WAY-316606 for hair loss. Will Wnt pathway drugs make finasteride obsolete? Haircafe 2026-09-30 | WAY-316606 for hair loss. Will Wnt pathway drugs make finasteride obsolete?
How verteporfin will revolutionize hair transplants Haircafe 2023-11-16 | Previous verteporfin videos:youtu.be/fLsm7L-2Fz8youtu.be/ePlIWf7y3lgSources:1. Donor Healing Study With Verteporfin By Dr. Barghouthi – Follicle Thought. Accessed October 13, 2022. folliclethought.com/donor-healing-study-with-verteporfin-by-dr-barghouthi2. FDA approved drug Verteporfin found to fully regenerate skin, including hair follicles. Hair Restoration Network - Community For and By Hair Loss Patients. Accessed August 16, 2021. hairrestorationnetwork.com/topic/60076-fda-approved-drug-verteporfin-found-to-fully-regenerate-skin-including-hair-follicles3. Mascharak S, desJardins-Park HE, Januszyk M, et al. Divergent molecular signatures of regeneration and fibrosis during wound repair. Published online December 18, 2020:2020.12.17.423181. doi:10.1101/2020.12.17.4231814. Clark RAF. To Scar or Not to Scar. n engl j med. Published online 2021:3.5. desJardins-Park HE, Mascharak S, Januszyk M, et al. 3: Multimodal Molecular Analysis Reveals Divergent Trajectories Of Wound Regeneration Versus Fibrosis. Plastic and Reconstructive Surgery – Global Open. 2021;9(7S):2-3. doi:10.1097/01.GOX.0000769936.79898.fc6. Mascharak S, desJardins-Park HE, Davitt MF, et al. Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring. Science. 2021;372(6540):eaba2374. doi:10.1126/science.aba23747. Gao N, Lu L, Ma X, Liu Z, Yang S, Han G. Targeted inhibition of YAP/TAZ alters the biological behaviours of keloid fibroblasts. Experimental Dermatology. 2022;31(3):320-329. doi:10.1111/exd.144668. Verteporfin HAIR REGENERATION HUMAN TRIAL Dr. Barghouthi *OFFICIAL THREAD. Hair Restoration Network - Community For and By Hair Loss Patients. Published July 22, 2022. Accessed November 15, 2023. hairrestorationnetwork.com/topic/64737-verteporfin-hair-regeneration-human-trial-dr-barghouthi-official-thread
Collagen supplements are a scam Haircafe 2023-11-14 | Linked videos:My skin care routine: youtu.be/A6DEhTtDhyQDr. Eric Berg: youtu.be/s3RbupD9LY0Paul Taylor and skull expansion: youtu.be/pTNJmKeAtiISelected Sources:1. Rapport D. THE SPECIFIC DYNAMIC ACTION OF GELATIN HYDROLYSATES. Journal of Biological Chemistry. 1926;71(1):75-86. doi:10.1016/S0021-9258(18)84446-52. Iwai K, Hasegawa T, Taguchi Y, et al. Identification of Food-Derived Collagen Peptides in Human Blood after Oral Ingestion of Gelatin Hydrolysates. J Agric Food Chem. 2005;53(16):6531-6536. doi:10.1021/jf050206p3. Knight J, Jiang J, Assimos D, Holmes R. Hydroxyproline ingestion and urinary oxalate and glycolate excretion. Kidney Int. 2006;70(11):1929-1934. doi:10.1038/sj.ki.50019064. Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. doi:10.1159/0003513765. Shigemura Y, Kubomura D, Sato Y, Sato K. Dose-dependent changes in the levels of free and peptide forms of hydroxyproline in human plasma after collagen hydrolysate ingestion. Food Chem. 2014;159:328-332. doi:10.1016/j.foodchem.2014.02.0916. Clemente Plaza N, Reig García-Galbis M, Martínez-Espinosa RM. Effects of the Usage of l-Cysteine (l-Cys) on Human Health. Molecules. 2018;23(3):575. doi:10.3390/molecules230305757. Bolke L, Schlippe G, Gerß J, Voss W. A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study. Nutrients. 2019;11(10):2494. doi:10.3390/nu111024948. Giglio BM, Schincaglia RM, da Silva AS, et al. Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study. Nutrients. 2019;11(9):2051. doi:10.3390/nu110920519. León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Álvarez G. Hydrolyzed Collagen—Sources and Applications. Molecules. 2019;24(22):4031. doi:10.3390/molecules2422403110. Paul C, Leser S, Oesser S. Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance. Nutrients. 2019;11(5):1079. doi:10.3390/nu1105107911. Hazards (BIOHAZ) EP on B, Koutsoumanis K, Allende A, et al. Potential BSE risk posed by the use of ruminant collagen and gelatine in feed for non-ruminant farmed animals. EFSA Journal. 2020;18(10):e06267. doi:10.2903/j.efsa.2020.626712. Katherine. Consumer Beware: These Popular Collagen Supplements Contain Heavy Metals. Organic Consumers. Published May 14, 2020. Accessed November 5, 2023. organicconsumers.org/consumer-beware-these-popular-collagen-supplements-contain-heavy-metals13. collagen_white_paper.pdf. Published 2020. Accessed November 5, 2023. organicconsumers.org/wp-content/uploads/2020/05/collagen_white_paper.pdf14. de Miranda RB, Weimer P, Rossi RC. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Int J Dermatol. 2021;60(12):1449-1461. doi:10.1111/ijd.1551815. Miyanaga M, Uchiyama T, Motoyama A, Ochiai N, Ueda O, Ogo M. Oral Supplementation of Collagen Peptides Improves Skin Hydration by Increasing the Natural Moisturizing Factor Content in the Stratum Corneum: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Skin Pharmacol Physiol. 2021;34(3):115-127. doi:10.1159/00051398816. Hwa Lee S, Kyong Park H, Ji Lee H, et al. Oral Supplementation with Low-molecular-weight Collagen Peptide Improves Hydration, Facial Lifting, Dermal Density, Skin Desquamation and Nails: A Randomized, Double-blind, Placebo-controlled, and Maintenance of Effect Study. JFNR. 2022;10(8):546-559. doi:10.12691/jfnr-10-8-317. Jerger S, Centner C, Lauber B, et al. Effects of specific collagen peptide supplementation combined with resistance training on Achilles tendon properties. Scand J Med Sci Sports. 2022;32(7):1131-1141. doi:10.1111/sms.1416418. Kim J, Lee SG, Lee J, et al. Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study. J Med Food. 2022;25(12):1146-1154. doi:10.1089/jmf.2022.K.009719. Rustad AM, Nickles MA, McKenney JE, Bilimoria SN, Lio PA. Myths and media in oral collagen supplementation for the skin, nails, and hair: A review. J Cosmet Dermatol. 2022;21(2):438-443. doi:10.1111/jocd.14567
Dr. Andrew Huberman: Gaslighting and concern trolling about hair loss and finasteride Haircafe 2023-11-08 | Linked videos:Dr; Huberman and Dr. Eisenberg video: youtu.be/pkJi9Raxikg?si=xFcNskMQZVCRhjo0 (note, finasteride segment starts at the 2 h 9 min mark.Previous video on Dr Huberman and hair loss: youtu.be/cR8qE8AEoaQDr. Attia videos: youtu.be/WsuoB4sqP_Yyoutu.be/DG2jeY-Feq4Baldness and quality, length of life: youtu.be/gxoj9jeizysyoutu.be/rWM9fYHWoyUManaging finasteride side effects:youtu.be/XH89LagYOIoFinasteride and fertility:youtu.be/dYpvl0XRQGYFinasteride and the law:youtu.be/5iR4mQaXyYQFinasteride and suicide:youtu.be/1p5RD1Yd6jESources:1. Kaufman KD, Olsen EA, Whiting D, et al. Finasteride in the treatment of men with androgenetic alopecia. Journal of the American Academy of Dermatology. 1998;39(4):578-589. doi:10.1016/S0190-9622(98)70007-62. Finasteride Male Pattern Hair Loss Study Group. Long-term (5-year) multinational experience with finasteride 1 mg in the treatment of men with androgenetic alopecia. Eur J Dermatol. 2002;12(1):38-49.3. Shapiro J, Kaufman KD. Use of Finasteride in the Treatment of Men With Androgenetic Alopecia (Male Pattern Hair Loss). Journal of Investigative Dermatology Symposium Proceedings. 2003;8(1):20-23. doi:10.1046/j.1523-1747.2003.12167.x4. Amory JK, Wang C, Swerdloff RS, et al. The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men. J Clin Endocrinol Metab. 2007;92(5):1659-1665. doi:10.1210/jc.2006-22035. Canguven O, Burnett AL. The effect of 5 alpha-reductase inhibitors on erectile function. J Androl. 2008;29(5):514-523. doi:10.2164/jandrol.108.0050256. Hawkes N. Dangers of research into chronic fatigue syndrome. BMJ. 2011;342(jun22 1):d3780-d3780. doi:10.1136/bmj.d37807. Basaria S, Jasuja R, Huang G, et al. Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss. J Clin Endocrinol Metab. 2016;101(12):4669-4680. doi:10.1210/jc.2016-27268. Andy G, John M, Mirna S, et al. Controversies in the treatment of androgenetic alopecia: The history of finasteride. Dermatologic Therapy. 2019;32(2):e12647. doi:10.1111/dth.126479. Pereira AFJR, Coelho TO de A. Post-finasteride syndrome. Anais Brasileiros de Dermatologia. 2020;95(3):271-277. doi:10.1016/j.abd.2020.02.00110. Ciaccio V, Di Giacomo D. Psychological Factors Related to Impotence as a Sexual Dysfunction in Young Men: A Literature Scan for Noteworthy Research Frameworks. Clin Pract. 2022;12(4):501-512. doi:10.3390/clinpract1204005411. Irwig MS, Sanz J, Lin D, Tan N, Dommasch E. Beliefs and counseling practices among dermatologists regarding sexual and other adverse effects of finasteride. International Journal of Impotence Research. Published online August 4, 2023. doi:10.1038/s41443-023-00750-0
Do low DHT levels cause erectile dysfunction? Haircafe 2023-10-30 | Linked videos:Truth about finasteride's side effects: youtu.be/rNwlasPw4WI]Truth about dutasteride's side effects: youtu.be/5Pi0aczc8SIWhat to do about finasteride side effects: youtu.be/XH89LagYOIoSources:1. Klugo RC, Cerny JC. Response of micropenis to topical testosterone and gonadotropin. J Urol. 1978;119(5):667-668. doi:10.1016/s0022-5347(17)57584-92. Bradshaw WG, Baum MJ, Awh CC. Attenuation by a 5 alpha-reductase inhibitor of the activational effect of testosterone propionate on penile erections in castrated male rats. Endocrinology. 1981;109(4):1047-1051. doi:10.1210/endo-109-4-10473. Baum MJ, Canick JA, Erskine MS, Gallagher CA, Shim JH. Normal Differentiation of Masculine Sexual Behavior in Male Ferrets Despite Neonatal Inhibition of Brain Aromatase or 5-Alpha-Reductase Activity. Neuroendocrinology. 1983;36(4):277-284. doi:10.1159/0001234684. Choi SK, Han SW, Kim DH, Lignieres BD. Transdermal Dihydrotestosterone Therapy and its Effects on Patients with Microphallus. Journal of Urology. 1993;150(2 Part 2):657-660. doi:10.1016/S0022-5347(17)35576-35. Cunningham GR, Hirshkowitz M. Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men. J Clin Endocrinol Metab. 1995;80(6):1934-1940. doi:10.1210/jcem.80.6.77756446. Anderson RA, Martin CW, Kung AWC, et al. 7α-Methyl-19-Nortestosterone Maintains Sexual Behavior and Mood in Hypogonadal Men*. The Journal of Clinical Endocrinology & Metabolism. 1999;84(10):3556-3562. doi:10.1210/jcem.84.10.60287. Seo SI, Kim SW, Paick JS. The effects of androgen on penile reflex, erectile response to electrical stimulation and penile NOS activity in the rat. Asian J Androl. 1999;1(4):169-174.8. Charmandari E, Dattani MT, Perry LA, Hindmarsh PC, Brook CGD. Kinetics and Effect of Percutaneous Administration of Dihydrotestosterone in Children. Horm Res Paediatr. 2001;56(5-6):177-181. doi:10.1159/0000481159. Corradi LS, Carvalho HF, Góes RM, Taboga SR. Inhibition of 5-α-reductase activity induces stromal remodeling and smooth muscle de-differentiation in adult gerbil ventral prostate. Differentiation. 2004;72(5):198-208. doi:10.1111/j.1432-0436.2004.07205004.x10. Traish A, Kim N. ORIGINAL RESEARCH—ENDOCRINOLOGY: The Physiological Role of Androgens in Penile Erection: Regulation of Corpus Cavernosum Structure and Function. The Journal of Sexual Medicine. 2005;2(6):759-770. doi:10.1111/j.1743-6109.2005.00094.x11. Canguven O, Burnett AL. The effect of 5 alpha-reductase inhibitors on erectile function. J Androl. 2008;29(5):514-523. doi:10.2164/jandrol.108.00502512. Spitzer M, Bhasin S, Travison TG, Davda MN, Stroh H, Basaria S. Sildenafil increases serum testosterone levels by a direct action on the testes. Andrology. 2013;1(6):913-918. doi:10.1111/j.2047-2927.2013.00131.x13. Sartorius GA, Ly LP, Handelsman DJ. Male sexual function can be maintained without aromatization: randomized placebo-controlled trial of dihydrotestosterone (DHT) in healthy, older men for 24 months. J Sex Med. 2014;11(10):2562-2570. doi:10.1111/jsm.1255014. Round P, Das S, Wu TS, Wähälä K, Van Petegem F, Hammond GL. Molecular interactions between sex hormone–binding globulin and nonsteroidal ligands that enhance androgen activity. J Biol Chem. 2020;295(5):1202-1211. doi:10.1074/jbc.RA119.01105115. Liu Y, Fan L, Wang X, Gong C. Exploring the efficacy of testosterone undecanoate in male children with 5α-reductase deficiency. Pediatric Investigation. 2021;5(4):249-254. doi:10.1002/ped4.12302
