Uploaded April 2019 | Updated September 2026, 2 weeks ago

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Structural biology has revealed how the BAX protein is activated. The blue and yellow region shows where BH3-only proteins transiently bind BAX to release its 'tail' (red) that anchors BAX into mitochondrial membrane.

This research helped to reveal how the transient ‘hit-and-run’ interaction between BAX and BH3-only proteins could be an important trigger for cell death.

Learn more: https://www.wehi.edu.au/news/cell-death-may-be-triggered-hit-and-run-interaction