Uploaded May 2026 | Updated September 2026, 8 hours ago
Cross-coupling methodology to form carbon-nitrogen bonds is an indispensable part of the everyday repertoire of synthetic organic chemists. This methodology has been widely employed throughout academia and industry. This lecture will include: 1) A description of how I came to be involved in this work, starting with my first introduction to chemistry. 2) An introduction to palladium-catalyzed carbon-heteroatom bond-forming reactions, including a historical overview. 3) A description of ligand and precatalyst development employing biarylphosphines, developed at MIT. 4) The applications of these catalysts in preparing compounds of relevance to the biopharma industry and human health.
Stephen L. Buchwald was born in 1955 in Bloomington, Indiana. He received his Sc.B. from Brown University in 1977, where he worked with Kathlyn A. Parker and David E. Cane, as well as Professor Gilbert Stork at Columbia University. He entered Harvard University as a National Science Foundation Predoctoral Fellow in 1977 and received his Ph.D. in 1982 under the supervision of Jeremy R. Knowles. He was then a Myron A. Bantrell postdoctoral fellow at Caltech with Professor Robert H. Grubbs. In 1984, he began as an assistant professor of chemistry at MIT. He was promoted to associate professor (1989), then to professor (1993), and was named the Camille Dreyfus Professor in 1997. He served as MIT’s Associate Head of the Chemistry Department from July 2015 to August 2023. He has received numerous honors, including the 2000 ACS Award in Organometallic Chemistry, the 2006 ACS Award for Creative Work in Synthetic Organic Chemistry, and the Gustavus J. Esselen Award for Chemistry in the Public Interest in 2010. He received the 2013 Arthur C. Cope Award (ACS), the Linus Pauling Medal Award, and the Ulysses Medal (2014). In 2015, he received the BBVA Frontiers in Knowledge Award in Basic Sciences (2014 Award). He also received the William H. Nichols Award from the New York ACS (2016). In 2022, he received the Paul Karrar Gold Medal from the University of Zürich. He is a fellow of the American Academy of Arts and Sciences and a member of the
This lecture is part of the IHMC Evening Lecture series.
ihmc.us/life/evening_lectures
Cross-coupling methodology to form carbon-nitrogen bonds is an indispensable part of the everyday repertoire of synthetic organic chemists. This methodology has been widely employed throughout academia and industry. This lecture will include: 1) A description of how I came to be involved in this work, starting with my first introduction to chemistry. 2) An introduction to palladium-catalyzed carbon-heteroatom bond-forming reactions, including a historical overview. 3) A description of ligand and precatalyst development employing biarylphosphines, developed at MIT. 4) The applications of these catalysts in preparing compounds of relevance to the biopharma industry and human health.
Stephen L. Buchwald was born in 1955 in Bloomington, Indiana. He received his Sc.B. from Brown University in 1977, where he worked with Kathlyn A. Parker and David E. Cane, as well as Professor Gilbert Stork at Columbia University. He entered Harvard University as a National Science Foundation Predoctoral Fellow in 1977 and received his Ph.D. in 1982 under the supervision of Jeremy R. Knowles. He was then a Myron A. Bantrell postdoctoral fellow at Caltech with Professor Robert H. Grubbs. In 1984, he began as an assistant professor of chemistry at MIT. He was promoted to associate professor (1989), then to professor (1993), and was named the Camille Dreyfus Professor in 1997. He served as MIT’s Associate Head of the Chemistry Department from July 2015 to August 2023. He has received numerous honors, including the 2000 ACS Award in Organometallic Chemistry, the 2006 ACS Award for Creative Work in Synthetic Organic Chemistry, and the Gustavus J. Esselen Award for Chemistry in the Public Interest in 2010. He received the 2013 Arthur C. Cope Award (ACS), the Linus Pauling Medal Award, and the Ulysses Medal (2014). In 2015, he received the BBVA Frontiers in Knowledge Award in Basic Sciences (2014 Award). He also received the William H. Nichols Award from the New York ACS (2016). In 2022, he received the Paul Karrar Gold Medal from the University of Zürich. He is a fellow of the American Academy of Arts and Sciences and a member of the
This lecture is part of the IHMC Evening Lecture series.
ihmc.us/life/evening_lectures