New research on laser therapy for hair loss. Does it work? Haircafe 2023-10-23 | Linked videos:LLLT: youtu.be/z2Leie5QjUYiRestore: youtu.be/W-Y5nOFZ0YoNew microneedling study: youtu.be/aNqMq3l0SOMSources:1. Kaiser MA, Almeida SM, Rodriguez M, Issa N, Issa NT, Jimenez JJ. Low-Level Light Therapy and Minoxidil Combination Treatment in Androgenetic Alopecia: A Review of the Literature. Skin Appendage Disord. 2023;9(2):104-110. doi:10.1159/0005277822. Bamps M, Dok R, Nuyts S. Low-Level Laser Therapy Stimulates Proliferation in Head and Neck Squamous Cell Carcinoma Cells. Front Oncol. 2018;8:343. doi:10.3389/fonc.2018.003433. Dodd EM, Winter MA, Hordinsky MK, Sadick NS, Farah RS. Photobiomodulation therapy for androgenetic alopecia: A clinician’s guide to home-use devices cleared by the Federal Drug Administration. Journal of Cosmetic and Laser Therapy. 2018;20(3):159-167. doi:10.1080/14764172.2017.13836134. Yoon J, Ku W, Lee J, Ahn H. Low-level light therapy using a helmet-type device for the treatment of androgenetic alopecia: A 16-week, multicenter, randomized, double-blind, sham device-controlled trial. Medicine. 2020;99:e21181. doi:10.1097/MD.00000000000211815. Frigo L, Luppi JSS, Favero GM, et al. The effect of low-level laser irradiation (In-Ga-Al-AsP - 660 nm) on melanoma in vitro and in vivo. BMC Cancer. 2009;9:404. doi:10.1186/1471-2407-9-4046. Qiu J, Yi Y, Jiang L, et al. Efficacy assessment for low-level laser therapy in the treatment of androgenetic alopecia: a real-world study on 1383 patients. Lasers Med Sci. 2022;37(6):2589-2594. doi:10.1007/s10103-022-03520-47. Sondagar DM, Mehta HH, Agharia RS, Jhavar MK. Efficacy of Low-Level Laser Therapy in Androgenetic Alopecia - A Randomized Controlled Trial. Int J Trichology. 2023;15(1):25-32. doi:10.4103/ijt.ijt_5_22
Why hair transplants last forever Haircafe 2023-10-18 | Linked video:Immunosupression and hair loss:youtu.be/En0S8fmhHnwSources:1. Osborn D. INHERITANCE OF BALDNESS. Journal of Heredity. 1916;7(8):347-355. doi:10.1093/oxfordjournals.jhered.a1107462. Orentreich N. AUTOGRAFTS IN ALOPECIAS AND OTHER SELECTED DERMATOLOGICAL CONDITIONS. Annals of the New York Academy of Sciences. 1959;83(3):463-479. doi:10.1111/j.1749-6632.1960.tb40920.x3. Orentreich N. Hair Transplants: Long-term Results and New Advances. Archives of Otolaryngology. 1970;92(6):576-582. doi:10.1001/archotol.1970.043100600480104. Farber GA, Burks JW, Salinger C. Hair transplants for male pattern baldness: long-term subjective evaluation. South Med J. 1972;65(11):1380-1383. doi:10.1097/00007611-197211000-000195. Nordström RE. Synchronous balding of scalp and hair-bearing grafts of scalp transplanted to the skin of the arm in male pattern baldness. Acta Derm Venereol. 1979;59(3):266-268.6. Van Neste D, De Brouwer B, Dumortier M. Reduced Linear Hair Growth Rates of Vellus and of Terminal Hairs Produced by Human Balding Scalp Grafted onto Nude Mice. Annals of the New York Academy of Sciences. 1991;642(1):480-482. doi:10.1111/j.1749-6632.1991.tb24425.x7. Hwang S, Kim JC, Ryu HS, et al. Does the recipient site influence the hair growth characteristics in hair transplantation? Dermatol Surg. 2002;28(9):795-798; discussion 798-799. doi:10.1046/j.1524-4725.2002.02041.x8. Krajcik RA, Vogelman JH, Malloy VL, Orentreich N. Transplants from balding and hairy androgenetic alopecia scalp regrow hair comparably well on immunodeficient mice. Journal of the American Academy of Dermatology. 2003;48(5):752-759. doi:10.1067/mjd.2003.959. Reddy S, El-Haddawi F, Fancourt M, et al. The Incidence and Risk Factors for Lower Limb Skin Graft Failure. Dermatology Research and Practice. 2014;2014:e582080. doi:10.1155/2014/58208010. Saxena K, Savant SS. Body to Scalp: Evolving Trends in Body Hair Transplantation. Indian Dermatol Online J. 2017;8(3):167-175. doi:10.4103/idoj.IDOJ_283_1611. Garg AK, Garg S. The Use of Body Hair with Scalp Hair for “Combination Grafting” to Enhance Visual Density of Hair Transplantation and Increase Coverage in Advanced Alopecia. Hair Transplant Forum International. 2018;28(6):217-223. doi:10.33589/28.6.021712. Kumaresan M, Subburathinam DM. Longevity of Hair Follicles after Follicular Unit Transplant Surgery. J Cutan Aesthet Surg. 2020;13(4):292-297. doi:10.4103/JCAS.JCAS_44_2013. English R. How Long Does a Hair Transplant Last? Perfect Hair Health. Published March 5, 2022. Accessed October 14, 2023. perfecthairhealth.com/how-long-does-a-hair-transplant-last
Is it safe to have children on finasteride? Haircafe 2023-10-10 | Linked videos:Finasteride and fertility: youtu.be/1s6HAFkbK8MOptimal finasteride dose: youtu.be/15PHO1m6D-cHair loss in women: youtu.be/74zQFT4ZmxUSplitting finasteride tablets: youtu.be/a0dvJBmYbmsSources:1. Imperato-McGinley J, Guerrero L, Gautier T, Peterson RE. Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science. 1974;186(4170):1213-1215. doi:10.1126/science.186.4170.12132. Clark RL, Antonello JM, Grossman SJ, et al. External genitalia abnormalities in male rats exposed in utero to finasteride, a 5α-reductase inhibitor. Teratology. 1990;42(1):91-100. doi:10.1002/tera.14204201113. Prahalada S, Tarantal AF, Harris GS, et al. Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta). Teratology. 1997;55(2):119-131. doi:10.1002/(SICI)1096-9926(199702)55:2:119:AID-TERA13.0.CO;2-Z4. Overstreet JW, Fuh VL, Gould J, et al. Chronic treatment with finasteride daily does not affect spermatogenesis or semen production in young men. J Urol. 1999;162(4):1295-1300.5. Amory JK, Wang C, Swerdloff RS, et al. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men. The Journal of Clinical Endocrinology & Metabolism. 2007;92(5):1659-1665. doi:10.1210/jc.2006-22036. Sallout BI, Al Wadi KA. Aphalangia possibly linked to unintended use of finasteride during early pregnancy. Ann Saudi Med. 2009;29(2):155. doi:10.4103/0256-4947.518057. Tu HYV, Zini A. Finasteride-induced secondary infertility associated with sperm DNA damage. Fertility and Sterility. 2011;95(6):2125.e13-2125.e14. doi:10.1016/j.fertnstert.2010.12.0618. Samplaski MK, Lo K, Grober E, Jarvi K. Finasteride use in the male infertility population: effects on semen and hormone parameters. Fertility and Sterility. 2013;100(6):1542-1546. doi:10.1016/j.fertnstert.2013.07.20009. AlSaad D, Lee BH, Al-Obaidly S. Finasteride use during pregnancy and early neonatal outcome: a case report. Int J Clin Pharm. 2018;40(4):803-805. doi:10.1007/s11096-018-0661-5
The dangers of finasteride, with Dr. Peter Attia Haircafe 2023-10-05 | Dr. Attia's video: Discussion on finasteride and PFS starts at about 1h24m.youtu.be/poTcAm_rknw?si=oWCG2QNrJfutegzKLinked videos:Dr. Attia 1: youtu.be/DG2jeY-Feq4Drs say PFS is fake news: youtu.be/K92-3kbKUbsHow to manage finasteride sides: youtu.be/XH89LagYOIoCan dutasteride cause hair loss: youtu.be/ObKrzxHT0n0Theory that explains everything: youtu.be/uJpeHKKGd74?si=tVD8Rc25pN2qmj9iLawsuits and drug companies: youtu.be/5iR4mQaXyYQOptimal dose of finasteride: youtu.be/15PHO1m6D-cFinasteride and prostate cancer: youtu.be/woHF0bvOAowSources:1. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia | NEJM. Accessed October 5, 2023. nejm.org/doi/full/10.1056/NEJM199210223271701#2. Drake L, Hordinsky M, Fiedler V, et al. The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. J Am Acad Dermatol. 1999;41(4):550-554.3. Statins, Other Common Drugs Lower PSA Levels. Published online August 10, 2010. Accessed October 5, 2023. theoncologypharmacist.com/authors?view=article&secid=11001:top-sec-11001&artid=11098:top-11098#4. PEM D, JEEWON R. Fruit and Vegetable Intake: Benefits and Progress of Nutrition Education Interventions- Narrative Review Article. Iran J Public Health. 2015;44(10):1309-1321. Accessed October 5, 2023. ncbi.nlm.nih.gov/pmc/articles/PMC46445755. Fertig RM, Gamret AC, Darwin E, Gaudi S. Sexual side effects of 5-α-reductase inhibitors finasteride and dutasteride: A comprehensive review. Dermatology Online Journal. 2017;23(11):20.6. Ciaccio V, Di Giacomo D. Psychological Factors Related to Impotence as a Sexual Dysfunction in Young Men: A Literature Scan for Noteworthy Research Frameworks. Clin Pract. 2022;12(4):501-512. doi:10.3390/clinpract12040054
Can dutasteride actually cause hair loss? Haircafe 2023-09-25 | Linked videos:Androgen receptor blockers: youtu.be/SGiPhPs0M-sTruth about dutasteride's side effects: youtu.be/5Pi0aczc8SIFinasteride stops hair loss forever: youtu.be/LsF9MwIM_AMTruth about finasteride's side effects: youtu.be/rNwlasPw4WI]Shedding: youtu.be/VxVYHP0WNfABroccoli theory: youtu.be/uJpeHKKGd74?si=tVD8Rc25pN2qmj9iHyperandrogenicity: youtu.be/iW8_1_5SSesWhy testosterone doesn't cause hair loss: youtu.be/AmUvPSNn0H4Muh Neurosteroids series:youtu.be/sHDdNR3MUeIyoutu.be/kkvxuqqRBOwyoutu.be/2hYqoY7kzi0youtu.be/EkS6_wub7W8youtu.be/EgYczERIkBgSources:1. Imperato-McGinley J. 5 alpha-metabolism in finasteride-treated subjects and male pseudohermaphrodites with inherited 5 alpha-reductase deficiency. A review. Eur Urol. 1991;20 Suppl 1:78-81. doi:10.1159/0004717512. Shapiro J, Kaufman KD. Use of Finasteride in the Treatment of Men With Androgenetic Alopecia (Male Pattern Hair Loss). J Investig Dermatol Symp Proc. 2003;8(1):20-23. doi:10.1046/j.1523-1747.2003.12167.x3. Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB, Hobbs S. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor. The Journal of Clinical Endocrinology & Metabolism. 2004;89(5):2179-2184. doi:10.1210/jc.2003-0303304. Roehrborn CG, Marks LS, Fenter T, et al. Efficacy and safety of dutasteride in the four-year treatment of men with benign prostatic hyperplasia. Urology. 2004;63(4):709-715. doi:10.1016/j.urology.2004.01.0015. Olsen EA, Hordinsky M, Whiting D, et al. The importance of dual 5α-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride. Journal of the American Academy of Dermatology. 2006;55(6):1014-1023. doi:10.1016/j.jaad.2006.05.0076. Rossi A, Cantisani C, SCARNò M, Trucchia A, Fortuna MC, Calvieri S. Finasteride, 1 mg daily administration on male androgenetic alopecia in different age groups: 10-year follow-up: Finasteride 10 year follow-up. Dermatologic Therapy. 2011;24(4):455-461. doi:10.1111/j.1529-8019.2011.01441.x7. Enatsu N, Miyake H, Haraguchi T, Chiba K, Fujisawa M. Effects of dutasteride on serum free-testosterone and clinical significance of testosterone changes. Andrologia. 2016;48(10):1195-1201. doi:10.1111/and.125608. Rhie A, Son HY, Kwak SJ, et al. Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia. PLoS One. 2019;14(9):e0222533. doi:10.1371/journal.pone.02225339. Pindado-Ortega C, Saceda-Corralo D, Moreno-Arrones ÓM, et al. Effectiveness of dutasteride in a large series of patients with frontal fibrosing alopecia in real clinical practice. J Am Acad Dermatol. 2021;84(5):1285-1294. doi:10.1016/j.jaad.2020.09.09310. Choi GS, Sim WY, Kang H, et al. Long-Term Effectiveness and Safety of Dutasteride versus Finasteride in Patients with Male Androgenic Alopecia in South Korea: A Multicentre Chart Review Study. Ann Dermatol. 2022;34(5):349-359. doi:10.5021/ad.22.02711. Grandys M, Majerczak J, Frolow M, Sztefko K, Chlopicki S, Zoladz JA. Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status. Experimental Gerontology. 2023;173:112104. doi:10.1016/j.exger.2023.112104
