Medlife Crisis
Can You Legally Buy a Real Human Skeleton?
updated
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This is a really different video for me. My Mum died in 2018, soon after I'd posted my second ever video to the internet. She had a horrible final year of life, consumed by anxiety and fear about how she would die, having been diagnosed with an incurable terminal disease. I explore the arguments for and against Assisted Dying, both as a son who cared for his mother through a horrible disease, and as a doctor.
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The BMJ's section on Assisted Dying: bmj.com/assisted-dying (lots of pieces contained therein)
UK Parliament Briefing researchbriefings.files.parliament.uk/documents/POST-PB-0047/POST-PB-0047.pdf
Article about Graham Mansfield theguardian.com/society/2022/jul/22/man-who-killed-his-wife-in-act-of-love-calls-for-assisted-dying-law
Concerns about Canadian slippery slope and social provisions theguardian.com/world/2022/may/11/canada-cases-right-to-die-laws
Links
Dignity in Dying dignityindying.org.uk
Assisted Dying Coalition Www.assisteddying.org
mydeath-mydecision.org.uk
My article that I mentioned about DNR and disability theguardian.com/healthcare-network/views-from-the-nhs-frontline/2016/may/09/good-death-should-doctors-patients-last-life-goal
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Short men are going to great lengths to increase their romantic chances, and overall confidence. Leg lengthening surgery is extremely costly, dangerous, and soaring in popularity. The Internet has boosted the ease with which people can undergo major life-changing operations, leading to the commodification of cosmetic surgery. But what should the medical profession's role be in all of this?
With huge thanks to @CharlesCornellStudios for making the Skee-Lo backing track, allowing me to truly butcher 'I Wish', and to @JordanHarrod for providing her voice for an article excerpt.
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@ContraPoints 'Beauty' youtube.com/watch?v=n9mspMJTNEY&ab_channel=ContraPoints
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References:
Original article: gq-magazine.co.uk/lifestyle/article/leg-lengthening-surgery-men
China's cosmetic surgery craze. Leg-lengthening operations to fight height predjudice can leave patients crippled pubmed.ncbi.nlm.nih.gov/15046120
Shortchanged: Height Discrimination and Strategies for Social Change on JSTOR jstor.org/stable/j.ctv1xx9jqm
China's cosmetic surgery craze. Leg-lengthening operations to fight height predjudice can leave patients crippled pubmed.ncbi.nlm.nih.gov/15046120
Cosmetic bilateral leg lengthening using intramedullary nail experience of 9 cases pubmed.ncbi.nlm.nih.gov/32055149
Kim Kardashian is the latest celeb to promote private full body MRI screening scans. She and the company claim they are life-saving. The scans themselves involve no radiation and you can learn information about your body. Surely that can't be bad, can it?
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References
Incidentalomas and general reading:
Incidental Findings and Low-Value Care | AJR ajronline.org/doi/full/10.2214/AJR.22.28926
The Economic Burden of Incidentally Detected Findings - PMC ncbi.nlm.nih.gov/pmc/articles/PMC3094927
The Economic Burden of Incidentally Detected Findings - PMC ncbi.nlm.nih.gov/pmc/articles/PMC3094927
Cascades of care:
The Important but Rarely Studied Cascade of Care | Health Policy | JAMA Network Open jamanetwork.com/journals/jamanetworkopen/fullarticle/2752986
Curbing Cascades of Care: What They Are and How to Stop Them | AAFP aafp.org/pubs/afp/issues/2022/0300/p228.html
Why Do Physicians Pursue Cascades of Care After Incidental Findings? A National Survey - PMC ncbi.nlm.nih.gov/pmc/articles/PMC7174496
When routine medical tests trigger a cascade of unnecessary care : Shots - Health News : NPR npr.org/sections/health-shots/2022/06/13/1104141886/cascade-of-care
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Everyone gets a muscle cramp from time to time. But do you know what actually causes them? Does anyone?!
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Check out Dr Mike Todorovic's channel with Dr Matt Barton: @DrMattDrMike !
And for all your imaging needs, go hit up @SonographicTendencies !
