Setmelanotide for the Treatment of Acquired Hypothalamic Obesity (TRANSCEND) @NEJMgroup
Setmelanotide for the Treatment of Acquired Hypothalamic Obesity (TRANSCEND)  @NEJMgroup
Uploaded July 2026 | Updated September 2026, 2 weeks ago
Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin-4 receptor agonist, led to significantly greater reductions in body-mass index and hunger than placebo at 52 weeks. Read the full TRANSCEND trial results at NEJM.org.
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Setmelanotide for the Treatment of Acquired Hypothalamic Obesity (TRANSCEND)

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