The cure for Hair Loss has been found…by an Orthodontist? Haircafe 2023-09-20 | Linked videos:Brian Dye's videos:youtu.be/yypvLGQ2n6o?si=rOLHZ3rOEZVXVCNfyoutu.be/2VF2ARMU-_4?si=39LBdbIE6bPufP33My first video on Dr. Dye:youtu.be/XMT9WYgWYD8Rob England:youtu.be/X5tVmX8mIF4youtu.be/P_UngSNEr98youtu.be/IfLvjEjdcnEPaul Taylor:youtu.be/pTNJmKeAtiIWhat I've Learned:youtu.be/X5tVmX8mIF4Shedding:youtu.be/VxVYHP0WNfAGenetics and hair loss:youtu.be/hnihVcIKw4ECetirizine:youtu.be/cUA_mO8hWCE?si=uvTPm6YPujBrSlQNSelected sources:1. Color Duplex Ultrasonography in the Diagnosis of Temporal Arteritis | NEJM. Accessed September 19, 2023. nejm.org/doi/full/10.1056/nejm1997110633719022. Hypoxia, human hair follicle stem cells’ niche and alopecia. Accessed September 19, 2023. http://www.dermocosmetica.net/index.php/abstracts/35-hypoxia-human-hair-follicle-stem-cells-niche-and-alopecia3. Osborn D. INHERITANCE OF BALDNESS. Journal of Heredity. 1916;7(8):347-355. doi:10.1093/oxfordjournals.jhered.a1107464. Osborn D. INHERITANCE OF BALDNESS. Journal of Heredity. 1916;7(8):347-355. doi:10.1093/oxfordjournals.jhered.a1107465. Proffit WR, Fields HW, Moray LJ. Prevalence of malocclusion and orthodontic treatment need in the United States: estimates from the NHANES III survey. Int J Adult Orthodon Orthognath Surg. 1998;13(2):97-106.6. Krupa Shankar D, Chakravarthi M, Shilpakar R. Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects. Int J Trichology. 2009;1(2):131-133. doi:10.4103/0974-7753.585567. Tellez-Segura R. Involvement of Mechanical Stress in Androgenetic Alopecia. Int J Trichology. 2015;7(3):95-99. doi:10.4103/0974-7753.1674688. Alhammadi MS, Halboub E, Fayed MS, Labib A, El-Saaidi C. Global distribution of malocclusion traits: A systematic review. Dental Press J Orthod. 2018;23(6):40.e1-40.e10. doi:10.1590/2177-6709.23.6.40.e1-10.onl9. Dye B. Malocclusion and Hair Loss: An Intimate Relationship. J Clin Exp Dermatol Res. 2019;10(5). doi:10.35248/2155-9554.10.505
What to do if you get side effects from finasteride Haircafe 2023-09-14 | Linked videos:Nocebo effect: youtu.be/wa5n5y0NJPMPFS series:youtu.be/CS9D5RVO3J0youtu.be/tx8c3BvfuWwyoutu.be/dXwO0E2A7LIyoutu.be/YM4DJbK9HQYyoutu.be/kHhxHtKGmBoyoutu.be/PVLJMwUFDvIyoutu.be/ykk3UVyeCiAyoutu.be/iDeDcBg4eskGyno: youtu.be/n2NGf3vzWFITruth about finasteride side effects:youtu.be/rNwlasPw4WI]Optimal dose of finasteride:youtu.be/15PHO1m6D-cTruth about dutasteride's side effects:youtu.be/5Pi0aczc8SITopical dutasteride, mes-therapy:youtu.be/kJdTn7laIQQTopical anti androgens:youtu.be/SGiPhPs0M-sReishi mushrooms:youtu.be/i1APPNP0c9gWhy finasteride stops hair loss forever:youtu.be/LsF9MwIM_AMSelected Sources:1. Vermeulen A, Giagulli VA, De Schepper P, Buntinx A. Hormonal effects of a 5 alpha-reductase inhibitor (finasteride) on hormonal levels in normal men and in patients with benign prostatic hyperplasia. Eur Urol. 1991;20 Suppl 1:82-86. doi:10.1159/0004717522. Wilton L, Pearce G, Edet E, Freemantle S, Stephens MD, Mann RD. The safety of finasteride used in benign prostatic hypertrophy: a non-interventional observational cohort study in 14,772 patients. Br J Urol. 1996;78(3):379-384. doi:10.1046/j.1464-410x.1996.00091.x3. Mazzarella G, Loconsole G, Cammisa G, Mastrolonardo G, Vena G. Topical finasteride in the treatment of androgenic alopecia. Preliminary evaluations after a 16-month therapy course. Journal of Dermatological Treatment. 1997;8(3):189-192. doi:10.3109/095466397091605174. Leyden J, Dunlap F, Miller B, et al. Finasteride in the treatment of men with frontal male pattern hair loss. J Am Acad Dermatol. 1999;40(6 Pt 1):930-937. doi:10.1016/s0190-9622(99)70081-25. Balunas MJ, Su B, Brueggemeier RW, Kinghorn AD. Natural Products as Aromatase Inhibitors. Anticancer Agents Med Chem. 2008;8(6):646-682. Accessed September 11, 2023. ncbi.nlm.nih.gov/pmc/articles/PMC30744866. Handa Y, Fujita H, Honma S, Minakami H, Kishi R. Estrogen concentrations in beef and human hormone-dependent cancers. Annals of Oncology. 2009;20(9):1610-1611. doi:10.1093/annonc/mdp3817. Brinkman MT, Baglietto L, Krishnan K, et al. Consumption of animal products, their nutrient components and postmenopausal circulating steroid hormone concentrations. Eur J Clin Nutr. 2010;64(2):176-183. doi:10.1038/ejcn.2009.1298. Chumsri S, Howes T, Bao T, Sabnis G, Brodie A. Aromatase, Aromatase Inhibitors, and Breast Cancer. J Steroid Biochem Mol Biol. 2011;125(1-2):13-22. doi:10.1016/j.jsbmb.2011.02.0019. Khan SI, Zhao J, Khan IA, Walker LA, Dasmahapatra AK. Potential utility of natural products as regulators of breast cancer-associated aromatase promoters. Reproductive Biology and Endocrinology. 2011;9(1):91. doi:10.1186/1477-7827-9-9110. Subbaramaiah K, Howe LR, Bhardwaj P, et al. Obesity Is Associated with Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland. Cancer Prevention Research. 2011;4(3):329-346. doi:10.1158/1940-6207.CAPR-10-038111. Bulun SE, Chen D, Moy I, Brooks DC, Zhao H. Aromatase, breast cancer and obesity: a complex interaction. Trends Endocrinol Metab. 2012;23(2):83-89. doi:10.1016/j.tem.2011.10.00312. Lephart ED. Modulation of Aromatase by Phytoestrogens. Enzyme Res. 2015;2015:594656. doi:10.1155/2015/59465613. Mitra S, Dash R. Natural Products for the Management and Prevention of Breast Cancer. Evid Based Complement Alternat Med. 2018;2018:8324696. doi:10.1155/2018/832469614. Traish AM, Krakowsky Y, Doros G, Morgentaler A. Do 5α-Reductase Inhibitors Raise Circulating Serum Testosterone Levels? A Comprehensive Review and Meta-Analysis to Explaining Paradoxical Results. Sexual Medicine Reviews. 2019;7(1):95-114. doi:10.1016/j.sxmr.2018.06.00215. El-Kersh DM, Ezzat SM, Salama MM, et al. Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer. Sci Rep. 2021;11(1):7121. doi:10.1038/s41598-021-86599-z16. Gupta AK, Talukder M. Topical finasteride for male and female pattern hair loss: Is it a safe and effective alternative? Journal of Cosmetic Dermatology. 2022;21(5):1841-1848. doi:10.1111/jocd.1489517. Pedrenho Neto R, dos Santos Sobreira Nunes R, C G Nascimento B, et al. Correlation between libido and testosterone: Estradiol ratio in men with sexual dysfunction. The Journal of Sexual Medicine. 2022;19(5, Supplement 2):S232. doi:10.1016/j.jsxm.2022.03.528
Why DHT can kill you (DHT is a trash hormone part IX) Haircafe 2023-09-08 | DHT trash hormone series:youtu.be/PS-kynh8pLEyoutu.be/G6XrzHQk_DIyoutu.be/Tzu_yWBR_rUyoutu.be/wRXZY-wY8b0youtu.be/eSVhcp0jmKEyoutu.be/H_07OCa_1h4youtu.be/nMWvPe5PQCgyoutu.be/UxcqZO3F6kAyoutu.be/MdmXIeH39FUyoutu.be/wRXZY-wY8b0Sources:1. Kolditz M, Halank M, Schulte-Hubbert B, Höffken G. Adrenal function is related to prognosis in moderate community-acquired pneumonia. European Respiratory Journal. 2010;36(3):615-621. doi:10.1183/09031936.001917092. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1459-1544. doi:10.1016/S0140-6736(16)31012-13. Nickler M, Ottiger M, Steuer C, et al. Time-dependent association of glucocorticoids with adverse outcome in community-acquired pneumonia: a 6-year prospective cohort study. Crit Care. 2017;21(1):72. doi:10.1186/s13054-017-1656-74. for the proHOSP study group, Zurfluh S, Nickler M, et al. Dihydrotestosterone is a predictor for mortality in males with community-acquired pneumonia: results of a 6-year follow-up study. Respir Res. 2018;19(1):240. doi:10.1186/s12931-018-0947-0
DHT | Compelling Research that DHT is a Trash Hormone Haircafe 2023-09-06 | Linked videos:Finasteride and beard growthyoutu.be/MxxEKG1DEb8Skull expansion theory:youtu.be/pTNJmKeAtiIRob England series:youtu.be/IfLvjEjdcnEyoutu.be/P_UngSNEr98youtu.be/X5tVmX8mIF4Senescent alopeciayoutu.be/6WD1mfNkErQDHT and skin:youtu.be/7xVs64JFlQwFinasteride stops hair loss forever:youtu.be/LsF9MwIM_AMHMI-115youtu.be/XHb8N6NfncAMasturbation video/Aprils Fool video:youtu.be/FCq8nYYXIy0youtu.be/phVavBPhzB8Neurosteroid series:youtu.be/sHDdNR3MUeIyoutu.be/kkvxuqqRBOwyoutu.be/2hYqoY7kzi0youtu.be/EkS6_wub7W8youtu.be/EgYczERIkBgFinasteride doesn’t cause suicide:youtu.be/1p5RD1Yd6jE?si=uH-1E_9rpHJBx6zuPFS series:youtu.be/CS9D5RVO3J0youtu.be/tx8c3BvfuWwyoutu.be/dXwO0E2A7LIyoutu.be/YM4DJbK9HQYyoutu.be/kHhxHtKGmBoyoutu.be/PVLJMwUFDvIyoutu.be/ykk3UVyeCiAyoutu.be/iDeDcBg4eskWhy going bald will ruin your lifeyoutu.be/gxoj9jeizysSources:1. Osborn D. INHERITANCE OF BALDNESS. Journal of Heredity. 1916;7(8):347-355. doi:10.1093/oxfordjournals.jhered.a1107462. Christiansen K, Knussmann R. Androgen levels and components of aggressive behavior in men. Horm Behav. 1987;21(2):170-180. doi:10.1016/0018-506x(87)90042-03. Cai LQ, Fratianni CM, Gautier T, Imperato-McGinley J. Dihydrotestosterone regulation of semen in male pseudohermaphrodites with 5 alpha-reductase-2 deficiency. J Clin Endocrinol Metab. 1994;79(2):409-414. doi:10.1210/jcem.79.2.80459564. Mantzoros CS, Georgiadis EI, Trichopoulos D. Contribution of dihydrotestosterone to male sexual behaviour. BMJ. 1995;310(6990):1289-1291. doi:10.1136/bmj.310.6990.12895. Shoemaker JK, Tiidus PM, Mader R. Failure of manual massage to alter limb blood flow: measures by Doppler ultrasound. Med Sci Sports Exerc. 1997;29(5):610-614. doi:10.1097/00005768-199705000-000046. Frye CA, Park D, Tanaka M, Rosellini R, Svare B. The testosterone metabolite and neurosteroid 3alpha-androstanediol may mediate the effects of testosterone on conditioned place preference. Psychoneuroendocrinology. 2001;26(7):731-750. doi:10.1016/s0306-4530(01)00027-07. Ly LP, Jimenez M, Zhuang TN, Celermajer DS, Conway AJ, Handelsman DJ. A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency. J Clin Endocrinol Metab. 2001;86(9):4078-4088. doi:10.1210/jcem.86.9.78218. Kunelius P, Lukkarinen O, Hannuksela ML, Itkonen O, Tapanainen JS. The Effects of Transdermal Dihydrotestosterone in the Aging Male: A Prospective, Randomized, Double Blind Study. Published online 2002.9. Cherrier MM, Craft S, Matsumoto AH. Cognitive Changes Associated With Supplementation of Testosterone or Dihydrotestosterone in Mildly Hypogonadal Men: A Preliminary Report. Journal of Andrology. 2003;24(4):568-576. doi:10.1002/j.1939-4640.2003.tb02708.x10. Vermeulen A. Androgen supplementation in elderly males: is dihydrotestosterone to be preferred? The Aging Male. 2004;7(4):325-327. doi:10.1080/1368553040001667211. Idan A, Griffiths KA, Harwood DT, et al. Long-Term Effects of Dihydrotestosterone Treatment on Prostate Growth in Healthy, Middle-Aged Men Without Prostate Disease: A Randomized, Placebo-Controlled Trial. Ann Intern Med. 2010;153(10):621. doi:10.7326/0003-4819-153-10-201011160-0000412. Ustuner ET. Cause of Androgenic Alopecia: Crux of the Matter. Plastic and Reconstructive Surgery – Global Open. 2013;1(7):e64. doi:10.1097/GOX.000000000000000513. Di Loreto C, La Marra F, Mazzon G, Belgrano E, Trombetta C, Cauci S. Immunohistochemical evaluation of androgen receptor and nerve structure density in human prepuce from patients with persistent sexual side effects after finasteride use for androgenetic alopecia. PLoS One. 2014;9(6):e100237. doi:10.1371/journal.pone.010023714. Hirshburg JM, Kelsey PA, Therrien CA, Gavino AC, Reichenberg JS. Adverse Effects and Safety of 5-alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review. J Clin Aesthet Dermatol. 2016;9(7):56-62.15. Chen X, Liu B, Li Y, et al. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture. Front Pharmacol. 2020;10:1528. doi:10.3389/fphar.2019.0152816. Garcia-Argibay M, Hiyoshi A, Fall K, Montgomery S. Association of 5α-Reductase Inhibitors With Dementia, Depression, and Suicide. JAMA Network Open. 2022;5(12):e2248135. doi:10.1001/jamanetworkopen.2022.48135