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References:
Nocturnal leg cramps pubmed.ncbi.nlm.nih.gov/22963024
Muscle Cramping During Exercise: Causes, Solutions, and Questions Remaining pubmed.ncbi.nlm.nih.gov/31696455
Aetiology of skeletal muscle 'cramps' during exercise: a novel hypothesis pubmed.ncbi.nlm.nih.gov/9232553
Exercise-induced muscle pain, soreness, and cramps pubmed.ncbi.nlm.nih.gov/7830383
Muscle cramps: A comparison of the two-leading hypothesis sciencedirect.com/science/article/abs/pii/S1050641118300919?via%3Dihub
Dill DB, Bock AV, Edwards HT, Kennedy PH. Industrial fatigue. J Ind Hyg Toxicol. 1936;18:417–431 cabdirect.org/cabdirect/abstract/19372700025
Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the therapeutics and technology assessment subcommittee of the American academy of neurology pubmed.ncbi.nlm.nih.gov/20177124
Muscle cramping in the marathon : aetiology and risk factors
Increased running speed and previous cramps rather than dehydration or serum sodium changes predict exercise-associated muscle cramping: a prospective cohort study in 210 Ironman triathletes
Water intake after dehydration makes muscles more susceptible to cramp but electrolytes reverse that effect ncbi.nlm.nih.gov/pmc/articles/PMC6407543/pubmed.ncbi.nlm.nih.gov/21148567/pubmed.ncbi.nlm.nih.gov/17465609
Electrolyte and Plasma Changes After Ingestion of Pickle Juice, Water, and a Common Carbohydrate-Electrolyte Solution ncbi.nlm.nih.gov/pmc/articles/PMC2742453
Increased HCN channel driven inward rectification in benign cramp fasciculation syndrome academic.oup.com/brain/article/138/11/3168/331171
Cramp-fasciculation syndrome in patients with and without neural autoantibodies onlinelibrary.wiley.com/doi/10.1002/mus.23935
Muscle Cramping in Athletes—Risk Factors, Clinical Assessment, and Management sciencedirect.com/science/article/abs/pii/S0278591907000907
Sweat and Sodium Losses in NCAA Football Players: A Precursor to Heat Cramps? journals.humankinetics.com/view/journals/ijsnem/15/6/article-p641.xml
This video is not sponsored, and I imagine it might be quite effective at ensuring none of my future videos are either. I genuinely do think Nebula is a great deal – and you can get 40% off an annual subscription when you sign up via my link: go.nebula.tv/medlifecrisis. This video has already been up there for 3 weeks!
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Check out @domainofscience's Map of Medicine video
References
Coloured pills pubmed.ncbi.nlm.nih.gov/4113531
Italian men link.springer.com/article/10.1007/BF00560290
Coloured packaging pubmed.ncbi.nlm.nih.gov/6786566
Four times a day placebo more effective than twice a day for duodenal ulcers ncbi.nlm.nih.gov/pmc/articles/PMC2014313
From Latin poetry to sham surgery: A history of placebos By Amir Imani canadianhealthcarenetwork.ca/latin-poetry-sham-surgery-history-placebos?check_logged_in=1
Honest placebo (IBS) journals.plos.org/plosone/article?id=10.1371/journal.pone.0015591
Honest placebo (back pain) journals.lww.com/pain/Abstract/2019/12000/Effects_of_open_label_placebo_on_pain,_functional.22.aspx
Overdose on placebo (nocebo) pubmed.ncbi.nlm.nih.gov/17484949
Fear and fentanyl misinformation medpagetoday.com/opinion/second-opinions/101577
Article about cops accidentally overdosing washingtonpost.com/news/morning-mix/wp/2017/05/16/i-was-in-total-shock-ohio-police-officer-accidentally-overdoses-after-traffic-stop
Arthroscopy landmark trial nejm.org/doi/10.1056/NEJMoa1305189?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov
Fake pacemakers jamanetwork.com/journals/jama/fullarticle/196492
Neural mechanism of pain and placebo youtube.com/watch?v=s7hrYwFqrLU&ab_channel=UCSFSchoolofMedicine
Music
Puppy Love (Sting) by Twin Musicom is licensed under a Creative Commons Attribution 4.0 licence. creativecommons.org/licenses/by/4.0
Artist: http://www.twinmusicom.org
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This is an in-depth interview with scientist, author and expert on longevity science, Dr Andrew Steele. We discuss what ageing even is, whether it should be regarded as a disease, how we differ from other animals, where the research is, what treatments look promising, health and economic policy, and what the future looks like.
Watch Andrew and I chat about all things wearable - what numbers you should care about, which you shouldn’t youtu.be/9H40yatCwo0
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Book: https://ageless.link
twitter.com/statto
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If you do want to listen to this as a podcast, it is available here (I hope!) open.acast.com/public/streams/63d64aa1452847001186943f/episodes/63e10209436c360011deab42.mp3
How to prevent almost ALL disease shows.acast.com/medlifecrisis/episodes/how-to-prevent-almost-all-disease via @acast
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I’ll add chapters as soon as I get home! Edit: many thanks to user Dihydrousoxide for making them, which I'm shamelessly stealing!
0:00 Intro
5:37 Why you got into the anti-ageing field?
7:15 Ageing as a cause of death
9:18 What is ageing?
13:32 Hallmarks of Ageing - Senescent Cells
17:25 How do we target senescent cells?
20:10 What are telomeres?
22:40 How do we stop telomeres shortening?
26:00 Evolution optimised for reproduction, not ageing well - BOFFFs
33:54 Autophagy - cellular recycling
42:00 Testing of rapamycin - Effective Dose
45:35 Why don't we have human data on rapamycin?
46:24 Metformin - TAME trial monetary issues
49:04 What is Metformin?
52:50 How does Metformin work as an anti-ageing drug?
54:03 What therapies excite you at the moment?
58:39 Thoughts on Calorie restriction
1:04:53 Rhesus Monkey Diet Trials
1:08:14 Potential Therapies - theoretical mechanistic science
1:12:46 Amyloid Studies
1:17:20 Should we stop ageing?
