Uploaded June 2025 | Updated September 2026, 1 week ago
Caption: Rendered animation showing the major stages of physically-applied digital restoration. From a scan of the damaged painting, a laminate mask is constructed and applied to restore various kinds of damage. Credit: Alex Kachkine
Abstract
Conservation of damaged oil paintings requires manual inpainting of losses, leading to months-long treatments of considerable expense; 70% of paintings in institutional collections are locked away from public view, in part because of treatment cost. Recent advancements in digital image reconstruction have helped to envision treatment results, although without any direct means of achieving them. Here I describe the physically applied digital restoration of a painting, a highly damaged oil-on-panel attributed to the Master of the Prado Adoration from the late fifteenth century. In parallel, 5,612 losses spanning 66,205 mm2 and 57,314 colours were infilled with a reversible laminate mask comprising a colour-accurate bilayer of printed pigments on polymeric films. To ensure the effectiveness of the restoration, ethical principles in painting conservation were implemented quantitatively for digital mask construction, a critically important foundation lacking in the current digital restoration literature. The infill process took 3.5 h, an estimated 66 times faster than conventional inpainting, and the result closely matched the simulation. This approach grants greatly increased foresight and flexibility to conservators, enabling the restoration of countless damaged paintings deemed unworthy of high conservation budgets.
Kachkine, A. Physical restoration of a painting with a digitally constructed mask. Nature 642, 343–350 (2025). doi.org/10.1038/s41586-025-09045-4
Caption: Rendered animation showing the major stages of physically-applied digital restoration. From a scan of the damaged painting, a laminate mask is constructed and applied to restore various kinds of damage. Credit: Alex Kachkine
Abstract
Conservation of damaged oil paintings requires manual inpainting of losses, leading to months-long treatments of considerable expense; 70% of paintings in institutional collections are locked away from public view, in part because of treatment cost. Recent advancements in digital image reconstruction have helped to envision treatment results, although without any direct means of achieving them. Here I describe the physically applied digital restoration of a painting, a highly damaged oil-on-panel attributed to the Master of the Prado Adoration from the late fifteenth century. In parallel, 5,612 losses spanning 66,205 mm2 and 57,314 colours were infilled with a reversible laminate mask comprising a colour-accurate bilayer of printed pigments on polymeric films. To ensure the effectiveness of the restoration, ethical principles in painting conservation were implemented quantitatively for digital mask construction, a critically important foundation lacking in the current digital restoration literature. The infill process took 3.5 h, an estimated 66 times faster than conventional inpainting, and the result closely matched the simulation. This approach grants greatly increased foresight and flexibility to conservators, enabling the restoration of countless damaged paintings deemed unworthy of high conservation budgets.
Kachkine, A. Physical restoration of a painting with a digitally constructed mask. Nature 642, 343–350 (2025). doi.org/10.1038/s41586-025-09045-4



![Pedaling in MRI machine
Purpose
To evaluate the effects of exercise on left ventricular parameters using exercise cardiac MRI in healthy adults without known cardiovascular disease and establish reference ranges stratified by age and sex.
Materials and Methods
This prospective study included healthy adult participants with no known cardiovascular disease or genetic variants associated with cardiomyopathy, enrolled between January 2018 and April 2021, who underwent exercise cardiac MRI evaluation. Participants were imaged at rest and after exercise, and parameters were measured by two readers. Prediction intervals were calculated and compared across sex and age groups.
Results
The study included 161 participants (mean age, 49 years ± 14 [SD]; 85 female). Compared with the resting state, exercise caused an increase in heart rate (64 beats per minute ± 9 vs 133 beats per minute ± 19, P less than .001), left ventricular end-diastolic volume (140 mL ± 32 vs 148 mL ± 35, P less than .001), stroke volume (82 mL ± 18 vs 102 mL ± 25, P less than .001), ejection fraction (59% ± 6 vs 69% ± 7, P less than .001), and cardiac output (5.2 L/min ± 1.1 vs 13.5 L/min ± 3.9, P less than .001) and a decrease in left ventricular end-systolic volume (58 mL ± 18 vs 46 mL ± 15, P less than .001). There were statistically significant differences in exercise response between groups stratified by sex and age for most parameters.
Conclusion
In healthy adults, an increase in cardiac output after exercise was driven by an increase in heart rate with both increased ventricular filling and emptying. Normal ranges for exercise response, stratified by age and sex, were established as a reference for the use of exercise cardiac MRI in clinical practice.
Ronny Schweitzer et al. Radiology: Cardiothoracic Imaging. Published Online:Jun 5 2025. https://doi.org/10.1148/ryct.240175 Pedaling in MRI machine](https://i.ytimg.com/vi/x-WuaLQc2Nc/mqdefault.jpg)