The Ultimate Guide to Mens Hormones - TIER LIST (DHT is a trash hormone part VIII) Haircafe 2023-08-30 | Linked videos:Team 3D Alpha tiered hormone video:youtu.be/XCrHI-DpeRU?si=am9m8mvUZKLCkGmVDHT trash hormone series:youtu.be/Tzu_yWBR_rUyoutu.be/wRXZY-wY8b0youtu.be/eSVhcp0jmKEyoutu.be/H_07OCa_1h4youtu.be/nMWvPe5PQCgyoutu.be/UxcqZO3F6kAyoutu.be/MdmXIeH39FUyoutu.be/wRXZY-wY8b0Neurosteroid series:youtu.be/sHDdNR3MUeIyoutu.be/kkvxuqqRBOwyoutu.be/2hYqoY7kzi0youtu.be/EkS6_wub7W8youtu.be/EgYczERIkBgOptimal dose of finasteride:youtu.be/15PHO1m6D-cWhy going bald will ruin your life:youtu.be/gxoj9jeizysFinasteride in the young:youtu.be/6zdK_YdE1nMFinasteride and beard growthyoutu.be/MxxEKG1DEb85AR blockers and depression, anxiety:youtu.be/1p5RD1Yd6jEyoutu.be/EgYczERIkBgDHT and musclesyoutube.com/watch?v=wRXZY-wY8b0&t=311syoutube.com/watch?v=bXDPx7Vp8GI&t=37sFinasteride and gynoyoutube.com/watch?v=n2NGf3vzWFI&t=246sWill finasteride shrink your penis:youtube.com/watch?v=M7ToUtnB5e4&t=7835ARIs and insulin resistance, diabetesyoutube.com/watch?v=2KxqUzctcVQ5ARIs and Blood Pressure & Heart Diseaseyoutube.com/watch?v=UxcqZO3F6kA&t=2sTruth about dutasteride's side-effectsyoutu.be/5Pi0aczc8SIAll the 5AR isoenzymes:youtu.be/Tzu_yWBR_rU5ARIs and prostate cancer:youtu.be/woHF0bvOAowWhy going bald can kill you:youtu.be/rWM9fYHWoyU?si=vklpE6K5chVlcdbVBludflow and hair lossyoutu.be/X5tVmX8mIF4youtu.be/icSupaq9hBAyoutu.be/yr-Atg3YFVgSources:1. Imperato-McGinley J, Guerrero L, Gautier T, Peterson RE. Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science. 1974;186(4170):1213-1215. doi:10.1126/science.186.4170.12132. Barud W, Palusiński R, Makaruk B, Hanzlik J. Dihydrotestosterone treatment in men with coronary artery disease. I. Influence on sex hormones, lipid profile, insulin resistance and fibrinogen. Ann Univ Mariae Curie Sklodowska Med. 2003;58(2):241-246.3. Bortolato M, Frau R, Orrù M, et al. Antipsychotic-Like Properties of 5-α-Reductase Inhibitors. Neuropsychopharmacol. 2008;33(13):3146-3156. doi:10.1038/npp.2008.394. Andriole GL, Bostwick DG, Brawley OW, et al. Effect of Dutasteride on the Risk of Prostate Cancer. New England Journal of Medicine. 2010;362(13):1192-1202. doi:10.1056/NEJMoa09081275. Mysore V. Finasteride and sexual side effects. Indian Dermatol Online J. 2012;3(1):62-65. doi:10.4103/2229-5178.934966. Beggs LA, Yarrow JF, Conover CF, et al. Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone. Am J Physiol Endocrinol Metab. 2014;307(5):E456-461. doi:10.1152/ajpendo.00184.20147. Upreti R, Hughes KA, Livingstone DEW, et al. 5α-reductase type 1 modulates insulin sensitivity in men. J Clin Endocrinol Metab. 2014;99(8):E1397-1406. doi:10.1210/jc.2014-13958. Joyce KE, Biggs ML, Djoussé L, et al. Testosterone, Dihydrotestosterone, Sex Hormone–Binding Globulin, and Incident Diabetes Among Older Men: The Cardiovascular Health Study. J Clin Endocrinol Metab. 2016;102(1):33-39. doi:10.1210/jc.2016-26239. Swerdloff RS, Dudley RE, Page ST, Wang C, Salameh WA. Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels. Endocrine Reviews. 2017;38(3):220-254. doi:10.1210/er.2016-106710. Da Silva MHA, Costa WS, Sampaio FJB, De Souza DB. The corpus cavernosum after treatment with dutasteride or finasteride: A histomorphometric study in a benign prostatic hyperplasia rodent model. Asian J Androl. 2018;20(5):505-510. doi:10.4103/aja.aja_28_1811. Goodman PJ, Tangen CM, Darke AK, et al. Long-Term Effects of Finasteride on Prostate Cancer Mortality. New England Journal of Medicine. 2019;380(4):393-394. doi:10.1056/NEJMc180996112. Wei L, Lai ECC, Kao-Yang YH, Walker BR, MacDonald TM, Andrew R. Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study. BMJ. 2019;365:l1204. doi:10.1136/bmj.l120413. Chen X, Liu B, Li Y, et al. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture. Frontiers in Pharmacology. 2020;10. Accessed August 29, 2023. frontiersin.org/articles/10.3389/fphar.2019.0152814. Round P, Das S, Wu TS, Wähälä K, Van Petegem F, Hammond GL. Molecular interactions between sex hormone–binding globulin and nonsteroidal ligands that enhance androgen activity. J Biol Chem. 2020;295(5):1202-1211. doi:10.1074/jbc.RA119.011051
DHT ages your skin and makes you ugly. DHT is a trash hormone episode VII. Haircafe 2023-08-22 | Linked videos:Senile alopecia: youtu.be/6WD1mfNkErQDr. Berg: youtu.be/s3RbupD9LY0DHT trash hormone series:youtu.be/Tzu_yWBR_rUyoutu.be/wRXZY-wY8b0youtu.be/eSVhcp0jmKEyoutu.be/H_07OCa_1h4youtu.be/nMWvPe5PQCgyoutu.be/UxcqZO3F6kAyoutu.be/MdmXIeH39FUyoutu.be/wRXZY-wY8b0Reflex hyperandrogenicity:youtu.be/AmUvPSNn0H4youtu.be/iW8_1_5SSesSources:1. Feldman HA, Longcope C, Derby CA, et al. Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study.2. Black MM, Shuster S, Bottoms E. Osteoporosis, skin collagen, and androgen. Br Med J. 1970;4(5738):773-774. doi:10.1136/bmj.4.5738.7733. Fischer GM, Swain ML. Effect of sex hormones on blood pressure and vascular connective tissue in castrated and noncastrated male rats. Am J Physiol. 1977;232(6):H617-621. doi:10.1152/ajpheart.1977.232.6.H6174. Hatakeyama H, Nishizawa M, Nakagawa A, Nakano S, Kigoshi T, Uchida K. Testosterone inhibits tumor necrosis factor-α-induced vascular cell adhesion molecule-1 expression in human aortic endothelial cells. FEBS Letters. 2002;530(1-3):129-132. doi:10.1016/S0014-5793(02)03440-35. Draelos ZD, Jacobson EL, Kim H, Kim M, Jacobson MK. A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia. J Cosmet Dermatol. 2005;4(4):258-261. doi:10.1111/j.1473-2165.2005.00201.x6. Natoli AK, Medley TL, Ahimastos AA, et al. Sex Steroids Modulate Human Aortic Smooth Muscle Cell Matrix Protein Deposition and Matrix Metalloproteinase Expression. Hypertension. 2005;46(5):1129-1134. doi:10.1161/01.HYP.0000187016.06549.967. Gilliver SC, Ashworth JJ, Mills SJ, Hardman MJ, Ashcroft GS. Androgens modulate the inflammatory response during acute wound healing. J Cell Sci. 2006;119(Pt 4):722-732. doi:10.1242/jcs.027868. Gilliver SC, Ruckshanthi JPD, Atkinson SJ, Ashcroft GS. Androgens influence expression of matrix proteins and proteolytic factors during cutaneous wound healing. Lab Invest. 2007;87(9):871-881. doi:10.1038/labinvest.37006279. Gilliver S, Ruckshanthi J, Hardman M, Zeef L, Ashcroft G. 5α-Dihydrotestosterone (DHT) retards wound closure by inhibiting re-epithelialization. The Journal of Pathology. 2009;217(1):73-82. doi:10.1002/path.244410. Stárka L, Pospíšilová H, Hill M. Free testosterone and free dihydrotestosterone throughout the life span of men. The Journal of Steroid Biochemistry and Molecular Biology. 2009;116(1-2):118-120. doi:10.1016/j.jsbmb.2009.05.00811. Bernard P, Scior T, Do QT. Modulating testosterone pathway: a new strategy to tackle male skin aging? Clin Interv Aging. 2012;7:351-361. doi:10.2147/CIA.S3403412. Amaro-Ortiz A, Yan B, D’Orazio JA. Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation. Molecules. 2014;19(5):6202-6219. doi:10.3390/molecules1905620213. Lai JJ, Chang P, Lai KP, Chen L, Chang C. The Role of Androgen and Androgen Receptor in the Skin-Related Disorders. Arch Dermatol Res. 2012;304(7):499-510. doi:10.1007/s00403-012-1265-x14. Sartorius G, Spasevska S, Idan A, et al. Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study. Clinical Endocrinology. 2012;77(5):755-763. doi:10.1111/j.1365-2265.2012.04432.x15. Round P, Das S, Wu TS, Wähälä K, Van Petegem F, Hammond GL. Molecular interactions between sex hormone–binding globulin and nonsteroidal ligands that enhance androgen activity. J Biol Chem. 2020;295(5):1202-1211. doi:10.1074/jbc.RA119.01105116. Shi H, Lo TH, Ma D, et al. Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice. IJMS. 2020;21(17):6231. doi:10.3390/ijms21176231
Grapefruit and hair loss. The theory that explains everything. Haircafe 2023-08-15 | Linked videos:Oral minoxidil:youtu.be/O-vXgXaYMNQyoutu.be/WP7rYUqET80youtu.be/Mi_k9BQnnz4youtu.be/CAoEP3pO7Poyoutu.be/2zxNnUB5PPQyoutu.be/t-QgZ5dmkYkTretinoin and minoxidil:youtu.be/hj4WU3hmc9wPerfect dose of dutasteride:youtu.be/wdSlHnSRi7gSources:1. Guo LQ, Fukuda K, Ohta T, Yamazoe Y. ROLE OF FURANOCOUMARIN DERIVATIVES ON GRAPEFRUIT JUICE-MEDIATED INHIBITION OF HUMAN CYP3A ACTIVITY.2. Hung WL, Suh JH, Wang Y. Chemistry and health effects of furanocoumarins in grapefruit. J Food Drug Anal. 25(1):71-83. doi:10.1016/j.jfda.2016.11.0083. Winchell GA, Gregoire S, Taylor AM, Hegland J, Hunninghake DB. Finasteride, A Steroid 5α-Reductase Inhibitor, Does Not Affect the Oxidative Metabolism of Antipyrine. The Journal of Clinical Pharmacology. 1993;33(10):967-970. doi:10.1002/j.1552-4604.1993.tb01931.x4. Steiner JF. Clinical Pharmacokinetics and Pharmacodynamics of Finasteride: Clinical Pharmacokinetics. 1996;30(1):16-27. doi:10.2165/00003088-199630010-000025. He K, Iyer KR, Hayes RN, Sinz MW, Woolf TF, Hollenberg PF. Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice. Chem Res Toxicol. 1998;11(4):252-259. doi:10.1021/tx970192k6. Lin H lien, Kent UM, Hollenberg PF. The Grapefruit Juice Effect Is Not Limited to Cytochrome P450 (P450) 3A4: Evidence for Bergamottin-Dependent Inactivation, Heme Destruction, and Covalent Binding to Protein in P450s 2B6 and 3A5. J Pharmacol Exp Ther. 2005;313(1):154-164. doi:10.1124/jpet.104.0796087. Bailey DG, Dresser G, Arnold JMO. Grapefruit–medication interactions: Forbidden fruit or avoidable consequences? CMAJ. 2013;185(4):309-316. doi:10.1503/cmaj.1209518. Ortiz de Montellano PR. Cytochrome P450-activated prodrugs. Future Med Chem. 2013;5(2):213-228. doi:10.4155/fmc.12.1979. Paśko P, Rodacki T, Domagała-Rodacka R, Owczarek D. Interactions between medications employed in treating benign prostatic hyperplasia and food - A short review. Biomed Pharmacother. 2016;83:1141-1145. doi:10.1016/j.biopha.2016.08.02110. Fatunde OA, Brown SA. The Role of CYP450 Drug Metabolism in Precision Cardio-Oncology. Int J Mol Sci. 2020;21(2):604. doi:10.3390/ijms21020604
Haircafe DEBUNKED! Part Deux, Electric Boogaloo Haircafe 2023-08-09 | Previous video:youtu.be/FmY5pYtmA6gArticles:1. Wessells H, Roy J, Bannow J, et al. Incidence and severity of sexual adverse experiences in finasteride and placebo-treated men with benign prostatic hyperplasia. Urology. 2003;61(3):579-584. doi:10.1016/S0090-4295(02)02401-92. Fertig R, Shapiro J, Bergfeld W, Tosti A. Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome. SAD. 2016;2(3-4):120-129. doi:10.1159/000450617
Most doctors agree that Post Finasteride Syndrome is fake news Haircafe 2023-08-08 | Videos on PFS:youtu.be/CS9D5RVO3J0youtu.be/tx8c3BvfuWwyoutu.be/dXwO0E2A7LIyoutu.be/YM4DJbK9HQYyoutu.be/kHhxHtKGmBoyoutu.be/PVLJMwUFDvIyoutu.be/ykk3UVyeCiAyoutu.be/iDeDcBg4eskSources:1. Irwig MS. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine. 2012;9(11):2927-2932. doi:10.1111/j.1743-6109.2012.02846.x2. Irwig MS. Safety concerns regarding 5α reductase inhibitors for the treatment of androgenetic alopecia. Current Opinion in Endocrinology, Diabetes & Obesity. 2015;22(3):248-253. doi:10.1097/MED.00000000000001583. Trüeb RM, Régnier A, Dutra Rezende H, Gavazzoni Dias MFR. Post-Finasteride Syndrome: An Induced Delusional Disorder with the Potential of a Mass Psychogenic Illness? SAD. 2019;5(5):320-326. doi:10.1159/0004973624. Irwig MS, Sanz J, Lin D, Tan N, Dommasch E. Beliefs and counseling practices among dermatologists regarding sexual and other adverse effects of finasteride. International Journal of Impotence Research. Published online August 4, 2023. doi:10.1038/s41443-023-00750-0
Haircafe DEBUNKED! Haircafe 2023-08-06 | Linked videos:PFS videos:youtu.be/CS9D5RVO3J0youtu.be/tx8c3BvfuWwyoutu.be/dXwO0E2A7LIyoutu.be/YM4DJbK9HQYyoutu.be/kHhxHtKGmBoyoutu.be/PVLJMwUFDvIyoutu.be/ykk3UVyeCiAyoutu.be/iDeDcBg4eskSources:1. Wessells H, Roy J, Bannow J, et al. Incidence and severity of sexual adverse experiences in finasteride and placebo-treated men with benign prostatic hyperplasia. Urology. 2003;61(3):579-584. doi:10.1016/S0090-4295(02)02401-92. Fertig R, Shapiro J, Bergfeld W, Tosti A. Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome. SAD. 2016;2(3-4):120-129. doi:10.1159/0004506173. Andy G, John M, Mirna S, et al. Controversies in the treatment of androgenetic alopecia: The history of finasteride. Dermatologic Therapy. 2019;32(2):e12647. doi:10.1111/dth.126474. Levine D. FDA requires disclosure of suicide risk for anti-baldness drug. Reuters. reuters.com/business/healthcare-pharmaceuticals/fda-requires-disclosure-suicide-risk-anti-baldness-drug-2022-06-10/. Published June 10, 2022. Accessed August 5, 2023.
New research shows grey hair will soon be cured Haircafe 2023-08-03 | Linked videos:WNT treatments:youtu.be/P9pYHfYaqMEyoutu.be/RUEQ0TtjlDASources:1. Sun Q, Lee W, Hu H, et al. Dedifferentiation maintains melanocyte stem cells in a dynamic niche. Nature. 2023;616(7958):774-782. doi:10.1038/s41586-023-05960-62. A New Study Says Gray Hair May Be Reversible. Popular Mechanics. Published May 2, 2023. Accessed July 31, 2023. popularmechanics.com/science/health/a43669473/gray-hair-may-be-reversible-new-study3. Study Links ‘Stuck’ Stem Cells to Hair Turning Gray. NYU Langone News. Accessed July 31, 2023. nyulangone.org/news/study-links-stuck-stem-cells-hair-turning-gray
Trying out the new Rogue Fitness Duffalo Bar. Haircafe 2023-07-30 | Squatting with the Rogue Fitness duffalo bar, aka the bow bar. Slightly awkward feeling but it is a bit easier on the shoulders and lower back compared to a traditional barbell. Also weighs 60 lbs so don't need to rack as many plates to get the weight you want.
