Uploaded December 2025 | Updated September 2026, 1 week ago
Microplastics and Cardiovascular Disease Letter: staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2
Winnow Affiliate Link (15% off): winnowlabs.com/STAYCURIOUS
Winnow is a first-in-class probiotic that binds microplastics to provide a microplastic shield from your inside. See the letter above for more details.
Inulin StayCurious Newsletter: staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2
Inulin Video: youtu.be/blNLHsww_Qs
Andrew Koutnik, Interview 1: youtu.be/2doAS18X9kA
Andrew Koutnik, Interview 2: youtu.be/-vdol1TSxoc
Andrew Koutnik, Interview 3: youtu.be/NrZlvtWIgBA
In this episode, Dr Andrew Koutnik and I dive deep into the science of fiber, keto, and more – focusing on two influential 2025 papers. First, we unpack the a new study revealing how a specific type of fiber can “immunize” the body against fructose by reshaping the microbiome, protecting the liver, reducing de novo lipogenesis, and boosting glutathione production. This isn’t “more fiber is better”—it’s precision nutrition.
Then we break down the keto mouse study that was widely discuss for claiming ketogenic diets cause fatty liver and glucose intolerance. We explain why this particular mouse model leads to misleading results, and how diet design specifics dramatically change outcomes. When viewed through these lenses, the scare headlines collapse.
We also explore how to think critically about nutrition science, why animal studies can both illuminate and mislead, how individuals can apply evidence with nuance, and why personal experimentation—combined with skepticism and curiosity—leads to better metabolic outcomes. If you're trying to understand fiber, fructose, ketogenic diets, diabetes, or simply want to make better decisions about your own metabolic health, this conversation provides clarity and actionable insight.
Chapters:
0:00 – Intro: Welcome Back Dr Andrew Koutnik PhD
1:40 – The Coolest Fiber Paper Ever!
21:19 – Probiotic That Binds Plastics
22:52 – Keto Mouse Myths: A Shady Study Skews the Truth
30:01 – Andrew Reflects on his Diary of a CEO Appearance
43:01 – Do Credentials Teach Curiosity, or Crush Them?
#NickNorwitz #AndrewKoutnik #MetabolicHealth #NutritionScience #Inulin #FiberScience #Microbiome #GutHealth #Fructose #HFCS #LiverHealth #NAFLD #Metabolism #InsulinResistance #KetogenicDiet #KetoScience #LowCarb #Type1Diabetes #PrecisionNutrition #LongevityScience #Healthspan #ScientificDebunk #DietStudies #EvidenceBasedNutrition #ScienceExplainer #StayCurious #Glutathione #Mitochondria #DeNovoLipogenesis #MicrobiomeResearch
Microplastics and Cardiovascular Disease Letter: staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2
Winnow Affiliate Link (15% off): winnowlabs.com/STAYCURIOUS
Winnow is a first-in-class probiotic that binds microplastics to provide a microplastic shield from your inside. See the letter above for more details.
Inulin StayCurious Newsletter: staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2
Inulin Video: youtu.be/blNLHsww_Qs
Andrew Koutnik, Interview 1: youtu.be/2doAS18X9kA
Andrew Koutnik, Interview 2: youtu.be/-vdol1TSxoc
Andrew Koutnik, Interview 3: youtu.be/NrZlvtWIgBA
In this episode, Dr Andrew Koutnik and I dive deep into the science of fiber, keto, and more – focusing on two influential 2025 papers. First, we unpack the a new study revealing how a specific type of fiber can “immunize” the body against fructose by reshaping the microbiome, protecting the liver, reducing de novo lipogenesis, and boosting glutathione production. This isn’t “more fiber is better”—it’s precision nutrition.
Then we break down the keto mouse study that was widely discuss for claiming ketogenic diets cause fatty liver and glucose intolerance. We explain why this particular mouse model leads to misleading results, and how diet design specifics dramatically change outcomes. When viewed through these lenses, the scare headlines collapse.
We also explore how to think critically about nutrition science, why animal studies can both illuminate and mislead, how individuals can apply evidence with nuance, and why personal experimentation—combined with skepticism and curiosity—leads to better metabolic outcomes. If you're trying to understand fiber, fructose, ketogenic diets, diabetes, or simply want to make better decisions about your own metabolic health, this conversation provides clarity and actionable insight.
Chapters:
0:00 – Intro: Welcome Back Dr Andrew Koutnik PhD
1:40 – The Coolest Fiber Paper Ever!
21:19 – Probiotic That Binds Plastics
22:52 – Keto Mouse Myths: A Shady Study Skews the Truth
30:01 – Andrew Reflects on his Diary of a CEO Appearance
43:01 – Do Credentials Teach Curiosity, or Crush Them?
#NickNorwitz #AndrewKoutnik #MetabolicHealth #NutritionScience #Inulin #FiberScience #Microbiome #GutHealth #Fructose #HFCS #LiverHealth #NAFLD #Metabolism #InsulinResistance #KetogenicDiet #KetoScience #LowCarb #Type1Diabetes #PrecisionNutrition #LongevityScience #Healthspan #ScientificDebunk #DietStudies #EvidenceBasedNutrition #ScienceExplainer #StayCurious #Glutathione #Mitochondria #DeNovoLipogenesis #MicrobiomeResearch
