Nutrition Made Simple! | Scientist reacts to Carnivore Doctor on Joe Rogan | Part II @NutritionMadeSimple | Uploaded December 2020 | Updated October 2024, 6 hours ago.
Dr. Paul Saladino's claims on the Joe Rogan podcast. Part II of the fact-check. Yet another Joe Rogan podcast touching on nutrition...
109:38 as long as you have high HDL, increasing LDL has very little risk. very little cardiac risk.
common idea that HDL-c makes up for high LDL-c. this idea of the protective HDL-C comes from correlation studies. bag 2. when it was tested directly, in randomized clinical trials, bag 3, raising HDL-C did not improve cv risk. meta-analysis of 39 clinical trials:
“observational studies suggest a simplistic hypothesis for HDL-cholesterol, that increasing it would reduce cardiovascular events, but substantial trials do not support this concept”
genetic studies confirm that higher or lower HDL-C determined genetically didn’t change cv risk
bottomline, for heart disease, raising HDL-C probably does nothing and certainly does not make up for high LDL-C
LDL-cholesterol and triglycerides are helpful markers but it's well understood that the real cause of heart disease is the number of lipoproteins, the vehicles that carry cholesterol and triglycerides. In most people, high LDL-C and high triglycerides indicates high concentration of lipoproteins, but some people are exceptions and may have high lipoproteins but normal LDL-C or vice versa.
111:21 insufficient evidence to say high LDL in someone who is metabolically healthy is the same as in someone who is metabolically unhealthy.
we’re acknowledging high LDL-cholesterol is a problem, but maybe if I’m metabolically healthy, if the high cholesterol is the only issue, maybe I'm an exception? meta-analysis: lowering LDL-cholesterol in different contexts.
‘there was a reduction in cardiovascular events (heart attacks, strokes) in people with diabetes which was similar to the effect observed in those without diabetes” and “There was a reduction in mortality with lower LDL cholesterol in people with diabetes, which was similar to the reduction in those without diabetes”. they conclude “Among all trials, the effects of cholesterol-lowering were similar with or without diabetes”
So whether they had diabetes or not, they benefited by bringing ldl-c down to normal levels.
Connect with me:
Facebook: facebook.com/DrGilCarvalho
Twitter: twitter.com/NutritionMadeS3
Animations: Even Topland @toplandmedia
References:
HDL-C: ncbi.nlm.nih.gov/pmc/articles/PMC4103514
LDL-C and context:
thelancet.com/journals/lancet/article/PIIS0140-6736(08)60104-X/fulltext
ncbi.nlm.nih.gov/pmc/articles/PMC3774022
jamanetwork.com/journals/jamainternalmedicine/article-abstract/1105661
sciencedirect.com/science/article/abs/pii/S0140673605673941
search.proquest.com/openview/c8e265fd285df54d6569bffc036e10f4/1
sciencedirect.com/science/article/pii/S0140673610613505
kidney-international.org/article/S0085-2538(17)30725-1/fulltext
sciencedirect.com/science/article/pii/S0140673610621745
jamanetwork.com/journals/jama/fullarticle/2749533
Minnesota and Sydney:
ahajournals.org/doi/full/10.1161/CIR.0000000000000510
ahajournals.org/doi/abs/10.1161/01.atv.9.1.129
CAC: academic.oup.com/jcem/article/105/12/dgaa674/5909161
RCTs on plants:
pubmed.ncbi.nlm.nih.gov/15867404
academic.oup.com/jn/article/149/9/1565/5512736
ahajournals.org/doi/full/10.1161/01.CIR.103.13.1823
nejm.org/doi/full/10.1056/NEJMoa1800389
pubmed.ncbi.nlm.nih.gov/29215971
nejm.org/doi/full/10.1056/nejm199704173361601
academic.oup.com/ajcn/article/111/2/307/5675325
academic.oup.com/ajcn/article/99/3/479/4577353
academic.oup.com/ajcn/article/92/4/733/4597497
ncbi.nlm.nih.gov/pmc/articles/PMC6221555
science.sciencemag.org/content/359/6380/1151.abstract
jamanetwork.com/journals/jama/fullarticle/196970
thelancet.com/journals/lancet/article/PIIS0140-6736(18)31809-9/fulltext
link.springer.com/article/10.1007%2Fs00394-010-0115-x
ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.035225
jandonline.org/article/S2212-2672(14)01633-5/fulltext
link.springer.com/article/10.1007/s11130-013-0336-2
academic.oup.com/ajcn/article/110/1/24/5494812
nature.com/articles/ejcn2014228
Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.