The truth about dutasteride’s side effects Haircafe 2023-07-28 | Linked videos:Truth about finasteride's side effects: youtu.be/rNwlasPw4WIOptimal dose of finasteride: youtu.be/15PHO1m6D-cPerfect dose of dutasteride: youtu.be/wdSlHnSRi7gMic the Vegan: youtu.be/tPoUJ17_jxULong term finasteride results: youtu.be/8D-UJ4EsZZgWhy do hair loss treatments cause shedding? youtu.be/VxVYHP0WNfASources:1. Drake L, Unger WP. The effects of f’masteride on scalp skin and serum androgen levels in men with androgenetic alopecia. Published online 1999:5.2. Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB, Hobbs S. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor. The Journal of Clinical Endocrinology & Metabolism. 2004;89(5):2179-2184. doi:10.1210/jc.2003-0303303. Olsen EA, Hordinsky M, Whiting D, et al. The importance of dual 5α-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride. Journal of the American Academy of Dermatology. 2006;55(6):1014-1023. doi:10.1016/j.jaad.2006.05.0074. Nickel JC, Gilling P, Tammela TL, Morrill B, Wilson TH, Rittmaster RS. Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia: the Enlarged Prostate International Comparator Study (EPICS). BJU International. 2011;108(3):388-394. doi:10.1111/j.1464-410X.2011.10195.x5. Kaplan SA, Chung DE, Lee RK, Scofield S, Te AE. A 5-year retrospective analysis of 5α-reductase inhibitors in men with benign prostatic hyperplasia: finasteride has comparable urinary symptom efficacy and prostate volume reduction, but less sexual side effects and breast complications than dutasteride. Int J Clin Pract. 2012;66(11):1052-1055. doi:10.1111/j.1742-1241.2012.03010.x6. Gubelin Harcha W, Barboza Martínez J, Tsai TF, et al. A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. Journal of the American Academy of Dermatology. 2014;70(3):489-498.e3. doi:10.1016/j.jaad.2013.10.0497. Shanshanwal SJS, Dhurat RS. Superiority of dutasteride over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: A randomized controlled open-label, evaluator-blinded study. Indian J Dermatol Venereol Leprol. 2017;83(1):47-54. doi:10.4103/0378-6323.1886528. Lee S, Lee YB, Choe SJ, Lee WS. Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis. Acta Derm Venereol. 2019;99(1):12-17. doi:10.2340/00015555-30359. Zhou Z, Song S, Gao Z, Wu J, Ma J, Cui Y. The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis. Clin Interv Aging. 2019;14:399-406. doi:10.2147/CIA.S19243510. Zhou Z, Cui Y, Wu J, Jin H. Efficacy and safety of dutasteride compared with finasteride in treating males with benign prostatic hyperplasia: A meta‑analysis of randomized controlled trials. Experimental and Therapeutic Medicine. 2020;20(2):1566-1574. doi:10.3892/etm.2020.885111. Choi GS, Sim WY, Kang H, et al. Long-Term Effectiveness and Safety of Dutasteride versus Finasteride in Patients with Male Androgenic Alopecia in South Korea: A Multicentre Chart Review Study. Annals of Dermatology. 2022;34(5):349-359. doi:10.5021/ad.22.02712. Laanani M, Weill A, Jollant F, Zureik M, Dray-Spira R. Suicidal risk associated with finasteride versus dutasteride among men treated for benign prostatic hyperplasia: nationwide cohort study | Scientific Reports. Scientific Reports. 2023;13(1):5308. doi:10.1038/s41598-023-32356-3
Is CosmeRNA a real hair loss treatment, or have we been scammed? Haircafe 2023-07-21 | Linked videos:youtu.be/3m3YzD8HmPMyoutu.be/isj37Z3BrjcCosmeRNA site:cosmerna.comSources:1. Yun SI, Lee SK, Goh EA, et al. Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia. Sci Rep. 2022;12(1):1607. doi:10.1038/s41598-022-05544-w2. Svoboda P. Key Mechanistic Principles and Considerations Concerning RNA Interference. Frontiers in Plant Science. 2020;11. Accessed February 15, 2022. frontiersin.org/article/10.3389/fpls.2020.01237
Does finasteride cause male breast cancer? Haircafe 2023-07-18 | Linked videos:Optimal dose of finasteride: youtu.be/15PHO1m6D-cVioxx, finasteride and Merck lawsuits: youtu.be/5iR4mQaXyYQFinasteride in women: youtu.be/74zQFT4ZmxUSources:1. Vermeulen A, Giagulli VA, De Schepper P, Buntinx A. Hormonal effects of a 5 alpha-reductase inhibitor (finasteride) on hormonal levels in normal men and in patients with benign prostatic hyperplasia. Eur Urol. 1991;20 Suppl 1:82-86. doi:10.1159/0004717522. Castro-Magana M, Angulo M, Fuentes B, et al. Effect of finasteride on human testicular steroidogenesis. J Androl. 1996;17(5):516-521.3. McConnell JD, Bruskewitz R, Walsh P, et al. The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. Finasteride Long-Term Efficacy and Safety Study Group. N Engl J Med. 1998;338(9):557-563. doi:10.1056/NEJM1998022633809014. Uygur MC, Arik AI, Altuğ U, Erol D. Effects of the 5 alpha-reductase inhibitor finasteride on serum levels of gonadal, adrenal, and hypophyseal hormones and its clinical significance: a prospective clinical study. Steroids. 1998;63(4):208-213. doi:10.1016/s0039-128x(98)00005-15. McConnell JD, Roehrborn CG, Bautista OM, et al. The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia. N Engl J Med. 2003;349(25):2387-2398. doi:10.1056/NEJMoa0306566. Roehrborn CG, Lee M, Meehan A, Waldstreicher J, PLESS Study Group. Effects of finasteride on serum testosterone and body mass index in men with benign prostatic hyperplasia. Urology. 2003;62(5):894-899. doi:10.1016/s0090-4295(03)00661-77. Lee SC, Ellis RJ. Male Breast Cancer During Finasteride Therapy. JNCI Journal of the National Cancer Institute. 2004;96(4):338-339. doi:10.1093/jnci/djh0628. Shenoy NK, Prabhakar SM. Finasteride and Male Breast Cancer: Does the MHRA Report Show a Link? J Cutan Aesthet Surg. 2010;3(2):102-105. doi:10.4103/0974-2077.690229. Bird ST, Brophy JM, Hartzema AG, Delaney JAC, Etminan M. Male breast cancer and 5α-reductase inhibitors finasteride and dutasteride. J Urol. 2013;190(5):1811-1814. doi:10.1016/j.juro.2013.04.13210. Duijnhoven RG, Straus SMJM, Souverein PC, et al. Long-term use of 5α-reductase inhibitors and the risk of male breast cancer. Cancer Causes Control. 2014;25(11):1577-1582. doi:10.1007/s10552-014-0455-611. Wiebe JP, Rivas MA, Mercogliano MF, Elizalde PV, Schillaci R. Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride. J Steroid Biochem Mol Biol. 2015;149:27-34. doi:10.1016/j.jsbmb.2015.01.00412. Hagberg KW, Divan HA, Fang SC, Nickel JC, Jick SS. Risk of gynecomastia and breast cancer associated with the use of 5-alpha reductase inhibitors for benign prostatic hyperplasia. Clin Epidemiol. 2017;9:83-91. doi:10.2147/CLEP.S12467413. Kim MW, Park HS, Park JS, Koh SJ, Cho S. Five-Alpha Reductase Inhibitor and Breast Cancer Risk in Men: A Systematic Review. Ann Dermatol. 2017;29(4):525-528. doi:10.5021/ad.2017.29.4.52514. Meijer M, Thygesen LC, Green A, et al. Finasteride treatment and male breast cancer: a register‐based cohort study in four Nordic countries. Cancer Med. 2017;7(1):254-260. doi:10.1002/cam4.127315. Kjærulff TM, Ersbøll AK, Green A, et al. Finasteride Use and Risk of Male Breast Cancer: A Case–Control Study Using Individual-Level Registry Data from Denmark, Finland, and Sweden. Cancer Epidemiology, Biomarkers & Prevention. 2019;28(5):980-986. doi:10.1158/1055-9965.EPI-18-090416. Vinogradova Y, Coupland C, Hippisley-Cox J. Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases. BMJ. 2020;371:m3873. doi:10.1136/bmj.m3873
Epristeride. The finasteride alternative that has been forgotten. Haircafe 2023-07-12 | Linked videos:Neurosteroid series:youtu.be/sHDdNR3MUeIyoutu.be/kkvxuqqRBOwyoutu.be/2hYqoY7kzi0youtu.be/EkS6_wub7W8youtu.be/EgYczERIkBgThe five 5AR isoenzymes:youtu.be/Tzu_yWBR_rUHow to compare 5AR blockers:youtu.be/SGiPhPs0M-sTopical cyclosporin:youtu.be/En0S8fmhHnwOptimal dose of finasteride:youtu.be/15PHO1m6D-cSources:1. Robinson EJ, Collins AT, Robson CN, Neal DE. Effects of a new 5α reductase inhibitor (epristeride) on human prostate cell cultures. The Prostate. 1997;32(4):259-265. doi:10.1002/(SICI)1097-0045(19970901)32:4 259::AID-PROS5 3.0.CO;2-E2. Imperato-McGinley J, Guerrero L, Gautier T, Peterson RE. Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science. 1974;186(4170):1213-1215. doi:10.1126/science.186.4170.12133. Andriole GL, Rittmaster RS, Loriaux DL, Kish ML, Linehan WM. The effect of 4MA, a potent inhibitor of 5 alpha-reductase, on the growth of androgen-responsive human genitourinary tumors grown in athymic nude mice. Prostate. 1987;10(3):189-197. doi:10.1002/pros.29901003024. Levy MA, Brandt M, Sheedy KM, et al. Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5α-reductase isoform 2. The Journal of Steroid Biochemistry and Molecular Biology. 1994;48(2):197-206. doi:10.1016/0960-0760(94)90145-75. Geldof AA, Dijkstra I, Newling DW, Rao BR. Inhibition of 3 beta-hydroxysteroid-dehydrogenase: an approach for prostate cancer treatment? Anticancer Res. 1995;15(4):1349-1354.6. Sun ZY, Wu HY, Wang MY, Tu ZH. The mechanism of epristeride against benign prostatic hyperplasia. European Journal of Pharmacology. 1999;371(2):227-233. doi:10.1016/S0014-2999(99)00109-07. Sun ZY, Xie H, Tu zeng H. Effects of finasteride and epristeride on steroid 5a-reductase kinetics-A comparative in vitro study. Indian Journal of Pharmacology. 1999;31(2):120. Accessed June 23, 2023. ijp-online.com/article.asp?issn=0253-7613;year=1999;volume=31;issue=2;spage=120;epage=123;aulast=Sun;type=08. Azzouni F, Godoy A, Li Y, Mohler J. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases. Advances in Urology. 2011;2012:e530121. doi:10.1155/2012/5301219. abstracts-of-papers-ninetyfourth-annual-meeting-the-hilton-hawai-1993.pdf
Post-finasteride syndrome is a lie, featuring Dr. Peter Attia Haircafe 2023-07-07 | Dr. Attia and Dr. Khera video: youtu.be/GNCpG1fkMBALinked videos:PFS series:youtu.be/CS9D5RVO3J0youtu.be/tx8c3BvfuWwyoutu.be/dXwO0E2A7LIyoutu.be/YM4DJbK9HQYyoutu.be/kHhxHtKGmBoyoutu.be/PVLJMwUFDvIyoutu.be/ykk3UVyeCiAyoutu.be/iDeDcBg4eskDHT is a trash hormone series:youtu.be/Tzu_yWBR_rUyoutu.be/wRXZY-wY8b0youtu.be/eSVhcp0jmKEyoutu.be/H_07OCa_1h4youtu.be/nMWvPe5PQCgyoutu.be/UxcqZO3F6kAyoutu.be/MdmXIeH39FUyoutu.be/wRXZY-wY8b0Finasteride and depression:youtu.be/1p5RD1Yd6jEyoutu.be/EgYczERIkBgFinasteride and Alzheimers:youtu.be/-AN7fDyET-gLawsuits against Merck:youtu.be/5iR4mQaXyYQBaldness and quality of life:youtu.be/gxoj9jeizysFinasteride and epigenetics:youtu.be/rNwlasPw4WINeurosteroids:youtu.be/sHDdNR3MUeIyoutu.be/kkvxuqqRBOwyoutu.be/2hYqoY7kzi0youtu.be/EkS6_wub7W8youtu.be/EgYczERIkBgSources:1. Marks LS. 5α-Reductase: History and Clinical Importance. Rev Urol. 2004;6(Suppl 9):S11-S21. Accessed July 5, 2023. ncbi.nlm.nih.gov/pmc/articles/PMC14729162. Dušková M, Hill M, Stárka L. The influence of low dose finasteride, a type II 5α-reductase inhibitor, on circulating neuroactive steroids. Hormone Molecular Biology and Clinical Investigation. 2010;1(2):95-102. doi:10.1515/HMBCI.2010.0103. Paba S, Frau R, Godar SC, Devoto P, Marrosu F. Steroid 5 -Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders. Published online 2011:17.4. Caruso D, Pesaresi M, Abbiati F, et al. Comparison of plasma and cerebrospinal fluid levels of neuroactive steroids with their brain, spinal cord and peripheral nerve levels in male and female rats. Psychoneuroendocrinology. 2013;38. doi:10.1016/j.psyneuen.2013.04.0165. Ganzer CA, Jacobs AR. Emotional Consequences of Finasteride: Fool’s Gold. Am J Mens Health. 2018;12(1):90-95. doi:10.1177/15579883166316246. Martin J, Plank E, Jungwirth B, Hapfelmeier A, Podtschaske A, Kagerbauer SM. Weak correlations between serum and cerebrospinal fluid levels of estradiol, progesterone and testosterone in males. BMC Neurosci. 2019;20(1):53. doi:10.1186/s12868-019-0535-37. Khera M, Than JK, Anaissie J, et al. Penile vascular abnormalities in young men with persistent side effects after finasteride use for the treatment of androgenic alopecia. Translational Andrology and Urology. 2020;9(3):1201-1209. doi:10.21037/tau.2020.03.218. Howell S, Song W, Pastuszak A, Khera M. Differential Gene Expression in Post-Finasteride Syndrome Patients. The Journal of Sexual Medicine. Published online July 2021:S1743609521005130. doi:10.1016/j.jsxm.2021.05.009
Why topical minoxidil is SUPERIOR to oral minoxidil for stopping hair loss Haircafe 2023-06-30 | Linked videos:Oral minoxidil:youtu.be/O-vXgXaYMNQyoutu.be/WP7rYUqET80youtu.be/Mi_k9BQnnz4youtu.be/CAoEP3pO7Poyoutu.be/2zxNnUB5PPQyoutu.be/t-QgZ5dmkYkTretinoin and topical minoxidil:youtu.be/hj4WU3hmc9w10-15% topical minoxidil:youtu.be/YUNdv782ByoOptimal dose of finasteride:youtu.be/15PHO1m6D-cTopical finasteride:youtu.be/GFcdqlTtVv0youtu.be/PDpwyNrB0B4youtu.be/zG6tYL4o9_ASources:1. Panchaprateep R, Lueangarun S. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment. Dermatol Ther (Heidelb). 2020;10(6):1345-1357. doi:10.1007/s13555-020-00448-x2. Pirmez R, Salas-Callo CI. Very-low-dose oral minoxidil in male androgenetic alopecia: A study with quantitative trichoscopic documentation. Journal of the American Academy of Dermatology. 2020;82(1):e21-e22. doi:10.1016/j.jaad.2019.08.0843. Ramos PM, Sinclair RD, Kasprzak M, Miot HA. Minoxidil 1 mg oral versus minoxidil 5% topical solution for the treatment of female-pattern hair loss: A randomized clinical trial. Journal of the American Academy of Dermatology. 2020;82(1):252-253. doi:10.1016/j.jaad.2019.08.0604. Ramos PM, Gohad P, McCoy J, Wambier C, Goren A. Minoxidil Sulfotransferase Enzyme (SULT1A1) genetic variants predicts response to oral minoxidil treatment for female pattern hair loss. J Eur Acad Dermatol Venereol. 2021;35(1):e24-e26. doi:10.1111/jdv.167655. Vañó-Galván S, Pirmez R, Hermosa-Gelbard A, et al. Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients. Journal of the American Academy of Dermatology. 2021;84(6):1644-1651. doi:10.1016/j.jaad.2021.02.0546. Gupta AK, Venkataraman M, Talukder M, Bamimore MA. Relative Efficacy of Minoxidil and the 5-α Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients: A Network Meta-analysis. JAMA Dermatology. 2022;158(3):266-274. doi:10.1001/jamadermatol.2021.5743
More evidence that oral minoxidil is dangerous, even at a low dose Haircafe 2023-06-25 | Linked videos:10-15% minoxidil:youtu.be/YUNdv782ByoTretinoin and minoxidilyoutu.be/hj4WU3hmc9wOral minoxidil:youtu.be/WP7rYUqET80youtu.be/Mi_k9BQnnz4youtu.be/CAoEP3pO7Poyoutu.be/2zxNnUB5PPQyoutu.be/t-QgZ5dmkYkSources:1. Reichgott MJ. Minoxidil and pericardial effusion: An idiosyncratic reaction. Clinical Pharmacology & Therapeutics. 1981;30(1):64-70. doi:10.1038/clpt.1981.1282. Vañó-Galván S, Pirmez R, Hermosa-Gelbard A, et al. Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients. J Am Acad Dermatol. 2021;84(6):1644-1651. doi:10.1016/j.jaad.2021.02.0543. Bentivegna K, Zhou AE, Adalsteinsson JA, Sloan B. Letter in reply: Pericarditis and peripheral edema in a healthy man on low-dose oral minoxidil therapy. JAAD Case Rep. 2022;29:110-111. doi:10.1016/j.jdcr.2022.08.0574. Dlova NC, Jacobs T, Singh S. Pericardial, pleural effusion and anasarca: A rare complication of low-dose oral minoxidil for hair loss. JAAD Case Rep. 2022;28:94-96. doi:10.1016/j.jdcr.2022.07.0445. Trüeb RM, Caballero-Uribe N, Luu NNC, Dmitriev A. Serious complication of low-dose oral minoxidil for hair loss. JAAD Case Rep. 2022;30:97-98. doi:10.1016/j.jdcr.2022.09.0356. Goodwin Cartwright BM, Wang M, Rodriguez P, et al. Changes in Minoxidil Prescribing After Media Attention About Oral Use for Hair Loss. JAMA Network Open. 2023;6(5):e2312477. doi:10.1001/jamanetworkopen.2023.124777. Oral Minoxidil for Hair Loss Soars After NYT article. Medscape. Published June 13, 2023. Accessed June 24, 2023. http://www.medscape.com/viewarticle/993188