1:31:29 Where do you see the anti-ageing field being in 2050?
1:43:03 Outro
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THANK YOU for your support in 2022. This Christmas I'm donating my sponsorship fee to charity via GiveWell because I know it'll help those in need. If you can join me in giving something, please do – anything helps. Have a wonderful festive season! www.givewell.org/medlife
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My video on vaccines and people’s reactions: youtu.be/5iABaxRWGxk
My video on bias, which mentions other failed therapies (two parter): youtu.be/ooWA4tM_gUs
Kevin Klatt’s post instagram.com/p/Cb72YXVLCf3
Andrew Steele’s dissection of ‘Blueprint’ longevity plan youtu.be/7rs_JK-pTTQ
Writing: Rohin Francis
Editing: Tanmay Nandanikar and Rohin Francis
Thumbnail design: Simon Buckmaster
0:00 Intro
3:41 The demarcation problem
6:44 Pseudoscience
9:06 Homeopathy and chiropractic
11:20 It's nice to feel nice
13:37 Bioplausibility
16:39 The mechanistic bias
17:06 Hard vs soft; clean vs messy science
20:25 Mechanistic examples: COVID Rx and masks
24:40 Diets
28:12 Vitamin D supplements
36:36 The Big Pharma graveyard
45:33 Most therapies don't work
47:07 Influencers' love of sexy mechanisms
50:25 Closing summary
References:
Convalescent plasma doesn’t work thelancet.com/journals/lancet/article/PIIS0140-6736(21)00897-7/fulltext
Meta-research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals elifesciences.org/articles/45183
Most healthcare interventions don’t work jclinepi.com/article/S0895-4356(22)00100-7/fulltext
COVID experts give Thanksgiving tips statnews.com/2022/11/21/how-infectious-disease-experts-are-responding-to-covid-nearly-three-years-in
VITAL study (vitamin D) nejm.org/doi/full/10.1056/NEJMoa2202106?query=featured_home nejm.org/doi/full/10.1056/NEJMe2205993
VITAL website vitalstudy.org/index.html
Vitamin D in kids jamanetwork.com/journals/jamapediatrics/article-abstract/2798998
MAST pants don’t work pubmed.ncbi.nlm.nih.gov/10796828
Nesiritide ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118.005440
REDOX nejm.org/doi/10.1056/NEJMoa1212722
PANTHER IPF nejm.org/doi/10.1056/NEJMoa1212722
OSCILLATE nejm.org/doi/10.1056/NEJMoa1215554
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Part 1 (this video except with an uncut version of my truly spectacular and life-changing student short video) nebula.tv/videos/medlifecrisis-unhelpful-doctor-answers-your-questions-for-53-straight-minutes-500k-sub-qa
Part 2 (Nebula only) nebula.tv/videos/medlifecrisis-unhelpful-doctor-answers-even-more-of-your-questions
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Video about heart cancer: youtu.be/-QF1rTygfzY
Video about sudden death from chest injury: youtu.be/bFai8NXgFVw
Raksha – The Guardian: youtu.be/GxJ2mHqFH-c (currently on 69 views, nice)
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References:
2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease: pubmed.ncbi.nlm.nih.gov/32860412
The proinflammatory effects of chronic excessive exercise: pubmed.ncbi.nlm.nih.gov/30884427
Source of the U-shaped curve: ncbi.nlm.nih.gov/pmc/articles/PMC4451435
Personalised exercise dose: pubmed.ncbi.nlm.nih.gov/29301027
The effects of endurance exercise on the heart: panacea or poison?: pubmed.ncbi.nlm.nih.gov/32152528
Exercise and the heart--the harm of too little and too much: pubmed.ncbi.nlm.nih.gov/25757005
Training for Longevity: The Reverse J-Curve for Exercise: pubmed.ncbi.nlm.nih.gov/32848273 (suggests a slightly lower upper limit for benefit)
0:00 Can you be so fit that you don't die
1:06 Why exercise is great, actually
4:49 Exercise dose - how much exercise
6:30 The U-shaped curve
8:42 Extreme exercise isn't benign
10:02 The main heart problem with endurance exercise
12:49 Coronary calcification
13:29 Other electrical problems
14:16 Some key messages
16:36 Why is this so important
17:29 On the roof
http://news.bbc.co.uk/2/hi/south_asia/7302649.stm
wired.com/2011/06/red-market-excerpt
My bone trade video:
youtu.be/QcudPWsyxzk
Both these stories came from my friend @sgcarney's horrifying and brilliant book, The Red Market scottcarney.com/the-red-market
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Many thanks to Dr Adam Rodman. Find his brilliant podcast here: http://bedside-rounds.org
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Reference: ncbi.nlm.nih.gov/pmc/articles/PMC1570491
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We have a problematic tendency to elevate scientists or doctors to rockstar status, which can lead to fraud, betrayal, malpractice and death. Explore three stories from the exciting but controversial field of regenerative medicine.
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The Ballad of Superstar Surgeon Paolo Macchiarini by @henrikwidegren (go check out his songs!)
