Uploaded April 2026 | Updated September 2026, 2 weeks ago
To support my work: patreon.com/statedclearly
To support ClockWork Biology: patreon.com/clockworkshow
Special thanks to @Clockworkbio and for @Spronk3d for their extremely useful protein animations.
How do proteins really work and evolve? This video is where you'll find out!
LEARN MORE:
To see David Goodsell's interactive protein tour, go here: cdn.rcsb.org/pdb101/molecular-machinery
To see David's amazing biochemistry art, go here: pdb101.rcsb.org/sci-art/goodsell-gallery
FURTHER READING:
Brownian Motion at the level of proteins: journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000694
How Lysozymes work as "Brownian motors": pmc.ncbi.nlm.nih.gov/articles/PMC4916960
How Lac Repressor works: pmc.ncbi.nlm.nih.gov/articles/PMC220206
For protein surface charges I used PyMol. Surface charges were estimated and colored using APBS Electrostatics by:
Dolinsky TJ, Nielsen JE, McCammon JA, Baker NA.
PDB2PQR: an automated pipeline for the setup, execution, and analysis of Poisson-Boltzmann electrostatics calculations. Nucleic Acids Research 32 W665-W667 (2004).
To support my work: patreon.com/statedclearly
To support ClockWork Biology: patreon.com/clockworkshow
Special thanks to @Clockworkbio and for @Spronk3d for their extremely useful protein animations.
How do proteins really work and evolve? This video is where you'll find out!
LEARN MORE:
To see David Goodsell's interactive protein tour, go here: cdn.rcsb.org/pdb101/molecular-machinery
To see David's amazing biochemistry art, go here: pdb101.rcsb.org/sci-art/goodsell-gallery
FURTHER READING:
Brownian Motion at the level of proteins: journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000694
How Lysozymes work as "Brownian motors": pmc.ncbi.nlm.nih.gov/articles/PMC4916960
How Lac Repressor works: pmc.ncbi.nlm.nih.gov/articles/PMC220206
For protein surface charges I used PyMol. Surface charges were estimated and colored using APBS Electrostatics by:
Dolinsky TJ, Nielsen JE, McCammon JA, Baker NA.
PDB2PQR: an automated pipeline for the setup, execution, and analysis of Poisson-Boltzmann electrostatics calculations. Nucleic Acids Research 32 W665-W667 (2004).