What is DHT scalp itch and how do you treat it? Haircafe 2023-06-19 | Sources:1. Imperato-McGinley J, Guerrero L, Gautier T, Peterson RE. Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science. 1974;186(4170):1213-1215. doi:10.1126/science.186.4170.12132. Stamatiadis D, Bulteau-Portois MC, Mowszowicz I. Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. Br J Dermatol. 1988;119(5):627-632. doi:10.1111/j.1365-2133.1988.tb03474.x3. Imperato-McGinley J, Gautier T, Cai LQ, Yee B, Epstein J, Pochi P. The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity. J Clin Endocrinol Metab. 1993;76(2):524-528. doi:10.1210/jcem.76.2.83818044. Thiboutot D, Harris G, Iles V, Cimis G, Gilliland K, Hagari S. Activity of the type 1 5 alpha-reductase exhibits regional differences in isolated sebaceous glands and whole skin. J Invest Dermatol. 1995;105(2):209-214. doi:10.1111/1523-1747.ep123171625. Bayne EK, Flanagan J, Einstein M, et al. Immunohistochemical localization of types 1 and 2 5a-reductase in human scalp. British Journal of Dermatology. Published online 1999.6. Thiboutot D, Gilliland K, Light J, Lookingbill D. Androgen Metabolism in Sebaceous Glands From Subjects With and Without Acne. Archives of Dermatology. 1999;135(9):1041-1045. doi:10.1001/archderm.135.9.10417. O’goshi K, Iguchi M, Tagami H. Functional analysis of the stratum corneum of scalp skin: studies in patients with alopecia areata and androgenetic alopecia. Arch Dermatol Res. 2000;292(12):605-611. doi:10.1007/s0040300001858. Lee W, Jung H, Chi S, et al. Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes. Archives of dermatological research. 2010;302:429-433. doi:10.1007/s00403-009-1019-69. saif GAB, Ericson ME, Yosipovitch G. The Itchy scalp - scratching for an explanation. Exp Dermatol. 2011;20(12):959-968. doi:10.1111/j.1600-0625.2011.01389.x10. Vázquez-Herrera NE, Sharma D, Aleid NM, Tosti A. Scalp Itch: A Systematic Review. Skin Appendage Disord. 2018;4(3):187-199. doi:10.1159/00048435411. Crocco EI, Bonifácio EB, Facchini G, et al. Modulation of skin androgenesis and sebum production by a dermocosmetic formulation. Journal of Cosmetic Dermatology. 2021;20(1):360-365. doi:10.1111/jocd.13503
Niostem. Worst of the hair loss industry. Haircafe 2023-06-15 | Related videos:Some previous awardees:youtu.be/s3RbupD9LY0youtu.be/pTNJmKeAtiIyoutu.be/X5tVmX8mIF4youtu.be/Ir7JARtgXcQOptimal dose of finasteride:youtu.be/15PHO1m6D-cWhy finasteride stops hair loss forever:youtu.be/LsF9MwIM_AMAlcohol and hair loss:youtu.be/wp5pp-v1Ol8Bludflow theory:youtu.be/cR8qE8AEoaQyoutu.be/icSupaq9hBABroccoli:youtu.be/uJpeHKKGd74Sources:1. niostem. niostem. Accessed June 15, 2023. niostem.com2. Maddin WS, Bell PW, James JH. The biological effects of a pulsed electrostatic field with specific reference to hair. Electrotrichogenesis. Int J Dermatol. 1990;29(6):446-450. doi:10.1111/j.1365-4362.1990.tb03837.x3. Maddin WS, Amara I, Sollecito WA. Electrotrichogenesis: further evidence of efficacy and safety on extended use. Int J Dermatol. 1992;31(12):878-880. doi:10.1111/j.1365-4362.1992.tb03550.x4. Chacón‐Martínez CA, Klose M, Niemann C, Glauche I, Wickström SA. Hair follicle stem cell cultures reveal self‐organizing plasticity of stem cells and their progeny. The EMBO Journal. 2017;36(2):151-164. doi:10.15252/embj.2016949025. Sánchez-Danés A, Blanpain C. Maintaining hair follicle stem cell identity in a dish. The EMBO Journal. 2017;36(2):132-134. doi:10.15252/embj.2016960516. Chacón-Martínez CA, Koester J, Wickström SA. Signaling in the stem cell niche: regulating cell fate, function and plasticity. Development. 2018;145(15):dev165399. doi:10.1242/dev.1653997. Yao G, Jiang D, Li J, et al. Self-Activated Electrical Stimulation for Effective Hair Regeneration via a Wearable Omnidirectional Pulse Generator. ACS Nano. 2019;13(11):12345-12356. doi:10.1021/acsnano.9b039128. Hwang D, Lee H, Lee J, et al. Micro-Current Stimulation Has Potential Effects of Hair Growth-Promotion on Human Hair Follicle-Derived Papilla Cells and Animal Model. International Journal of Molecular Sciences. 2021;22(9):4361. doi:10.3390/ijms220943619. Allmeroth K, Kim CS, Annibal A, et al. N 1-acetylspermidine is a determinant of hair follicle stem cell fate. Journal of Cell Science. 2021;134(9):jcs252767. doi:10.1242/jcs.25276710. Kim CS, Ding X, Allmeroth K, et al. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle. Cell Metabolism. 2020;32(4):629-642.e8. doi:10.1016/j.cmet.2020.08.01111. Koester J, Miroshnikova YA, Ghatak S, et al. Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility. Nat Cell Biol. 2021;23(7):771-781. doi:10.1038/s41556-021-00705-x12. Rehimi R, Crispatzu G, Chacón-Martínez CA, et al. Epigenomic Profiling of Stem Cells within the Pilosebaceous Unit Identifies PRDM16 as a Regulator of Sebaceous Gland Homeostasis. Cell Biology; 2021. doi:10.1101/2021.04.12.439446
TDM-105795 - a new hair growth stimulant that works differently from minoxidil Haircafe 2023-06-06 | Related videos:youtu.be/3m3YzD8HmPMyoutu.be/mNNp_084wWQyoutu.be/Ue64wnn_EYYyoutu.be/owqFni-y-HkSources:1. Medicines T. Technoderma Medicines Initiates TDM-105795 Androgenetic Alopecia Phase 2 Clinical Trial. Accessed June 4, 2023. prnewswire.com/news-releases/technoderma-medicines-initiates-tdm-105795-androgenetic-alopecia-phase-2-clinical-trial-301800212.html2. Technoderma Medicines Doses TDM-105795 in Phase 1b (MAD) Androgenetic Alopecia Multi-Dose Escalation Clinical Trial. Accessed June 4, 2023. news.marketersmedia.com/technoderma-medicines-doses-tdm-105795-in-phase-1b-mad-androgenetic-alopecia-multi-dose-escalation-clinical-trial/890652993. TechnoDerma Medicines Inc. Accessed June 6, 2023. http://tkskin.com/en4. Technoderma Medicines Initiates TDM-105795 Androgenetic Alopecia Phase 2 Clinical Trial. BioSpace. Accessed June 4, 2023. biospace.com/article/technoderma-medicines-initiates-tdm-105795-androgenetic-alopecia-phase-2-clinical-trial5. US Patent for Small molecule compound and synthesizing method and uses thereof Patent (Patent # 9,920,022 issued March 20, 2018) - Justia Patents Search. Accessed June 4, 2023. patents.justia.com/patent/99200226. Li JJ, Mitchell LH, Dow RL. Thyroid receptor agonists for the treatment of androgenetic alopecia. Bioorg Med Chem Lett. 2010;20(1):306-308. doi:10.1016/j.bmcl.2009.10.1097. Contreras-Jurado C, García-Serrano L, Martínez-Fernández M, Ruiz-Llorente L, Paramio JM, Aranda A. Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors. Plateroti M, ed. PLoS ONE. 2014;9(9):e108137. doi:10.1371/journal.pone.01081378. Technoderma Medicines Inc. A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group, Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Dose TDM-105795 Topical Solution in Healthy Male Subjects With AGA. clinicaltrials.gov; 2022. Accessed June 2, 2023. clinicaltrials.gov/ct2/show/NCT049135199. Technoderma Medicines Inc. A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group, Multi-Dose Study to Evaluate the Efficacy and Safety of TDM-105795 in Male Subjects With Androgenetic Alopecia. clinicaltrials.gov; 2023. Accessed June 2, 2023. clinicaltrials.gov/ct2/show/NCT05802173
I grew my own Lions Mane mushrooms! Haircafe 2023-06-02 | My other Lion's Mane videos:youtu.be/DpoKCHsRI50youtu.be/CS9D5RVO3J0
Ozempic causes weight loss. Does it cause hair loss? Haircafe 2023-06-01 | Sources:1. Mechanism of action of GLP-1 [25]. | Download Scientific Diagram. Accessed May 28, 2023. researchgate.net/figure/Mechanism-of-action-of-GLP-1-25_fig1_2562892222. Malkud S. Telogen Effluvium: A Review. J Clin Diagn Res. 2015;9(9):WE01-WE03. doi:10.7860/JCDR/2015/15219.64923. Marso SP, Bain SC, Consoli A, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. New England Journal of Medicine. 2016;375(19):1834-1844. doi:10.1056/NEJMoa16071414. Zhang W, Fan M, Wang C, et al. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis. OBES SURG. 2021;31(6):2649-2659. doi:10.1007/s11695-021-05311-25. Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022;387(3):205-216. doi:10.1056/NEJMoa22060386. Singh G, Krauthamer M, Bjalme-Evans M. Wegovy (semaglutide): a new weight loss drug for chronic weight management. J Investig Med. 2022;70(1):5-13. doi:10.1136/jim-2021-0019527. Tirzepatide Once Weekly for the Treatment of Obesity | NEJM. Published 2022. Accessed May 25, 2023. nejm.org/doi/full/10.1056/NEJMoa22060388. Are weight-loss drugs Wegovy and Ozempic making people lose their hair? NBC News. Published April 22, 2023. Accessed May 25, 2023. nbcnews.com/health/health-news/weight-loss-drugs-and-hair-loss-rcna797989. Does Ozempic Cause Hair Loss? Medscape. Published May 25, 2023. Accessed May 25, 2023. medscape.com/viewarticle/992377
How oral minoxidil destroys your heart Haircafe 2023-05-23 | Linked videos:Oral minoxidil:youtu.be/Mi_k9BQnnz4youtu.be/CAoEP3pO7Poyoutu.be/2zxNnUB5PPQyoutu.be/t-QgZ5dmkYkPost-finasteride syndromeyoutu.be/CS9D5RVO3J0youtu.be/tx8c3BvfuWwyoutu.be/dXwO0E2A7LIyoutu.be/YM4DJbK9HQYyoutu.be/kHhxHtKGmBoyoutu.be/PVLJMwUFDvIyoutu.be/ykk3UVyeCiAyoutu.be/iDeDcBg4eskSources:1. Imperato-McGinley J, Guerrero L, Gautier T, Peterson RE. Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science. 1974;186(4170):1213-1215. doi:10.1126/science.186.4170.12132. Reichgott MJ. Minoxidil and pericardial effusion: An idiosyncratic reaction. Clinical Pharmacology & Therapeutics. 1981;30(1):64-70. doi:10.1038/clpt.1981.1283. Grange DK, Lorch SM, Cole PL, Singh GK. Cantu syndrome in a woman and her two daughters: Further confirmation of autosomal dominant inheritance and review of the cardiac manifestations. Am J Med Genet A. 2006;140(15):1673-1680. doi:10.1002/ajmg.a.313484. Scurr I, Wilson L, Lees M, et al. Cantú syndrome: report of nine new cases and expansion of the clinical phenotype. Am J Med Genet A. 2011;155A(3):508-518. doi:10.1002/ajmg.a.338855. Harakalova M, van Harssel JJT, Terhal PA, et al. Dominant missense mutations in ABCC9 cause Cantú syndrome. Nat Genet. 2012;44(7):793-796. doi:10.1038/ng.23246. van Bon BWM, Gilissen C, Grange DK, et al. Cantú Syndrome Is Caused by Mutations in ABCC9. Am J Hum Genet. 2012;90(6):1094-1101. doi:10.1016/j.ajhg.2012.04.0147. Trüeb RM, Régnier A, Dutra Rezende H, Gavazzoni Dias MFR. Post-Finasteride Syndrome: An Induced Delusional Disorder with the Potential of a Mass Psychogenic Illness? Skin Appendage Disord. 2019;5(5):320-326. doi:10.1159/0004973628. Vañó-Galván S, Pirmez R, Hermosa-Gelbard A, et al. Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients. Journal of the American Academy of Dermatology. 2021;84(6):1644-1651. doi:10.1016/j.jaad.2021.02.0549. Dlova NC, Jacobs T, Singh S. Pericardial, pleural effusion and anasarca: A rare complication of low-dose oral minoxidil for hair loss. JAAD Case Rep. 2022;28:94-96. doi:10.1016/j.jdcr.2022.07.04410. Trüeb RM, Caballero-Uribe N, Luu NNC, Dmitriev A. Serious complication of low-dose oral minoxidil for hair loss. JAAD Case Rep. 2022;30:97-98. doi:10.1016/j.jdcr.2022.09.035
New evidence proves oral minoxidil for hair loss is not safe Haircafe 2023-05-18 | Videos linked:10-15% minoxidil: youtu.be/YUNdv782ByoTretinoin plus minoxidilyoutu.be/hj4WU3hmc9wOral minoxidil:youtu.be/CAoEP3pO7Poyoutu.be/2zxNnUB5PPQyoutu.be/t-QgZ5dmkYkSources:1. Lowenthal DT, Affrime MB. Pharmacology and pharmacokinetics of minoxidil. J Cardiovasc Pharmacol. 1980;2 Suppl 2:S93-106. doi:10.1097/00005344-198000022-000022. Reichgott MJ. Minoxidil and pericardial effusion: An idiosyncratic reaction. Clinical Pharmacology & Therapeutics. 1981;30(1):64-70. doi:10.1038/clpt.1981.1283. Ferry JJ, Shepard JH, Szpunar GJ. Relationship between contact time of applied dose and percutaneous absorption of minoxidil from a topical solution. J Pharm Sci. 1990;79(6):483-486. doi:10.1002/jps.26007906054. Shirwany A, D’Cruz IA, Munir A. Very large pericardial effusion attributable to minoxidil: resolution without drainage of fluid. Echocardiography. 2002;19(6):513-516. doi:10.1046/j.1540-8175.2002.00513.x5. Sica DA. Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension. The Journal of Clinical Hypertension. 2004;6(5):283-287. doi:10.1111/j.1524-6175.2004.03585.x6. Sinclair RD. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Int J Dermatol. 2018;57(1):104-109. doi:10.1111/ijd.138387. Tanaka Y, Aso T, Ono J, Hosoi R, Kaneko T. Androgenetic Alopecia Treatment in Asian Men. J Clin Aesthet Dermatol. 2018;11(7):32-35. Accessed May 15, 2023. ncbi.nlm.nih.gov/pmc/articles/PMC60577318. do Nascimento IJB, Harries M, Rocha VB, et al. Effect of Oral Minoxidil for Alopecia: Systematic Review. Int J Trichology. 2020;12(4):147-155. doi:10.4103/ijt.ijt_19_209. Sharma AN, Michelle L, Juhasz M, Muller Ramos P, Atanaskova Mesinkovska N. Low-dose oral minoxidil as treatment for non-scarring alopecia: a systematic review. International Journal of Dermatology. 2020;59(8):1013-1019. doi:10.1111/ijd.1493310. Randolph M, Tosti A. Oral minoxidil treatment for hair loss: A review of efficacy and safety. Journal of the American Academy of Dermatology. 2021;84(3):737-746. doi:10.1016/j.jaad.2020.06.100911. Dlova NC, Jacobs T, Singh S. Pericardial, pleural effusion and anasarca: A rare complication of low-dose oral minoxidil for hair loss. JAAD Case Rep. 2022;28:94-96. doi:10.1016/j.jdcr.2022.07.044
Pyrilutamide is almost here! Hair loss sufferers, rejoice! Haircafe 2023-05-12 | Videos:Pyrilutamide:youtu.be/cJSn9V1cU8syoutu.be/XzsjfesaQUgyoutu.be/pds3VttTbnYGT20029:youtu.be/mNNp_084wWQyoutu.be/vVOPcOl0lv4youtu.be/uhPtGX4fjUQTopical anti-androgen comparison:youtu.be/SGiPhPs0M-sOptimal dose of finasteride:youtu.be/15PHO1m6D-cSource:https://en.kintor.com.cn/news/245.html
The truth about creatine and hair loss Haircafe 2023-05-10 | Relevant videos:Earlier creatine videos:youtu.be/40KCJJNaHhYyoutu.be/47mR1N0I5ugExercise and testosterone don't cause hair loss:youtu.be/bXDPx7Vp8GIyoutu.be/wRXZY-wY8b0youtu.be/AmUvPSNn0H4Sources:1. van der Merwe J, Brooks NE, Myburgh KH. Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. Clin J Sport Med. 2009;19(5):399-404. doi:10.1097/JSM.0b013e3181b8b52f2. Antonio J, Candow DG, Forbes SC, et al. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? J Int Soc Sports Nutr. 2021;18:13. doi:10.1186/s12970-021-00412-w3. Sgrò P, Minganti C, Lista M, et al. Dihydrotestosterone (DHT) rapidly increase after maximal aerobic exercise in healthy males: the lowering effect of phosphodiesterase’s type 5 inhibitors on DHT response to exercise-related stress. J Endocrinol Invest. 2021;44(6):1219-1228. doi:10.1007/s40618-020-01409-z
Vegan Lions Mane Steak Haircafe 2023-05-05 | I have more hair loss content coming soon, but for now I'm hungry. So come join me for lunch and let's chow down on some Lion's Mane steaks!