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Edited by Tanmay Nandanikar
References:
Link to RetractionWatch: retractionwatch.com
Piero Anversa write up in the NYT https://t.co/K0EtQRYIhT
Piero Anversa STAT News statnews.com/2018/10/14/harvard-brigham-retractions-stem-cell
Vanity Fair article on Macchiarini vanityfair.com/news/2016/01/celebrity-surgeon-nbc-news-producer-scam
For Better Science Macchiarini write up: forbetterscience.com/2017/11/07/how-trachea-transplanters-tricked-andemariam-beyene-to-sacrifice-himself-for-a-lancet-paper
ABC 20/20 made a documentary about Macchiarini too, which I only found after finishing this. However, I didn't want to necessarily go into too much detail about the awful complications that patients suffered. Here's a clip: twitter.com/ABC2020/status/1360249049295642628?s=20&t=n8yghqPXAOBVVob7FmWjjg
0:00 The Great Men of Medicine
4:20 A change of mind: Head Transplants
9:26 Harvard's house of cards: Cardiac Stem Cells
13:30 He lied about everything: Synthetic Tracheas
22:37 Crime doesn't exist in a vacuum: The Enablers
24:20 Welcome to Maaariokaaart
25:03 Doomed to repeat history
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This set was recorded at a ‘best of’ live gig hosted by Festival of the Spoken Nerd at London’s Bloomsbury Theatre. It was my first live gig for two and a half years or so (can’t think why), and I’m sure it shows but it was great fun. Especially at such a cool venue!
Find their new series of “A Podcast Of Unnecessary Detail” wherever you get your podcasts, or at @UnnecessaryDetail. I'm in episode 1, which is out TODAY! But don’t let that put you off.
Podcast link: festivalofthespokennerd.com/podcast
Their constituent parts are:
@HelenArney
@SteveMould
@standupmaths
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I can't actually recall how I found this, I just stumbled on it on twitter and had no idea what I was watching. The videos at the time had about 100 views each, the first one has now ticked past 180k views. One MIGHT suggest that I had secretly invested in these NFTs and I've just given them free publicity...muahaha. Well not really, as they're not on sale yet. Plus I'm not that smart anyway.
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I hope it's evident that I am not seeking drama and am working on the assumption that most/all of these medfluencers didn't get the full story, but I'd probably recommend others give NFTs a wide berth. Wanting to raise money for charity is a noble goal, but there are ways to do it without all this scammy overlay. NFT minting is ultimately a way of raising money from gullible people who receive very little in exchange. If the goal is delivering healthcare to remote areas, again the web3 angle seems unnecessary.
twitter.com/MedCrisis/status/1514373761469980677
metadocsnft.com
Million rupee studio a reference to @Coffeezilla
Dan Olson a reference to his phenomenal video about NFTs @FoldingIdeas youtu.be/YQ_xWvX1n9g
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What happens when the worlds of Silicon Valley tech and medicine meet? Does more data always make the answer more straightforward?
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0:00 When techbros and medicine collide
1:06 Medical grifters hiding in plain sight
6:53 Should you get that full body scan?
11:59 How much AF is too much?
14:20 Should you continuously monitor your glucose?
17:42 Antifragile biology
18:58 Summary - we're not computers
Editor: Tanmay Nandanikar
If you want to access Nebula for only $14.79 for A WHOLE YEAR you also get year's subscription to CuriosityStream thrown in for free! curiositystream.com/medlife. It's the best way to support me to keep making videos.
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Watch a bonus companion video exclusively on Nebula, of my chat with space doctor Sindu: https://nebula.app/videos/medlifecrisis-bonus-cpr-in-space-interview-with-dr-sindujen-sriharan-companion-video
This video isn't sponsored. Earthworks kindly sent me an ICON PRO microphone without any strings attached, so do please check them out at earthworksaudio.com/streaming-microphones/icon-pro
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References:
Sindu’s paper: pubmed.ncbi.nlm.nih.gov/33468291
ESAM guidelines: chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/viewer.html?pdfurl=https%3A%2F%2Flink.springer.com%2Fcontent%2Fpdf%2F10.1186%2Fs13049-020-00793-y.pdf&clen=771091&chunk=true&pdffilename=Hinkelbein2020_Article_CardiopulmonaryResuscitationCP.pdf
I got to do some real science in weightlessness! A total of 23 whole astro minutes in freefall. This wasn't a tourist flight but a real life science campaign with the European Space Agency and NASA. It really was a dream come true. I've wanted to do a parabolic flight ever since I watched 'The Making of Apollo 13' (the movie not the actual event) as a kid and learnt how they filmed it. I guess this will be the closest I'll get to going into space!
Huge thank you to Neil Melville, Ruth McAvinia, Anne-Clotilde Duchesne, Sébastien Turay, Karina Marshall-Goebel, Rosita Suenson, Lars, and all the scientists I met and chatted to on the campaign.
