Uploaded October 2025 | Updated September 2026, 2 weeks ago
In this special Complex Care Journal Club podcast episode, co-hosts Kilby Mann, Kristie Malik, and Kathleen Huth interview presenters of posters relevant to the care of children with medical complexity at the American Academy of Pediatrics 2025 National Conference & Exhibition. Speakers describe their study findings and implications for practice. Dr. Rishi Agrawal discusses the role of the Council on Children with Disabilities in translating research into improved clinical care and advocacy for children with medical complexity.
SPEAKERS
Rishi Agrawal, MD, MPH
Professor of Pediatrics,
Northwestern University Feinberg School of Medicine,
Attending Physician,
Ann & Robert H. Lurie Children's Hospital of Chicago
Elizabeth Avery Hill, DO
Assistant Professor,
University of Utah
Michelle Melicosta, MD, MPH, MSC
Associate Chief Medical Officer,
Kennedy Krieger Institute,
Assistant Professor,
Johns Hopkins University School of Medicine
Patricia Notario, MD
Medical Director of the Pediatric Complex Care Program,
Billings Clinic
Prasiddha Parthasarathy, MD
Resident,
University of Toronto
HOSTS
Kristina Malik, MD
Assistant Professor of Pediatrics,
University of Colorado School of Medicine
Medical Director, KidStreet
Pediatrician, Special Care Clinic,
Children's Hospital Colorado
Kilby Mann, MD
Assistant Professor
Pediatric Rehabilitation Medicine
Children's Hospital Colorado
Kathleen Huth, MD, MMSc
Pediatrician, Complex Care Service, Division of General Pediatrics
Boston Children's Hospital
Assistant Professor of Pediatrics
Harvard Medical School
DATE
Initial publication date: October 14, 2025.
RESOURCES REFERENCED
Project ECHO/ECHO Model: https://projectecho.unm.edu/model/
Council on Children with Disabilities (COCWD): aap.org/en/community/aap-councils/council-on-children-with-disabilities
AAP Experience National Conference Denver 2025 - Conference Schedule: aapexperience.org/schedule
TRANSCRIPT
cdn.bfldr.com/D6LGWP8S/at/m48sjfwmqfnrfwnxg8p7p88/CCJCP_2025_AAP_conference_10-13-25.pdf
Clinicians across healthcare professions, advocates, researchers, and patients/families are all encouraged to engage and provide feedback! You can recommend an article for discussion using this form: https://forms.gle/Bdxb86Sw5qq1uFhW6.
Please visit: openpediatrics.org
OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access, thus at no expense to the user.
For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
Please note: OPENPediatrics does not support or control any related videos in the sidebar; these are placed by YouTube. We apologize for any inconvenience this may cause.
CITATION
Mann K, Malik K, Agrawal R, Hill EA, Melicosta M, Notario P, Parthasarathy P, Huth K. Practice-Changing Research in Complex Care at the American Academy of Pediatrics Conference 2025. 10/2025. OPENPediatrics. Online Podcast. youtu.be/hF43kyuU268.
In this special Complex Care Journal Club podcast episode, co-hosts Kilby Mann, Kristie Malik, and Kathleen Huth interview presenters of posters relevant to the care of children with medical complexity at the American Academy of Pediatrics 2025 National Conference & Exhibition. Speakers describe their study findings and implications for practice. Dr. Rishi Agrawal discusses the role of the Council on Children with Disabilities in translating research into improved clinical care and advocacy for children with medical complexity.
SPEAKERS
Rishi Agrawal, MD, MPH
Professor of Pediatrics,
Northwestern University Feinberg School of Medicine,
Attending Physician,
Ann & Robert H. Lurie Children's Hospital of Chicago
Elizabeth Avery Hill, DO
Assistant Professor,
University of Utah
Michelle Melicosta, MD, MPH, MSC
Associate Chief Medical Officer,
Kennedy Krieger Institute,
Assistant Professor,
Johns Hopkins University School of Medicine
Patricia Notario, MD
Medical Director of the Pediatric Complex Care Program,
Billings Clinic
Prasiddha Parthasarathy, MD
Resident,
University of Toronto
HOSTS
Kristina Malik, MD
Assistant Professor of Pediatrics,
University of Colorado School of Medicine
Medical Director, KidStreet
Pediatrician, Special Care Clinic,
Children's Hospital Colorado
Kilby Mann, MD
Assistant Professor
Pediatric Rehabilitation Medicine
Children's Hospital Colorado
Kathleen Huth, MD, MMSc
Pediatrician, Complex Care Service, Division of General Pediatrics
Boston Children's Hospital
Assistant Professor of Pediatrics
Harvard Medical School
DATE
Initial publication date: October 14, 2025.
