Peter Attia MD | Protein’s impact on appetite, and uric acid's link to disease & how to manage (AMA 62 sneak peek) @PeterAttiaMD | Uploaded August 2024 | Updated October 2024, 8 hours ago.
View show notes here: bit.ly/3ykzdJb
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In this “Ask Me Anything” (AMA) episode, Peter dives into two important health topics: uric acid and protein, examining them from unique perspectives. For uric acid, he explores its metabolic role and connection to various diseases, focusing on the potential causal link with cardiovascular disease. He also discusses factors influencing uric acid levels, such as diet, genetics, and lifestyle, providing practical tips for effective management. Shifting to protein, Peter delves into its role in appetite and weight management, the consequences of insufficient protein, and the “protein leverage hypothesis” linking protein deficiency to obesity. He covers optimal protein intake and its impact on energy expenditure, and he compares the satiety effects of solid versus liquid protein. Finally, Peter shares his strategy for incorporating protein into a comprehensive weight management plan.
We discuss:
00:12 - Overview of episode topics (and an important discussion on fanny packs)
03:03 - Understanding uric acid: its role in metabolic processes, its association with gout and kidney stones, its impact on blood pressure, and more
10:03 - Non-modifiable factors that influence uric acid levels
13:39 - Modifiable factors that influence uric acid levels
20:05 - Association between high uric acid levels and cardiovascular disease
In the full episode, we also discuss:
-Evidence suggesting a causal link between high uric acid levels and cardiovascular disease [24:00];
-Inconclusive evidence about the cardiovascular benefits of lowering uric acid pharmacologically [28:15];
-Exploring the potential risks of low uric acid levels in neurodegenerative diseases [37:00];
-Managing uric acid levels: dietary interventions and pharmacological approaches [42:00];
-The impact of protein on appetite and weight management [44:00];
-The consequences of insufficient protein on eating behaviors and satiety [52:15];
-The relationship between protein deficiency and obesity: exploring the “protein leverage hypothesis” [57:15];
-The impact of protein intake on energy expenditure [1:02:15];
-Determining optimal protein intake to avoid deficiency and support health [1:05:45];
-The role of different amino acids and protein sources in promoting satiety [1:08:15];
-Comparing the satiety effects of solid vs. liquid protein sources [1:10:30];
-Peter’s framework for incorporating protein intake into a strategy for controlling body weight [1:12:00]
-More.
--------
About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
Learn more: peterattiamd.com
Connect with Peter on:
Facebook: bit.ly/PeterAttiaMDFB
Twitter: bit.ly/PeterAttiaMDTW
Instagram: bit.ly/PeterAttiaMDIG
Subscribe to The Drive:
Apple Podcast: bit.ly/TheDriveApplePodcasts
Overcast: bit.ly/TheDriveOvercast
Spotify: bit.ly/TheDriveSpotify
Google Podcasts: bit.ly/TheDriveGoogle
Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies. For a full list of our registered and unregistered trademarks, trade names, and service marks, please review our Terms of Use: peterattiamd.com/terms-of-use
View show notes here: bit.ly/3ykzdJb
Become a member to receive exclusive content: peterattiamd.com/subscribe
Sign up to receive Peter's email newsletter: peterattiamd.com/newsletter
In this “Ask Me Anything” (AMA) episode, Peter dives into two important health topics: uric acid and protein, examining them from unique perspectives. For uric acid, he explores its metabolic role and connection to various diseases, focusing on the potential causal link with cardiovascular disease. He also discusses factors influencing uric acid levels, such as diet, genetics, and lifestyle, providing practical tips for effective management. Shifting to protein, Peter delves into its role in appetite and weight management, the consequences of insufficient protein, and the “protein leverage hypothesis” linking protein deficiency to obesity. He covers optimal protein intake and its impact on energy expenditure, and he compares the satiety effects of solid versus liquid protein. Finally, Peter shares his strategy for incorporating protein into a comprehensive weight management plan.
We discuss:
00:12 - Overview of episode topics (and an important discussion on fanny packs)
03:03 - Understanding uric acid: its role in metabolic processes, its association with gout and kidney stones, its impact on blood pressure, and more
10:03 - Non-modifiable factors that influence uric acid levels
13:39 - Modifiable factors that influence uric acid levels
20:05 - Association between high uric acid levels and cardiovascular disease
In the full episode, we also discuss:
-Evidence suggesting a causal link between high uric acid levels and cardiovascular disease [24:00];
-Inconclusive evidence about the cardiovascular benefits of lowering uric acid pharmacologically [28:15];
-Exploring the potential risks of low uric acid levels in neurodegenerative diseases [37:00];
-Managing uric acid levels: dietary interventions and pharmacological approaches [42:00];
-The impact of protein on appetite and weight management [44:00];
-The consequences of insufficient protein on eating behaviors and satiety [52:15];
-The relationship between protein deficiency and obesity: exploring the “protein leverage hypothesis” [57:15];
-The impact of protein intake on energy expenditure [1:02:15];
-Determining optimal protein intake to avoid deficiency and support health [1:05:45];
-The role of different amino acids and protein sources in promoting satiety [1:08:15];
-Comparing the satiety effects of solid vs. liquid protein sources [1:10:30];
-Peter’s framework for incorporating protein intake into a strategy for controlling body weight [1:12:00]
-More.
--------
About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
Learn more: peterattiamd.com
Connect with Peter on:
Facebook: bit.ly/PeterAttiaMDFB
Twitter: bit.ly/PeterAttiaMDTW
Instagram: bit.ly/PeterAttiaMDIG
Subscribe to The Drive:
Apple Podcast: bit.ly/TheDriveApplePodcasts
Overcast: bit.ly/TheDriveOvercast
Spotify: bit.ly/TheDriveSpotify
Google Podcasts: bit.ly/TheDriveGoogle
Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies. For a full list of our registered and unregistered trademarks, trade names, and service marks, please review our Terms of Use: peterattiamd.com/terms-of-use
