Uploaded December 2025 | Updated September 2026, 2 weeks ago
A clip from another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!
This episode is brought to you by:
Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: Qlosi.com/Tim
David Protein Bars with 28g of protein, 150 calories, and 0g of sugar: davidprotein.com/Tim (Buy 4 cartons, get the 5th free.)
Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $400 off your very own Pod 5 Ultra)
Coyote the card game, which I co-created with Exploding Kittens: coyotegame.com
Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded one billion downloads and been selected for “Best of Apple Podcasts” three years running.
Sign up for "5-Bullet Friday" (Tim's free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
Follow Tim Ferriss on Twitter: twitter.com/tferriss
Follow Tim Ferriss on Instagram: instagram.com/timferriss
Like Tim Ferriss on Facebook: facebook.com/TimFerriss
A clip from another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!
This episode is brought to you by:
Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: Qlosi.com/Tim
David Protein Bars with 28g of protein, 150 calories, and 0g of sugar: davidprotein.com/Tim (Buy 4 cartons, get the 5th free.)
Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $400 off your very own Pod 5 Ultra)
Coyote the card game, which I co-created with Exploding Kittens: coyotegame.com
Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded one billion downloads and been selected for “Best of Apple Podcasts” three years running.
Sign up for "5-Bullet Friday" (Tim's free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
Follow Tim Ferriss on Twitter: twitter.com/tferriss
Follow Tim Ferriss on Instagram: instagram.com/timferriss
Like Tim Ferriss on Facebook: facebook.com/TimFerriss


![All Things Ketones, How to Boost Cognition, Sardine Fasting, Diet Rules, & More — Dr. Dom D’Agostino
Dr. Dominic D’Agostino is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.
This episode is brought to you by:
Momentous high-quality creatine: https://livemomentous.com/tim (code TIM for up to 35% off)
Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)
AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs)
Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded 900 million downloads and been selected for “Best of Apple Podcasts” three years running.
Sign up for 5-Bullet Friday (Tims free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
Follow Tim Ferriss on Twitter: https://twitter.com/tferriss/
Follow Tim Ferriss on Instagram: https://www.instagram.com/timferriss/
Like Tim Ferriss on Facebook: https://www.facebook.com/TimFerriss/
[00:00] Start
[00:42] Why Im interested in ketogenic strategies for neurodegenerative prevention.
[02:17] Mary and Steve Newports ketone-linked temporary cognitive improvements.
[04:31] A mechanisms overview for Alzheimers/dementia.
[07:45] The immune system as longevitys fifth horseman — and why metabolic control is key.
[08:26] How to measure ketones and GKI.
[09:26] Fasting vs. ketogenic diet.
[10:48] Theres nothing fishy about sardine fasting.
[15:05] My hiatal hernia discovery and increased cancer risk concerns.
[16:46] HSCRP as a superior biomarker to LDL for cardiovascular risk.
[18:39] Glucose tolerance testing revelations and CGM importance.
[24:12] Upgrading the metabolic machinery through keto without getting bored.
[27:43] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.
[31:43] Doms day-to-day diet regimen.
[37:29] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.
[41:50] Supplementing for sleep disruption while fasting.
[45:20] Why Dom doesnt have misgivings about melatonin.
[46:09] Shingles prevention through fasting protocols.
[46:32] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.
[50:15] Dom at 50-something: Current meal timing and composition.
[53:35] Blue zone observations: Greek and Sardinian longevity habits.
[54:39] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.
[01:01:49] Ketone metabolic therapy for cancer.
[01:04:54] The metabolic psychiatry revolution.
[01:08:49] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.
[01:15:10] Metformin vs. berberine.
[01:18:29] The low-dose neuroprotective potential of GLP-1 drugs.
[01:21:44] NAD research: MIB-626 and stabilized forms for mitochondrial health.
[01:26:38] Idebenone, CoQ10, and the Deanna protocol for ALS.
[01:28:55] Doms supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.
[01:31:36] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts. All Things Ketones, How to Boost Cognition, Sardine Fasting, Diet Rules, & More — Dr. Dom D’Agostino](https://i.ytimg.com/vi/NB02_mF8qTs/mqdefault.jpg)
![Q&A with Tim — The Art of Male Friendship, Reinvention in The Age of AI, & More
In this wide-ranging Q&A, Tim explores reinvention, enduring skills for the age of AI, friendship, mental health, fitness, language learning, privacy, cognitive longevity, and more.
This episode is brought to you by:
Gusto simple and easy payroll, HR, and benefits platform used by 400,000+ businesses: https://Gusto.com/Tim
Momentous high-quality creatine for cognitive and muscular support: https://LiveMomentous.com/Tim
Helix Sleep premium mattresses: https://HelixSleep.com/Tim
Wealthfront high-yield cash account: https://Wealthfront.com/Tim
New clients get 3.30% base APY from program banks + additional 0.75% boost for 3 months on your uninvested cash (max $150k balance). Terms and conditions apply. The Cash Account offered by Wealthfront Brokerage LLC (“WFB”) member FINRA/SIPC, not a bank. The base APY as of 1/30/26 is representative, can change, and requires no minimum. Tim Ferriss, a non-client, receives compensation from WFB for advertising and holds a non-controlling equity interest in the corporate parent of WFB, which creates a conflict of interest. Individual experiences and outcomes will differ. Instant withdrawals may be limited by your receiving firm and other factors. Investment advisory services provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, not bank-guaranteed or FDIC-insured, and may lose value.
