Uploaded December 2018 | Updated September 2026, 2 hours ago

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Experience the PGI enzyme in a unique way. Dive into the active site, examine the reaction mechanism, and explore the interactions that stabilize an protein dimer.

Link to a 3D version of this video: youtu.be/SqwrDMYarGg

Model your own proteins!
pymol.org/edu/?q=educational
jmol.sourceforge.net/download

Find PGI in the PDB: rcsb.org
PDB files used in this video: 1dqr, 1hox, 1g98, 1jih

Primary References: •Jeffery, C. J., Bahnson, B. J., Chien, W., Ringe, D., & Petsko, G. A. Biochemistry, 2000, 39(5), 955-964.
• Lee, J. H., Chang, K. Z., Patel, V., & Jeffery, C. J. Biochemistry, 2001, 40(26), 7799-7805.