#NutritionMadeSimple #GilCarvalho
Dr. Paul Saladino's claims on the Joe Rogan podcast. Part II of the fact-check. Yet another Joe Rogan podcast touching on nutrition...
109:38 as long as you have high HDL, increasing LDL has very little risk. very little cardiac risk.
common idea that HDL-c makes up for high LDL-c. this idea of the protective HDL-C comes from correlation studies. bag 2. when it was tested directly, in randomized clinical trials, bag 3, raising HDL-C did not improve cv risk. meta-analysis of 39 clinical trials:
“observational studies suggest a simplistic hypothesis for HDL-cholesterol, that increasing it would reduce cardiovascular events, but substantial trials do not support this concept”
genetic studies confirm that higher or lower HDL-C determined genetically didn’t change cv risk
bottomline, for heart disease, raising HDL-C probably does nothing and certainly does not make up for high LDL-C
LDL-cholesterol and triglycerides are helpful markers but it's well understood that the real cause of heart disease is the number of lipoproteins, the vehicles that carry cholesterol and triglycerides. In most people, high LDL-C and high triglycerides indicates high concentration of lipoproteins, but some people are exceptions and may have high lipoproteins but normal LDL-C or vice versa.
111:21 insufficient evidence to say high LDL in someone who is metabolically healthy is the same as in someone who is metabolically unhealthy.
we’re acknowledging high LDL-cholesterol is a problem, but maybe if I’m metabolically healthy, if the high cholesterol is the only issue, maybe I'm an exception? meta-analysis: lowering LDL-cholesterol in different contexts.
‘there was a reduction in cardiovascular events (heart attacks, strokes) in people with diabetes which was similar to the effect observed in those without diabetes” and “There was a reduction in mortality with lower LDL cholesterol in people with diabetes, which was similar to the reduction in those without diabetes”. they conclude “Among all trials, the effects of cholesterol-lowering were similar with or without diabetes”
So whether they had diabetes or not, they benefited by bringing ldl-c down to normal levels.
Connect with me:
Facebook: facebook.com/DrGilCarvalho
Twitter: twitter.com/NutritionMadeS3
Animations: Even Topland @toplandmedia
References:
HDL-C: ncbi.nlm.nih.gov/pmc/articles/PMC4103514
LDL-C and context:
thelancet.com/journals/lancet/article/PIIS0140-6736(08)60104-X/fulltext
ncbi.nlm.nih.gov/pmc/articles/PMC3774022
jamanetwork.com/journals/jamainternalmedicine/article-abstract/1105661
sciencedirect.com/science/article/abs/pii/S0140673605673941
search.proquest.com/openview/c8e265fd285df54d6569bffc036e10f4/1
sciencedirect.com/science/article/pii/S0140673610613505
kidney-international.org/article/S0085-2538(17)30725-1/fulltext
sciencedirect.com/science/article/pii/S0140673610621745
jamanetwork.com/journals/jama/fullarticle/2749533
Minnesota and Sydney:
ahajournals.org/doi/full/10.1161/CIR.0000000000000510
ahajournals.org/doi/abs/10.1161/01.atv.9.1.129
CAC: academic.oup.com/jcem/article/105/12/dgaa674/5909161
RCTs on plants:
pubmed.ncbi.nlm.nih.gov/15867404
academic.oup.com/jn/article/149/9/1565/5512736
ahajournals.org/doi/full/10.1161/01.CIR.103.13.1823
nejm.org/doi/full/10.1056/NEJMoa1800389
pubmed.ncbi.nlm.nih.gov/29215971
nejm.org/doi/full/10.1056/nejm199704173361601
academic.oup.com/ajcn/article/111/2/307/5675325
academic.oup.com/ajcn/article/99/3/479/4577353
academic.oup.com/ajcn/article/92/4/733/4597497
ncbi.nlm.nih.gov/pmc/articles/PMC6221555
science.sciencemag.org/content/359/6380/1151.abstract
jamanetwork.com/journals/jama/fullarticle/196970
thelancet.com/journals/lancet/article/PIIS0140-6736(18)31809-9/fulltext
link.springer.com/article/10.1007%2Fs00394-010-0115-x
ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.035225
jandonline.org/article/S2212-2672(14)01633-5/fulltext
link.springer.com/article/10.1007/s11130-013-0336-2
academic.oup.com/ajcn/article/110/1/24/5494812
nature.com/articles/ejcn2014228
Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.
#NutritionMadeSimple #GilCarvalho