[00:00:00] Coming Up.
[00:00:39] How to go from hyper-optimized to grounded.
[00:04:09] Reinvention in your late 40s: there are more than two options.
[00:08:15] Five meta-skills for the age of AI.
[00:14:27] Post-sabbatical rules that re-focused this podcast.
[00:19:19] Why male friendship is built shoulder-to-shoulder, not face-to-face.
[00:23:26] Love for women authors.
[00:23:47] SAINT, TMS, and Ampa’s one-day brain reset.
[00:25:52] How to build a fanbase by being your authentically weird self.
[00:27:18] My “something is better than nothing” workout routine.
[00:29:02] Staying fit in mind and soul via the past-year review.
[00:29:42] The 4-Hour Body workout routines I still follow.
[00:31:26] Spotting the future titan hiding in an average teen.
[00:32:46] Vacation, burnout, or an outgrown life? Take a mini-retirement.
[00:37:12] Guiding kids through our digital dystopia.
[00:39:43] Does AI kill language learning? What does a new language really give you?
[00:50:18] Muted movies as late-night writing company.
[00:51:03] Best sub-$100 buy: seven seasons of wholesome Pawnee.
[00:52:19] Why two hours of walking fixes almost everything.
[00:54:13] Sleep, unsexily solved: less water, more sun, more exhaustion.
[00:56:26] Privacy as the new luxury in the age of shrinking fame.
[00:59:54] Luxuries worth overspending on: massage, easy travel, and health.
[01:05:00] The best defense against cognitive decline: exercise, exercise, exercise.
[01:08:54] Parting thoughts.
Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded one billion downloads and been selected for “Best of Apple Podcasts” three years running.
Sign up for 5-Bullet Friday (Tims free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
Follow Tim Ferriss on Twitter: https://twitter.com/tferriss/
Follow Tim Ferriss on Instagram: https://www.instagram.com/timferriss/
Like Tim Ferriss on Facebook: https://www.facebook.com/TimFerriss/ Q&A with Tim — The Art of Male Friendship, Reinvention in The Age of AI, & More](https://i.ytimg.com/vi/NRjgAC-EcsY/mqdefault.jpg)






![KneesOverToesGuy — Workouts That Produce Wild Results and Lessons from Charles Poliquin
My workout with Ben: https://www.youtube.com/watch?v=xpM4V6O9f6w
Ben Patrick, better known as “Kneesovertoesguy” (@TheKneesovertoesguy) is the founder of Athletic Truth Group (ATG), an online and brick-and-mortar training system rooted in rehabilitative strength and joint health. After years of debilitating knee and shin pain (including multiple surgeries), he rebuilt his body and performance, going from a sub-20″ vertical to a documented 42″ leap.
This episode is brought to you by:
Momentous high-quality creatine for cognitive and muscular support: https://livemomentous.com/Tim (Code TIM for 35% off your first subscription.)
Monarch track, budget, plan, and do more with your money: Monarch.com/Tim (50% off your first year at monarchmoney.com with code TIM)
David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim (Buy 4 cartons, get the 5th free.)
[00:00] Preview
[00:42] How Ben went from Old Man Patrick to Knees Over Toes Guy.
[04:29] Backward sled dragging for safe strength building and rehab.
[11:46] Full range of motion squatting (deep squats vs. 90-degree limitation).
[12:35] “Strength is gained in the range it is trained.” — Charles Poliquin
[14:50] ATG split squat (front foot elevated split squat).
[15:53] Heel elevation and counterbalancing techniques.
[23:26] Ben’s mother’s transformation — from hip deterioration to sprinting at age 71.
[23:42] Ben’s vertical jump progression — unable to grab rim in high school to dunking at 34.
[24:21] Most effective exercises Ben’s mom might recommend.
[25:51] Ben and I reflect on what Charles Poliquin (RIP) gave to us.
[32:37] How backwards sled pulling became a revered exercise.
[35:12] Mr. Universe Bob Gajda’s contributions to Ben’s regimen.
[38:15] ATG prioritizes offering American-made products when possible.
[39:12] Tibialis raises without equipment.
[40:24] Why I included the ATG wrist bar in a recent 5-Bullet Friday.
[43:19] Ben’s videos he most recommends.
[49:27] Applying the minimum effective dose (MED) for maximum results in any endeavor.
[54:40] What I would include in The 4-Hour Body if it were written or revised today.
[56:02] A space-saving alternative for people who want to enjoy the benefits of sled work.
[56:47] Real examples of high-yield workouts that require a low investment of time.
[01:00:53] Ben’s basketball warmup protocols.
[01:01:53] Regularly skip leg day? Try Arnold Schwarzenegger’s one simple trick.
[01:03:46] Maintaining integrity in the ever-fickle world of content creation.
[01:27:15] Parting thoughts.
Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded 900 million downloads and been selected for “Best of Apple Podcasts” three years running.
Sign up for 5-Bullet Friday (Tims free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
Follow Tim Ferriss on Twitter: https://twitter.com/tferriss/
Follow Tim Ferriss on Instagram: https://www.instagram.com/timferriss/
Like Tim Ferriss on Facebook: https://www.facebook.com/TimFerriss/ KneesOverToesGuy — Workouts That Produce Wild Results and Lessons from Charles Poliquin](https://i.ytimg.com/vi/PELnYpZedWo/mqdefault.jpg)