Uploaded August 2026 | Updated September 2026, 2 weeks ago

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Our favorite moments with the incredible Johnny Depp.
(Air dates: 12/7/2010, 10/27/2011, 2/21/2013, 4/3/2014)

#johnnydepp #letterman #lateshow #bestof

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Welcome to the Letterman YouTube Channel, home to all your favorite clips from Late Night and Late Show - as well as conversations with the writers, producers and performers who helped make it all happen. And for those of you who like Miscellaneous, you may very well find some Miscellaneous here.