Uploaded August 2026 | Updated September 2026, 2 weeks ago
From the Radiolab podcast: The shadowy figure at the center of the greatest mysteries.
The greatest mysteries have a shadowy figure at the center—someone who sets things in motion and holds the key to how the story unfolds. In epidemiology, this central character is known as Patient Zero—the case at the heart of an outbreak. This hour, Radiolab digs up an episode we first produced in 2011 and hunts for Patient Zeroes from all over the map. We start with the story of perhaps the most iconic Patient Zero of all time: Typhoid Mary. Then, we dive into a molecular detective story to pinpoint the beginning of the AIDS, and we re-imagine the moment the virus that caused the global pandemic sprang to life. After that, we're left wondering if you can trace the spread of an idea the way you can trace the spread of a disease. In the end, we find ourselves faced with a choice between competing claims about the origin of the high five.
Episode Segments:
0:00 Chapter 1
15:37 Chapter 2
35:32 Chapter 3
50:00 Credits
51:06 Support
🎧 Subscribe to Radiolab wherever you listen to podcasts: lnk.to/radiolab!youtube
🔎 Subscribe to Radiolab on YouTube: bit.ly/3I9KI53
🖋 Subscribe to Radiolab’s Newsletter: radiolab.org/newsletter
🌱 Check out Radiolab's Starter Kit Playlist: bit.ly/3sX8f4P
👍 Like this video ✏️ and leave us a comment!
Follow Radiolab:
Instagram — instagram.com/radiolab
X — https://x.com/Radiolab
Facebook — facebook.com/Radiolab
Threads — threads.net/@radiolab
TikTok — tiktok.com/@radiolab
Our newsletter includes short essays, recommendations, and details about other ways to interact with the show. Sign up here: radiolab.org/newsletter
Support Radiolab by becoming a member of The Lab today: radiolab.org/the-lab
Video by Joanna Strogatz
From the Radiolab podcast: The shadowy figure at the center of the greatest mysteries.
The greatest mysteries have a shadowy figure at the center—someone who sets things in motion and holds the key to how the story unfolds. In epidemiology, this central character is known as Patient Zero—the case at the heart of an outbreak. This hour, Radiolab digs up an episode we first produced in 2011 and hunts for Patient Zeroes from all over the map. We start with the story of perhaps the most iconic Patient Zero of all time: Typhoid Mary. Then, we dive into a molecular detective story to pinpoint the beginning of the AIDS, and we re-imagine the moment the virus that caused the global pandemic sprang to life. After that, we're left wondering if you can trace the spread of an idea the way you can trace the spread of a disease. In the end, we find ourselves faced with a choice between competing claims about the origin of the high five.
Episode Segments:
0:00 Chapter 1
15:37 Chapter 2
35:32 Chapter 3
50:00 Credits
51:06 Support
🎧 Subscribe to Radiolab wherever you listen to podcasts: lnk.to/radiolab!youtube
🔎 Subscribe to Radiolab on YouTube: bit.ly/3I9KI53
🖋 Subscribe to Radiolab’s Newsletter: radiolab.org/newsletter
🌱 Check out Radiolab's Starter Kit Playlist: bit.ly/3sX8f4P
👍 Like this video ✏️ and leave us a comment!
Follow Radiolab:
Instagram — instagram.com/radiolab
X — https://x.com/Radiolab
Facebook — facebook.com/Radiolab
Threads — threads.net/@radiolab
TikTok — tiktok.com/@radiolab
Our newsletter includes short essays, recommendations, and details about other ways to interact with the show. Sign up here: radiolab.org/newsletter
Support Radiolab by becoming a member of The Lab today: radiolab.org/the-lab
Video by Joanna Strogatz
