Uploaded December 2020 | Updated September 2026, 47 minutes ago

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By bringing DNA sequencing out of the sequencer and directly to cells, MIT scientists have revealed an entirely new view of the genome. With a new method for in situ genome sequencing reported December 31, 2020, in the journal Science, researchers can, for the first time, see exactly how DNA sequences are organized and packed inside cells. Learn more: https://mcgovern.mit.edu/2020/12/31/sequencing-inside-cells

This video shows in situ sequenced DNA loci in a mouse zygote colored by chromosome of origin.

Video: Andrew Payne, Zack Chiang, Paul Reginato