Uploaded March 2025 | Updated September 2026, 1 hour ago
Lecture by 2001 and 2022 Nobel laureate in Chemistry K.Barry Sharpless, Scripps Research Institute, at the Molecular Frontiers Symposium "Frontiers of New Knowledge in Science" in Hong Kong, Nov 15-17, 2024.
ABSTRACT
Click chemistry is a modular approach that denotes the development of a set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds in search of function.This strategy depends largely on using spring- loaded reactants to construct carbon–heteroatom bonds. Click chemistry has many important applications, such as in the fields of chemical synthesis, materials science, chemical biology, and drug development.
Click chemistry was introduced in 1998 as a conceptual framework for functional molecular assembly, emphasizing the importance of carbon-heteroatom linkages in joining modular building blocks with a few nearly perfect reactions. Click reactions were identified as processes that work under operationally simple, oxygen- and water-tolerant conditions, not influenced by pH, temperature, presence of other functional groups and generate products in high yields with minimal requirements for product purification. The goal was to accelerate the process of discovery, optimization, and delivery, especially those in drug discovery, through practical synthesis.
Lecture by 2001 and 2022 Nobel laureate in Chemistry K.Barry Sharpless, Scripps Research Institute, at the Molecular Frontiers Symposium "Frontiers of New Knowledge in Science" in Hong Kong, Nov 15-17, 2024.
ABSTRACT
Click chemistry is a modular approach that denotes the development of a set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds in search of function.This strategy depends largely on using spring- loaded reactants to construct carbon–heteroatom bonds. Click chemistry has many important applications, such as in the fields of chemical synthesis, materials science, chemical biology, and drug development.
Click chemistry was introduced in 1998 as a conceptual framework for functional molecular assembly, emphasizing the importance of carbon-heteroatom linkages in joining modular building blocks with a few nearly perfect reactions. Click reactions were identified as processes that work under operationally simple, oxygen- and water-tolerant conditions, not influenced by pH, temperature, presence of other functional groups and generate products in high yields with minimal requirements for product purification. The goal was to accelerate the process of discovery, optimization, and delivery, especially those in drug discovery, through practical synthesis.
