Patrick Kelly | The Origin of Aspirin: From Willow Bark to the Pharmacy Shelf @PatKellyTeaches | Uploaded August 2024 | Updated October 2024, 1 hour ago.
In this video, Patrick Kelly tells the story of aspirin, the iconic painkiller tablet, from its ancient origins with willow bark aspirin to modern pharmacology. Learn how aspirin is prepared from salicylic acid and see how it compares to other popular pain relievers like ibuprofen and Tylenol (acetaminophen/paracetamol).
☠️NONE OF THE INFORMATION IN THIS VIDEO SHOULD BE USED AS MEDICAL ADVICE OR OPINION. IT IS FOR GENERAL EDUCATION AND ENTERTAINMENT☠️
🔗 L I N K S 🔗
📱Instagram: instagram.com/patkellyteaches
🐦Twitter: twitter.com/PatKellyTeaches
💰Patreon: patreon.com/corporis
🔬Old channel: youtube.com/corporis
📚My favorite books docs.google.com/document/d/1wuG-8EiF2lMbFdEG-9k1qi1d1KZAdGK1o41o7SYed_k/edit?usp=sharing
🔑 P A T R O N S 🔑
Oxytocin Tier: Mike W | Joanne K | Jim C Jr. | Jody O | Paul R | Daphne P | Oli W
Growth Hormone Tier: Dane M | Brendan P | Brandon K | Richardion G | Joe B | Mindi F | Sal F | Michael G | Brian B | Eileen H | Waffles the Dog | Brian T | Brian H | Michael R | Karen S | Sarah B | Robin B | Jacob S | Hyeon-S | Pranav M | Paul | Lucy Fur | huynhy | elnombre91 | Alcedo | Magmania | Josef K | Kyle K | Dab Brills | Robert M | Kristal C | Unsalted Pecan | Jiggs | TierZoo | Skasi | Jane G | Jack M | Hailey H | Matthew B | Michelle J | Helena SB | Eric L | Marshall K | David S | Ryne CJ | Kilian | Dean M | Ben | Cody S | Michelle L | Joseph G | Aryan Y | GD Annin | Vic K | Becca S | StealthyInk | Jesse B | Aleksander F | gidoo | Roxana A | Marc M | Munsu J | Doyle V
📜 S O U R C E S 📜
Annotated fact checked script on Patreon: patreon.com/posts/110687991
The Drug Hunters (affiliate link) amzn.to/3SCfoDP
The Discovery of Aspirin's Antithrombotic Effects (2007) ncbi.nlm.nih.gov/pmc/articles/PMC1894700
The first 3500 years of aspirin history from its roots – A concise summary (2019)
sciencedirect.com/science/article/abs/pii/S1537189118303549
Traveling through time with aspirin, a healing companion (2011) journals.sagepub.com/doi/pdf/10.1177/1721727X1100900102
The discovery of aspirin: a reappraisal (2000)
ncbi.nlm.nih.gov/pmc/articles/PMC1119266
Rev Stone Willow paper (1763) royalsocietypublishing.org/doi/10.1098/rstl.1763.0033
THE LIFE CYCLE OF STERLING DRUG, INC. (2000) https://acshist.scs.illinois.edu/bulletin_open_access/v25-1/v25-1%20p22-27.pdf
Prostaglandin in the inflammatory response
ncbi.nlm.nih.gov/pmc/articles/PMC3081099
Painkillers and prostaglandins (2003) nature.com/articles/nsb0403-233
ASPIRIN IN THE TREATMENT OF VASCULAR DISEASES (1948) sciencedirect.com/science/article/abs/pii/S0140673649918292
Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs (1969) nature.com/articles/223029a0
1974 Elwood trial ncbi.nlm.nih.gov/pmc/articles/PMC1633246/pdf/brmedj02178-0046.pdf
Aspirin as a Therapeutic Agent in Cardiovascular Disease : A Statement for Healthcare Professionals From the AHA (1997) ahajournals.org/doi/full/10.1161/01.cir.96.8.2751
Pharmacology of ibuprofen ncbi.nlm.nih.gov/pmc/articles/PMC3191627
The development of COX2 inhibitors (2003) nature.com/articles/nrd1034
Future of COX-2 inhibitors (2005) nature.com/articles/nrd1755#citeas
VIGOR study (2000) nejm.org/doi/full/10.1056/NEJM200011233432103
The sad story of Vioxx, and what we should learn from it (2004) ccjm.org/content/ccjom/71/12/933.full.pdf
ISIS-2 (1998) bmj.com/content/bmj/316/7141/1337.full.pdf
💻 C O N T A C T 💻
patkellyteaches [at] gmail.com
⌛T I M E S T A M P S ⌛
0:00 intro
0:32 How did Aspirin come from Willow?