Post-Finasteride Syndrome is a myth Haircafe 2023-05-02 | Reaction to Ryan Russo's Post-Lion's Mane Syndrome video: youtu.be/ZY3X72dFPZoRyan's YouTube page: youtube.com/@russoliftsTime stamps0:00 Intro2:11 Start of Ryan’s video3:23 “I have PFS”5:33 What is Lion’s Mane?6:43 Reishi mushrooms7:02 Gorilla Shroom 1.0 was fine7:43 Other drug use8:26 “full-blown castration”9:11 Shrinking penis10:52 Effects of psychotropic drugs11:56 Post-Lion’s Mane Syndrome is booming14:14 Medical effects of Lion’s Mane15:23 Is Lion’s Mane a 5AR blocker?18:52 Polish Lion’s Mane anecdote20:17 Avoiding the ER21:12 Aside on the PFS network24:26 More length changes26:00 Effects on libido27:28 Ryan is depressed28:43 Can’t sleep29:21 Recovery30:21 Lost physique33:27 Nocebo effect and loud YouTubers38:07 Suicide after finasteride39:58 Muh epigenetics41:32 Western medicine system42:59 Formula for recovery44:22 Penis size again45:01 Politics behind this?45:54 Physique again46:29 Warcraft III47:14 Just one pill of finasteride?51:32 Carpet bomb approach52:39 Final remarksVideos mentioned:PFS videos:youtu.be/tx8c3BvfuWwyoutu.be/dXwO0E2A7LIyoutu.be/YM4DJbK9HQYyoutu.be/kHhxHtKGmBoyoutu.be/PVLJMwUFDvIyoutu.be/ykk3UVyeCiAyoutu.be/iDeDcBg4eskNeurosteroids:youtu.be/sHDdNR3MUeIyoutu.be/kkvxuqqRBOwyoutu.be/2hYqoY7kzi0youtu.be/EkS6_wub7W8youtu.be/EgYczERIkBgDHT trash hormone series:youtu.be/Tzu_yWBR_rUyoutu.be/wRXZY-wY8b0youtu.be/eSVhcp0jmKEyoutu.be/H_07OCa_1h4youtu.be/nMWvPe5PQCgyoutu.be/UxcqZO3F6kAyoutu.be/MdmXIeH39FUyoutu.be/wRXZY-wY8b0Reishi mushrooms:youtu.be/i1APPNP0c9gWhy going bald can ruin your life:youtu.be/gxoj9jeizysDark side of finasteride:youtu.be/kHhxHtKGmBoSources:1. Fujita R, Liu J, Shimizu K, et al. Anti-androgenic activities of Ganoderma lucidum. Journal of Ethnopharmacology. 2005;102(1):107-112. doi:10.1016/j.jep.2005.05.0412. Mondaini N, Gontero P, Giubilei G, et al. Finasteride 5 mg and sexual side effects: how many of these are related to a nocebo phenomenon? J Sex Med. 2007;4(6):1708-1712. doi:10.1111/j.1743-6109.2007.00563.x3. Stults-Kolehmainen MA, Sinha R. The Effects of Stress on Physical Activity and Exercise. Sports Med. 2014;44(1):81-121. doi:10.1007/s40279-013-0090-54. Spelman K, Sutherland E, Bagade A. Neurological Activity of Lion’s Mane ( Hericium erinaceus ). j restorat med. 2017;6(1):19-26. doi:10.14200/jrm.2017.6.01085. Li IC, Lee LY, Tzeng TT, et al. Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines. Behav Neurol. 2018;2018:5802634. doi:10.1155/2018/58026346. Andy G, John M, Mirna S, et al. Controversies in the treatment of androgenetic alopecia: The history of finasteride. Dermatologic Therapy. 2019;32(2):e12647. doi:10.1111/dth.126477. Chong PS, Fung ML, Wong KH, Lim LW. Therapeutic Potential of Hericium erinaceus for Depressive Disorder. Int J Mol Sci. 2019;21(1):163. doi:10.3390/ijms210101638. Melcangi RC, Casarini L, Marino M, et al. Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study. Endocr Connect. 2019;8(8):1118-1125. doi:10.1530/EC-19-01999. Aday JS, Mitzkovitz CM, Bloesch EK, Davoli CC, Davis AK. Long-term effects of psychedelic drugs: A systematic review. Neuroscience & Biobehavioral Reviews. 2020;113:179-189. doi:10.1016/j.neubiorev.2020.03.01710. Almeida FB, Barros HMT, Pinna G. Neurosteroids and Neurotrophic Factors: What Is Their Promise as Biomarkers for Major Depression and PTSD? Int J Mol Sci. 2021;22(4):1758. doi:10.3390/ijms2204175811. Martínez-Mármol R, Chai Y, Conroy JN, et al. Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. J Neurochem. Published online January 20, 2023. doi:10.1111/jnc.15767
The Broscience of Hair Loss, DHT, and Bludflow with Andrew Huberman Haircafe 2023-04-19 | 00:00 Introduction05:02 Bludflow11:12 Minoxidil12:40 Minoxidil and prolactin14:19 Caffeine16:00 Botox19:23 Microneedling21:10 Saw palmetto22:33 DHT23:50 Post-finasteride syndrome25:14 ConclusionVideos mentioned:PFS videos:youtu.be/tx8c3BvfuWwyoutu.be/dXwO0E2A7LIyoutu.be/YM4DJbK9HQYyoutu.be/kHhxHtKGmBoyoutu.be/PVLJMwUFDvIyoutu.be/ykk3UVyeCiAyoutu.be/iDeDcBg4eskBludflow, scalp massage:youtu.be/icSupaq9hBAyoutu.be/P_UngSNEr98youtu.be/IfLvjEjdcnEWhat I've Learned:youtu.be/X5tVmX8mIF4Tretinoin:youtu.be/hj4WU3hmc9wCaffeine:youtu.be/la8ryTZFUQINew microneedling study:youtu.be/aNqMq3l0SOMReishi mushrooms:youtu.be/i1APPNP0c9gDHT trash hormone series:youtu.be/Tzu_yWBR_rUyoutu.be/wRXZY-wY8b0youtu.be/eSVhcp0jmKEyoutu.be/H_07OCa_1h4youtu.be/nMWvPe5PQCgyoutu.be/UxcqZO3F6kAyoutu.be/MdmXIeH39FUyoutu.be/wRXZY-wY8b0Neurosteroids:youtu.be/sHDdNR3MUeIyoutu.be/kkvxuqqRBOwyoutu.be/2hYqoY7kzi0youtu.be/EkS6_wub7W8youtu.be/EgYczERIkBgSources:1. Minoxidil: Package Insert. Drugs.com. Accessed April 17, 2023. drugs.com/pro/minoxidil.html2. Osborn D. INHERITANCE OF BALDNESS. Journal of Heredity. 1916;7(8):347-355. doi:10.1093/oxfordjournals.jhered.a1107463. Goldman BE, Fisher DM, Ringler SL. Transcutaneous PO2 of the scalp in male pattern baldness: a new piece to the puzzle. Plast Reconstr Surg. 1996;97(6):1109-1116; discussion 1117. doi:10.1097/00006534-199605000-000034. Shoemaker JK, Tiidus PM, Mader R. Failure of manual massage to alter limb blood flow: measures by Doppler ultrasound. Med Sci Sports Exerc. 1997;29(5):610-614. doi:10.1097/00005768-199705000-000045. van Broekhoven F, Verkes RJ. Neurosteroids in depression: a review. Psychopharmacology. 2003;165(2):97-110. doi:10.1007/s00213-002-1257-16. Messenger AG, Rundegren J. Minoxidil: mechanisms of action on hair growth. Br J Dermatol. 2004;150(2):186-194. doi:10.1111/j.1365-2133.2004.05785.x7. Freund BJ, Schwartz M. Treatment of Male Pattern Baldness with Botulinum Toxin: A Pilot Study. Plastic and Reconstructive Surgery. 2010;126(5):246e. doi:10.1097/PRS.0b013e3181ef816d8. Fischer TW, Herczeg‐Lisztes E, Funk W, Zillikens D, Bíró T, Paus R. Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles in vitro. Br J Dermatol. 2014;171(5):1031-1043. doi:10.1111/bjd.131149. Basaria S, Jasuja R, Huang G, et al. Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss. The Journal of Clinical Endocrinology & Metabolism. 2016;101(12):4669-4680. doi:10.1210/jc.2016-272610. Di Pietro A, Piraccini BM. Frontal Alopecia after Repeated Botulinum Toxin Type A Injections for Forehead Wrinkles: An Underestimated Entity? Skin Appendage Disord. 2016;2(1-2):67-69. doi:10.1159/00044838011. Dhurat R, Chitallia J, May TW, et al. An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia. Skin Pharmacol Physiol. 2018;30(6):298-305. doi:10.1159/00048114112. Kim S, Kim SN, Jeong G, et al. Efficacy of Caffeine in Promoting Hair Growth by Enhancing Intracellular Activity of Hair Follicles. Korea Journal of Cosmetic Science. 2019;1(1):11-18. doi:10.15230/SCSK.2019.1.1.1113. Shon U, Kim MH, Lee DY, Kim SH, Park BC. The effect of intradermal botulinum toxin on androgenetic alopecia and its possible mechanism. J Am Acad Dermatol. 2020;83(6):1838-1839. doi:10.1016/j.jaad.2020.04.08214. Völker JM, Koch N, Becker M, Klenk A. Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review. SPP. 2020;33(3):153-169. doi:10.1159/00050822815. Zhou Y, Chen C, Qu Q, et al. The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta-analysis. Dermatologic Therapy. 2020;33(4):e13741. doi:10.1111/dth.1374116. Ye J, Tang X, Long Y, Chu Z, Zhou Q, Lin B. The effect of hypoxia on the proliferation capacity of dermal papilla cell by regulating lactate dehydrogenase. Journal of Cosmetic Dermatology. 2021;20(2):684-690. doi:10.1111/jocd.1357817. Kinter KJ, Anekar AA. Biochemistry, Dihydrotestosterone. In: StatPearls. StatPearls Publishing; 2022. Accessed December 28, 2022. http://www.ncbi.nlm.nih.gov/books/NBK557634
New study shows that microneedling is an ineffective hair loss treatment Haircafe 2023-04-13 | Videos mentioned:youtu.be/tHWEoYR5-7oyoutu.be/hnihVcIKw4ESources:1. English RS, Ruiz S, DoAmaral P. Microneedling and Its Use in Hair Loss Disorders: A Systematic Review. Dermatol Ther (Heidelb). 2022;12(1):41-60. doi:10.1007/s13555-021-00653-22. Kakizaki P, Contin LA, Barletta M, et al. Efficacy and Safety of Scalp Microneedling in Male Pattern Hair Loss. Skin Appendage Disord. 2023;9(1):18-26. doi:10.1159/000526215
Why does hair loss get worse as we get older even though testosterone and DHT levels drop? Haircafe 2023-04-08 | Videos mentioned:youtu.be/LsF9MwIM_AMyoutu.be/X5tVmX8mIF4youtu.be/XMT9WYgWYD8youtu.be/icSupaq9hBAyoutu.be/P_UngSNEr98youtu.be/IfLvjEjdcnESources:1. Kligman AM. The comparative histopathology of male-pattern baldness and senescent baldness. Clin Dermatol. 1988;6(4):108-118. doi:10.1016/0738-081x(88)90074-02. Stárka L, Pospíšilová H, Hill M. Free testosterone and free dihydrotestosterone throughout the life span of men. The Journal of Steroid Biochemistry and Molecular Biology. 2009;116(1-2):118-120. doi:10.1016/j.jsbmb.2009.05.0083. Whiting DA. How real is senescent alopecia? A histopathologic approach. Clinics in Dermatology. 2011;29(1):49-53. doi:10.1016/j.clindermatol.2010.07.0074. Robbins C, Mirmirani P, Messenger AG, et al. What women want - quantifying the perception of hair amount: an analysis of hair diameter and density changes with age in caucasian women. Br J Dermatol. 2012;167(2):324-332. doi:10.1111/j.1365-2133.2012.11010.x5. Karnik P, Shah S, Dvorkin-Wininger Y, Oshtory S, Mirmirani P. Microarray analysis of androgenetic and senescent alopecia: Comparison of gene expression shows two distinct profiles. J Dermatol Sci. 2013;72(2):183-186. doi:10.1016/j.jdermsci.2013.06.0176. Trueb RM, Rezende HD, Dias MFRG. A comment on the science of hair aging. International Journal of Trichology. 2018;10(6):245. doi:10.4103/ijt.ijt_56_187. Fu D, Huang J, Li K, et al. Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia. Biomedicine & Pharmacotherapy. 2021;137:111247. doi:10.1016/j.biopha.2021.1112478. Courtois M, Loussouarn G, Hourseau C, Grollier JF. Ageing and hair cycles. Br J Dermatol. 1995;132(1):86-93. doi:10.1111/j.1365-2133.1995.tb08630.x
Does finasteride cause insomnia? Haircafe 2023-04-02 | Videos mentioned:PFS series:youtu.be/tx8c3BvfuWwyoutu.be/dXwO0E2A7LIyoutu.be/YM4DJbK9HQYyoutu.be/kHhxHtKGmBoyoutu.be/PVLJMwUFDvIyoutu.be/ykk3UVyeCiAyoutu.be/iDeDcBg4eskNeurosteroid series:youtu.be/sHDdNR3MUeIyoutu.be/kkvxuqqRBOwyoutu.be/EkS6_wub7W8Sources:1. Chowdhuri S, Bascom A, Mohan D, Diamond MP, Badr MS. Testosterone Conversion Blockade Increases Breathing Stability in Healthy Men during NREM Sleep. Sleep. 2013;36(12):1793-1798. doi:10.5665/sleep.32022. Wittert G. The relationship between sleep disorders and testosterone in men. Asian J Androl. 2014;16(2):262-265. doi:10.4103/1008-682X.1225863. Goldstein MR, Cook JD, Plante DT. The 5α-reductase inhibitor finasteride is not associated with alterations in sleep spindles in men referred for polysomnography. Hum Psychopharmacol. 2016;31(1):70-74. doi:10.1002/hup.25024. Frau R, Bini V, Soggiu A, et al. The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation | Neuropsychopharmacology. Neuropsychopharmacology. 2017;42(11):2196-2205. doi:10.1038/npp.2017.135. Gupta MA, Vujcic B, Gupta AK. Finasteride Use Is Associated with Higher Odds of Obstructive Sleep Apnea: Results from the US Food and Drug Administration Adverse Events Reporting System. Skinmed. 2020;18(3):146-150.6. Traish AM. Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It’s Time to Sound the Alarm. World J Mens Health. 2020;38(3):323. doi:10.5534/wjmh.200012