As the channel scales up, I'm really trying to commit to things I've wanted to do but previously told myself I don't have time or money to address. The first on that list is subtitles, which I'm going to do my best to provide for every video if I can. Sometimes they're uploaded a bit last minute/impromptu and I'll endeavour to get them up afterwards, but I'm now working with a company to get subtitles in place before publication if possible. To everyone who uses subtitles – sorry it took so long.
Link to Karina's 2019 paper about jugular flow on the International Space Station:
jamanetwork.com/journals/jamanetworkopen/fullarticle/2755307
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References:
Xenotransplantation review (open access) - ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.048186
Heart xenotransplantation (sci hub link) - https://sci-hub.st/10.1097/MOT.0000000000000461
Comparison of human and pig hearts - ncbi.nlm.nih.gov/pmc/articles/PMC1467827
Human-mouse glial chimeras - jneurosci.org/content/34/48/16153.long
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#shorts
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This is my second video in a row that could be listened to as a podcast. So stop pestering me about still not having gotten around to starting that podcast. This is actually supreme efficiency pal. But seriously, I know it's kinda boring, it would make me happy if you just stuck it at x2 speed.
I haven't watched this back fully but I hope my message came across reasonably clearly. The last thing I would want to be doing is stoking the culture wars or misinformation which both surround COVID topics, especially vaccination. I'm just trying to say that...shit's complicated, ya get me?
References from the video:
ICNARC data (UK ICUs) data: icnarc.org/Our-Audit/Audits/Cmp/Reports
UK briefing with data showing booster efficacy dropping off to 40% after 2.5 months: assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1043807/technical-briefing-33.pdf
Myocarditis risk vs COVID myocarditis risk: nature.com/articles/s41591-021-01630-0.pdf
Preprint of subsequent breakdown: medrxiv.org/content/10.1101/2021.12.23.21268276v1.full.pdf
CDC guidance on children: cdc.gov/vaccines/covid-19/planning/children.html
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00:00 Why Prof Nutt is a hero
01:51 The Nutt case & Nutt sack
04:55 Interview start
05:25 Politicians vs scientists 2009 to 2021
07:42 Slap in the face
09:03 Does the UK get anything right?
09:31 Medical cannabis & its promise
12:50 Why don't doctors prescribe cannabis?
15:09 What can HCWs do to help?
17:06 How to learn more
17:56 Why drug research is so hard
19:28 "They'll steal the heroin!"
21:20 Who killed psychedelic research?
25:34 Did recreational drug use ruin things?
26:55 What is a psychedelic?
28:00 MDMA is the opposite of a psychedelic
28:50 Did drugs help humans evolve?
30:24 A lost sleep revolution & how the brain makes humans human
34:12 CTRL+ALT+DEL for the brain?
37:18 The power of psychedelic psychotherapy
39:24 Psilocybin vs SSRI antidepressants
43:47 Timothy Leary was wrong
46:26 Aldous Huxley, mescaline & opening the brain
47:05 "You probably haven't seen those since you were a baby"
48:25 The brain orchestra and default mode network
49:44 How psychedelics break habits
51:41 Fly on the wall for psychedelic therapy
53:50 "Fuck off I'm talking to God!"
55:20 Ayahuasca retreats vs conventional therapy
57:32 Does psychedelic hype worry you?
59:27 Steve Jobs & the role of money
01:01:20 Stigma against mental health
01:02:09 Is the USA leading the way?
01:03:08 Harnessing the power of placebo
01:04:22 Silicon Valley & Micro-dosing
01:09:16 Closing
The Drug Science charity, independent unbiased drug information: drugscience.org.uk
Check out the Drug Science podcast as well open.spotify.com/show/2hLSRIS777SKphWxv4HyDK
References mentioned:
Trial of Psilocybin versus Escitalopram for Depression nejm.org/doi/full/10.1056/NEJMoa2032994
Self-blinding citizen science to explore psychedelic microdosing elifesciences.org/articles/62878
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420k subscribers drug themed Q&A – I tried to answer as many of your questions as I could, this is the longest one yet. Plenty of non-drug questions too.
Sign up for my newsletter here: medlife.substack.com
00:00 Intro
01:12 NOT the sponsor
04:52 Wee announcement
06:45 What should be legal that isn't?
10:17 Disclaimer (don't get me fired)
11:30 LSD, shrooms – no side effects?
15:26 Why are journals so expensive?
16:41 Why do surgeons exist?
17:30 YouTuber mansion tour
18:00 Does being the boss feel different?
18:08 Psychedelics are supernatural?
19:36 Moderate drug use = good?
21:58 Which world leader should do drugs?
22:48 Cocaine = wake up during CPR?
27:12 Which sport, but drunk?
27:37 Spunk for strep?
28:50 Is "his heart was too big" a thing?
31:08 Which doctors most fun when stoned?
32:03 Opinion on legalisation/regulation?
34:12 Why so many medics addicts?
37:51 Should doctors do weed?
39:24 Diff'rent booze for diff'rent folks?
40:15 Microdosing & nootropics
41:42 Should docs have drug tests?
42:58 Have you made mistakes?
