The Disease You Will Never Survive @MinuteEarth

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Check out DeepMind's AlphaFold - and marvel at the complex 3D structure of proteins - at alphafold.ebi.ac.uk

A simple mis-folding in a certain brain protein causes a disease for which we have no cure.

LEARN MORE
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To learn more about this topic, start your googling with these keywords:
- Prion: an abnormal pathogenic agent that is transmissible and able to induce abnormal folding of specific normal cellular proteins called prion proteins that are found most abundantly in the brain.
- Spongiform encephalopathies: a group of rare degenerative brain disorders caused by prions and characterized by tiny holes that give the brain a “spongy” appearance.
- Amyloid: an abnormal aggregate of protein.
- Creutzfeldt-Jakob disease: also known as subacute spongiform encephalopathy or neurocognitive disorder due to prion disease, is an invariably fatal degenerative brain disorder. Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances. Later symptoms include dementia, involuntary movements, blindness, weakness, and coma. About 70% of people die within a year of diagnosis.

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- Share this video with your friends and family
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CREDITS
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Lizah van der Aart | Script Writing, Narration, Illustration, Video Editing and Animation
Kate Yoshida | Script Editor and Video Director
Nathaniel Schroeder | Music

A huge thanks to Dr. Emmanuelle Vire for sharing her expertise on prion biology and epigenetics.

MinuteEarth is produced by Neptune Studios LLC
neptunestudios.info

OUR STAFF
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Lizah van der Aart • Sarah Berman • Cameron Duke
Arcadi Garcia i Rius • David Goldenberg • Melissa Hayes
Alex Reich • Henry Reich • Peter Reich
Ever Salazar • Leonardo Souza • Kate Yoshida

OUR LINKS
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Youtube | youtube.com/MinuteEarth
TikTok | tiktok.com/@minuteearth
Twitter | twitter.com/MinuteEarth
Instagram | instagram.com/minute_earth
Facebook | facebook.com/Minuteearth
Website | minuteearth.com
Apple Podcasts| podcasts.apple.com/us/podcast/minuteearth/id649211176

REFERENCES
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Dabin LC, Guntoro F, Campbell T, Bélicard T, Smith AR, Smith RG, Raybould R, Schott JM, Lunnon K, Sarkies P, Collinge J, Mead S, Viré E (2020). Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease. Acta Neuropathology 140(6):863-879. doi.org/10.1007/s00401-020-02224-9

Miller G. (2009) Neurodegeneration. Acting like a prion isn't always bad. Science 326 (5958):1338. doi.org/10.1126/science.326.5958.1338

Quartararo, AJ. (2020) Synthesis of Proteins by Automated Flow Chemistry. Science 368 (6494): 980– 987, doi.org/10.1126/science.abb2491

Sabate R. (2014) When amyloids become prions. Prion 8 (3):233-9. doi.org/10.4161/19336896.2014.968464

Scheckel, C., Aguzzi, A. (2018) Prions, prionoids and protein misfolding disorders. Nature Reviews Genetics 19, 405–418. doi.org/10.1038/s41576-018-0011-4

Vastag, B. (2009) The beneficial side of prions. Nature doi.org/10.1038/news.2009.23