I was wrong about finasteride. DHT is NOT a trash hormone. Haircafe 2023-04-01 | Videos mentioned:Dark side of finasteride video: youtu.be/kHhxHtKGmBoDHT trash hormone series:youtu.be/Tzu_yWBR_rUyoutu.be/wRXZY-wY8b0youtu.be/eSVhcp0jmKEyoutu.be/H_07OCa_1h4youtu.be/nMWvPe5PQCgyoutu.be/UxcqZO3F6kAyoutu.be/MdmXIeH39FUyoutu.be/wRXZY-wY8b0Sources:1. Mantzoros CS, Georgiadis EI, Trichopoulos D. Contribution of dihydrotestosterone to male sexual behaviour. BMJ. 1995;310(6990):1289-1291. doi:10.1136/bmj.310.6990.12892. Traish AM, Mulgaonkar A, Giordano N. The Dark Side of 5α-Reductase Inhibitors’ Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression. Korean J Urol. 2014;55(6):367-379. doi:10.4111/kju.2014.55.6.3673. Dramatic-Level4981. Dht is Not a Trash Hormone Guys. r/tressless. Published March 29, 2023. Accessed March 30, 2023. www.reddit.com/r/tressless/comments/125xctm/dht_is_not_a_trash_hormone_guys
Does finasteride cause dry eyes? Haircafe 2023-03-25 | Shedding video:youtu.be/VxVYHP0WNfADHT trash hormone series:youtu.be/wRXZY-wY8b0youtu.be/eSVhcp0jmKEyoutu.be/H_07OCa_1h4youtu.be/nMWvPe5PQCgyoutu.be/UxcqZO3F6kAyoutu.be/MdmXIeH39FUyoutu.be/wRXZY-wY8b0Dark side of finasteride:youtu.be/kHhxHtKGmBoFinasteride and depression:youtu.be/1p5RD1Yd6jEyoutu.be/EgYczERIkBgSources:1. Cermak JM, Krenzer KL, Sullivan RM, Dana MR, Sullivan DA. Is complete androgen insensitivity syndrome associated with alterations in the meibomian gland and ocular surface? Cornea. 2003;22(6):516-521. doi:10.1097/00003226-200308000-000062. Rocha E, Wickham L, da Silveira LA, et al. Identification of androgen receptor protein and 5α-reductase mRNA in human ocular tissues. Br J Ophthalmol. 2000;84(1):76-84. doi:10.1136/bjo.84.1.763. Schaumberg DA, Dana R, Buring JE, Sullivan DA. Prevalence of Dry Eye Disease among US Men: Estimates from the Physicians’ Health Studies. Arch Ophthalmol. 2009;127(6):763-768. doi:10.1001/archophthalmol.2009.1034. Ding J, Sullivan DA. Aging and dry eye disease. Exp Gerontol. 2012;47(7):483-490. doi:10.1016/j.exger.2012.03.0205. Moisseiev E, Holmes AJ, Moshiri A, Morse LS. Finasteride is effective for the treatment of central serous chorioretinopathy | Eye. Eye. 2016;30(6):850-856. doi:10.1038/eye.2016.536. Li K, Zhang C, Yang Z, Wang Y, Si H. Evaluation of a novel dry eye model induced by oral administration of finasteride. Mol Med Rep. 2017;16(6):8763-8770. doi:10.3892/mmr.2017.77547. Traish AM. Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It’s Time to Sound the Alarm. World J Mens Health. 2020;38(3):323. doi:10.5534/wjmh.2000128. Wang LX, Deng YP. Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications. Int J Ophthalmol. 2021;14(6):915-922. doi:10.18240/ijo.2021.06.189. The effect of finasteride on dry eye disease | IOVS | ARVO Journals. Published 2022. Accessed March 22, 2023. iovs.arvojournals.org/article.aspx?articleid=2778997
Is once daily topical minoxidil enough to stop hair loss? Haircafe 2023-03-20 | Related videos:youtu.be/O73--OFFRzkyoutu.be/pbVUEpGukAQyoutu.be/t-QgZ5dmkYkyoutu.be/2zxNnUB5PPQyoutu.be/hj4WU3hmc9wyoutu.be/YUNdv782Byoyoutu.be/CAoEP3pO7Poyoutu.be/7AhZrAHBflUSources:1. Novak E, Franz TJ, Headington JT, Wester RC. Topically Applied Minoxidil in Baldness. International Journal of Dermatology. 1985;24(2):82-87. doi:10.1111/j.1365-4362.1985.tb05727.x2. Franz TJ. Percutaneous absorption of minoxidil in man. Arch Dermatol. 1985;121(2):203-206.3. Olsen EA, Weiner MS, Delong ER, Pinnell SR. Topical minoxidil in early male pattern baldness. Journal of the American Academy of Dermatology. 1985;13(2, Part 1):185-192. doi:10.1016/S0190-9622(85)70157-04. Civatte J, Laux B, Simpson NB, Vickers CF. 2% topical minoxidil solution in male-pattern baldness: preliminary European results. Dermatologica. 1987;175 Suppl 2:42-49. doi:10.1159/0002489025. Kreindler TG. Topical minoxidil in early androgenetic alopecia. J Am Acad Dermatol. 1987;16(3 Pt 2):718-724. doi:10.1016/s0190-9622(87)70093-06. Olsen EA, DeLong ER, Weiner MS. Long-term follow-up of men with male pattern baldness treated with topical minoxidil. Journal of the American Academy of Dermatology. 1987;16(3, Part 2):688-695. doi:10.1016/S0190-9622(87)70089-97. Eller MG, Szpunar GJ, Della-Coletta AA. Absorption of minoxidil after topical application: effect of frequency and site of application. Clin Pharmacol Ther. 1989;45(4):396-402. doi:10.1038/clpt.1989.468. Ferry JJ, Shepard JH, Szpunar GJ. Relationship between contact time of applied dose and percutaneous absorption of minoxidil from a topical solution. J Pharm Sci. 1990;79(6):483-486. doi:10.1002/jps.26007906059. Anderson RJ, Kudlacek PE, Clemens DL. Sulfation of minoxidil by multiple human cytosolic sulfotransferases. Chem Biol Interact. 1998;109(1-3):53-67. doi:10.1016/s0009-2797(97)00120-810. Olsen EA, Dunlap FE, Funicella T, et al. A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol. 2002;47(3):377-385. doi:10.1067/mjd.2002.12408811. Blume-Peytavi U, Shapiro J, Messenger AG, et al. Efficacy and Safety of Once-Daily Minoxidil Foam 5% Versus Twice-Daily Minoxidil Solution 2% in Female Pattern Hair Loss: A Phase III, Randomized, Investigator-Blinded Study. J Drugs Dermatol. 2016;15(7):883-889.12. Gupta AK, Talukder M, Venkataraman M, Bamimore MA. Minoxidil: a comprehensive review. J Dermatolog Treat. 2022;33(4):1896-1906. doi:10.1080/09546634.2021.194552713. Suchonwanit P, Thammarucha S, Leerunyakul K. Minoxidil and its use in hair disorders: a review. Drug Des Devel Ther. 2019;13:2777-2786. doi:10.2147/DDDT.S214907
PAI-1 and ET-02: the secret to stopping hair loss and reversing aging? Haircafe 2023-03-15 | Videos mentioned:Finasteride and heart disease: youtu.be/UxcqZO3F6kAHMI-115 update: youtu.be/XHb8N6NfncAProlactin and hair loss: youtu.be/Y9_1tR3WM0YGene replacement: youtu.be/hnihVcIKw4ESources:1. Eirion Therapeutics - Crunchbase Company Profile & Funding. Crunchbase. Accessed March 14, 2023. crunchbase.com/organization/eirion-therapeutics2. Kortlever RM, Higgins PJ, Bernards R. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol. 2006;8(8):877-884. doi:10.1038/ncb14483. Eren M, Gleaves LA, Atkinson JB, King LE, Declerck PJ, Vaughan DE. Reactive site-dependent phenotypic alterations in plasminogen activator inhibitor-1 transgenic mice. J Thromb Haemost. 2007;5(7):1500-1508. doi:10.1111/j.1538-7836.2007.02587.x4. Vaughan DE, De Taeye BM, Eren M. PAI-1 antagonists: predictable indications and unconventional applications. Curr Drug Targets. 2007;8(9):962-970. doi:10.2174/1389450077816623645. Kumar TR, Larson M, Wang H, McDermott J, Bronshteyn I. Transgenic Mouse Technology: Principles and Methods. Methods Mol Biol. 2009;590:335-362. doi:10.1007/978-1-60327-378-7_226. Vaughan DE. PAI-1 Antagonists: The Promise and the Peril. Trans Am Clin Climatol Assoc. 2011;122:312-325. Accessed March 11, 2023. ncbi.nlm.nih.gov/pmc/articles/PMC31163357. Khan SS, Shah SJ, Klyachko E, et al. A null mutation in SERPINE1 protects against biological aging in humans. Science Advances. 2017;3(11):eaao1617. doi:10.1126/sciadv.aao16178. Edelson J. Uses of plasminogen activator inhibitor 1 (pai-1) inhibitors. Published online March 19, 2020. Accessed March 14, 2023. patents.google.com/patent/WO2020056191A1/en9. Colavincenzo M. Evaluating PAI-1 Expression in the Hair Follicles of Patients With Non-Scarring Hair Loss. clinicaltrials.gov; 2022. Accessed March 9, 2023. clinicaltrials.gov/ct2/show/NCT02548689
How CRISPR gene editing will cure hair loss in the near future Haircafe 2023-03-08 | Videos mentioned:5AR enzyme: youtu.be/Tzu_yWBR_rUNeurosteroid trilogy:youtu.be/sHDdNR3MUeIyoutu.be/kkvxuqqRBOwyoutu.be/2hYqoY7kzi0Earlier neurosteroid videos:youtu.be/EkS6_wub7W8youtu.be/EgYczERIkBgSources:Video on CRISPR edited from CRISPR website: crisprtx.comOther sources:1. Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Sueishi M. Sonoporation: Gene transfer using ultrasound. World J Methodol. 2013;3(4):39-44. doi:10.5662/wjm.v3.i4.392. Ryu JY, Won EJ, Lee HAR, et al. Ultrasound-activated particles as CRISPR/Cas9 delivery system for androgenic alopecia therapy. Biomaterials. 2020;232:119736. doi:10.1016/j.biomaterials.2019.1197363. Gillmore JD, Gane E, Taubel J, et al. CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis. New England Journal of Medicine. 2021;385(6):493-502. doi:10.1056/NEJMoa21074544. Bhat P, Garibyan L. The Potential of CRISPR-Guided Therapies in the Dermatology Clinic. JID Innov. 2022;2(2):100103. doi:10.1016/j.xjidi.2022.100103
CosmeRNA, brand new hair loss treatment coming out this month! Does it work? Haircafe 2023-03-02 | Previous video on SAMiRNA:youtu.be/isj37Z3BrjcSources:1. SAMiRNA Drug Development. Accessed March 1, 2023. us.bioneer.com/SAMiRNA/products/SAMiRNA.aspx?AspxAutoDetectCookieSupport=12. Biosciences T. RNA Therapeutics: RNA. Accessed February 16, 2022. taconic.com/taconic-insights/genetics/sirna-gene-expression-therapeutics.html4. Yun SI, Lee SK, Goh EA, et al. Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia. Sci Rep. 2022;12(1):1607. doi:10.1038/s41598-022-05544-w5. 바이오니아, 탈모화장품 대세 인증...`매출 1600억·영업익 720억 전망`. ZUM 뉴스. Published February 21, 2023. Accessed March 1, 2023. news.zum.com/articles/81414102
Will splitting finasteride tablets make them less effective for fighting hair loss? Haircafe 2023-02-24 | Optimal dose of finasteride video: youtu.be/15PHO1m6D-cSources:1. Imperato-McGinley J, Guerrero L, Gautier T, Peterson RE. Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science. 1974;186(4170):1213-1215. doi:10.1126/science.186.4170.12132. Gormley GJ, Stoner E, Bruskewitz RC, et al. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia. New England Journal of Medicine. 1992;327(17):1185-1191. doi:10.1056/NEJM1992102232717013. Roberts JL, Whiting D, DeViUez R, et al. Clinical dose ranging studies with finasteride, a type 2 5cz-reductase inhibitor, in men with male pattern hair loss. Published online 1999:9.4. Hulin-Curtis SL, Petit D, Figg WD, Hsing AW, Reichardt JK. Finasteride metabolism and pharmacogenetics: new approaches to personalized prevention of prostate cancer. Future Oncol. 2010;6(12):1897-1913. doi:10.2217/fon.10.1495. Sammartino MP, Castrucci M, Ruiu D, Visco G, Campanella L. Photostability and toxicity of finasteride, diclofenac and naproxen under simulating sunlight exposure: evaluation of the toxicity trend and of the packaging photoprotection. Chem Cent J. 2013;7:181. doi:10.1186/1752-153X-7-181Hospital guidelines for crushing tablets (including finasteride): stch.org.uk/wp-content/uploads/pct-version-neemmc-guidelines-for-tablet-crushing-april-2012.pdfProscar package insert:accessdata.fda.gov/drugsatfda_docs/label/2010/020180s037lbl.pdfProcess for preparing finasteride patent:patents.google.com/patent/US7550593B2/en