43:44 Drinking as a teen
46:00 This questioner is now blocked
46:21 Aspirin vs paracetamol
47:30 Airborne emergencies
48:03 Stigma from medics to addicts
51:01 Coke vs weed
51:22 Skillshare! Great way to support this channel
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Go subscribe to @SabineHossenfelder and watch the other half of this video, where I ask her some questions about physics! youtube.com/watch?v=bIT8_lS4vRY
And make sure you're subscribed to the Royal Institution's channel too as you'll see a third instalment in this epic trilogy there some time soon!
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00:00 History being made
01:40 Does the heart have 5 chambers
03:23 How does the heart actually beat
07:16 Should you do CPR in a bed
09:22 Favourite surgery
11:59 Am I weird
12:08 Why don't we have a good artificial heart yet
16:30 How long can you live without a heart
17:18 Why do doctors use such long words
19:50 Close & Sabine's video
Watch @chubbyemu's counterpart video to this one, about another rare complication of energy drinks youtu.be/tAtaIZD0Ebs
I use (or attempt to use) humour in my videos in order to educate, with the butt of jokes being either myself or abstract subjects; never patients.
Many thanks to Dr Andrew D'Silva for talking to me about the case he published with his team, available here: pubmed.ncbi.nlm.nih.gov/33858880
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00:00 Acaffoscaff RS
01:43 Intro
02:47 21 years old & seriously unwell
05:50 Cardiology conference
06:34 Interview with case author
08:52 Advice to energy drink fans
10:20 Patient perspective
11:29 Close
This was my first video made with help from someone who knows what they’re doing! Many thanks to @DomBurgess and Standard Studios for transforming my flat into these exotic locations.
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Sign up for my free monthly(ish) newsletter at http://www.medlifecrisis.co.uk to stay up to date with other projects I'm working on but also for some longer form writing on topics that might or might not find a home on YouTube.
Thank you to everyone at Royal Papworth Hospital who made this video possible. It was originally shot for the British Society for Heart Failure's annual meeting and then re-edited for YouTube.
For more information about heart failure and what you can do to help, start at bsh.org.uk/.
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00:00 Intro
03:00 Pre-modern Pioneers
09:38 Blue Babies
26:56 Transplant and the Death Debate
41:48 Balloons and Bacteria
53:26 Conclusion
This was recorded as a talk in a single take so is a bit more natural in terms of delivery than a standard youtube video. Hope you can carve out a little while to give it a watch to appreciate the fascinating history of this organ and field, and why I love them so much. Cheers!
Get A FULL YEAR of CuriosityStream and Nebula for under $15 at curiositystream.com/medlife with code 'medlife'. Signing up to get thousands of amazing titles at both sites gives you something brilliant for a cheap price, but also helps me continue making videos on this channel.
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I've applied for astronaut selection to the European Space Agency. It's a once in a lifetime opportunity and I have absolutely no chance. But that won't stop me making a video about it.
A huge thank you to the amazing, awe-inspiring space doctors who explained their analogue space missions:
Squadron Leader Dr Bonnie Posselt twitter.com/Bonposselt
Dr Beth Healey twitter.com/Bethahealey
Watch the full interviews with them both here: https://nebula.app/videos/medlife-crisis-analog-astronauts-interview-with-2-space-doctors-bonus
Watch this vid ad-free: https://nebula.app/videos/medlife-crisis-im-applying-to-become-an-astronaut-not-the-billionaire-type
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References:
Women in the early space race: thespacereview.com/article/3515/1
Ad Astra: An Illustrated Guide to Leaving the Planet (2017) by Dallas Campbell (book - highly recommended)
Posselt B et al. Safety and healthcare provision in space analogs. sciencedirect.com/science/article/abs/pii/S009457652100271X
Source videos:
Mars Simulator? | RAF recreates living on Mars with Doctor Bonnie Posselt youtube.com/watch?v=h-KAeeSi2TY&ab_channel=STARRSHIP
This is 100% genuine archive footage from the Old England Journal of Medicine circa 1901, concerning Dr August Bier's infamous study examining cocaine as a spinal anaesthetic. Do not try this at home.
I can actually do a better German accent, which is basically just me doing a Werner Herzog impression, but I really tried hard to make this one appropriate for the period. Unfortunately I think it's just come out really stilted and monotonous but hey ho. Special thanks to Leon from @neoexplains who kindly recorded an old school German accent for me, and @SabineHossenfelder for her tips. If you're not a fan of me hamfisting accents, or facial topiary, you might want to skip another video coming soon.
The backgrounds are the Royal College of Physicians in London, and the Jesuit Library in Cologne.
Rejected titles: A fine crack, That time doctors tested cocaine on themselves, That time a German doctor injected cocaine into his subordinate and beat the living sh*t out of him.
References:
Translated from Bier, August: Versusche ueber Cocainisirung des
Rueckenmarkes. Deutsche Zeitschrift fuer Chirurgie, 1899; 51: 361-8
zenodo.org/record/1428422#.YM5uOpNKj_o
researchgate.net/publication/272857287_Cocaine_What_is_the_Crack_A_Brief_History_of_the_Use_of_Cocaine_as_an_Anesthetic
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What happened, and is this common?