8:45 Bayer's Marketing Plan
15:22 Mechanism of Action
17:57 Pharmacology of aspirin
🎵M U S I C🎵
Backed Vibes Clean - Rollin at 5 by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. creativecommons.org/licenses/by/4.0
Source: incompetech.com/music/royalty-free/index.html?isrc=USUAN1400029
Artist: incompetech.com
#historyofmedicine #medicalhistory
In this video, Patrick Kelly tells the story of aspirin, the iconic painkiller tablet, from its ancient origins with willow bark aspirin to modern pharmacology. Learn how aspirin is prepared from salicylic acid and see how it compares to other popular pain relievers like ibuprofen and Tylenol (acetaminophen/paracetamol).
☠️NONE OF THE INFORMATION IN THIS VIDEO SHOULD BE USED AS MEDICAL ADVICE OR OPINION. IT IS FOR GENERAL EDUCATION AND ENTERTAINMENT☠️
🔗 L I N K S 🔗
📱Instagram: instagram.com/patkellyteaches
🐦Twitter: twitter.com/PatKellyTeaches
💰Patreon: patreon.com/corporis
🔬Old channel: youtube.com/corporis
📚My favorite books docs.google.com/document/d/1wuG-8EiF2lMbFdEG-9k1qi1d1KZAdGK1o41o7SYed_k/edit?usp=sharing
🔑 P A T R O N S 🔑
Oxytocin Tier: Mike W | Joanne K | Jim C Jr. | Jody O | Paul R | Daphne P | Oli W
Growth Hormone Tier: Dane M | Brendan P | Brandon K | Richardion G | Joe B | Mindi F | Sal F | Michael G | Brian B | Eileen H | Waffles the Dog | Brian T | Brian H | Michael R | Karen S | Sarah B | Robin B | Jacob S | Hyeon-S | Pranav M | Paul | Lucy Fur | huynhy | elnombre91 | Alcedo | Magmania | Josef K | Kyle K | Dab Brills | Robert M | Kristal C | Unsalted Pecan | Jiggs | TierZoo | Skasi | Jane G | Jack M | Hailey H | Matthew B | Michelle J | Helena SB | Eric L | Marshall K | David S | Ryne CJ | Kilian | Dean M | Ben | Cody S | Michelle L | Joseph G | Aryan Y | GD Annin | Vic K | Becca S | StealthyInk | Jesse B | Aleksander F | gidoo | Roxana A | Marc M | Munsu J | Doyle V
📜 S O U R C E S 📜
Annotated fact checked script on Patreon: patreon.com/posts/110687991
The Drug Hunters (affiliate link) amzn.to/3SCfoDP
The Discovery of Aspirin's Antithrombotic Effects (2007) ncbi.nlm.nih.gov/pmc/articles/PMC1894700
The first 3500 years of aspirin history from its roots – A concise summary (2019)
sciencedirect.com/science/article/abs/pii/S1537189118303549
Traveling through time with aspirin, a healing companion (2011) journals.sagepub.com/doi/pdf/10.1177/1721727X1100900102
The discovery of aspirin: a reappraisal (2000)
ncbi.nlm.nih.gov/pmc/articles/PMC1119266
Rev Stone Willow paper (1763) royalsocietypublishing.org/doi/10.1098/rstl.1763.0033
THE LIFE CYCLE OF STERLING DRUG, INC. (2000) https://acshist.scs.illinois.edu/bulletin_open_access/v25-1/v25-1%20p22-27.pdf
Prostaglandin in the inflammatory response
ncbi.nlm.nih.gov/pmc/articles/PMC3081099
Painkillers and prostaglandins (2003) nature.com/articles/nsb0403-233
ASPIRIN IN THE TREATMENT OF VASCULAR DISEASES (1948) sciencedirect.com/science/article/abs/pii/S0140673649918292
Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs (1969) nature.com/articles/223029a0
1974 Elwood trial ncbi.nlm.nih.gov/pmc/articles/PMC1633246/pdf/brmedj02178-0046.pdf
Aspirin as a Therapeutic Agent in Cardiovascular Disease : A Statement for Healthcare Professionals From the AHA (1997) ahajournals.org/doi/full/10.1161/01.cir.96.8.2751
Pharmacology of ibuprofen ncbi.nlm.nih.gov/pmc/articles/PMC3191627
The development of COX2 inhibitors (2003) nature.com/articles/nrd1034
Future of COX-2 inhibitors (2005) nature.com/articles/nrd1755#citeas
VIGOR study (2000) nejm.org/doi/full/10.1056/NEJM200011233432103
The sad story of Vioxx, and what we should learn from it (2004) ccjm.org/content/ccjom/71/12/933.full.pdf
ISIS-2 (1998) bmj.com/content/bmj/316/7141/1337.full.pdf
💻 C O N T A C T 💻
patkellyteaches [at] gmail.com
⌛T I M E S T A M P S ⌛
0:00 intro
0:32 How did Aspirin come from Willow?
8:45 Bayer's Marketing Plan
15:22 Mechanism of Action
17:57 Pharmacology of aspirin
🎵M U S I C🎵
Backed Vibes Clean - Rollin at 5 by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. creativecommons.org/licenses/by/4.0
Source: incompetech.com/music/royalty-free/index.html?isrc=USUAN1400029
Artist: incompetech.com
#historyofmedicine #medicalhistory
