Uploaded August 2026 | Updated September 2026, 2 weeks ago
Lesson 2 from analyzing 1,000 studies: GLP-1 drugs may do more than reduce body fat.
Early research suggests that GLP-1 receptor agonists may also improve liver health and potentially slow—or partially reverse—changes associated with osteoarthritis.
Preclinical research on retatrutide is also especially interesting: animals lost weight while maintaining energy expenditure, unlike animals losing the same amount of weight through calorie restriction.
That metabolism-preserving finding has not yet been firmly established in humans, so it remains preliminary.
These drugs can also cause side effects, particularly gastrointestinal discomfort, and should be used under medical supervision.
The full analysis is available to Physionic Insiders through the link in my bio of all my YouTube videos.
References:
Qin H, et al. Cell Metab. 2026;38:582-597. doi:10.1016/j.cmet.2026.01.008
Gonzalez-Rellan MJ, et al. Cell Metab. Published online 2026. doi:10.1016/j.cmet.2026.03.011
Newsome PN, et al. N Engl J Med. 2021;384(12):1113-1124. doi:10.1056/NEJMoa2028395
Sanyal AJ, et al. N Engl J Med. 2025;392(21):2089-2099. doi:10.1056/NEJMoa2413258
Coskun T, et al. Cell Metab. 2022;34(9):1234-1247. doi:10.1016/j.cmet.2022.07.013
Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526. doi:10.1056/NEJMoa2301972
Lesson 2 from analyzing 1,000 studies: GLP-1 drugs may do more than reduce body fat.
Early research suggests that GLP-1 receptor agonists may also improve liver health and potentially slow—or partially reverse—changes associated with osteoarthritis.
Preclinical research on retatrutide is also especially interesting: animals lost weight while maintaining energy expenditure, unlike animals losing the same amount of weight through calorie restriction.
That metabolism-preserving finding has not yet been firmly established in humans, so it remains preliminary.
These drugs can also cause side effects, particularly gastrointestinal discomfort, and should be used under medical supervision.
The full analysis is available to Physionic Insiders through the link in my bio of all my YouTube videos.
References:
Qin H, et al. Cell Metab. 2026;38:582-597. doi:10.1016/j.cmet.2026.01.008
Gonzalez-Rellan MJ, et al. Cell Metab. Published online 2026. doi:10.1016/j.cmet.2026.03.011
Newsome PN, et al. N Engl J Med. 2021;384(12):1113-1124. doi:10.1056/NEJMoa2028395
Sanyal AJ, et al. N Engl J Med. 2025;392(21):2089-2099. doi:10.1056/NEJMoa2413258
Coskun T, et al. Cell Metab. 2022;34(9):1234-1247. doi:10.1016/j.cmet.2022.07.013
Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526. doi:10.1056/NEJMoa2301972