What could’ve caused it and why are athletes' hearts special?
Why wasn’t this picked up in screening?
Is this anything to do with COVID or the vaccine?
What can you do if something like this happens to someone you know?
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I do really want to make some non-COVID, more produced videos. But I keep finding myself making these sh*tty looking basic low-effort ones to respond to something topical. Just when I thought I was out, they pull me back in.
Original clip: twitter.com/JimmyKimmelLive/status/1389793339566739460
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covid.giveindia.org
khalsaaid.org
hemkuntfoundation.com/oxygen-cylinder
List of charities: docs.google.com/document/d/10ca5YH5YUtp7Qe63sVNX1SlepQcvzc4RCwLhMBvTJyE/mobilebasic
My friend's parents so can vouch for this one: ketto.org/fundraiser/OnebillionLiterates
indiatimes.com/trending/social-relevance/donate-for-covid-19-oxygen-ventilator-india-539031.html
Some further reading/references:
1. Why should the US help India qz.com/india/2001436/why-should-the-us-help-india-overcome-its-covid-19-second-wave
2. Source of Devi Shetty quote: timesofindia.indiatimes.com/blogs/toi-edit-page/the-crisis-thats-coming-soon-we-will-run-out-of-skilled-personnel-to-treat-covid-heres-how-to-tackle-this/?source=app&frmapp=yes
3. The Indian mutant originating in Kent thetimes.co.uk/article/from-the-garden-of-england-to-the-slums-of-calcutta-our-kent-covid-variant-is-now-theirs-nszptr3sz
4. Sandhya Ramesh is a superb science writer in India, and always a good starting point for understanding issues affecting India. This is a very useful article about what works and what doesn’t - one to circulate to friends and relatives https://theprint.in/health/dexamethasone-remdesivir-plasma-doxycycline-which-works-for-covid-and-which-doesnt/645982/
5. Why this is the world’s problem theguardian.com/world/2021/apr/25/the-world-must-act-indias-covid-crisis-is-a-dire-problem-for-us-all
00:00 Intro
01:25 Contents
02:20 Email from the frontline
03:31 Summary of current situation
08:15 Why does this matter to the world?
09:37 Where did it go wrong?
11:28 Magical thinking
14:56 Opened up too soon?
16:04 A scientific temper
17:35 Let them inject cake
18:12 Slow vaccination
19:18 Interview with a junior doctor
25:19 Collateral damage
25:35 Censorship
26:22 What's next for Indians?
28:19 HOW YOU CAN HELP
30:18 What can we all learn from India?
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Huge thanks to:
Eleonor Frost twitter.com/Astrosurgery
Jeff Goldstein and the LevelEx team levelex.com
If you want to see that extra interview with Jeff, check out this video on Nebula. To sign up, visit curiositystream.com/medlife and use the code 'medlife' to get a year of Nebula and CuriosityStream for only $15. This video is not sponsored, but that's still the cheapest way for you to get both.
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This is one of the most requested topics I get, and while not the most exciting, it's an important one. So I hope it helps at least one person make a decision.
I wanted to keep it short to ensure people actually watched - an in-depth lecture would of course have offered the chance to really dive into the details but my objective here is to help as many people as possible.
If you find statins confusing, you're not alone! Cardiologists and GPs probably prescribe these more often than anyone else and yet even I took a long time to really understand the enormous mass of data and coverage (which of course is impossible to read in its entirety). I want to specifically credit Professor Darrel Francis from Imperial College in London for helping me see statins in the kind of reference frame that I present in the video. Prior to that, my understanding was that kind of vague "oh this will help you, probably. I think." that you might get if you just read guidelines, which of course exist to maximise health for a whole population.
References:
thelancet.com/journals/lancet/article/PIIS0140-6736(16)31357-5/fulltext
thelancet.com/pdfs/journals/lancet/PIIS0140-6736(10)61350-5.pdf
SAMSON n=1 study: nejm.org/doi/full/10.1056/NEJMc2031173
sciencemediacentre.org/expert-reaction-to-analysis-of-clinical-trial-data-on-cholesterol-lowering-drugs-and-targets-for-bad-cholesterol-levels/?cli_action=1617720731.908
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Visit curiositystream.com/medlife & sign up for both CuriosityStream and Nebula, where you'll find the full uncut interviews with Drs Poerio and Gill. You can help me make more videos and get yourself access to all the 1000s of titles on both platforms by signing up using the code ‘medlife’. Only £11 for a year! Serious tingles!
One day I was looking up medical videos and before I knew it I was tumbling down a tingly rabbit hole into the fascinating world of ASMR (Autonomous Sensory Meridian Response). Huge thanks to Dr Giulia Poerio of the University of Essex and @DrJamesGill, GP and Warwick Medical School Lecturer.
Go subscribe to James's channel! youtube.com/channel/UCApL0DjgL7e1ZmvMM40A9Uw
Giulia is looking for volunteers! Do you want to help ASMR research? Full website coming soon, but some info about it here: https://crowd.science/campaigns/asmrnet-establishing-a-global-research-network-and-prioritised-agenda-for-asmr/. If you're interested and think you have something to offer, drop Giulia an email (address at the end of the vid in the link).
