Uploaded May 2026 | Updated September 2026, 3 weeks ago
Editor’s note: In our first BioHub pod with Priscilla and Mark they discussed their acquisition of EvoScale, led by Alex Rives, who is now Head of Science at BioHub. With ESM-1 they trained language models on millions of protein sequences drawn from across life, with a simple “next token” objective: predict the amino acids that have been randomly masked out, based on the context of the rest of the sequence. But they soon found that these models also learned biological structure and function, including properties the model had never been explicitly shown AND that this ability scales predictably with compute, leading to ESM2 and ESM3.
Today, Alex announced ESMFold 2, an open scientific engine to power prediction, design, and discovery across protein biology. https://x.com/alexrives/status/2059622778945343669
Editor’s note: In our first BioHub pod with Priscilla and Mark they discussed their acquisition of EvoScale, led by Alex Rives, who is now Head of Science at BioHub. With ESM-1 they trained language models on millions of protein sequences drawn from across life, with a simple “next token” objective: predict the amino acids that have been randomly masked out, based on the context of the rest of the sequence. But they soon found that these models also learned biological structure and function, including properties the model had never been explicitly shown AND that this ability scales predictably with compute, leading to ESM2 and ESM3.
Today, Alex announced ESMFold 2, an open scientific engine to power prediction, design, and discovery across protein biology. https://x.com/alexrives/status/2059622778945343669
![AI Agents Need a Planning Stage to Complete Complex Tasks [Anthropic] #ai #coding #podcast](https://i.ytimg.com/vi/YnyAV_Jzpc0/mqdefault.jpg "AI Agents Need a Planning Stage to Complete Complex Tasks [Anthropic] #ai #coding #podcast
AI Agents Need a Planning Stage to Complete Complex Tasks [Anthropic] #ai #coding #podcast")