$How Do Some Waves Get SO Big? Get 10% off all orders with code MINUTEEARTH now through May 31. After that, code is valid on 6 and 8.5 only. Shop now on https://bit.ly/MinuteEarthGlobes. All over the world, giant wave breaks appear because of underwater geology that supercharges their wave energy. LEARN MORE ************** To learn more about this topic, start your googling with these keywords: Amplitude - The distance between the crest and trough of a wave. Bathymetry - The measurement of depth of water in oceans, seas, or lakes. Nazaré Canyon - An undersea canyon just off the coast of Nazaré, Portugal, in the eastern North Atlantic Ocean. It is the largest submarine canyon in Europe, reaching depths of about 5,000 meters (16,000 ft) deep and a length of about 230 kilometers (140 mi). Plunging Breaker - Occurs when there are rapid depth changes. The crest of the wave becomes very steep, and the rear of the wave violently plunges over the front. Reef Break - A location where waves break over a reef, often amplifying them. Spilling Breaker - Occurs when the seafloor slopes gradually. As the wave becomes unstable, energy is dissipated by water spilling over the crest of the wave. Swell - a slow, regular movement of the sea in rolling waves that do not break. Wave period - The time between waves. SUPPORT MINUTEEARTH ************************** If you like what we do, you can help us!: - Become our patron: https://patreon.com/MinuteEarth - Share this video with your friends and family - Leave us a comment (we read them!) CREDITS ********* Cameron Duke | Script Writer Kate Yoshida | Narrator David Goldenberg | Director Sarah Berman | Illustration, Video Editing, and Animation Nathaniel Schroeder | Music MinuteEarth is produced by Neptune Studios LLC https://neptunestudios.info OUR STAFF ************ Sarah Berman • Arcadi Garcia Rius David Goldenberg • Julián Gustavo Gómez Melissa Hayes • Alex Reich • Henry Reich Peter Reich • Ever Salazar • Kate Yoshida OUR LINKS ************ Youtube | https://youtube.com/MinuteEarth TikTok | https://tiktok.com/@minuteearth Twitter | https://twitter.com/MinuteEarth Instagram | https://instagram.com/minute_earth Facebook | https://facebook.com/Minuteearth Website | https://minuteearth.com Apple Podcasts| https://podcasts.apple.com/us/podcast/minuteearth/id649211176 REFERENCES ************** Babanin, A. V., Rogers, W. E., de Camargo, R., Doble, M., Durrant, T., Filchuk, K., Ewans, K., Hemer, M., Janssen, T., Kelly-Gerreyn, B., Machutchon, K., McComb, P., Qiao, F., Schulz, E., Skvortsov, A., Thomson, J., Vichi, M., Violante-Carvalho, N., Wang, D., & Waseda, T. (2019). Waves and Swells in High Wind and Extreme Fetches, Measurements in the Southern Ocean. Frontiers in Marine Science, 6. Retrieved from: https://doi.org/10.3389/fmars.2019.00361 Editor At Surfertoday.com. (2013, November 5). The canyon that makes waves. Surfertoday; SurferToday.com | The Ultimate Surfing News Website. Retrieved from: https://www.surfertoday.com/surfing/the-canyon-that-makes-waves Griffiths, L. S., & Porter, R. (2012). Focusing of surface waves by variable bathymetry. Applied Ocean Research, 34, 150–163. Retrieved from: https://doi.org/10.1016/j.apor.2011.08.004 Inman, D. (2021). Living with Coastal Change - Coastal Basics - Wave Refraction Model - Jaws, Hawaii. Ucsd.edu. Retrieved from: http://coastalchange.ucsd.edu/st3_basics/p_waverefrac.html#bathymetric_map Keating, S. (2020, January 6). The story of a wave: from wind-blown ripples to breaking on the beach. The Conversation. Retrieved from: https://theconversation.com/the-story-of-a-wave-from-wind-blown-ripples-to-breaking-on-the-beach-128458 Pedro Proença Cunha, & Margarida, M. (2015, February). The Nazaré coast, the submarine canyon and the giant waves - a synthesis. ResearchGate; Universidade de Coimbra. Retrieved from: https://www.researchgate.net/publication/275522569_The_Nazare_coast_the_submarine_canyon_and_the_giant_waves a_synthesis Pinet, P. R. (2009). Invitation to oceanography (5th ed.). Jones & Bartlett Learning. The generation and propagation of ocean waves and swell. I. Wave periods and velocities | Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences. (2017). Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences. Retrieved from: https://royalsocietypublishing.org/doi/10.1098/rsta.1948.0005 Warner, S. (2020). What makes the world’s biggest surfable waves? The Conversation. Retrieved from: https://theconversation.com/what-makes-the-worlds-biggest-surfable-waves-150600 Warner, S. (2021). Department of Environmental Studies, Brandeis University. Personal Communication. Homepage: https://www.brandeis.edu/facultyguide/person.html?emplid=6cf46554ff6936fa51d9e22d0414e63798a5c4a1$

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