Uploaded February 2026 | Updated September 2026, 2 weeks ago
For decades, the KRAS mutation was considered 'undruggable.' Now, a groundbreaking Spanish study has achieved complete tumor regression. Here is how they broke the barrier.
Let's review this groundbreaking Spanish study that has successfully regressed the pancreatic cancer; while also preventing cancer's resistance to the drugs.
š Want to support this work?
ā Buy me a coffee: buymeacoffee.com/DrMobeenSyed
š„ Become a patron: patreon.com/mobeensyed?fan_landing=true
šµ PayPal: paypal.me/mobeensyed?locale.x=en_US
š¬ My Substack: mobeensyedmd.substack.com
š Medical Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health-related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References:
Worthwhile course to study to understand more about these mechanisms:
Inflammation | DrBeen
members.drbeen.com/courses/inflammation/HkvpMzD8A
Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer | Nature Reviews Gastroenterology & Hepatology
nature.com/articles/s41575-019-0245-4
THE STUDY:
A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance | PNAS
pnas.org/doi/10.1073/pnas.2523039122
Scientists achieve pancreatic tumour regression in breakthrough study | Euronews
euronews.com/health/2026/01/28/scientists-achieve-pancreatic-tumour-regression-in-breakthrough-study
Born at UC Berkeley: a breakthrough in the treatment of sickle cell disease | Letters & Science
https://ls.berkeley.edu/news/born-uc-berkeley-breakthrough-treatment-sickle-cell-disease
Born at UC Berkeley: a breakthrough in the treatment of sickle cell disease - Berkeley News
https://news.berkeley.edu/2026/01/22/born-at-uc-berkeley-a-breakthrough-in-the-treatment-of-sickle-cell-disease/
Patient Cured of Sickle Cell Anemia With Innovative Gene Therapy | Pharmacy Times
pharmacytimes.com/view/patient-cured-of-sickle-cell-anemia-with-innovative-gene-therapy
Mariano Barbacid - Wikipedia
en.wikipedia.org/wiki/Mariano_Barbacid
Shokat Lab
https://shokatlab.ucsf.edu/
For related topics and reference diagram:
KRAS Inhibitor Tumor Resistance Mechanisms Identified | Inside Precision Medicine
insideprecisionmedicine.com/news-and-features/kras-inhibitor-tumor-resistance-mechanisms-identified
ERK Feedback Mechanism that keeps the tumor going when KRAS is activated.
See figure 1
Relaxation oscillations and hierarchy of feedbacks in MAPK signaling | Scientific Reports
nature.com/articles/srep38244
Diagram for KRAS pathway
See Figure 3
KRAS Mutations in Cancer: Understanding Signaling Pathways to Immune Regulation and the Potential of Immunotherapy
mdpi.com/2072-6694/17/5/785
Diagram
Functional roles of SRC signaling in pancreatic cancer: Recent insights provide novel therapeutic opportunities | Oncogene
nature.com/articles/s41388-023-02701-x
Diagram
KRAS Inhibitorsā yes but what next? Direct targeting of KRASā vaccines, adoptive T cell therapy and beyond - ScienceDirect
sciencedirect.com/science/article/pii/S0305737221001572
STAT3 activation and enrichment in ALDH+ cells in EGFR-mutant NSCLC.... | Download Scientific Diagram
researchgate.net/figure/STAT3-activation-and-enrichment-in-ALDH-cells-in-EGFR-mutant-NSCLC-Activation-of-EGFR_fig6_317016447
What is FYN Protein - Creative BioMart
creativebiomart.net/resource/articles-what-is-fyn-protein-654.htm
SD-36 | PROTAC STAT3 Degrader | MedChemExpress
medchemexpress.com/sd-36.html#:~:text=Due%20to%20the%20winter%20storm,select%20Quantity%20before%20adding%20items
For decades, the KRAS mutation was considered 'undruggable.' Now, a groundbreaking Spanish study has achieved complete tumor regression. Here is how they broke the barrier.
Let's review this groundbreaking Spanish study that has successfully regressed the pancreatic cancer; while also preventing cancer's resistance to the drugs.
š Want to support this work?
ā Buy me a coffee: buymeacoffee.com/DrMobeenSyed
š„ Become a patron: patreon.com/mobeensyed?fan_landing=true
šµ PayPal: paypal.me/mobeensyed?locale.x=en_US
š¬ My Substack: mobeensyedmd.substack.com
š Medical Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health-related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References:
Worthwhile course to study to understand more about these mechanisms:
Inflammation | DrBeen
members.drbeen.com/courses/inflammation/HkvpMzD8A
Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer | Nature Reviews Gastroenterology & Hepatology
nature.com/articles/s41575-019-0245-4
THE STUDY:
A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance | PNAS
pnas.org/doi/10.1073/pnas.2523039122
Scientists achieve pancreatic tumour regression in breakthrough study | Euronews
euronews.com/health/2026/01/28/scientists-achieve-pancreatic-tumour-regression-in-breakthrough-study
Born at UC Berkeley: a breakthrough in the treatment of sickle cell disease | Letters & Science
https://ls.berkeley.edu/news/born-uc-berkeley-breakthrough-treatment-sickle-cell-disease
Born at UC Berkeley: a breakthrough in the treatment of sickle cell disease - Berkeley News
https://news.berkeley.edu/2026/01/22/born-at-uc-berkeley-a-breakthrough-in-the-treatment-of-sickle-cell-disease/
Patient Cured of Sickle Cell Anemia With Innovative Gene Therapy | Pharmacy Times
pharmacytimes.com/view/patient-cured-of-sickle-cell-anemia-with-innovative-gene-therapy
Mariano Barbacid - Wikipedia
en.wikipedia.org/wiki/Mariano_Barbacid
Shokat Lab
https://shokatlab.ucsf.edu/
For related topics and reference diagram:
KRAS Inhibitor Tumor Resistance Mechanisms Identified | Inside Precision Medicine
insideprecisionmedicine.com/news-and-features/kras-inhibitor-tumor-resistance-mechanisms-identified
ERK Feedback Mechanism that keeps the tumor going when KRAS is activated.
See figure 1
Relaxation oscillations and hierarchy of feedbacks in MAPK signaling | Scientific Reports
nature.com/articles/srep38244
Diagram for KRAS pathway
See Figure 3
KRAS Mutations in Cancer: Understanding Signaling Pathways to Immune Regulation and the Potential of Immunotherapy
mdpi.com/2072-6694/17/5/785
Diagram
Functional roles of SRC signaling in pancreatic cancer: Recent insights provide novel therapeutic opportunities | Oncogene
nature.com/articles/s41388-023-02701-x
Diagram
KRAS Inhibitorsā yes but what next? Direct targeting of KRASā vaccines, adoptive T cell therapy and beyond - ScienceDirect
sciencedirect.com/science/article/pii/S0305737221001572
STAT3 activation and enrichment in ALDH+ cells in EGFR-mutant NSCLC.... | Download Scientific Diagram
researchgate.net/figure/STAT3-activation-and-enrichment-in-ALDH-cells-in-EGFR-mutant-NSCLC-Activation-of-EGFR_fig6_317016447
What is FYN Protein - Creative BioMart
creativebiomart.net/resource/articles-what-is-fyn-protein-654.htm
SD-36 | PROTAC STAT3 Degrader | MedChemExpress
medchemexpress.com/sd-36.html#:~:text=Due%20to%20the%20winter%20storm,select%20Quantity%20before%20adding%20items