RESOURCES REFERENCED
Project ECHO/ECHO Model: https://projectecho.unm.edu/model/
Council on Children with Disabilities (COCWD): aap.org/en/community/aap-councils/council-on-children-with-disabilities
AAP Experience National Conference Denver 2025 - Conference Schedule: aapexperience.org/schedule
TRANSCRIPT
cdn.bfldr.com/D6LGWP8S/at/m48sjfwmqfnrfwnxg8p7p88/CCJCP_2025_AAP_conference_10-13-25.pdf
Clinicians across healthcare professions, advocates, researchers, and patients/families are all encouraged to engage and provide feedback! You can recommend an article for discussion using this form: https://forms.gle/Bdxb86Sw5qq1uFhW6.
Please visit: openpediatrics.org
OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access, thus at no expense to the user.
For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
Please note: OPENPediatrics does not support or control any related videos in the sidebar; these are placed by YouTube. We apologize for any inconvenience this may cause.
CITATION
Mann K, Malik K, Agrawal R, Hill EA, Melicosta M, Notario P, Parthasarathy P, Huth K. Practice-Changing Research in Complex Care at the American Academy of Pediatrics Conference 2025. 10/2025. OPENPediatrics. Online Podcast. youtu.be/hF43kyuU268.
![Immunoparalysis and the Future of Personalized Immunotherapy for Critically Ill Children by M. Hall
In this World Shared Practice Forum Podcast, Dr. Mark Hall discusses immunology and inflammation in pediatric sepsis treatment, using immune phenotyping to personalize treatment for pediatric sepsis.
LEARNING OBJECTIVES
Upon listening to this presentation, learners will be able to:
- Recall the history of understanding the inflammatory response in critically ill children
- Identify the distinction between the pro-inflammatory response and the immune paralysis phenomenon
- Describe the study of immune phenotyping to personalize treatment for pediatric sepsis
AUTHORS
Mark W. Hall, MD, FAAP, FCCM
Chief, Division of Critical Care Medicine
Nationwide Childrens Hospital
Professor in the Department of Pediatrics
Division of Critical Care Medicine
Nationwide Childrens Hospital and The Ohio State University College of Medicine
Jeffrey Burns, MD, MPH
Chief and Shapiro Chair, Division of Critical Care Medicine; Executive Chair, International Health Services
Senior Associate in Critical Care Medicine; Department of Anesthesiology, Critical Care and Pain Medicine
Boston Childrens Hospital
Professor of Anesthesia
Harvard Medical School
DATES
Initial publication: November 27, 2023.
ARTICLES REFERENCED
15:48: Cornell TT, Sun L, Hall MW, et al. Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2012;143(5):1160-1166.e1. doi:10.1016/j.jtcvs.2011.09.011
16:10 Collaborative Pediatric Critical Care Research Network, https://www.cpccrn.org/
17:04 VanBuren JM, Hall M, Zuppa AF, et al. The Design of Nested Adaptive Clinical Trials of Multiple Organ Dysfunction Syndrome Children in a Single Study [published online ahead of print, 2023 Jul 27]. Pediatr Crit Care Med. 2023;10.1097/PCC.0000000000003332. doi:10.1097/PCC.0000000000003332
Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
CITATION
Hall MW, O’Hara JE, Burns JP. Immunoparalysis and the Future of Personalized Immunotherapy for Critically Ill Children. 11/2023. OPENPediatrics. Online Podcast. https://youtu.be/hImZGqcd1Uo. Immunoparalysis and the Future of Personalized Immunotherapy for Critically Ill Children by M. Hall](https://i.ytimg.com/vi/hImZGqcd1Uo/mqdefault.jpg)