References:
Giulia's main study - journals.plos.org/plosone/article?id=10.1371/journal.pone.0196645
Review from Giulia and colleagues - pubmed.ncbi.nlm.nih.gov/31128572
One of the early articles - peerj.com/articles/851
Personality traits - frontiersin.org/articles/10.3389/fpsyg.2017.00247/full
ASMR University (good resource compiling information, but be aware there is no quality control) asmruniversity.com
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00:00 Intro
01:17 What is ASMR?
02:32 I'm a gopher at a Furry convention
04:06 The problem with a loose definition for ASMR
05:30 Dr Giulia Poerio Q1 Is ASMR real?
06:16 Q2 Why do only some people get it?
08:20 Q3 The role of personal care
09:57 Q4 ASMR in the era of loneliness
11:51 Q5 Therapeutic uses and medical ASMR
14:02 Long winded set up for a bad joke
15:09 Wishy washy science
15:45 The man, the myth, the legend, the Gill
17:30 Q2 When did you learn of your ASMR legacy
18:14 Q3 What ASMR can teach doctors
20:00 What I've learnt from ASMR/close
21:54 Watch this bit or I starve
24:10 Diagnosis: TERMINAL TINGLITIS
The five lessons:
1. Who should prove what
2. Placebo ain't a dirty word, but...
3. Old doesn't mean good
4. Celebs need to watch what they're promoting
5. Special bonus surprise
- Rohin 'The Doc' Francis, WrestleMedica 2021
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Wikipedia is a good place to start to get a general overview
en.wikipedia.org/wiki/Cupping_therapy
A more in-depth article, explaining cupping’s roots in bloodletting
sciencebasedmedicine.org/cupping-olympic-pseudoscience
Hijama, the traditional Islamic medicine practice sometimes called ‘wet cupping’ because it causes bleeding
bbc.co.uk/news/health-32653971
An open-minded article from Harvard Health Blog
https://www.health.harvard.edu/blog/what-exactly-is-cupping-2016093010402
Scientific meta-analyses (ie combining the results of hundreds of studies into one mega-study)
ncbi.nlm.nih.gov/pmc/articles/PMC3289625
ncbi.nlm.nih.gov/pmc/articles/PMC3000376
jpain.org/article/S1526-5900(20)30003-1/fulltext
Apologies for the basic nature of the video, I spent what time I had today researching and filming, meaning there was none left to make it look fancy and you are stuck with my bookshelf as a backdrop, and a zip in my washing machine as the soundtrack.
For further reading:
Closing schools is not evidence-based and it harms children, BMJ - bmj.com/content/372/bmj.n521?utm_source=twitter&utm_medium=social&utm_term=hootsuite&utm_content=sme&utm_campaign=usage
A useful review for the UK - theguardian.com/commentisfree/2021/jan/12/when-should-uk-schools-reopen-safe-covid
A useful review for the USA - medpagetoday.com/blogs/vinay-prasad/90658
Excellent summary of evidence around COVID-19 and children - dontforgetthebubbles.com/evidence-summary-paediatric-covid-19-literature
Goldacre 12 million no risk adult death - medrxiv.org/content/10.1101/2020.11.01.20222315v1?ijkey=4abc16ae672d46e844687e9a2128ea018bae8b21&keytype2=tf_ipsecsha
Reopening schools during the COVID-19 pandemic: governments must balance the uncertainty and risks of reopening schools against the clear harms associated with prolonged closure (Ara Darzi's team) - adc.bmj.com/content/106/2/111.long
European Centre for Disease Control and Prevention Executive Summary - https://www.ecdc.europa.eu/sites/default/files/documents/COVID-19-schools-transmission-August%202020.pdf
European Centre for Disease Prevention and Control school reopening review - https://www.ecdc.europa.eu/en/publications-data/children-and-school-settings-covid-19-transmission
Open Schools, Covid-19, and Child and Teacher Morbidity in Sweden - nejm.org/doi/full/10.1056/NEJMc2026670?query=TOC
WHO review (staff spread is more important than staff-student spread) - https://www.who.int/docs/default-source/coronaviruse/risk-comms-updates/epi-win-update40-overview-of-the-pandemic.pdf?sfvrsn=8d355bcd_4,%20https://www.medrxiv.org/content/10.1101/2020.10.29.20220426v1
Japan childhood obesity - sciencedirect.com/science/article/pii/S0047272720302280?dgcid=raven_sd_aip_email
German study about school reopening - cream-migration.org/publ_uploads/CDP_22_20.pdf
I will continue to update this, I just need to go to sleep now! Worked last nightshift to cover a colleague that came down with COVID - we're still a way off being out of this.
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Argh, this is what happens when you try to write/record/edit/upload on the same day. Typo at 00:07:14 - should read "this does *not* imply it is the ONLY option..."
Original study by Kevin Hall et al: nature.com/articles/s41591-020-01209-1
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