png
https://www.gettyimages.com/detail/video/structure-of-the-human-line-1-orf1p-trimer-stock-footage/1456762175
https://www.gettyimages.com/detail/video/dna-sequence-animation-stock-footage/468606238
https://commons.wikimedia.org/wiki/File:DNA_Transposon.png
https://www.gettyimages.com/detail/video/dna-test-stock-footage/1169799928
https://www.gettyimages.com/detail/video/extreme-close-up-of-human-blood-under-microscope-stock-footage/1475978712
https://www.gettyimages.com/detail/video/cancer-cells-stock-footage/1405578892
https://www.gettyimages.com/detail/video/colonography-or-ct-scan-of-colon-3d-rendering-image-with-stock-footage/1214297625
https://www.gettyimages.com/detail/video/strand-molecule-model-stock-footage/1297346034
https://commons.wikimedia.org/wiki/File:P53.png
https://www.gettyimages.com/detail/video/cancer-cell-growth-animation-stock-footage/537984570
https://www.gettyimages.com/detail/video/body-loop-stock-footage/472896811
https://www.gettyimages.com/detail/video/red-blood-cells-in-artery-stock-footage/1398259189
https://www.gettyimages.com/detail/video/doctor-talks-with-patient-and-takes-notes-stock-footage/1456004480
https://www.gettyimages.com/detail/video/male-patient-getting-a-cat-scan-at-the-hospita-stock-footage/1455615261
https://www.gettyimages.com/detail/video/finger-pricking-to-measure-blood-glucose-extreme-macro-stock-footage/1126442691
